october, 2018

12oct1:00 pm- 2:00 pmIBEST VISITING LECTURER SERIES: DR. AMY ROWAT

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Event Details

Title:  “Harnessing Cellular Mechanotype: From Screening to Disease Biophysics”

Amy Rowat, PhD, Harvard University Postdoctoral Research Fellow, University of California, Los Angeles

iBEST Visiting Lecturer Series (Amy Rowat, October 12th, 2018)

Presenting on behalf of the Biomedical Delivery Systems (BDS) Research Theme.
Date: October 12th, 2018 | 1-2pm
Location: Allan Waters Family Auditorium, 2nd floor, Li Ka Shing Knowledge Institute, 209 Victoria Street, St. Michael’s Hospital

RESEARCH

My laboratory aims to characterize the physical and mechanical properties of biological matter, infer their molecular origins, and uncover their role in physiological processes. We focus on two broad questions: (1) What are the molecular origins of cell and nuclear physical properties? (2) What are the consequences of cell and nuclear physical properties in physiology and disease? The physical properties of cells and nuclei are central to genome integrity, gene expression, and mechanotransduction; while altered cell mechanotype is the hallmark of a wide variety of diseases from cancer to laminopathies, the origins and consequences of these physical changes are incompletely understood. To achieve this goal, we study the mechanical properties of populations of single cells, using insights from physics and engineering to design new experiments and analyze biological processes ranging from metastasis to mechanotransduction. We also develop novel high throughput technologies to screen cells based on their mechanotype. Our focus on cell mechanotype in physiology and disease is multifaceted and involves the integration of mechanotyping results with data from gene and protein expression, bioinformatics analyses, and functional assays. This new class of experiments will enable us to build a deeper fundamental understanding of the origins of cell mechanical properties and advance mechanotype for clinical applications.

No sign-up required. For more information contact the iBEST Coordinator, Imran Sheikh (ibest@ryerson.ca).

Time

(Friday) 1:00 pm - 2:00 pm

Location

Allan Waters Family Auditorium, 2nd floor, Li Ka Shing Knowledge Institute, 209 Victoria Street, St. Michael’s Hospital

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