The Subarachnoid Hemorrhage International Trialists (SAHIT)

The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository is a combined database of many of the most recent clinical trials that have been conducted in subarachnoid hemorrhage.

The aim of this database is to provide a pooled resource from which more representative analyses could be performed that researchers around the world use to plan future clinical trials. This pooled resource will guide clinical trials in subarachnoid hemorrhage as well as aid in the development of prognostic models of subarachnoid hemorrhage. This repository currently contains data on 14,000+ SAH patients from sites all over North America, Europe, Asia, and Australia.

This project includes individuals from an abundance of backgrounds participating including; St. Michael’s Hospital, University of Toronto (Canada); Heinrich Heine University (Germany); University of Iowa, Columbia University, University of Pennsylvania (United States of America); Oxford University, The General Infirmary, King’s College London (United Kingdom); Medical Center Utrecht (The Netherlands); Chinese University of Hong Kong (People’s Republic of China).

Our Collaborators

Data


No. of PatientsCourtesy of/ Facilitator/ Principal Investigator
IHAST: Intraoperative hypothermia for aneurysm surgery trial1001Michael Todd
ALISAH: Albumin in Subarachnoid Hemorrhage trial47Jose Suarez
MAPS: Matrix and platinum science trials228Clay S. Johnston
ISAT: International subarachnoid aneurysm trial2143Andrew Molyneux
HHU: Concomitant Intraventricular Fibrinolysis and Low-Frequency Rotation After Severe Subarachnoid Hemorrhage Trial of Heinrick Heine University, Germany60Nima Etminan and Daniel Hangg
BRANT: British Nimodipine trial554Gordon Murray and John Pickard
Tirilazad trials3552R. Loch Macdonald
CONSCIOUS-1 trial413R. Loch Macdonald
MASH: Magnesium sulfate in aneurysmal subarachnoid hemorrhage trial1484Walter M. van den Bergh
EPO/Statin: Systemic erythropoietin/ Pravastatin therapy in SAH trial160Ming-Yuan Tseng and Peter J. Kirkpatrick
IMASH: Intravenous magnesium sulphate for aneurysmal subarachnoid327George Wong
DataNo. of PatientsCourtesy of/ Facilitator/ Principal Investigator
CARAT:cerebral aneurysm rerupture after
treatment
1010Clay S. Johnston
Utretch: University Medical Center Utrecht, The Netherlands433Mervyn Vergouwen, Gabriel Rinkel
SMH: St. Michael's Hospital, Toronto173R. Loch Macdonald
Leeds: University of Leeds Neurocognitive observation117Audrey Quinn
Durham: Observational neurocognitive study from University of Durham105Adam Noble, Thomas Schenk
D-SAT: Database of Subarachnoid treatment of the University of Washington439Peter Le Roux
Chicago: SAH registry of the University of Chicago75R. Loch Macdonald
SHOP: Subarachnoid hemorrhage
outcomes project of Columbia University
1500Stephan Mayer

Current Projects

SAHIT Member Login
To access this area you must be a SAHIT member. Email sahit@smh.ca for more information.

Publications

  • Jaja BN, Lingsma H, Schweizer TA, Thorpe KE, Steyerberg EW, Macdonald RL; on behalf of the SAHIT collaboration.Prognostic value of premorbid hypertension and neurological status in aneurysmal subarachnoid hemorrhage: pooled analyses of individual patient data in the SAHIT repository. J Neurosurg. 2015 Jan 2:1-9.
  • Jaja BN, Attalla D, Macdonald RL, Schweizer TA, Cusimano MD, Etminan N, Hanggi D, Hasan D, Johnston SC, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Noble A, Quinn A, Schenk T, Spears J, Singh J, Todd M, Torner J, Tseng M, van den Bergh W, Vergouwen MD, Wong GK.The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage. Neurocrit Care. 2014 Dec;21(3):551-9. doi: 10.1007/s12028-014-9990-y.
  • Macdonald RL, Jaja B, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK, Singh J; SAHIT Collaboration. SAHIT Investigators–on the outcome of some subarachnoid hemorrhage clinical trials. Transl Stroke Res. 2013 Jun;4(3):286-96. doi: 10.1007/s12975-012-0242-1. Epub 2013 Jan 7.
  • Macdonald RL, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Jaja B, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK; SAHIT Collaboration. Subarachnoid Hemorrhage International Trialists data repository (SAHIT). World Neurosurg. 2013 Mar-Apr;79(3-4):418-22. doi: 10.1016/j.wneu.2013.01.006. Epub 2013 Jan 4.
  • Jaja BN, Cusimano MD, Etminan N, Hanggi D, Hasan D, Ilodigwe D, Lantigua H, Le Roux P, Lo B, Louffat-Olivares A, Mayer S, Molyneux A, Quinn A, Schweizer TA, Schenk T, Spears J, Todd M, Torner J, Vergouwen MD, Wong GK, Singh J, Macdonald RL. Clinical prediction models for aneurysmal subarachnoid hemorrhage: a systematic review. Neurocrit Care. 2013 Feb;18(1):143-53. doi: 10.1007/s12028-012-9792-z.
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