Trauma

Our focus is to derive and evaluate processes of care and timely interventions that improve outcomes for patients who suffer life threatening trauma in the out of hospital setting. We have recently received awards for outstanding work in trauma from the American Heart Association and the National Association of EMS Physicians.


Featured Studies

Prehospital Tranexamic Acid Use for Traumatic Brain Injury: TXA Study

The Resuscitation Outcome Consortium’s (ROC) TXA Study is a phase II multi-site, randomized double-blind placebo controlled trial. This study looks at individuals with life threatening or life altering traumatic brain injury, to assess if they do better when they receive a drug known as Tranexamic Acid, in order to stabilize their bleeding compared to when they do not receive the drug in a prehospital setting. 

This study will be conducted in 10 participating ROC sites across the United States and Canada with a total expected enrollment of 963 patients.  The study is funded by the United States Department of Defense, the National Institute of Health, Defense Research and Development Canada, and the Heart and Stroke Foundation of Canada. The participating Emergency Paramedic Services from the Toronto Regional RescuNet are Toronto Paramedic Services and Air Ornge.  

The Toronto site ROC Principal Investigator for the study is Dr. Laurie Morrison, St. Michael’s Hospital; the study site investigators are Dr. Sandro Rizoli (St. Michael’s) and Dr. Barto Nascimento (Sunnybrook). 

ClinicalTrial.gov: NCT01990768

Update – Jan 25, 2017: ROC TXA study has enrolled 55 patients for the Toronto Site and 882 patients across all ROC sites.

Below are the most recent enrollment numbers for Toronto:

 Toronto Paramedic ServicesOrnge
St. Michael's Hospital710
Sunnybrook 2413
Other Hospital1


Completed Studies

  • ALPS – Amiodarone, lidocaine or placebo for out-of-hospital cardiac arrest due to ventricular fibrillation or tachycardia
  • BLAST – Biomarker Lactate Assessment of Shock in Trauma
  • CCC – Continuous Compressions vs Standard CPR
  • HS – Hypertonic Saline in Trauma Patients in Shock
  • PRIMED – Prehospital Resuscitation using an IMpedance valve and Early vs Delayed analysis
  • PROPHET – Prospective Observational Prehospital and Hospital Registry for Trauma
  • PROPPR – Pragmatic, Randomized Optimal Platelet and Plasma Ratios

For information on completed ROC studies click here

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