Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Abrams, D, MacLaren, G, Lorusso, R, Price, S, Yannopoulos, D, Vercaemst, L et al.. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive Care Med. 2021; :. doi: 10.1007/s00134-021-06514-y. PubMed PMID:34505911 PubMed Central PMC8429884.
  2. Amado-Rodríguez, L, Del Busto, C, López-Alonso, I, Parra, D, Mayordomo-Colunga, J, Arias-Guillén, M et al.. Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial. Ann Intensive Care. 2021;11 (1):132. doi: 10.1186/s13613-021-00919-0. PubMed PMID:34453620 PubMed Central PMC8397875.
  3. REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher, EC, Bradbury, CA, McVerry, BJ et al.. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):777-789. doi: 10.1056/NEJMoa2103417. PubMed PMID:34351722 PubMed Central PMC8362592.
  4. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler, PR, Goligher, EC, Berger, JS et al.. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):790-802. doi: 10.1056/NEJMoa2105911. PubMed PMID:34351721 PubMed Central PMC8362594.
  5. Costa, ELV, Slutsky, AS, Amato, MBP. Reply to Camporota et al.: The 4DPRR Index and Mechanical Power: A Step Ahead or 4 Steps Backward?. Am J Respir Crit Care Med. 2021;204 (4):492-493. doi: 10.1164/rccm.202105-1113LE. PubMed PMID:34081876 .
  6. Trahtemberg, U, Fritzler, MJ, On behalf of the COVID-19 chapter of the “Longitudinal Biomarkers in Lung Injury” study group. COVID-19-associated autoimmunity as a feature of acute respiratory failure. Intensive Care Med. 2021;47 (7):801-804. doi: 10.1007/s00134-021-06408-z. PubMed PMID:33928414 PubMed Central PMC8084710.
  7. Trahtemberg, U, Rottapel, R, Dos Santos, CC, Slutsky, AS, Baker, A, Fritzler, MJ et al.. Anticardiolipin and other antiphospholipid antibodies in critically ill COVID-19 positive and negative patients. Ann Rheum Dis. 2021;80 (9):1236-1240. doi: 10.1136/annrheumdis-2021-220206. PubMed PMID:33903092 PubMed Central PMC8076626.
  8. Madotto, F, McNicholas, B, Rezoagli, E, Pham, T, Laffey, JG, Bellani, G et al.. Death in hospital following ICU discharge: insights from the LUNG SAFE study. Crit Care. 2021;25 (1):144. doi: 10.1186/s13054-021-03465-0. PubMed PMID:33849625 PubMed Central PMC8043098.
  9. Costa, ELV, Slutsky, AS, Brochard, LJ, Brower, R, Serpa-Neto, A, Cavalcanti, AB et al.. Ventilatory Variables and Mechanical Power in Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2021;204 (3):303-311. doi: 10.1164/rccm.202009-3467OC. PubMed PMID:33784486 .
  10. Burns, KEA, Rizvi, L, Cook, DJ, Lebovic, G, Dodek, P, Villar, J et al.. Ventilator Weaning and Discontinuation Practices for Critically Ill Patients. JAMA. 2021;325 (12):1173-1184. doi: 10.1001/jama.2021.2384. PubMed PMID:33755077 PubMed Central PMC7988370.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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