Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Del Sorbo, L, Hubmayr, R, Slutsky, AS. Mechanical Ventilation in Acute Respiratory Distress Syndrome: Time Heals All Wounds, or Does It?. Anesthesiology. 2019; :. doi: 10.1097/ALN.0000000000002671. PubMed PMID:30870162 .
  2. Abrams, D, Ferguson, ND, Brochard, L, Fan, E, Mercat, A, Combes, A et al.. ECMO for ARDS: from salvage to standard of care?. Lancet Respir Med. 2019;7 (2):108-110. doi: 10.1016/S2213-2600(18)30506-X. PubMed PMID:30642778 .
  3. Dufresne, J, Bowden, P, Thavarajah, T, Florentinus-Mefailoski, A, Chen, ZZ, Tucholska, M et al.. The plasma peptides of ovarian cancer. Clin Proteomics. 2018;15 :41. doi: 10.1186/s12014-018-9215-z. PubMed PMID:30598658 PubMed Central PMC6302491.
  4. Dufresne, J, Bowden, P, Thavarajah, T, Florentinus-Mefailoski, A, Chen, ZZ, Tucholska, M et al.. The plasma peptidome. Clin Proteomics. 2018;15 :39. doi: 10.1186/s12014-018-9211-3. PubMed PMID:30519149 PubMed Central PMC6271647.
  5. Pham, T, Serpa Neto, A, Pelosi, P, Laffey, JG, De Haro, C, Lorente, JA et al.. Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study. Anesthesiology. 2019;130 (2):263-283. doi: 10.1097/ALN.0000000000002508. PubMed PMID:30499850 .
  6. Boyle, AJ, Sklar, MC, McNamee, JJ, Brodie, D, Slutsky, AS, Brochard, L et al.. Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future. Lancet Respir Med. 2018;6 (11):874-884. doi: 10.1016/S2213-2600(18)30326-6. PubMed PMID:30484429 .
  7. Fujiwara, S, Hoshizaki, M, Ichida, Y, Lex, D, Kuroda, E, Ishii, KJ et al.. Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nat Microbiol. 2019;4 (2):258-268. doi: 10.1038/s41564-018-0289-1. PubMed PMID:30455472 .
  8. Goligher, EC, Brochard, LJ, Reid, WD, Fan, E, Saarela, O, Slutsky, AS et al.. Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure. Lancet Respir Med. 2019;7 (1):90-98. doi: 10.1016/S2213-2600(18)30366-7. PubMed PMID:30455078 .
  9. Liu, L, Yang, Y, Gao, Z, Li, M, Mu, X, Ma, X et al.. Practice of diagnosis and management of acute respiratory distress syndrome in mainland China: a cross-sectional study. J Thorac Dis. 2018;10 (9):5394-5404. doi: 10.21037/jtd.2018.08.137. PubMed PMID:30416787 PubMed Central PMC6196194.
  10. Villar, J, Zhang, H, Slutsky, AS. Lung Repair and Regeneration in ARDS: Role of PECAM1 and Wnt Signaling. Chest. 2019;155 (3):587-594. doi: 10.1016/j.chest.2018.10.022. PubMed PMID:30392791 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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