Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Vice President, Research

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Abrams, D, Garan, AR, Abdelbary, A, Bacchetta, M, Bartlett, RH, Beck, J et al.. Position paper for the organization of ECMO programs for cardiac failure in adults. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5064-5. PubMed PMID:29450594 .
  2. Filewod, NC, Batt, J, Kapus, A, Szaszi, K, Fairn, GD, Slutsky, AS et al.. Should basic science matter to clinicians?. Lancet. 2018;391 (10119):410-412. doi: 10.1016/S0140-6736(18)30199-5. PubMed PMID:29407017 .
  3. Brodie, D, Vincent, JL, Brochard, LJ, Combes, A, Ferguson, ND, Hodgson, CL et al.. Research in Extracorporeal Life Support: A Call to Action. Chest. 2018; :. doi: 10.1016/j.chest.2017.12.024. PubMed PMID:29355550 .
  4. Slutsky, AS. Giants in Chest Medicine: Jeffrey M. Drazen, MD, FCCP. Chest. 2018;153 (1):14-15. doi: 10.1016/j.chest.2017.10.041. PubMed PMID:29307415 .
  5. Goligher, EC, Amato, MBP, Slutsky, AS. Reply to: Precision Medicine for Extracorporeal CORemoval for ARDS: COPhysiological Considerations. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201711-2226LE. PubMed PMID:29211496 .
  6. Laffey, JG, Bellani, G, Pham, T, Fan, E, Madotto, F, Bajwa, EK et al.. Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. Intensive Care Med. 2018;44 (1):157-165. doi: 10.1007/s00134-017-4981-z. PubMed PMID:29138899 .
  7. Del Sorbo, L, Goligher, EC, McAuley, DF, Rubenfeld, GD, Brochard, LJ, Gattinoni, L et al.. Mechanical Ventilation in Adults with Acute Respiratory Distress Syndrome. Summary of the Experimental Evidence for the Clinical Practice Guideline. Ann Am Thorac Soc. 2017;14 (Supplement_4):S261-S270. doi: 10.1513/AnnalsATS.201704-345OT. PubMed PMID:28985479 .
  8. Goligher, EC, Dres, M, Fan, E, Rubenfeld, GD, Scales, DC, Herridge, MS et al.. Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes. Am. J. Respir. Crit. Care Med. 2018;197 (2):204-213. doi: 10.1164/rccm.201703-0536OC. PubMed PMID:28930478 .
  9. Chiumello, D, Brochard, L, Marini, JJ, Slutsky, AS, Mancebo, J, Ranieri, VM et al.. Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Crit Care. 2017;21 (1):240. doi: 10.1186/s13054-017-1820-0. PubMed PMID:28899408 PubMed Central PMC5596474.
  10. Pham, T, Brochard, LJ, Slutsky, AS. Mechanical Ventilation: State of the Art. Mayo Clin. Proc. 2017;92 (9):1382-1400. doi: 10.1016/j.mayocp.2017.05.004. PubMed PMID:28870355 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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