Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Vice President, Research

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

Please note: Dr. Slutsky is not taking any summer students in 2017.

Recent Publications

  1. Goligher, EC, Amato, MBP, Slutsky, AS. Applying Precision Medicine to Trial Design Using Physiology: Extracorporeal CO2 Removal for ARDS. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201701-0248CP. PubMed PMID:28636403 .
  2. Laffey, JG, Madotto, F, Bellani, G, Pham, T, Fan, E, Brochard, L et al.. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. Lancet Respir Med. 2017; :. doi: 10.1016/S2213-2600(17)30213-8. PubMed PMID:28624388 .
  3. Philip, AM, Wang, Y, Mauro, A, El-Rass, S, Marshall, JC, Lee, WL et al.. Development of a zebrafish sepsis model for high-throughput drug discovery. Mol. Med. 2017;23 :. doi: 10.2119/molmed.2016.00188. PubMed PMID:28598490 .
  4. Goligher, EC, Slutsky, AS. Not Just Oxygen? Mechanisms of Benefit from High-Flow Nasal Cannula in Hypoxemic Respiratory Failure. Am. J. Respir. Crit. Care Med. 2017;195 (9):1128-1131. doi: 10.1164/rccm.201701-0006ED. PubMed PMID:28459344 .
  5. Fan, E, Brodie, D, Slutsky, AS. Fifty Years of Research in ARDS. Mechanical Ventilation during Extracorporeal Support for Acute Respiratory Distress Syndrome. For Now, a Necessary Evil. Am. J. Respir. Crit. Care Med. 2017;195 (9):1137-1139. doi: 10.1164/rccm.201702-0292ED. PubMed PMID:28459339 .
  6. Fan, E, Del Sorbo, L, Goligher, EC, Hodgson, CL, Munshi, L, Walkey, AJ et al.. An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2017;195 (9):1253-1263. doi: 10.1164/rccm.201703-0548ST. PubMed PMID:28459336 .
  7. Russell, JA, Lee, T, Singer, J, Boyd, JH, Walley, KR, Vasopressin and Septic Shock Trial (VASST) Group et al.. The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience. Crit. Care Med. 2017;45 (6):940-948. doi: 10.1097/CCM.0000000000002323. PubMed PMID:28333757 .
  8. Meade, MO, Young, D, Hanna, S, Zhou, Q, Bachman, TE, Bollen, C et al.. Severity of Hypoxemia and Effect of High Frequency Oscillatory Ventilation in ARDS. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201609-1938OC. PubMed PMID:28245137 .
  9. Kapur, R, Kim, M, Aslam, R, McVey, MJ, Tabuchi, A, Luo, A et al.. T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. Blood. 2017;129 (18):2557-2569. doi: 10.1182/blood-2016-12-758185. PubMed PMID:28202460 PubMed Central PMC5418638.
  10. Brander, L, Moerer, O, Hedenstierna, G, Beck, J, Takala, J, Slutsky, AS et al.. Neural control of ventilation prevents both over-distension and de-recruitment of experimentally injured lungs. Respir Physiol Neurobiol. 2017;237 :57-67. doi: 10.1016/j.resp.2016.12.010. PubMed PMID:28013057 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario