Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Vice President, Research

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Goligher, EC, Dres, M, Fan, E, Rubenfeld, GD, Scales, DC, Herridge, MS et al.. Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201703-0536OC. PubMed PMID:28930478 .
  2. Chiumello, D, Brochard, L, Marini, JJ, Slutsky, AS, Mancebo, J, Ranieri, VM et al.. Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Crit Care. 2017;21 (1):240. doi: 10.1186/s13054-017-1820-0. PubMed PMID:28899408 PubMed Central PMC5596474.
  3. Pham, T, Brochard, LJ, Slutsky, AS. Mechanical Ventilation: State of the Art. Mayo Clin. Proc. 2017;92 (9):1382-1400. doi: 10.1016/j.mayocp.2017.05.004. PubMed PMID:28870355 .
  4. García-Laorden, MI, Lorente, JA, Flores, C, Slutsky, AS, Villar, J. Biomarkers for the acute respiratory distress syndrome: how to make the diagnosis more precise. Ann Transl Med. 2017;5 (14):283. doi: 10.21037/atm.2017.06.49. PubMed PMID:28828358 PubMed Central PMC5537109.
  5. Goligher, EC, Amato, MBP, Slutsky, AS. Applying Precision Medicine to Trial Design Using Physiology. Extracorporeal CO2 Removal for Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2017;196 (5):558-568. doi: 10.1164/rccm.201701-0248CP. PubMed PMID:28636403 .
  6. Laffey, JG, Madotto, F, Bellani, G, Pham, T, Fan, E, Brochard, L et al.. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. Lancet Respir Med. 2017;5 (8):627-638. doi: 10.1016/S2213-2600(17)30213-8. PubMed PMID:28624388 .
  7. Philip, AM, Wang, Y, Mauro, A, El-Rass, S, Marshall, JC, Lee, WL et al.. Development of a zebrafish sepsis model for high-throughput drug discovery. Mol. Med. 2017;23 :. doi: 10.2119/molmed.2016.00188. PubMed PMID:28598490 PubMed Central PMC5522968.
  8. Goligher, EC, Slutsky, AS. Not Just Oxygen? Mechanisms of Benefit from High-Flow Nasal Cannula in Hypoxemic Respiratory Failure. Am. J. Respir. Crit. Care Med. 2017;195 (9):1128-1131. doi: 10.1164/rccm.201701-0006ED. PubMed PMID:28459344 .
  9. Fan, E, Brodie, D, Slutsky, AS. Fifty Years of Research in ARDS. Mechanical Ventilation during Extracorporeal Support for Acute Respiratory Distress Syndrome. For Now, a Necessary Evil. Am. J. Respir. Crit. Care Med. 2017;195 (9):1137-1139. doi: 10.1164/rccm.201702-0292ED. PubMed PMID:28459339 .
  10. Fan, E, Del Sorbo, L, Goligher, EC, Hodgson, CL, Munshi, L, Walkey, AJ et al.. An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2017;195 (9):1253-1263. doi: 10.1164/rccm.201703-0548ST. PubMed PMID:28459336 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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