Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Dufresne, J, Bowden, P, Thavarajah, T, Florentinus-Mefailoski, A, Chen, ZZ, Tucholska, M et al.. The plasma peptidome. Clin Proteomics. 2018;15 :39. doi: 10.1186/s12014-018-9211-3. PubMed PMID:30519149 PubMed Central PMC6271647.
  2. Boyle, AJ, Sklar, MC, McNamee, JJ, Brodie, D, Slutsky, AS, Brochard, L et al.. Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future. Lancet Respir Med. 2018;6 (11):874-884. doi: 10.1016/S2213-2600(18)30326-6. PubMed PMID:30484429 .
  3. Fujiwara, S, Hoshizaki, M, Ichida, Y, Lex, D, Kuroda, E, Ishii, KJ et al.. Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nat Microbiol. 2018; :. doi: 10.1038/s41564-018-0289-1. PubMed PMID:30455472 .
  4. Goligher, EC, Brochard, LJ, Reid, WD, Fan, E, Saarela, O, Slutsky, AS et al.. Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure. Lancet Respir Med. 2018; :. doi: 10.1016/S2213-2600(18)30366-7. PubMed PMID:30455078 .
  5. Liu, L, Yang, Y, Gao, Z, Li, M, Mu, X, Ma, X et al.. Practice of diagnosis and management of acute respiratory distress syndrome in mainland China: a cross-sectional study. J Thorac Dis. 2018;10 (9):5394-5404. doi: 10.21037/jtd.2018.08.137. PubMed PMID:30416787 PubMed Central PMC6196194.
  6. Villar, J, Zhang, H, Slutsky, AS. Lung Repair and Regeneration in Acute Respiratory Distress Syndrome: Role of PECAM1 and Wnt Signaling. Chest. 2018; :. doi: 10.1016/j.chest.2018.10.022. PubMed PMID:30392791 .
  7. Goligher, EC, Tomlinson, G, Hajage, D, Wijeysundera, DN, Fan, E, Jüni, P et al.. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial. JAMA. 2018;320 (21):2251-2259. doi: 10.1001/jama.2018.14276. PubMed PMID:30347031 .
  8. Combes, A, Slutsky, AS, Brodie, D. ECMO for Severe Acute Respiratory Distress Syndrome. N. Engl. J. Med. 2018;379 (11):1091-2. doi: 10.1056/NEJMc1808731. PubMed PMID:30207913 .
  9. Abe, T, Madotto, F, Pham, T, Nagata, I, Uchida, M, Tamiya, N et al.. Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries. Crit Care. 2018;22 (1):195. doi: 10.1186/s13054-018-2126-6. PubMed PMID:30115127 PubMed Central PMC6097245.
  10. Husain-Syed, F, Ricci, Z, Brodie, D, Vincent, JL, Ranieri, VM, Slutsky, AS et al.. Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk. Intensive Care Med. 2018;44 (9):1447-1459. doi: 10.1007/s00134-018-5329-z. PubMed PMID:30043276 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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