Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Sklar, MC, Dres, M, Fan, E, Rubenfeld, GD, Scales, DC, Herridge, MS et al.. Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults. JAMA Netw Open. 2020;3 (2):e1921520. doi: 10.1001/jamanetworkopen.2019.21520. PubMed PMID:32074293 .
  2. Zhang, B, Ratano, D, Brochard, LJ, Georgopoulos, D, Duffin, J, Long, M et al.. A physiology-based mathematical model for the selection of appropriate ventilator controls for lung and diaphragm protection. J Clin Monit Comput. 2020; :. doi: 10.1007/s10877-020-00479-x. PubMed PMID:32008149 .
  3. Dufresne, J, Bowden, P, Thavarajah, T, Florentinus-Mefailoski, A, Chen, ZZ, Tucholska, M et al.. The plasma peptides of breast versus ovarian cancer. Clin Proteomics. 2019;16 :43. doi: 10.1186/s12014-019-9262-0. PubMed PMID:31889940 PubMed Central PMC6927194.
  4. Bertoni, M, Telias, I, Urner, M, Long, M, Del Sorbo, L, Fan, E et al.. A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation. Crit Care. 2019;23 (1):346. doi: 10.1186/s13054-019-2617-0. PubMed PMID:31694692 PubMed Central PMC6836358.
  5. Henzler, D, Schmidt, A, Xu, Z, Ismaiel, N, Zhang, H, Slutsky, AS et al.. Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury. Intensive Care Med Exp. 2019;7 (1):60. doi: 10.1186/s40635-019-0272-z. PubMed PMID:31691042 PubMed Central PMC6831786.
  6. Cypel, M, Feld, JJ, Galasso, M, Pinto Ribeiro, RV, Marks, N, Kuczynski, M et al.. Prevention of viral transmission during lung transplantation with hepatitis C-viraemic donors: an open-label, single-centre, pilot trial. Lancet Respir Med. 2020;8 (2):192-201. doi: 10.1016/S2213-2600(19)30268-1. PubMed PMID:31606437 .
  7. Burns, KEA, Rizvi, L, Cook, DJ, Dodek, P, Slutsky, AS, Jones, A et al.. Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study. BMJ Open. 2019;9 (9):e031775. doi: 10.1136/bmjopen-2019-031775. PubMed PMID:31501132 PubMed Central PMC6738743.
  8. Goligher, EC, Combes, A, Brodie, D, Ferguson, ND, Pesenti, AM, Ranieri, VM et al.. Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design. Intensive Care Med. 2019;45 (9):1219-1230. doi: 10.1007/s00134-019-05708-9. PubMed PMID:31432216 .
  9. Brodie, D, Slutsky, AS, Combes, A. Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review. JAMA. 2019;322 (6):557-568. doi: 10.1001/jama.2019.9302. PubMed PMID:31408142 .
  10. Abrams, D, Pham, T, Burns, KEA, Combes, A, Curtis, JR, Mueller, T et al.. Practice Patterns and Ethical Considerations in the Management of Venovenous Extracorporeal Membrane Oxygenation Patients: An International Survey. Crit. Care Med. 2019;47 (10):1346-1355. doi: 10.1097/CCM.0000000000003910. PubMed PMID:31356471 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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