Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Vice President, Research


My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).


Recent Publications

  1. Husain-Syed, F, Ricci, Z, Brodie, D, Vincent, JL, Ranieri, VM, Slutsky, AS et al.. Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5329-z. PubMed PMID:30043276 .
  2. Chan, MC, Chao, WC, Liang, SJ, Tseng, CH, Wang, HC, Chien, YC et al.. First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome. J. Formos. Med. Assoc. 2018; :. doi: 10.1016/j.jfma.2018.06.010. PubMed PMID:30041997 .
  3. Fan, E, Brodie, D, Slutsky, AS. Diagnosis and Treatment in Acute Respiratory Distress Syndrome-Reply. JAMA. 2018;320 (3):306. doi: 10.1001/jama.2018.5932. PubMed PMID:30027245 .
  4. Montero, S, Slutsky, AS, Schmidt, M. The PRESET-Score: the extrapulmonary predictive survival model for extracorporeal membrane oxygenation in severe acute respiratory distress syndrome. J Thorac Dis. 2018;10 (Suppl 17):S2040-S2044. doi: 10.21037/jtd.2018.05.184. PubMed PMID:30023113 PubMed Central PMC6036012.
  5. Wu, J, Han, B, Fanelli, V, Wen, X, Huang, Y, Luo, A et al.. Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome. Crit. Care Med. 2018;46 (9):e921-e927. doi: 10.1097/CCM.0000000000003265. PubMed PMID:29979223 .
  6. Cortegiani, A, Madotto, F, Gregoretti, C, Bellani, G, Laffey, JG, Pham, T et al.. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Crit Care. 2018;22 (1):157. doi: 10.1186/s13054-018-2079-9. PubMed PMID:29895331 PubMed Central PMC5998562.
  7. Combes, A, Hajage, D, Capellier, G, Demoule, A, Lavoué, S, Guervilly, C et al.. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N. Engl. J. Med. 2018;378 (21):1965-1975. doi: 10.1056/NEJMoa1800385. PubMed PMID:29791822 .
  8. Madotto, F, Pham, T, Bellani, G, Bos, LD, Simonis, FD, Fan, E et al.. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Intensive Care Med. 2018;44 (5):564-577. doi: 10.1007/s00134-018-5152-6. PubMed PMID:29632996 .
  9. Fan, E, Brodie, D, Slutsky, AS. Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment. JAMA. 2018;319 (7):698-710. doi: 10.1001/jama.2017.21907. PubMed PMID:29466596 .
  10. Abrams, D, Garan, AR, Abdelbary, A, Bacchetta, M, Bartlett, RH, Beck, J et al.. Position paper for the organization of ECMO programs for cardiac failure in adults. Intensive Care Med. 2018;44 (6):717-729. doi: 10.1007/s00134-018-5064-5. PubMed PMID:29450594 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario