Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Vice President, Research

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

Please note: Dr. Slutsky is not taking any summer students in 2017.

Recent Publications

  1. Meade, MO, Young, D, Hanna, S, Zhou, Q, Bachman, TE, Bollen, C et al.. Severity of Hypoxemia and Effect of High Frequency Oscillatory Ventilation in ARDS. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201609-1938OC. PubMed PMID:28245137 .
  2. Kapur, R, Kim, M, Aslam, R, McVey, MJ, Tabuchi, A, Luo, A et al.. T Regulatory Cells and Dendritic Cells Protect Against Transfusion-Related Acute Lung Injury via IL-10. Blood. 2017; :. doi: 10.1182/blood-2016-12-758185. PubMed PMID:28202460 .
  3. Brander, L, Moerer, O, Hedenstierna, G, Beck, J, Takala, J, Slutsky, AS et al.. Neural control of ventilation prevents both over-distension and de-recruitment of experimentally injured lungs. Respir Physiol Neurobiol. 2017;237 :57-67. doi: 10.1016/j.resp.2016.12.010. PubMed PMID:28013057 .
  4. Villar, J, Slutsky, AS. GOLDEN anniversary of the acute respiratory distress syndrome: still much work to do!. Curr Opin Crit Care. 2017;23 (1):4-9. doi: 10.1097/MCC.0000000000000378. PubMed PMID:27898436 .
  5. Laffey, JG, Bellani, G, Pham, T, Fan, E, Madotto, F, Bajwa, EK et al.. Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. Intensive Care Med. 2016;42 (12):1865-1876. doi: 10.1007/s00134-016-4571-5. PubMed PMID:27757516 .
  6. Serpa Neto, A, Schmidt, M, Azevedo, LC, Bein, T, Brochard, L, Beutel, G et al.. Associations between ventilator settings during extracorporeal membrane oxygenation for refractory hypoxemia and outcome in patients with acute respiratory distress syndrome: a pooled individual patient data analysis : Mechanical ventilation during ECMO. Intensive Care Med. 2016;42 (11):1672-1684. doi: 10.1007/s00134-016-4507-0. PubMed PMID:27586996 .
  7. Bellani, G, Laffey, JG, Pham, T, Madotto, F, Fan, E, Brochard, L et al.. Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study. Am. J. Respir. Crit. Care Med. 2017;195 (1):67-77. doi: 10.1164/rccm.201606-1306OC. PubMed PMID:27753501 .
  8. Vincent, JL, Slutsky, AS, Gattinoni, L. Intensive care medicine in 2050: the future of ICU treatments. Intensive Care Med. 2016; :. doi: 10.1007/s00134-016-4556-4. PubMed PMID:27704150 .
  9. Kasenda, B, Sauerbrei, W, Royston, P, Mercat, A, Slutsky, AS, Cook, D et al.. Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS. BMJ Open. 2016;6 (9):e011148. doi: 10.1136/bmjopen-2016-011148. PubMed PMID:27609843 PubMed Central PMC5020750.
  10. Mao, P, Li, J, Huang, Y, Wu, S, Pang, X, He, W et al.. MicroRNA-19b Mediates Lung Epithelial-Mesenchymal Transition via Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase in Response to Mechanical Stretch. Am. J. Respir. Cell Mol. Biol. 2017;56 (1):11-19. doi: 10.1165/rcmb.2015-0377OC. PubMed PMID:27508324 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario