Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Vice President, Research


My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).


Recent Publications

  1. Combes, A, Slutsky, AS, Brodie, D. ECMO for Severe Acute Respiratory Distress Syndrome. N. Engl. J. Med. 2018;379 (11):1091-2. doi: 10.1056/NEJMc1808731. PubMed PMID:30207913 .
  2. Abe, T, Madotto, F, Pham, T, Nagata, I, Uchida, M, Tamiya, N et al.. Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries. Crit Care. 2018;22 (1):195. doi: 10.1186/s13054-018-2126-6. PubMed PMID:30115127 PubMed Central PMC6097245.
  3. Husain-Syed, F, Ricci, Z, Brodie, D, Vincent, JL, Ranieri, VM, Slutsky, AS et al.. Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: from native to artificial organ crosstalk. Intensive Care Med. 2018;44 (9):1447-1459. doi: 10.1007/s00134-018-5329-z. PubMed PMID:30043276 .
  4. Chan, MC, Chao, WC, Liang, SJ, Tseng, CH, Wang, HC, Chien, YC et al.. First tidal volume greater than 8 mL/kg is associated with increased mortality in complicated influenza infection with acute respiratory distress syndrome. J. Formos. Med. Assoc. 2018; :. doi: 10.1016/j.jfma.2018.06.010. PubMed PMID:30041997 .
  5. Fan, E, Brodie, D, Slutsky, AS. Diagnosis and Treatment in Acute Respiratory Distress Syndrome-Reply. JAMA. 2018;320 (3):306. doi: 10.1001/jama.2018.5932. PubMed PMID:30027245 .
  6. Montero, S, Slutsky, AS, Schmidt, M. The PRESET-Score: the extrapulmonary predictive survival model for extracorporeal membrane oxygenation in severe acute respiratory distress syndrome. J Thorac Dis. 2018;10 (Suppl 17):S2040-S2044. doi: 10.21037/jtd.2018.05.184. PubMed PMID:30023113 PubMed Central PMC6036012.
  7. Wu, J, Han, B, Fanelli, V, Wen, X, Huang, Y, Luo, A et al.. Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome. Crit. Care Med. 2018;46 (9):e921-e927. doi: 10.1097/CCM.0000000000003265. PubMed PMID:29979223 .
  8. Cortegiani, A, Madotto, F, Gregoretti, C, Bellani, G, Laffey, JG, Pham, T et al.. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Crit Care. 2018;22 (1):157. doi: 10.1186/s13054-018-2079-9. PubMed PMID:29895331 PubMed Central PMC5998562.
  9. Combes, A, Hajage, D, Capellier, G, Demoule, A, Lavoué, S, Guervilly, C et al.. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N. Engl. J. Med. 2018;378 (21):1965-1975. doi: 10.1056/NEJMoa1800385. PubMed PMID:29791822 .
  10. Madotto, F, Pham, T, Bellani, G, Bos, LD, Simonis, FD, Fan, E et al.. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Intensive Care Med. 2018;44 (5):564-577. doi: 10.1007/s00134-018-5152-6. PubMed PMID:29632996 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario