Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Vice President, Research


My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).


Recent Publications

  1. Cortegiani, A, Madotto, F, Gregoretti, C, Bellani, G, Laffey, JG, Pham, T et al.. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Crit Care. 2018;22 (1):157. doi: 10.1186/s13054-018-2079-9. PubMed PMID:29895331 .
  2. Combes, A, Hajage, D, Capellier, G, Demoule, A, Lavoué, S, Guervilly, C et al.. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N. Engl. J. Med. 2018;378 (21):1965-1975. doi: 10.1056/NEJMoa1800385. PubMed PMID:29791822 .
  3. Madotto, F, Pham, T, Bellani, G, Bos, LD, Simonis, FD, Fan, E et al.. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5152-6. PubMed PMID:29632996 .
  4. Fan, E, Brodie, D, Slutsky, AS. Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment. JAMA. 2018;319 (7):698-710. doi: 10.1001/jama.2017.21907. PubMed PMID:29466596 .
  5. Abrams, D, Garan, AR, Abdelbary, A, Bacchetta, M, Bartlett, RH, Beck, J et al.. Position paper for the organization of ECMO programs for cardiac failure in adults. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5064-5. PubMed PMID:29450594 .
  6. Filewod, NC, Batt, J, Kapus, A, Szaszi, K, Fairn, GD, Slutsky, AS et al.. Should basic science matter to clinicians?. Lancet. 2018;391 (10119):410-412. doi: 10.1016/S0140-6736(18)30199-5. PubMed PMID:29407017 .
  7. Brodie, D, Vincent, JL, Brochard, LJ, Combes, A, Ferguson, ND, Hodgson, CL et al.. Research in Extracorporeal Life Support: A Call to Action. Chest. 2018;153 (4):788-791. doi: 10.1016/j.chest.2017.12.024. PubMed PMID:29355550 .
  8. Slutsky, AS. Giants in Chest Medicine: Jeffrey M. Drazen, MD, FCCP. Chest. 2018;153 (1):14-15. doi: 10.1016/j.chest.2017.10.041. PubMed PMID:29307415 .
  9. Goligher, EC, Amato, MBP, Slutsky, AS. Reply to Morales-Quinteros et al.: Precision Medicine for Extracorporeal CO Removal for Acute Respiratory Distress Syndrome: CO Physiological Considerations. Am. J. Respir. Crit. Care Med. 2018;197 (8):1091-1092. doi: 10.1164/rccm.201711-2226LE. PubMed PMID:29211496 .
  10. Laffey, JG, Bellani, G, Pham, T, Fan, E, Madotto, F, Bajwa, EK et al.. Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. Intensive Care Med. 2018;44 (1):157-165. doi: 10.1007/s00134-017-4981-z. PubMed PMID:29138899 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario