Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Barbaro, RP, MacLaren, G, Swol, J, Slutsky, AS, Brodie, D. COVID-19 ARDS: getting ventilation right - Authors' reply. Lancet. 2022;399 (10319):22-23. doi: 10.1016/S0140-6736(21)02448-X. PubMed PMID:34973715 PubMed Central PMC8718350.
  2. Ranieri, VM, Tonetti, T, Navalesi, P, Nava, S, Antonelli, M, Pesenti, A et al.. High Flow Nasal Oxygen for Severe Hypoxemia: Oxygenation Response and Outcome in COVID-19 Patients. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202109-2163OC. PubMed PMID:34861135 .
  3. Karagiannidis, C, Slutsky, AS, Bein, T, Windisch, W, Weber-Carstens, S, Brodie, D et al.. Complete countrywide mortality in COVID patients receiving ECMO in Germany throughout the first three waves of the pandemic. Crit Care. 2021;25 (1):413. doi: 10.1186/s13054-021-03831-y. PubMed PMID:34844657 PubMed Central PMC8628273.
  4. Fernando, SM, Tran, A, Sadeghirad, B, Burns, KEA, Fan, E, Brodie, D et al.. Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis. Intensive Care Med. 2021; :. doi: 10.1007/s00134-021-06581-1. PubMed PMID:34825256 .
  5. Verma, AA, Slutsky, AS, Razak, F. The consequences of neglecting to collect multisectoral data to monitor the COVID-19 pandemic. CMAJ. 2021;193 (41):E1600. doi: 10.1503/cmaj.80136. PubMed PMID:34663605 PubMed Central PMC8547243.
  6. López-Fernández, YM, Martínez-de-Azagra, A, González-Gómez, JM, Pérez-Caballero Macarrón, C, García-González, M, Parrilla-Parrilla, J et al.. Acute Hypoxemic Respiratory Failure in Children at the Start of COVID-19 Outbreak: A Nationwide Experience. J Clin Med. 2021;10 (19):. doi: 10.3390/jcm10194301. PubMed PMID:34640318 PubMed Central PMC8509571.
  7. Tran, A, Fernando, SM, Brochard, LJ, Fan, E, Inaba, K, Ferguson, ND et al.. Prognostic factors for development of acute respiratory distress syndrome following traumatic injury - a systematic review and meta-analysis. Eur Respir J. 2021; :. doi: 10.1183/13993003.00857-2021. PubMed PMID:34625477 .
  8. Barbaro, RP, MacLaren, G, Boonstra, PS, Combes, A, Agerstrand, C, Annich, G et al.. Extracorporeal membrane oxygenation for COVID-19: evolving outcomes from the international Extracorporeal Life Support Organization Registry. Lancet. 2021;398 (10307):1230-1238. doi: 10.1016/S0140-6736(21)01960-7. PubMed PMID:34599878 PubMed Central PMC8480964.
  9. Tonetti, T, Grasselli, G, Rucci, P, Alessandri, F, Dell'Olio, A, Boscolo, A et al.. Synergistic Effect of Static Compliance and D-dimers to Predict Outcome of Patients with COVID-19-ARDS: A Prospective Multicenter Study. Biomedicines. 2021;9 (9):. doi: 10.3390/biomedicines9091228. PubMed PMID:34572414 PubMed Central PMC8467668.
  10. Abrams, D, MacLaren, G, Lorusso, R, Price, S, Yannopoulos, D, Vercaemst, L et al.. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive Care Med. 2022;48 (1):1-15. doi: 10.1007/s00134-021-06514-y. PubMed PMID:34505911 PubMed Central PMC8429884.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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