Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Costa, ELV, Slutsky, AS, Amato, MBP. Reply to: The 4DPRR Index and Mechanical Power: A Step Ahead or 4 Steps Backwards?. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202105-1113LE. PubMed PMID:34081876 .
  2. Trahtemberg, U, Fritzler, MJ, On behalf of the COVID-19 chapter of the “Longitudinal Biomarkers in Lung Injury” study group. COVID-19-associated autoimmunity as a feature of acute respiratory failure. Intensive Care Med. 2021; :. doi: 10.1007/s00134-021-06408-z. PubMed PMID:33928414 PubMed Central PMC8084710.
  3. Trahtemberg, U, Rottapel, R, Dos Santos, CC, Slutsky, AS, Baker, A, Fritzler, MJ et al.. Anticardiolipin and other antiphospholipid antibodies in critically ill COVID-19 positive and negative patients. Ann Rheum Dis. 2021; :. doi: 10.1136/annrheumdis-2021-220206. PubMed PMID:33903092 PubMed Central PMC8076626.
  4. Madotto, F, McNicholas, B, Rezoagli, E, Pham, T, Laffey, JG, Bellani, G et al.. Death in hospital following ICU discharge: insights from the LUNG SAFE study. Crit Care. 2021;25 (1):144. doi: 10.1186/s13054-021-03465-0. PubMed PMID:33849625 PubMed Central PMC8043098.
  5. Burns, KEA, Rizvi, L, Cook, DJ, Lebovic, G, Dodek, P, Villar, J et al.. Ventilator Weaning and Discontinuation Practices for Critically Ill Patients. JAMA. 2021;325 (12):1173-1184. doi: 10.1001/jama.2021.2384. PubMed PMID:33755077 PubMed Central PMC7988370.
  6. Madahar, P, Wunsch, H, Jha, P, Slutsky, AS, Brodie, D. Trends in COVID-19-related in-hospital mortality: lessons learned from nationwide samples. Lancet Respir Med. 2021;9 (4):322-324. doi: 10.1016/S2213-2600(21)00080-1. PubMed PMID:33600776 PubMed Central PMC7906680.
  7. Morris, AH, Stagg, B, Lanspa, M, Orme, J, Clemmer, TP, Weaver, LK et al.. Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions. J Am Med Inform Assoc. 2021;28 (6):1330-1344. doi: 10.1093/jamia/ocaa294. PubMed PMID:33594410 .
  8. Liu, L, Xie, J, Wu, W, Chen, H, Li, S, He, H et al.. A simple nomogram for predicting failure of non-invasive respiratory strategies in adults with COVID-19: a retrospective multicentre study. Lancet Digit Health. 2021;3 (3):e166-e174. doi: 10.1016/S2589-7500(20)30316-2. PubMed PMID:33573999 PubMed Central PMC7906717.
  9. Goligher, EC, Costa, ELV, Yarnell, CJ, Brochard, LJ, Stewart, TE, Tomlinson, G et al.. Effect of Lowering Vt on Mortality in Acute Respiratory Distress Syndrome Varies with Respiratory System Elastance. Am J Respir Crit Care Med. 2021;203 (11):1378-1385. doi: 10.1164/rccm.202009-3536OC. PubMed PMID:33439781 .
  10. Fernando, SM, Mathew, R, Slutsky, AS, Rochwerg, B, Kyeremanteng, K, Combes, A et al.. Media Portrayals of Outcomes After Extracorporeal Membrane Oxygenation. JAMA Intern Med. 2021;181 (3):391-394. doi: 10.1001/jamainternmed.2020.6094. PubMed PMID:33393994 PubMed Central PMC7783587.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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