Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Madahar, P, Wunsch, H, Jha, P, Slutsky, AS, Brodie, D. Trends in COVID-19-related in-hospital mortality: lessons learned from nationwide samples. Lancet Respir Med. 2021; :. doi: 10.1016/S2213-2600(21)00080-1. PubMed PMID:33600776 PubMed Central PMC7906680.
  2. Morris, AH, Stagg, B, Lanspa, M, Orme, J, Clemmer, TP, Weaver, LK et al.. Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions. J Am Med Inform Assoc. 2021; :. doi: 10.1093/jamia/ocaa294. PubMed PMID:33594410 .
  3. Liu, L, Xie, J, Wu, W, Chen, H, Li, S, He, H et al.. A simple nomogram for predicting failure of non-invasive respiratory strategies in adults with COVID-19: a retrospective multicentre study. Lancet Digit Health. 2021;3 (3):e166-e174. doi: 10.1016/S2589-7500(20)30316-2. PubMed PMID:33573999 PubMed Central PMC7906717.
  4. Goligher, EC, Costa, ELV, Yarnell, CJ, Brochard, LJ, Stewart, TE, Tomlinson, G et al.. Effect of Lowering Tidal Volume on Mortality in ARDS Varies with Respiratory System Elastance. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202009-3536OC. PubMed PMID:33439781 .
  5. Fernando, SM, Mathew, R, Slutsky, AS, Rochwerg, B, Kyeremanteng, K, Combes, A et al.. Media Portrayals of Outcomes After Extracorporeal Membrane Oxygenation. JAMA Intern Med. 2021;181 (3):391-394. doi: 10.1001/jamainternmed.2020.6094. PubMed PMID:33393994 PubMed Central PMC7783587.
  6. Godoy, LC, Goligher, EC, Lawler, PR, Slutsky, AS, Zarychanski, R. CMAJ. 2020;192 (50):E1816-E1822. doi: 10.1503/cmaj.201240-f. PubMed PMID:33318097 PubMed Central PMC7759103.
  7. Mody, P, Pandey, A, Slutsky, AS, Segar, MW, Kiss, A, Dorian, P et al.. Gender-Based Differences in Outcomes Among Resuscitated Patients With Out-of-Hospital Cardiac Arrest. Circulation. 2021;143 (7):641-649. doi: 10.1161/CIRCULATIONAHA.120.050427. PubMed PMID:33317326 .
  8. Sahetya, SK, Goligher, EC, Slutsky, AS. Searching for the Optimal PEEP in Patients Without ARDS: High, Low, or in Between?. JAMA. 2020;324 (24):2490-2492. doi: 10.1001/jama.2020.23067. PubMed PMID:33295963 .
  9. Ferrando, C, Suarez-Sipmann, F, Mellado-Artigas, R, Hernández, M, Gea, A, Arruti, E et al.. Correction to: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS. Intensive Care Med. 2021;47 (1):144-146. doi: 10.1007/s00134-020-06251-8. PubMed PMID:33263817 PubMed Central PMC7709481.
  10. Goligher, EC, Ranieri, VM, Slutsky, AS. Is severe COVID-19 pneumonia a typical or atypical form of ARDS? And does it matter?. Intensive Care Med. 2021;47 (1):83-85. doi: 10.1007/s00134-020-06320-y. PubMed PMID:33237346 PubMed Central PMC7686835.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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