Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Goligher, EC, Ranieri, VM, Slutsky, AS. Is severe COVID-19 pneumonia a typical or atypical form of ARDS? And does it matter?. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06320-y. PubMed PMID:33237346 PubMed Central PMC7686835.
  2. Yarnell, CJ, Abrams, D, Baldwin, MR, Brodie, D, Fan, E, Ferguson, ND et al.. Clinical trials in critical care: can a Bayesian approach enhance clinical and scientific decision making?. Lancet Respir Med. 2020; :. doi: 10.1016/S2213-2600(20)30471-9. PubMed PMID:33227237 .
  3. Rochwerg, B, Einav, S, Chaudhuri, D, Mancebo, J, Mauri, T, Helviz, Y et al.. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06312-y. PubMed PMID:33201321 PubMed Central PMC7670292.
  4. Grasselli, G, Tonetti, T, Filippini, C, Slutsky, AS, Pesenti, A, Ranieri, VM et al.. Pathophysiology of COVID-19-associated acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2020; :. doi: 10.1016/S2213-2600(20)30525-7. PubMed PMID:33197387 .
  5. Menk, M, Estenssoro, E, Sahetya, SK, Neto, AS, Sinha, P, Slutsky, AS et al.. Current and evolving standards of care for patients with ARDS. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06299-6. PubMed PMID:33156382 PubMed Central PMC7646492.
  6. Combes, A, Schmidt, M, Hodgson, CL, Fan, E, Ferguson, ND, Fraser, JF et al.. Extracorporeal life support for adults with acute respiratory distress syndrome. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06290-1. PubMed PMID:33140180 PubMed Central PMC7605473.
  7. Jüni, P, Rothenbühler, M, Bobos, P, Thorpe, KE, da Costa, BR, Fisman, DN et al.. CMAJ. 2020;192 (44):E1374-E1382. doi: 10.1503/cmaj.200920-f. PubMed PMID:33139430 PubMed Central PMC7647477.
  8. Zoufaly, A, Poglitsch, M, Aberle, JH, Hoepler, W, Seitz, T, Traugott, M et al.. Human recombinant soluble ACE2 in severe COVID-19. Lancet Respir Med. 2020;8 (11):1154-1158. doi: 10.1016/S2213-2600(20)30418-5. PubMed PMID:33131609 PubMed Central PMC7515587.
  9. Jaber, S, Citerio, G, Slutsky, AS. Acute respiratory failure and mechanical ventilation in the context of the COVID-19 pandemic: why a special issue in ICM?. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06298-7. PubMed PMID:33123785 PubMed Central PMC7594991.
  10. Dianti, J, Slutsky, AS, Goligher, EC. Validity of Empirical Estimates of the Ratio of Dead Space to Tidal Volume in ARDS. Respir Care. 2020; :. doi: 10.4187/respcare.08246. PubMed PMID:33082218 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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