C. David Mazer

MD with Great Distinction

Associate Scientist, Keenan Research Centre for Biomedical Science

Biography

My research interests include cardiac anesthesia and critical care. My basic science program focuses on perioperative blood conservation, cardiac physiology and metabolism and perioperative organ protection. I am also actively engaged in translational research as an investigator in both pre-clinical and clinical studies in these areas.

 

Recent Publications

  1. Barron, CC, Lalu, MM, Stewart, DJ, Fergusson, D, Yang, H, Moher, D et al.. Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol. Syst Rev. 2017;6 (1):226. doi: 10.1186/s13643-017-0601-9. PubMed PMID:29116020 .
  2. Mehta, RH, Leimberger, JD, van Diepen, S, Meza, J, Wang, A, Jankowich, R et al.. Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery. N. Engl. J. Med. 2017;376 (21):2032-2042. doi: 10.1056/NEJMoa1616218. PubMed PMID:28316276 .
  3. Deschamps, A, Hall, R, Grocott, H, Mazer, CD, Choi, PT, Turgeon, AF et al.. Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation during High-risk Cardiac Surgery: A Randomized Controlled Feasibility Trial. Anesthesiology. 2016;124 (4):826-36. doi: 10.1097/ALN.0000000000001029. PubMed PMID:26808629 .
  4. Hébert, PC, Fergusson, DA, Hutton, B, Mazer, CD, Fremes, S, Blajchman, M et al.. Regulatory decisions pertaining to aprotinin may be putting patients at risk. CMAJ. 2014;186 (18):1379-86. doi: 10.1503/cmaj.131582. PubMed PMID:25267766 PubMed Central PMC4259771.
  5. Wiesenthal, JD, Fazio, LM, Perks, AE, Blew, BD, Mazer, D, Hare, G et al.. Effect of pneumoperitoneum on renal tissue oxygenation and blood flow in a rat model. Urology. 2011;77 (6):1508.e9-15. doi: 10.1016/j.urology.2011.02.022. PubMed PMID:21507469 .
  6. Fitchett, D, Eikelboom, J, Fremes, S, Mazer, D, Singh, S, Bittira, B et al.. Dual antiplatelet therapy in patients requiring urgent coronary artery bypass grafting surgery: a position statement of the Canadian Cardiovascular Society. Can J Cardiol. 2009;25 (12):683-9. . PubMed PMID:19960127 PubMed Central PMC2807829.
  7. Schuler, TD, Perks, AE, Fazio, LM, Blew, BD, Mazer, D, Hare, G et al.. Impact of arterial and arteriovenous renal clamping with and without intrarenal cooling on renal oxygenation and temperature in a porcine model. J. Endourol. 2008;22 (10):2367-72. doi: 10.1089/end.2008.9710. PubMed PMID:18837656 .
  8. Baker, AJ, Park, E, Hare, GM, Liu, E, Sikich, N, Mazer, DC et al.. Effects of resuscitation fluid on neurologic physiology after cerebral trauma and hemorrhage. J Trauma. 2008;64 (2):348-57. doi: 10.1097/01.ta.0000245973.71929.db. PubMed PMID:18301197 .
  9. Karkouti, K, Wijeysundera, DN, Beattie, WS, Callum, JL, Cheng, D, Dupuis, JY et al.. Variability and predictability of large-volume red blood cell transfusion in cardiac surgery: a multicenter study. Transfusion. 2007;47 (11):2081-8. doi: 10.1111/j.1537-2995.2007.01432.x. PubMed PMID:17958538 .
  10. Leytin, V, Mazer, D, Mody, M, Garvey, B, Freedman, J. Hemolink, an o-raffinose cross-linked haemoglobin-based oxygen carrier, does not affect activation and function of human platelets in whole blood in vitro. Br. J. Haematol. 2003;120 (3):535-41. . PubMed PMID:12580976 .
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Affiliations & Other Activities

  • Associate Scientist, Li Ka Shing Knowledge Institute,  St. Michael’s Hospital
  • Vice-Chair for Research, Department of Anesthesia, University of Toronto
  • Professor, Department of Anesthesia, University of Toronto
  • Professor, Department of Physiology (cross appointment), University of Toronto
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