Charles de Mestral


Scientist, Li Ka Shing Knowledge Institute


Dr. Charles de Mestral is a vascular surgeon at St. Michael’s Hospital and a Surgeon-Scientist in the Department of Surgery of the University of Toronto. He conducts research on clinical effectiveness, as well as the provision, quality and costs of surgical care. His work is based out of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital and the Institute for Clinical Evaluative Sciences.

Please note: Dr. de Mestral is no longer accepting summer students in 2018.


Recent Publications

  1. de Mestral, C, Hsu, AT, Talarico, R, Lee, DS, Hussain, MA, Salata, K et al.. End-of-life care following leg amputation in patients with peripheral artery disease or diabetes. Br J Surg. 2019; :. doi: 10.1002/bjs.11367. PubMed PMID:31609482 .
  2. Papadopoulos, A, Devries, S, Montbriand, J, Eisenberg, N, de Mestral, C, Roche-Nagle, G et al.. Unplanned early hospital readmissions in a vascular surgery population. Can J Surg. 2019;62 (6):010318. doi: 10.1503/cjs.010318. PubMed PMID:31545573 .
  3. Hussain, MA, Al-Omran, M, Salata, K, Sivaswamy, A, Forbes, TL, Sattar, N et al.. Population-based secular trends in lower-extremity amputation for diabetes and peripheral artery disease. CMAJ. 2019;191 (35):E955-E961. doi: 10.1503/cmaj.190134. PubMed PMID:31481423 PubMed Central PMC6721859.
  4. Salata, K, Hussain, MA, de Mestral, C, Greco, E, Aljabri, BA, Mamdani, M et al.. Comparison of Outcomes in Elective Endovascular Aortic Repair vs Open Surgical Repair of Abdominal Aortic Aneurysms. JAMA Netw Open. 2019;2 (7):e196578. doi: 10.1001/jamanetworkopen.2019.6578. PubMed PMID:31290986 PubMed Central PMC6624804.
  5. Salata, K, Hussain, MA, de Mestral, C, Greco, E, Aljabri, BA, Sabongui, S et al.. Trends in elective and ruptured abdominal aortic aneurysm repair by practice setting in Ontario, Canada, from 2003 to 2016: a population-based time-series analysis. CMAJ Open. ;7 (2):E379-E384. doi: 10.9778/cmajo.20180173. PubMed PMID:31147379 PubMed Central PMC6544505.
  6. Li, B, Khan, S, Salata, K, Hussain, MA, de Mestral, C, Greco, E et al.. A systematic review and meta-analysis of the long-term outcomes of endovascular versus open repair of abdominal aortic aneurysm. J. Vasc. Surg. 2019;70 (3):954-969.e30. doi: 10.1016/j.jvs.2019.01.076. PubMed PMID:31147117 .
  7. de Mestral, C, Kayssi, A, Al-Omran, M, Salata, K, Hussain, MA, Roche-Nagle, G et al.. Home care nursing after elective vascular surgery: an opportunity to reduce emergency department visits and hospital readmission. BMJ Qual Saf. 2019; :. doi: 10.1136/bmjqs-2018-009161. PubMed PMID:31127067 .
  8. Jacob-Brassard, J, Salata, K, Kayssi, A, Hussain, MA, Forbes, TL, Al-Omran, M et al.. A systematic review of nonoperative management in blunt thoracic aortic injury. J. Vasc. Surg. 2019; :. doi: 10.1016/j.jvs.2019.02.023. PubMed PMID:31126762 .
  9. Khan, S, Li, B, Salata, K, Aljabri, BA, Hussain, MA, Khan, M et al.. The Current Status of Lithoplasty in Vascular Calcifications: A Systematic Review. Surg Innov. 2019;26 (5):588-598. doi: 10.1177/1553350619848557. PubMed PMID:31074330 .
  10. Li, B, Salata, K, de Mestral, C, Hussain, MA, Aljabri, BA, Lindsay, TF et al.. Perceptions of Canadian Vascular Surgeons Toward Pharmacologic Risk Reduction in Patients with Peripheral Artery Disease: 2018 Update. Ann Vasc Surg. 2019;58 :166-173.e4. doi: 10.1016/j.avsg.2018.11.034. PubMed PMID:30771465 .
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Affiliations & Other Activities

  • Surgeon, Division of Vascular Surgery, St. Michael’s Hospital
  • Assistant Professor, Department of Surgery, University of Toronto
  • Adjunct Scientist, Institute for Clinical Evaluative Sciences