Charles de Mestral




Dr. Charles de Mestral is a vascular surgeon at St. Michael’s Hospital and a Surgeon-Scientist in the Department of Surgery of the University of Toronto. He conducts research on clinical effectiveness, as well as the provision, quality and costs of surgical care.  His primary research focus is amputation prevention in people with diabetes and peripheral artery disease. His work is based out of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital and ICES.

Please note: Dr. de Mestral is no longer accepting summer students.


Recent Publications

  1. Alsuwailem, B, Zamzam, A, Syed, MH, Greco, E, Wheatcroft, M, de Mestral, C et al.. Elevated plasma levels of NT-proBNP in ambulatory patients with peripheral arterial disease. PLoS One. 2021;16 (7):e0253792. doi: 10.1371/journal.pone.0253792. PubMed PMID:34288948 .
  2. Jacob-Brassard, J, Al-Omran, M, Hussain, MA, Mamdani, M, Stukel, TA, Lee, DS et al.. Temporal Trends in Hospitalization for Lower Extremity Peripheral Artery Disease in Ontario: The Importance of Diabetes. Can J Cardiol. 2021; :. doi: 10.1016/j.cjca.2021.07.004. PubMed PMID:34273474 .
  3. Jacob-Brassard, J, Al-Omran, M, Stukel, TA, Mamdani, M, Lee, DS, De Mestral, C et al.. Validation of Diagnosis and Procedure Codes for Revascularization for Peripheral Artery Disease in Ontario Administrative Databases. Clin Invest Med. 2021;44 (2):E36-43. doi: 10.25011/cim.v44i2.36354. PubMed PMID:34152705 .
  4. Tillmann, BW, Guttman, MP, Nathens, AB, de Mestral, C, Kayssi, A, Haas, B et al.. The timing of amputation of mangled lower extremities does not predict post-injury outcomes and mortality: a retrospective analysis from the ACS TQIP database. J Trauma Acute Care Surg. 2021; :. doi: 10.1097/TA.0000000000003302. PubMed PMID:34039934 .
  5. Gomez, D, Simpson, AN, Sue-Chue-Lam, C, de Mestral, C, Dossa, F, Nantais, J et al.. A population-based analysis of the impact of the COVID-19 pandemic on common abdominal and gynecological emergency department visits. CMAJ. 2021;193 (21):E753-E760. doi: 10.1503/cmaj.202821. PubMed PMID:34035055 PubMed Central PMC8177921.
  6. Sue-Chue-Lam, C, Zhang, DDQ, Baxter, NN, Zywiel, MG, de Mestral, C. Hyaluronate carboxymethylcellulose sheets for the prevention of adhesive complications: a model-based cost-utility analysis. Colorectal Dis. 2021; :. doi: 10.1111/codi.15724. PubMed PMID:33973319 .
  7. de Mestral, C, Gomez, D, Sue-Chue-Lam, C, Dossa, F, Nantais, J, Simpson, AN et al.. Variable impact of COVID-19 on urgent intervention in Ontario. Br J Surg. 2021; :. doi: 10.1093/bjs/znab121. PubMed PMID:33899084 PubMed Central PMC8135473.
  8. Ramsay, L, Richardson, M, Sander, B, Rahal, M, Wu, D, Setterfield, M et al.. Predicting surgery waiting list volumes and health outcomes among people with an abdominal aortic aneurysm. Br J Surg. 2021;108 (6):e221-e223. doi: 10.1093/bjs/znab074. PubMed PMID:33748853 .
  9. Jacob-Brassard, J, Al-Omran, M, Salata, K, Hussain, MA, Kayssi, A, Roche-Nagle, G et al.. A survey of Canadian surgeons on the indications for home care nursing following vascular surgery. Can J Surg. 2021;64 (2):E149-E154. doi: 10.1503/cjs.001220. PubMed PMID:33666391 PubMed Central PMC8064247.
  10. Gomez, D, Dossa, F, Sue-Chue-Lam, C, Wilton, AS, de Mestral, C, Urbach, D et al.. Impact of COVID 19 on the provision of surgical services in Ontario, Canada: population-based analysis. Br J Surg. 2021;108 (1):e15-e17. doi: 10.1093/bjs/znaa043. PubMed PMID:33640924 PubMed Central PMC7799281.
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Affiliations & Other Activities

  • Surgeon, Division of Vascular Surgery, St. Michael’s Hospital
  • Assistant Professor, Department of Surgery, University of Toronto
  • Adjunct Scientist, Institute for Clinical Evaluative Sciences