Christer Sinderby

PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Christer Sinderby is a physiologist who obtained a MSc at Karolinska Institute, Stockholm, and PhD degree at University of Gothenburg in the late 80’s. He trained as a postdoctoral fellow for half a decade at the Meakins Christie Laboratories, McGill University in the early 90’s and then became an independent researcher at the University of Montreal. In 2003, Dr. Sinderby took the position as a Staff Scientist in the Critical Care Department at St Michael’s Hospital, University of Toronto.

Major achievements in his career would include standardized technology for measuring diaphragm electrical activity, which 1) has been used to dissociate between neural and mechanical efforts in respiratory muscle failure and 2) led up to the invention of technology for Neurally Adjusted Ventilatory Assist in humans. This technology is now clinically used world wide.

Current research interest are: 1) neural control of mechanical ventilation, 2) patient-ventilator interaction 3) control of breathing during mechanical ventilation, especially during acute lung injury/ acute respiratory distress syndrome.

Recent Publications

  1. Takahashi, D, Liu, L, Sinderby, C, Beck, J. Feasibility of neurally synchronized and proportional negative pressure ventilation in a small animal model. Physiol Rep. 2020;8 (13):e14499. doi: 10.14814/phy2.14499. PubMed PMID:32633080 PubMed Central PMC7379043.
  2. Rochon, ME, Lodygensky, G, Tabone, L, Essouri, S, Morneau, S, Sinderby, C et al.. Continuous neurally adjusted ventilation: a feasibility study in preterm infants. Arch. Dis. Child. Fetal Neonatal Ed. 2020; :. doi: 10.1136/archdischild-2019-318660. PubMed PMID:32269148 .
  3. Matlock, DN, Bai, S, Weisner, MD, Comtois, N, Beck, J, Sinderby, C et al.. Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation. Respir Care. 2020;65 (7):946-953. doi: 10.4187/respcare.07257. PubMed PMID:32071130 .
  4. Bertoni, M, Telias, I, Urner, M, Long, M, Del Sorbo, L, Fan, E et al.. A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation. Crit Care. 2019;23 (1):346. doi: 10.1186/s13054-019-2617-0. PubMed PMID:31694692 PubMed Central PMC6836358.
  5. Roesthuis, L, van der Hoeven, H, Sinderby, C, Frenzel, T, Ottenheijm, C, Brochard, L et al.. Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation. Intensive Care Med. 2019;45 (10):1372-1381. doi: 10.1007/s00134-019-05767-y. PubMed PMID:31576436 PubMed Central PMC6773912.
  6. Jonkman, AH, Jansen, D, Gadgil, S, Keijzer, C, Girbes, ARJ, Scheffer, GJ et al.. Monitoring patient-ventilator breath contribution in the critically ill during neurally adjusted ventilatory assist: reliability and improved algorithms for bedside use. J. Appl. Physiol. 2019;127 (1):264-271. doi: 10.1152/japplphysiol.00071.2019. PubMed PMID:31161879 .
  7. Karagiannidis, C, Strassmann, S, Schwarz, S, Merten, M, Fan, E, Beck, J et al.. Control of respiratory drive by extracorporeal CO2 removal in acute exacerbation of COPD breathing on non-invasive NAVA. Crit Care. 2019;23 (1):135. doi: 10.1186/s13054-019-2404-y. PubMed PMID:31014366 PubMed Central PMC6480839.
  8. Matlock, DN, Bai, S, Weisner, MD, Comtois, N, Beck, J, Sinderby, C et al.. Tidal volume transmission during non-synchronized nasal intermittent positive pressure ventilation via RAM® cannula. J Perinatol. 2019;39 (5):723-729. doi: 10.1038/s41372-019-0333-x. PubMed PMID:30755718 .
  9. Jansen, D, Jonkman, AH, Roesthuis, L, Gadgil, S, van der Hoeven, JG, Scheffer, GJ et al.. Estimation of the diaphragm neuromuscular efficiency index in mechanically ventilated critically ill patients. Crit Care. 2018;22 (1):238. doi: 10.1186/s13054-018-2172-0. PubMed PMID:30261920 PubMed Central PMC6161422.
  10. Mortamet, G, Larouche, A, Ducharme-Crevier, L, Fléchelles, O, Constantin, G, Essouri, S et al.. Patient-ventilator asynchrony during conventional mechanical ventilation in children. Ann Intensive Care. 2017;7 (1):122. doi: 10.1186/s13613-017-0344-8. PubMed PMID:29264742 PubMed Central PMC5738329.
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Affiliations & Other Activities

  • Member, iBEST
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