Christer Sinderby


Scientist, Keenan Research Centre for Biomedical Science


Dr. Christer Sinderby is a physiologist who obtained a MSc at Karolinska Institute, Stockholm, and PhD degree at University of Gothenburg in the late 80’s. He trained as a postdoctoral fellow for half a decade at the Meakins Christie Laboratories, McGill University in the early 90’s and then became an independent researcher at the University of Montreal. In 2003, Dr. Sinderby took the position as a Staff Scientist in the Critical Care Department at St Michael’s Hospital, University of Toronto.

Major achievements in his career would include standardized technology for measuring diaphragm electrical activity, which 1) has been used to dissociate between neural and mechanical efforts in respiratory muscle failure and 2) led up to the invention of technology for Neurally Adjusted Ventilatory Assist in humans. This technology is now clinically used world wide.

Current research interest are: 1) neural control of mechanical ventilation, 2) patient-ventilator interaction 3) control of breathing during mechanical ventilation, especially during acute lung injury/ acute respiratory distress syndrome.

Recent Publications

  1. Jonkman, AH, Jansen, D, Gadgil, S, Keijzer, C, Girbes, ARJ, Scheffer, GJ et al.. Monitoring patient-ventilator breath contribution in the critically ill during neurally adjusted ventilatory assist: reliability and improved algorithms for bedside use. J. Appl. Physiol. 2019;127 (1):264-271. doi: 10.1152/japplphysiol.00071.2019. PubMed PMID:31161879 .
  2. Karagiannidis, C, Strassmann, S, Schwarz, S, Merten, M, Fan, E, Beck, J et al.. Control of respiratory drive by extracorporeal CO2 removal in acute exacerbation of COPD breathing on non-invasive NAVA. Crit Care. 2019;23 (1):135. doi: 10.1186/s13054-019-2404-y. PubMed PMID:31014366 PubMed Central PMC6480839.
  3. Matlock, DN, Bai, S, Weisner, MD, Comtois, N, Beck, J, Sinderby, C et al.. Tidal volume transmission during non-synchronized nasal intermittent positive pressure ventilation via RAM® cannula. J Perinatol. 2019;39 (5):723-729. doi: 10.1038/s41372-019-0333-x. PubMed PMID:30755718 .
  4. Jansen, D, Jonkman, AH, Roesthuis, L, Gadgil, S, van der Hoeven, JG, Scheffer, GJ et al.. Estimation of the diaphragm neuromuscular efficiency index in mechanically ventilated critically ill patients. Crit Care. 2018;22 (1):238. doi: 10.1186/s13054-018-2172-0. PubMed PMID:30261920 PubMed Central PMC6161422.
  5. Mortamet, G, Larouche, A, Ducharme-Crevier, L, Fléchelles, O, Constantin, G, Essouri, S et al.. Patient-ventilator asynchrony during conventional mechanical ventilation in children. Ann Intensive Care. 2017;7 (1):122. doi: 10.1186/s13613-017-0344-8. PubMed PMID:29264742 PubMed Central PMC5738329.
  6. Mally, PV, Beck, J, Sinderby, C, Caprio, M, Bailey, SM. Neural Breathing Pattern and Patient-Ventilator Interaction During Neurally Adjusted Ventilatory Assist and Conventional Ventilation in Newborns. Pediatr Crit Care Med. 2018;19 (1):48-55. doi: 10.1097/PCC.0000000000001385. PubMed PMID:29189671 .
  7. Iyer, NP, Dickson, J, Ruiz, ME, Chatburn, R, Beck, J, Sinderby, C et al.. Neural breathing pattern in newborn infants pre- and postextubation. Acta Paediatr. 2017;106 (12):1928-1933. doi: 10.1111/apa.14040. PubMed PMID:28833570 .
  8. Beloncle, F, Piquilloud, L, Rittayamai, N, Sinderby, C, Rozé, H, Brochard, L et al.. A diaphragmatic electrical activity-based optimization strategy during pressure support ventilation improves synchronization but does not impact work of breathing. Crit Care. 2017;21 (1):21. doi: 10.1186/s13054-017-1599-z. PubMed PMID:28137269 PubMed Central PMC5282691.
  9. Sinderby, C, Demoule, A, Similowski, T. How to compare clinical outcome of complementary modes of mechanical ventilation?. Intensive Care Med. 2017;43 (2):293-295. doi: 10.1007/s00134-016-4647-2. PubMed PMID:28070604 .
  10. Brander, L, Moerer, O, Hedenstierna, G, Beck, J, Takala, J, Slutsky, AS et al.. Neural control of ventilation prevents both over-distension and de-recruitment of experimentally injured lungs. Respir Physiol Neurobiol. 2017;237 :57-67. doi: 10.1016/j.resp.2016.12.010. PubMed PMID:28013057 .
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Affiliations & Other Activities

  • Member, iBEST