Christer Sinderby

PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Christer Sinderby is a physiologist who obtained a MSc at Karolinska Institute, Stockholm, and PhD degree at University of Gothenburg in the late 80’s. He trained as a postdoctoral fellow for half a decade at the Meakins Christie Laboratories, McGill University in the early 90’s and then became an independent researcher at the University of Montreal. In 2003, Dr. Sinderby took the position as a Staff Scientist in the Critical Care Department at St Michael’s Hospital, University of Toronto.

Major achievements in his career would include standardized technology for measuring diaphragm electrical activity, which 1) has been used to dissociate between neural and mechanical efforts in respiratory muscle failure and 2) led up to the invention of technology for Neurally Adjusted Ventilatory Assist in humans. This technology is now clinically used world wide.

Current research interest are: 1) neural control of mechanical ventilation, 2) patient-ventilator interaction 3) control of breathing during mechanical ventilation, especially during acute lung injury/ acute respiratory distress syndrome.

Recent Publications

  1. Iyer, NP, Dickson, J, Ruiz, ME, Chatburn, R, Beck, J, Sinderby, C et al.. Neural breathing pattern in newborn infants pre- and postextubation. Acta Paediatr. 2017;106 (12):1928-1933. doi: 10.1111/apa.14040. PubMed PMID:28833570 .
  2. Beloncle, F, Piquilloud, L, Rittayamai, N, Sinderby, C, Rozé, H, Brochard, L et al.. A diaphragmatic electrical activity-based optimization strategy during pressure support ventilation improves synchronization but does not impact work of breathing. Crit Care. 2017;21 (1):21. doi: 10.1186/s13054-017-1599-z. PubMed PMID:28137269 PubMed Central PMC5282691.
  3. Sinderby, C, Demoule, A, Similowski, T. How to compare clinical outcome of complementary modes of mechanical ventilation?. Intensive Care Med. 2017;43 (2):293-295. doi: 10.1007/s00134-016-4647-2. PubMed PMID:28070604 .
  4. Brander, L, Moerer, O, Hedenstierna, G, Beck, J, Takala, J, Slutsky, AS et al.. Neural control of ventilation prevents both over-distension and de-recruitment of experimentally injured lungs. Respir Physiol Neurobiol. 2017;237 :57-67. doi: 10.1016/j.resp.2016.12.010. PubMed PMID:28013057 .
  5. Doorduin, J, Nollet, JL, Roesthuis, LH, van Hees, HW, Brochard, LJ, Sinderby, CA et al.. Partial Neuromuscular Blockade during Partial Ventilatory Support in Sedated Patients with High Tidal Volumes. Am. J. Respir. Crit. Care Med. 2017;195 (8):1033-1042. doi: 10.1164/rccm.201605-1016OC. PubMed PMID:27748627 .
  6. Beck, J, Emeriaud, G, Liu, Y, Sinderby, C. Neurally-adjusted ventilatory assist (NAVA) in children: a systematic review. Minerva Anestesiol. 2016;82 (8):874-83. . PubMed PMID:26375790 .
  7. Liu, L, Takahashi, D, Qui, H, Slutsky, AS, Sinderby, C, Beck, J et al.. Feasibility of neurally adjusted positive end-expiratory pressure in rabbits with early experimental lung injury. BMC Anesthesiol. 2015;15 :124. doi: 10.1186/s12871-015-0103-z. PubMed PMID:26369672 PubMed Central PMC4570554.
  8. Liu, L, Xia, F, Yang, Y, Longhini, F, Navalesi, P, Beck, J et al.. Neural versus pneumatic control of pressure support in patients with chronic obstructive pulmonary diseases at different levels of positive end expiratory pressure: a physiological study. Crit Care. 2015;19 :244. doi: 10.1186/s13054-015-0971-0. PubMed PMID:26059238 PubMed Central PMC4487968.
  9. Doorduin, J, Sinderby, CA, Beck, J, van der Hoeven, JG, Heunks, LM. Assisted Ventilation in Patients with Acute Respiratory Distress Syndrome: Lung-distending Pressure and Patient-Ventilator Interaction. Anesthesiology. 2015;123 (1):181-90. doi: 10.1097/ALN.0000000000000694. PubMed PMID:25955983 .
  10. Larouche, A, Massicotte, E, Constantin, G, Ducharme-Crevier, L, Essouri, S, Sinderby, C et al.. Tonic diaphragmatic activity in critically ill children with and without ventilatory support. Pediatr. Pulmonol. 2015;50 (12):1304-12. doi: 10.1002/ppul.23182. PubMed PMID:25940232 .
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Affiliations & Other Activities

  • Member, iBEST
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