Claudia dos Santos

MD, MSc, BSc

Scientist, Li Ka Shing Knowledge Institute

Biography

My major research interest is in acute lung injury, which can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. My lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals who are at higher risk for developing lung injury, in addition to diagnosing, treating and monitoring improvement from injury. To accomplish our goals, we have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. We exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. We are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions, my lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.

Recent Publications

  1. Samary, CS, Ramos, AB, Maia, LA, Rocha, NN, Santos, CL, Magalhães, RF et al.. Focal ischemic stroke leads to lung injury and reduces alveolar macrophage phagocytic capability in rats. Crit Care. 2018;22 (1):249. doi: 10.1186/s13054-018-2164-0. PubMed PMID:30290827 PubMed Central PMC6173845.
  2. Dos Santos, CC, Gopal, B, Verma, S. Metformin: An Old Dog with a New Trick?. Cell Metab. 2018;28 (3):334-336. doi: 10.1016/j.cmet.2018.08.018. PubMed PMID:30184483 .
  3. López-Alonso, I, Blázquez-Prieto, J, Amado-Rodríguez, L, González-López, A, Astudillo, A, Sánchez, M et al.. Preventing loss of mechanosensation by the nuclear membranes of alveolar cells reduces lung injury in mice during mechanical ventilation. Sci Transl Med. 2018;10 (456):. doi: 10.1126/scitranslmed.aam7598. PubMed PMID:30158154 .
  4. Lichner, Z, Saleeb, R, Butz, H, Ding, Q, Nofech-Mozes, R, Riad, S et al.. Sunitinib induces early histomolecular changes in a subset of renal cancer cells that contribute to resistance. FASEB J. 2018; :fj201800596R. doi: 10.1096/fj.201800596R. PubMed PMID:30148679 .
  5. Collins, JJP, Lithopoulos, MA, Dos Santos, CC, Issa, N, Möbius, MA, Ito, C et al.. Impaired Angiogenic Supportive Capacity and Altered Gene Expression Profile of Resident CD146+ Mesenchymal Stromal Cells Isolated from Hyperoxia-Injured Neonatal Rat Lungs. Stem Cells Dev. 2018;27 (16):1109-1124. doi: 10.1089/scd.2017.0145. PubMed PMID:29957134 .
  6. Silva, LHA, Antunes, MA, Dos Santos, CC, Weiss, DJ, Cruz, FF, Rocco, PRM et al.. Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases. Stem Cell Res Ther. 2018;9 (1):45. doi: 10.1186/s13287-018-0802-8. PubMed PMID:29482654 PubMed Central PMC5828113.
  7. Ciccocioppo, R, Dos Santos, CC, Baumgart, DC, Cangemi, GC, Cardinale, V, Ciacci, C et al.. Proceedings of the signature series event of the international society for cellular therapy: "Advancements in cellular therapies and regenerative medicine in digestive diseases," London, United Kingdom, May 3, 2017. Cytotherapy. 2018;20 (3):461-476. doi: 10.1016/j.jcyt.2017.12.004. PubMed PMID:29398624 .
  8. Azoulay, E, Vincent, JL, Angus, DC, Arabi, YM, Brochard, L, Brett, SJ et al.. Recovery after critical illness: putting the puzzle together-a consensus of 29. Crit Care. 2017;21 (1):296. doi: 10.1186/s13054-017-1887-7. PubMed PMID:29208005 PubMed Central PMC5718148.
  9. Dos Santos, CC, Reynolds, S, Batt, J. Searching for the "Spark" in Ventilator-induced Diaphragm Dysfunction. Am. J. Respir. Crit. Care Med. 2017;196 (12):1498-1500. doi: 10.1164/rccm.201708-1716ED. PubMed PMID:28954198 .
  10. Amatullah, H, Shan, Y, Beauchamp, BL, Gali, PL, Gupta, S, Maron-Gutierrez, T et al.. DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis. Am. J. Respir. Crit. Care Med. 2017;195 (7):889-905. doi: 10.1164/rccm.201604-0730OC. PubMed PMID:27735193 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Clinician Scientist, Research, University of Toronto
  • Associate Professor of Medicine, Department of Medicine, University of Toronto
  • Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto
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