Claudia dos Santos

MD, MSc, BSc

Scientist

Biography

My major research interest is in acute lung injury, which can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. My lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals who are at higher risk for developing lung injury, in addition to diagnosing, treating and monitoring improvement from injury. To accomplish our goals, we have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. We exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. We are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions, my lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.

Recent Publications

  1. Tsoporis, JN, Drosatos, IA, Gupta, S, Amatullah, H, Izhar, S, Dos Santos, CC et al.. Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology. Molecules. 2021;26 (13):. doi: 10.3390/molecules26133795. PubMed PMID:34206441 PubMed Central PMC8270312.
  2. Dos Santos, CC, Amatullah, H, Vaswani, CM, Maron-Gutierrez, T, Kim, M, Mei, SHJ et al.. Mesenchymal Stromal (stem) Cell (MSC) therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury. Eur Respir J. 2021; :. doi: 10.1183/13993003.04216-2020. PubMed PMID:34112731 .
  3. Rolandsson Enes, S, Krasnodembskaya, AD, English, K, Dos Santos, CC, Weiss, DJ. Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases. Front Pharmacol. 2021;12 :647652. doi: 10.3389/fphar.2021.647652. PubMed PMID:33953680 PubMed Central PMC8089479.
  4. Trahtemberg, U, Fritzler, MJ, On behalf of the COVID-19 chapter of the “Longitudinal Biomarkers in Lung Injury” study group. COVID-19-associated autoimmunity as a feature of acute respiratory failure. Intensive Care Med. 2021;47 (7):801-804. doi: 10.1007/s00134-021-06408-z. PubMed PMID:33928414 PubMed Central PMC8084710.
  5. Trahtemberg, U, Rottapel, R, Dos Santos, CC, Slutsky, AS, Baker, A, Fritzler, MJ et al.. Anticardiolipin and other antiphospholipid antibodies in critically ill COVID-19 positive and negative patients. Ann Rheum Dis. 2021; :. doi: 10.1136/annrheumdis-2021-220206. PubMed PMID:33903092 PubMed Central PMC8076626.
  6. Rolandsson Enes, S, Hampton, TH, Barua, J, McKenna, DH, Dos Santos, CC, Amiel, E et al.. Healthy versus inflamed lung environments differentially effect MSCs. Eur Respir J. 2021; :. doi: 10.1183/13993003.04149-2020. PubMed PMID:33795318 .
  7. Varkouhi, AK, He, X, Teixeira Monteiro, AP, Amatullah, H, Tsoporis, JN, Gupta, S et al.. Immunophenotypic characterization and therapeutics effects of human bone marrow- and umbilical cord-derived mesenchymal stromal cells in an experimental model of sepsis. Exp Cell Res. 2021;399 (2):112473. doi: 10.1016/j.yexcr.2021.112473. PubMed PMID:33428902 .
  8. Ektesabi, AM, Mori, K, Tsoporis, JN, Vaswani, CM, Gupta, S, Walsh, C et al.. Mesenchymal Stem/Stromal Cells Increase Cardiac miR-187-3p Expression in a Polymicrobial Animal Model of Sepsis. Shock. 2021;56 (1):133-141. doi: 10.1097/SHK.0000000000001701. PubMed PMID:33378320 PubMed Central PMC8240645.
  9. Gupta, S, Tsoporis, JN, Jia, SH, Dos Santos, CC, Parker, TG, Marshall, JC et al.. Toll-Like Receptors, Associated Biochemical Signaling Networks, and S100 Ligands. Shock. 2021;56 (2):167-177. doi: 10.1097/SHK.0000000000001704. PubMed PMID:33350801 .
  10. McGinn, R, Fergusson, DA, Stewart, DJ, Kristof, AS, Barron, CC, Thebaud, B et al.. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021;49 (2):311-323. doi: 10.1097/CCM.0000000000004734. PubMed PMID:33332817 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Clinician Scientist, Research, University of Toronto
  • Associate Professor of Medicine, Department of Medicine, University of Toronto
  • Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto
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