Claudia dos Santos

MD, MSc, BSc

Scientist, Li Ka Shing Knowledge Institute

Biography

My major research interest is acute lung injury, which can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. My lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals, who are at higher risk for developing lung injury, diagnose, treat and monitor improvement from injury. To accomplish our goals, we have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. We exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. We are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions my lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.

Recent Publications

  1. Amatullah, H, Shan, Y, Beauchamp, BL, Gali, PL, Gupta, S, Maron-Gutierrez, T et al.. DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis. Am. J. Respir. Crit. Care Med. 2017;195 (7):889-905. doi: 10.1164/rccm.201604-0730OC. PubMed PMID:27735193 .
  2. Walsh, CJ, Hu, P, Batt, J, Dos Santos, CC. Discovering MicroRNA-Regulatory Modules in Multi-Dimensional Cancer Genomic Data: A Survey of Computational Methods. Cancer Inform. 2016;15 (Suppl 2):25-42. doi: 10.4137/CIN.S39369. PubMed PMID:27721651 PubMed Central PMC5051584.
  3. Dos Santos, CC, Herridge, M, Batt, J. Early goal directed mobility in the ICU: 'something in the way you move'. J Thorac Dis. 2016;8 (8):E784-7. doi: 10.21037/jtd.2016.05.96. PubMed PMID:27620874 PubMed Central PMC4999664.
  4. Mei, SH, Dos Santos, CC, Stewart, DJ. Advances in Stem Cell and Cell-Based Gene Therapy Approaches for Experimental Acute Lung Injury: A Review of Preclinical Studies. Hum. Gene Ther. 2016;27 (10):802-812. doi: 10.1089/hum.2016.063. PubMed PMID:27531647 .
  5. Walsh, CJ, Batt, J, Herridge, MS, Mathur, S, Bader, GD, Hu, P et al.. Transcriptomic analysis reveals abnormal muscle repair and remodeling in survivors of critical illness with sustained weakness. Sci Rep. 2016;6 :29334. doi: 10.1038/srep29334. PubMed PMID:27411715 PubMed Central PMC4944143.
  6. Siddiqi, FS, Majumder, S, Thai, K, Abdalla, M, Hu, P, Advani, SL et al.. The Histone Methyltransferase Enzyme Enhancer of Zeste Homolog 2 Protects against Podocyte Oxidative Stress and Renal Injury in Diabetes. J. Am. Soc. Nephrol. 2016;27 (7):2021-34. doi: 10.1681/ASN.2014090898. PubMed PMID:26534922 PubMed Central PMC4926960.
  7. Dos Santos, CC. Shedding metabo'light' on the search for sepsis biomarkers. Crit Care. 2015;19 :277. doi: 10.1186/s13054-015-0969-7. PubMed PMID:26148483 PubMed Central PMC4493818.
  8. Walsh, CJ, Batt, J, Herridge, MS, Dos Santos, CC. Muscle wasting and early mobilization in acute respiratory distress syndrome. Clin. Chest Med. 2014;35 (4):811-26. doi: 10.1016/j.ccm.2014.08.016. PubMed PMID:25453427 .
  9. Shan, Y, Akram, A, Amatullah, H, Zhou, DY, Gali, PL, Maron-Gutierrez, T et al.. ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation. Antioxid. Redox Signal. 2015;22 (8):651-68. doi: 10.1089/ars.2014.5987. PubMed PMID:25401197 PubMed Central PMC4346377.
  10. Binnie, A, Tsang, JL, dos Santos, CC. Biomarkers in acute respiratory distress syndrome. Curr Opin Crit Care. 2014;20 (1):47-55. doi: 10.1097/MCC.0000000000000048. PubMed PMID:24296379 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Clinician Scientist, Research, University of Toronto
  • Associate Professor of Medicine, Department of Medicine, University of Toronto
  • Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto
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