Claudia dos Santos

MD, MSc, BSc

Scientist

Biography

My major research interest is in acute lung injury, which can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. My lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals who are at higher risk for developing lung injury, in addition to diagnosing, treating and monitoring improvement from injury. To accomplish our goals, we have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. We exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. We are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions, my lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.

Recent Publications

  1. Varkouhi, AK, He, X, Teixeira Monteiro, AP, Amatullah, H, Tsoporis, JN, Gupta, S et al.. Immunophenotypic Characterization and Therapeutics Effects of Human Bone Marrow- and Umbilical Cord-derived Mesenchymal Stromal Cells in an Experimental Model of Sepsis. Exp Cell Res. 2021; :112473. doi: 10.1016/j.yexcr.2021.112473. PubMed PMID:33428902 .
  2. Ektesabi, AM, Mori, K, Tsoporis, J, Vaswani, C, Gupta, S, Walsh, C et al.. Mesenchymal Stem/Stromal Cells Increase Cardiac MIR-187-3P Expression in Polymicrobial Animal Model of Sepsis. Shock. 2020;Publish Ahead of Print :. doi: 10.1097/SHK.0000000000001701. PubMed PMID:33378320 .
  3. Gupta, S, Tsoporis, JN, Jia, SH, Dos Santos, CC, Parker, TG, Marshall, JC et al.. Toll-Like Receptors, Associated Biochemical Signaling Networks, and S100 Ligands. Shock. 2020;Publish Ahead of Print :. doi: 10.1097/SHK.0000000000001704. PubMed PMID:33350801 .
  4. McGinn, R, Fergusson, DA, Stewart, DJ, Kristof, AS, Barron, CC, Thebaud, B et al.. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021;49 (2):311-323. doi: 10.1097/CCM.0000000000004734. PubMed PMID:33332817 .
  5. Gill, SE, Dos Santos, CC, O'Gorman, DB, Carter, DE, Patterson, EK, Slessarev, M et al.. Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation. Intensive Care Med Exp. 2020;8 (1):75. doi: 10.1186/s40635-020-00361-9. PubMed PMID:33306162 PubMed Central PMC7729690.
  6. Tran, A, Walsh, CJ, Batt, J, Dos Santos, CC, Hu, P. A machine learning-based clinical tool for diagnosing myopathy using multi-cohort microarray expression profiles. J Transl Med. 2020;18 (1):454. doi: 10.1186/s12967-020-02630-3. PubMed PMID:33256785 PubMed Central PMC7708151.
  7. Amatullah, H, Maron-Gutierrez, T, Shan, Y, Gupta, S, Tsoporis, JN, Varkouhi, AK et al.. Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury. Redox Biol. 2021;38 :101796. doi: 10.1016/j.redox.2020.101796. PubMed PMID:33246293 PubMed Central PMC7695876.
  8. Lad, H, Saumur, TM, Herridge, MS, Dos Santos, CC, Mathur, S, Batt, J et al.. Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition. Int J Mol Sci. 2020;21 (21):. doi: 10.3390/ijms21217840. PubMed PMID:33105809 PubMed Central PMC7660068.
  9. Dos Santos, CC, Zehnbauer, BA, Trahtemberg, U, Marshall, J. Molecular Diagnosis of Coronavirus Disease 2019. Crit Care Explor. 2020;2 (9):e0184. doi: 10.1097/CCE.0000000000000184. PubMed PMID:33063040 PubMed Central PMC7515613.
  10. Fraser, DD, Patterson, EK, Slessarev, M, Gill, SE, Martin, C, Daley, M et al.. Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation. Crit Care Explor. 2020;2 (9):e0194. doi: 10.1097/CCE.0000000000000194. PubMed PMID:32904031 PubMed Central PMC7449254.
Search PubMed

Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Clinician Scientist, Research, University of Toronto
  • Associate Professor of Medicine, Department of Medicine, University of Toronto
  • Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto
X