Claudia dos Santos

MD, MSc, BSc

Clinician Scientist, Li Ka Shing Knowledge Institute

Biography

My major research interest is in acute lung injury, which can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. My lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals who are at higher risk for developing lung injury, in addition to diagnosing, treating and monitoring improvement from injury. To accomplish our goals, we have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. We exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. We are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions, my lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.

Recent Publications

  1. Fraser, DD, Cepinskas, G, Slessarev, M, Martin, C, Daley, M, Miller, MR et al.. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Crit Care Explor. 2020;2 (6):e0144. doi: 10.1097/CCE.0000000000000144. PubMed PMID:32696007 PubMed Central PMC7314329.
  2. Varkouhi, AK, Monteiro, APT, Tsoporis, JN, Mei, SHJ, Stewart, DJ, Dos Santos, CC et al.. Genetically Modified Mesenchymal Stromal/Stem Cells: Application in Critical Illness. Stem Cell Rev Rep. 2020; :. doi: 10.1007/s12015-020-10000-1. PubMed PMID:32671645 PubMed Central PMC7363458.
  3. Battaglini, D, Pimentel-Coelho, PM, Robba, C, Dos Santos, CC, Cruz, FF, Pelosi, P et al.. Gut Microbiota in Acute Ischemic Stroke: From Pathophysiology to Therapeutic Implications. Front Neurol. 2020;11 :598. doi: 10.3389/fneur.2020.00598. PubMed PMID:32670191 PubMed Central PMC7330114.
  4. Thavarajah, T, Dos Santos, CC, Slutsky, AS, Marshall, JC, Bowden, P, Romaschin, A et al.. The plasma peptides of sepsis. Clin Proteomics. 2020;17 :26. doi: 10.1186/s12014-020-09288-5. PubMed PMID:32636717 PubMed Central PMC7331219.
  5. Younes, N, Zhou, L, Amatullah, H, Mei, SHJ, Herrero, R, Lorente, JA et al.. Mesenchymal stromal/stem cells modulate response to experimental sepsis-induced lung injury via regulation of miR-27a-5p in recipient mice. Thorax. 2020;75 (7):556-567. doi: 10.1136/thoraxjnl-2019-213561. PubMed PMID:32546573 PubMed Central PMC7361025.
  6. Abdalla, M, Abdalla, M, Siddiqi, FS, Geldenhuys, L, Batchu, SN, Tolosa, MF et al.. A common glomerular transcriptomic signature distinguishes diabetic kidney disease from other kidney diseases in humans and mice. Curr Res Transl Med. 2020; :. doi: 10.1016/j.retram.2020.05.001. PubMed PMID:32499177 .
  7. Binnie, A, Tsang, JLY, Hu, P, Carrasqueiro, G, Castelo-Branco, P, Dos Santos, CC et al.. Epigenetics of Sepsis. Crit. Care Med. 2020;48 (5):745-756. doi: 10.1097/CCM.0000000000004247. PubMed PMID:32167492 .
  8. Wong, A, Zamel, R, Yeung, J, Bader, GD, Dos Santos, CC, Bai, X et al.. Potential therapeutic targets for lung repair during human ex vivo lung perfusion. Eur. Respir. J. 2020;55 (4):. doi: 10.1183/13993003.02222-2019. PubMed PMID:32060066 .
  9. Binnie, A, Walsh, CJ, Hu, P, Dwivedi, DJ, Fox-Robichaud, A, Liaw, PC et al.. Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness. Crit. Care Med. 2020;48 (2):142-150. doi: 10.1097/CCM.0000000000004097. PubMed PMID:31939781 .
  10. Dufresne, J, Bowden, P, Thavarajah, T, Florentinus-Mefailoski, A, Chen, ZZ, Tucholska, M et al.. The plasma peptides of breast versus ovarian cancer. Clin Proteomics. 2019;16 :43. doi: 10.1186/s12014-019-9262-0. PubMed PMID:31889940 PubMed Central PMC6927194.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Clinician Scientist, Research, University of Toronto
  • Associate Professor of Medicine, Department of Medicine, University of Toronto
  • Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto
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