Claudia dos Santos

MD, MSc, BSc

Clinician Scientist, Li Ka Shing Knowledge Institute

Biography

My major research interest is in acute lung injury, which can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. My lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals who are at higher risk for developing lung injury, in addition to diagnosing, treating and monitoring improvement from injury. To accomplish our goals, we have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. We exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. We are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions, my lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.

Recent Publications

  1. Binnie, A, Tsang, JLY, Hu, P, Carrasqueiro, G, Castelo-Branco, P, Dos Santos, CC et al.. Epigenetics of Sepsis. Crit. Care Med. 2020;48 (5):745-756. doi: 10.1097/CCM.0000000000004247. PubMed PMID:32167492 .
  2. Wong, A, Zamel, R, Yeung, J, Bader, GD, Dos Santos, CC, Bai, X et al.. Potential therapeutic targets for lung repair during human ex vivo lung perfusion. Eur. Respir. J. 2020;55 (4):. doi: 10.1183/13993003.02222-2019. PubMed PMID:32060066 .
  3. Binnie, A, Walsh, CJ, Hu, P, Dwivedi, DJ, Fox-Robichaud, A, Liaw, PC et al.. Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness. Crit. Care Med. 2020;48 (2):142-150. doi: 10.1097/CCM.0000000000004097. PubMed PMID:31939781 .
  4. Dufresne, J, Bowden, P, Thavarajah, T, Florentinus-Mefailoski, A, Chen, ZZ, Tucholska, M et al.. The plasma peptides of breast versus ovarian cancer. Clin Proteomics. 2019;16 :43. doi: 10.1186/s12014-019-9262-0. PubMed PMID:31889940 PubMed Central PMC6927194.
  5. Binnie, A, Walsh, CJ, Hu, P, Dwivedi, DJ, Fox-Robichaud, A, Liaw, PC et al.. Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness. Crit. Care Med. 2019; :. doi: 10.1097/CCM.0000000000004097. PubMed PMID:31833902 .
  6. Abreu, SC, Rolandsson Enes, S, Dearborn, J, Goodwin, M, Coffey, A, Borg, ZD et al.. Lung inflammatory environments differentially alter mesenchymal stromal cell behavior. Am. J. Physiol. Lung Cell Mol. Physiol. 2019;317 (6):L823-L831. doi: 10.1152/ajplung.00263.2019. PubMed PMID:31553626 PubMed Central PMC6962599.
  7. Silva, JD, de Castro, LL, Braga, CL, Oliveira, GP, Trivelin, SA, Barbosa-Junior, CM et al.. Mesenchymal Stromal Cells Are More Effective Than Their Extracellular Vesicles at Reducing Lung Injury Regardless of Acute Respiratory Distress Syndrome Etiology. Stem Cells Int. 2019;2019 :8262849. doi: 10.1155/2019/8262849. PubMed PMID:31531026 PubMed Central PMC6720722.
  8. Batt, J, Herridge, MS, Dos Santos, CC. From skeletal muscle weakness to functional outcomes following critical illness: a translational biology perspective. Thorax. 2019;74 (11):1091-1098. doi: 10.1136/thoraxjnl-2016-208312. PubMed PMID:31431489 .
  9. Ciccocioppo, R, Baumgart, DC, Dos Santos, CC, Galipeau, J, Klersy, C, Orlando, G et al.. Perspectives of the International Society for Cell & Gene Therapy Gastrointestinal Scientific Committee on the Intravenous Use of Mesenchymal Stromal Cells in Inflammatory Bowel Disease (PeMeGi). Cytotherapy. 2019;21 (8):824-839. doi: 10.1016/j.jcyt.2019.05.003. PubMed PMID:31201092 .
  10. Varkouhi, AK, Jerkic, M, Ormesher, L, Gagnon, S, Goyal, S, Rabani, R et al.. Extracellular Vesicles from Interferon-γ-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats. Anesthesiology. 2019;130 (5):778-790. doi: 10.1097/ALN.0000000000002655. PubMed PMID:30870158 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Clinician Scientist, Research, University of Toronto
  • Associate Professor of Medicine, Department of Medicine, University of Toronto
  • Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto
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