Corinne E. Fischer

MD

Associate Scientist, Li Ka Shing Knowledge Institute

Research Programs

Biography

My major research focus includes the study of neuropsychiatric symptoms in dementia, specifically delusions and their neurocognitive/neurobiological correlates. I also have an interest in functional outcome studies in dementia, examining the impact of cognitive decline on real world activities such as driving, etc. As well, I have an interest in understanding how cognitive reserve (education, art, bilingualism) protects against development of dementia. Finally, I have an interest in health system issues as they apply to the elderly.

Recent Publications

  1. Kapoor, A, Bartha, R, Black, SE, Borrie, M, Freedman, M, Gao, F et al.. Structural Brain Magnetic Resonance Imaging to Rule Out Comorbid Pathology in the Assessment of Alzheimer's Disease Dementia: Findings from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study and Clinical Trials Over the Past 10 Years. J. Alzheimers Dis. 2020; :. doi: 10.3233/JAD-191097. PubMed PMID:32116253 .
  2. Atayde, AL, Fischer, CE, Schweizer, TA, Munoz, DG. Neuropsychiatric Inventory-Assessed Nighttime Behavior Accompanies, but Does Not Precede, Progressive Cognitive Decline Independent of Alzheimer's Disease Histopathology. J. Alzheimers Dis. 2020; :. doi: 10.3233/JAD-190907. PubMed PMID:32116249 .
  3. Fischer, CE, Ismail, Z, Youakim, JM, Creese, B, Kumar, S, Nuñez, N et al.. Revisiting Criteria for Psychosis in Alzheimer's Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research. J. Alzheimers Dis. 2020;73 (3):1143-1156. doi: 10.3233/JAD-190828. PubMed PMID:31884469 .
  4. Garcia-Segura, ME, Fischer, CE, Schweizer, TA, Munoz, DG. APOE ɛ4/ɛ4 Is Associated with Aberrant Motor Behavior Through Both Lewy Body and Cerebral Amyloid Angiopathy Pathology in High Alzheimer's Disease Pathological Load. J. Alzheimers Dis. 2019;72 (4):1077-1087. doi: 10.3233/JAD-190643. PubMed PMID:31744003 .
  5. Lo, TWB, Karameh, WK, Barfett, JJ, Fornazzari, LR, Munoz, DG, Schweizer, TA et al.. Association Between Neuropsychiatric Symptom Trajectory and Conversion to Alzheimer Disease. Alzheimer Dis Assoc Disord. 2019; :. doi: 10.1097/WAD.0000000000000356. PubMed PMID:31633557 .
  6. Ledger, C, Karameh, WK, Munoz, DG, Fischer, CE, Schweizer, TA. Gender role in sleep disturbances among older adults with traumatic brain injury. Int Rev Psychiatry. 2020;32 (1):39-45. doi: 10.1080/09540261.2019.1657384. PubMed PMID:31544552 .
  7. Showraki, A, Murari, G, Ismail, Z, Barfett, JJ, Fornazzari, L, Munoz, DG et al.. Cerebrospinal Fluid Correlates of Neuropsychiatric Symptoms in Patients with Alzheimer's Disease/Mild Cognitive Impairment: A Systematic Review. J. Alzheimers Dis. 2019;71 (2):477-501. doi: 10.3233/JAD-190365. PubMed PMID:31424398 .
  8. Brown, EE, Rashidi-Ranjbar, N, Caravaggio, F, Gerretsen, P, Pollock, BG, Mulsant, BH et al.. Brain Amyloid PET Tracer Delivery is Related to White Matter Integrity in Patients with Mild Cognitive Impairment. J Neuroimaging. 2019;29 (6):721-729. doi: 10.1111/jon.12646. PubMed PMID:31270885 .
  9. Qian, W, Fischer, CE, Churchill, NW, Kumar, S, Rajji, T, Schweizer, TA et al.. Delusions in Alzheimer Disease are Associated With Decreased Default Mode Network Functional Connectivity. Am J Geriatr Psychiatry. 2019;27 (10):1060-1068. doi: 10.1016/j.jagp.2019.03.020. PubMed PMID:31130416 .
  10. Yuen, K, Rashidi-Ranjbar, N, Verhoeff, NPLG, Kumar, S, Gallagher, D, Flint, AJ et al.. Association between Sleep Disturbances and Medial Temporal Lobe Volume in Older Adults with Mild Cognitive Impairment Free of Lifetime History of Depression. J. Alzheimers Dis. 2019;69 (2):413-421. doi: 10.3233/JAD-190160. PubMed PMID:31104028 .
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Affiliations & Other Activities

  • Director of Geriatric Psychiatry, Psychiatry, St. Michael’s Hospital
  • Director of Memory Disorders Clinic, Psychiatry, St. Michael’s Hospital
  • Director of the Geriatric Mental Health Outreach Program, Psychiatry, St. Michael’s Hospital
  • Associate Professor, Department of Psychiatry, University of Toronto
  • Associate Member, IMS
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