Corinne E. Fischer


Associate Scientist, Li Ka Shing Knowledge Institute

Research Programs


My major research focus includes the study of neuropsychiatric symptoms in dementia, specifically delusions and their neurocognitive/neurobiological correlates. I also have an interest in functional outcome studies in dementia, examining the impact of cognitive decline on real world activities such as driving, etc. As well, I have an interest in understanding how cognitive reserve (education, art, bilingualism) protects against development of dementia. Finally, I have an interest in health system issues as they apply to the elderly.

Recent Publications

  1. Kapoor, A, Bartha, R, Black, SE, Borrie, M, Freedman, M, Gao, F et al.. Structural Brain Magnetic Resonance Imaging to Rule Out Comorbid Pathology in the Assessment of Alzheimer's Disease Dementia: Findings from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study and Clinical Trials Over the Past 10 Years. J. Alzheimers Dis. 2020; :. doi: 10.3233/JAD-191097. PubMed PMID:32116253 .
  2. Atayde, AL, Fischer, CE, Schweizer, TA, Munoz, DG. Neuropsychiatric Inventory-Assessed Nighttime Behavior Accompanies, but Does Not Precede, Progressive Cognitive Decline Independent of Alzheimer's Disease Histopathology. J. Alzheimers Dis. 2020; :. doi: 10.3233/JAD-190907. PubMed PMID:32116249 .
  3. Fischer, CE, Ismail, Z, Youakim, JM, Creese, B, Kumar, S, Nuñez, N et al.. Revisiting Criteria for Psychosis in Alzheimer's Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research. J. Alzheimers Dis. 2020;73 (3):1143-1156. doi: 10.3233/JAD-190828. PubMed PMID:31884469 .
  4. Garcia-Segura, ME, Fischer, CE, Schweizer, TA, Munoz, DG. APOE ɛ4/ɛ4 Is Associated with Aberrant Motor Behavior Through Both Lewy Body and Cerebral Amyloid Angiopathy Pathology in High Alzheimer's Disease Pathological Load. J. Alzheimers Dis. 2019;72 (4):1077-1087. doi: 10.3233/JAD-190643. PubMed PMID:31744003 .
  5. Lo, TWB, Karameh, WK, Barfett, JJ, Fornazzari, LR, Munoz, DG, Schweizer, TA et al.. Association Between Neuropsychiatric Symptom Trajectory and Conversion to Alzheimer Disease. Alzheimer Dis Assoc Disord. 2019; :. doi: 10.1097/WAD.0000000000000356. PubMed PMID:31633557 .
  6. Ledger, C, Karameh, WK, Munoz, DG, Fischer, CE, Schweizer, TA. Gender role in sleep disturbances among older adults with traumatic brain injury. Int Rev Psychiatry. 2020;32 (1):39-45. doi: 10.1080/09540261.2019.1657384. PubMed PMID:31544552 .
  7. Showraki, A, Murari, G, Ismail, Z, Barfett, JJ, Fornazzari, L, Munoz, DG et al.. Cerebrospinal Fluid Correlates of Neuropsychiatric Symptoms in Patients with Alzheimer's Disease/Mild Cognitive Impairment: A Systematic Review. J. Alzheimers Dis. 2019;71 (2):477-501. doi: 10.3233/JAD-190365. PubMed PMID:31424398 .
  8. Brown, EE, Rashidi-Ranjbar, N, Caravaggio, F, Gerretsen, P, Pollock, BG, Mulsant, BH et al.. Brain Amyloid PET Tracer Delivery is Related to White Matter Integrity in Patients with Mild Cognitive Impairment. J Neuroimaging. 2019;29 (6):721-729. doi: 10.1111/jon.12646. PubMed PMID:31270885 .
  9. Qian, W, Fischer, CE, Churchill, NW, Kumar, S, Rajji, T, Schweizer, TA et al.. Delusions in Alzheimer Disease are Associated With Decreased Default Mode Network Functional Connectivity. Am J Geriatr Psychiatry. 2019;27 (10):1060-1068. doi: 10.1016/j.jagp.2019.03.020. PubMed PMID:31130416 .
  10. Yuen, K, Rashidi-Ranjbar, N, Verhoeff, NPLG, Kumar, S, Gallagher, D, Flint, AJ et al.. Association between Sleep Disturbances and Medial Temporal Lobe Volume in Older Adults with Mild Cognitive Impairment Free of Lifetime History of Depression. J. Alzheimers Dis. 2019;69 (2):413-421. doi: 10.3233/JAD-190160. PubMed PMID:31104028 .
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Affiliations & Other Activities

  • Director of Geriatric Psychiatry, Psychiatry, St. Michael’s Hospital
  • Director of Memory Disorders Clinic, Psychiatry, St. Michael’s Hospital
  • Director of the Geriatric Mental Health Outreach Program, Psychiatry, St. Michael’s Hospital
  • Associate Professor, Department of Psychiatry, University of Toronto
  • Associate Member, IMS