Corinne E. Fischer

MD

Associate Scientist, Li Ka Shing Knowledge Institute

Research Programs

Biography

My major research focus includes the study of neuropsychiatric symptoms in dementia, specifically delusions and their neurocognitive/neurobiological correlates. I also have an interest in functional outcome studies in dementia, examining the impact of cognitive decline on real world activities such as driving, etc. As well, I have an interest in understanding how cognitive reserve (education, art, bilingualism) protects against development of dementia. Finally, I have an interest in health system issues as they apply to the elderly.

Recent Publications

  1. Brooks, H, Goodman, MS, Bowie, CR, Zomorrodi, R, Blumberger, DM, Butters, MA et al.. Theta-gamma coupling and ordering information: a stable brain-behavior relationship across cognitive tasks and clinical conditions. Neuropsychopharmacology. 2020; :. doi: 10.1038/s41386-020-0759-z. PubMed PMID:32682324 .
  2. Rajji, TK, Bowie, CR, Herrmann, N, Pollock, BG, Bikson, M, Blumberger, DM et al.. Design and Rationale of the PACt-MD Randomized Clinical Trial: Prevention of Alzheimer's dementia with Cognitive remediation plus transcranial direct current stimulation in Mild cognitive impairment and Depression. J. Alzheimers Dis. 2020;76 (2):733-751. doi: 10.3233/JAD-200141. PubMed PMID:32568198 .
  3. Rashidi-Ranjbar, N, Rajji, TK, Kumar, S, Herrmann, N, Mah, L, Flint, AJ et al.. Frontal-executive and corticolimbic structural brain circuitry in older people with remitted depression, mild cognitive impairment, Alzheimer's dementia, and normal cognition. Neuropsychopharmacology. 2020;45 (9):1567-1578. doi: 10.1038/s41386-020-0715-y. PubMed PMID:32422643 PubMed Central PMC7360554.
  4. Fornazzari, L, Haladyn, J, Toledo, T, Leggieri, M, Friszberg, I, Barfett, J et al.. Do painters need their whole brain to excel?. Neurocase. 2020;26 (3):131-136. doi: 10.1080/13554794.2020.1764055. PubMed PMID:32420807 .
  5. Thaut, MH, Fischer, CE, Leggieri, M, Vuong, V, Churchill, NW, Fornazzari, LR et al.. Neural Basis of Long-term Musical Memory in Cognitively Impaired Older Persons. Alzheimer Dis Assoc Disord. ;34 (3):267-271. doi: 10.1097/WAD.0000000000000382. PubMed PMID:32384286 .
  6. Shivji, S, Wong, W, Fischer, CE, Fornazzari, LR, Masellis, M, Keith, J et al.. Parkinsonism in C9orf72 expansion without co-existing Lewy body pathology; a case report and review of the literature. Neuropathol. Appl. Neurobiol. 2020; :. doi: 10.1111/nan.12623. PubMed PMID:32339329 .
  7. Dham, P, Bingham, KS, Bowie, CR, Butters, MA, Fischer, CE, Flint, A et al.. Functional Competence and Cognition in Individuals With Amnestic Mild Cognitive Impairment. J Am Geriatr Soc. 2020;68 (8):1787-1795. doi: 10.1111/jgs.16454. PubMed PMID:32323313 .
  8. Kapoor, A, Bartha, R, Black, SE, Borrie, M, Freedman, M, Gao, F et al.. Structural Brain Magnetic Resonance Imaging to Rule Out Comorbid Pathology in the Assessment of Alzheimer's Disease Dementia: Findings from the Ontario Neurodegenerative Disease Research Initiative (ONDRI) Study and Clinical Trials Over the Past 10 Years. J. Alzheimers Dis. 2020;74 (3):747-757. doi: 10.3233/JAD-191097. PubMed PMID:32116253 PubMed Central PMC7242844.
  9. Atayde, AL, Fischer, CE, Schweizer, TA, Munoz, DG. Neuropsychiatric Inventory-Assessed Nighttime Behavior Accompanies, but Does Not Precede, Progressive Cognitive Decline Independent of Alzheimer's Disease Histopathology. J. Alzheimers Dis. 2020;74 (3):839-850. doi: 10.3233/JAD-190907. PubMed PMID:32116249 .
  10. Fischer, CE, Ismail, Z, Youakim, JM, Creese, B, Kumar, S, Nuñez, N et al.. Revisiting Criteria for Psychosis in Alzheimer's Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research. J. Alzheimers Dis. 2020;73 (3):1143-1156. doi: 10.3233/JAD-190828. PubMed PMID:31884469 .
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Affiliations & Other Activities

  • Director of Geriatric Psychiatry, Psychiatry, St. Michael’s Hospital
  • Director of Memory Disorders Clinic, Psychiatry, St. Michael’s Hospital
  • Director of the Geriatric Mental Health Outreach Program, Psychiatry, St. Michael’s Hospital
  • Associate Professor, Department of Psychiatry, University of Toronto
  • Associate Member, IMS
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