Cynthia T. Luk

MD, PhD, FRCPC

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Cynthia T. Luk is an endocrinologist and clinician scientist at St. Michael’s Hospital. She completed her MD at the University of Alberta, followed by internal medicine residency at McGill University, and endocrinology and metabolism fellowship at the University of Toronto. She is also a graduate of the Eliot Phillipson Clinician-Scientist Training Program and Clinician Investigator Program. She received her PhD from the Institute of Medical Science at the University of Toronto with Dr. Minna Woo.

Dr. Luk’s interests stem from her love of discovery and clinical experience. Her work focuses on identifying novel links between obesity and diabetes, and determining the role of adipose tissue in metabolic syndrome. She studies fundamental cell death or related signaling pathways to determine their role in obesity, diabetes or related health problems, to help us better understand and address these conditions.

Recent Publications

  1. Desai, HR, Sivasubramaniyam, T, Revelo, XS, Schroer, SA, Luk, CT, Rikkala, PR et al.. Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation. Sci Rep. 2017;7 (1):7653. doi: 10.1038/s41598-017-07923-0. PubMed PMID:28794431 PubMed Central PMC5550513.
  2. Sivasubramaniyam, T, Schroer, SA, Li, A, Luk, CT, Shi, SY, Besla, R et al.. Hepatic JAK2 protects against atherosclerosis through circulating IGF-1. JCI Insight. 2017;2 (14):. doi: 10.1172/jci.insight.93735. PubMed PMID:28724798 PubMed Central PMC5518558.
  3. Luk, CT, Shi, SY, Cai, EP, Sivasubramaniyam, T, Krishnamurthy, M, Brunt, JJ et al.. FAK signalling controls insulin sensitivity through regulation of adipocyte survival. Nat Commun. 2017;8 :14360. doi: 10.1038/ncomms14360. PubMed PMID:28165007 PubMed Central PMC5303880.
  4. Shi, SY, Luk, CT, Schroer, SA, Kim, MJ, Dodington, DW, Sivasubramaniyam, T et al.. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. J. Biol. Chem. 2017;292 (9):3789-3799. doi: 10.1074/jbc.M116.752519. PubMed PMID:28100771 PubMed Central PMC5339761.
  5. Luk, CT, Schroer, SA, Woo, M. Methods for Assessing the In Vivo Role of PTEN in Glucose Homeostasis. Methods Mol. Biol. 2016;1388 :75-91. doi: 10.1007/978-1-4939-3299-3_7. PubMed PMID:27033072 .
  6. Shi, SY, Zhang, W, Luk, CT, Sivasubramaniyam, T, Brunt, JJ, Schroer, SA et al.. JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. Diabetologia. 2016;59 (1):187-96. doi: 10.1007/s00125-015-3786-2. PubMed PMID:26515423 .
  7. Shi, SY, Lu, SY, Sivasubramaniyam, T, Revelo, XS, Cai, EP, Luk, CT et al.. DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice. Nat Commun. 2015;6 :7415. doi: 10.1038/ncomms8415. PubMed PMID:26077864 PubMed Central PMC4490365.
  8. Luck, H, Tsai, S, Chung, J, Clemente-Casares, X, Ghazarian, M, Revelo, XS et al.. Regulation of obesity-related insulin resistance with gut anti-inflammatory agents. Cell Metab. 2015;21 (4):527-42. doi: 10.1016/j.cmet.2015.03.001. PubMed PMID:25863246 .
  9. Cai, EP, Luk, CT, Wu, X, Schroer, SA, Shi, SY, Sivasubramaniyam, T et al.. Rb and p107 are required for alpha cell survival, beta cell cycle control and glucagon-like peptide-1 action. Diabetologia. 2014;57 (12):2555-65. doi: 10.1007/s00125-014-3381-y. PubMed PMID:25249236 .
  10. Wang, L, Luk, CT, Cai, EP, Schroer, SA, Allister, EM, Shi, SY et al.. PTEN deletion in pancreatic α-cells protects against high-fat diet-induced hyperglucagonemia and insulin resistance. Diabetes. 2015;64 (1):147-57. doi: 10.2337/db13-1715. PubMed PMID:25092678 .
Search PubMed

Affiliations & Other Activities

  • Assistant Professor, Faculty of Medicine, University of Toronto
X