Darrell Tan

MD, FRCPC, PhD

Scientist, Li Ka Shing Knowledge Institute

Biography

Dr. Darrell Tan is an infectious diseases physician, clinician-scientist and Canadian Institutes of Health Research (CIHR) New Investigator whose research focuses on clinical trials in human immunodeficiency virus (HIV) prevention and HIV/sexual transmitted infection (STI) co-infection. As Director of the University of Toronto Clinical Research Unit on HIV Prevention and co-leader of the CIHR Canadian HIV Trials Network Biomedical Prevention Working Group, he is leading multiple efforts to optimize the implementation of HIV pre- and post-exposure prophylaxis (PrEP and PEP) in Canada. These include Canada’s first demonstration project of daily oral TDF/FTC-based PrEP in Toronto MSM, the development of national Clinical Practice Guidelines on PEP & PrEP use, exploration of the relationship between syndemic health problems and clinical outcomes of PEP & PrEP, studies of nurse-led PEP & PrEP, and evaluations of novel antiretroviral PEP regimens.

Additional research interests are in the interaction between HIV and common co-infections such as herpes simplex virus type 2 (HSV-2) and syphilis, and the role of systemic inflammation in driving clinical outcomes in people living with HIV. He is also Co-Principle Investigator on two CIHR-supported multicentre randomized control trials including the a trial of anti-herpes medication for attenuating HIV disease progression, and a trial of enhanced syphilis screening in HIV-positive men.

Recent Publications

  1. Yanagawa, B, Bahji, A, Lamba, W, Tan, DH, Cheema, A, Syed, I et al.. Endocarditis in the setting of IDU: multidisciplinary management. Curr. Opin. Cardiol. 2017; :. doi: 10.1097/HCO.0000000000000493. PubMed PMID:29232248 .
  2. Grace, D, Jollimore, J, MacPherson, P, Strang, MJP, Tan, DHS. The Pre-Exposure Prophylaxis (PrEP)-Stigma Paradox: Learning from Canada's First Wave of PrEP Users. AIDS Patient Care STDS. 2017; :. doi: 10.1089/apc.2017.0153. PubMed PMID:29185801 .
  3. Tan, DHS, Hull, MW, Yoong, D, Tremblay, C, O'Byrne, P, Thomas, R et al.. Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis. CMAJ. 2017;189 (47):E1448-E1458. doi: 10.1503/cmaj.170494. PubMed PMID:29180384 PubMed Central PMC5703677.
  4. Wilton, J, Mishra, S, Tan, DHS. Considerations for Using the HIRI-MSM Screening Tool to Identify MSM Who Would Benefit Most From PrEP. J. Acquir. Immune Defic. Syndr. 2017;76 (2):e58-e61. doi: 10.1097/QAI.0000000000001472. PubMed PMID:28903127 .
  5. Tan, DH. PrEP on demand or every day?. Lancet HIV. 2017;4 (9):e379-e380. doi: 10.1016/S2352-3018(17)30088-7. PubMed PMID:28747273 .
  6. Sivarajah, V, Venus, K, Yudin, MH, Murphy, KE, Morrison, SA, Tan, DH et al.. Does maternal HSV-2 coinfection increase mother-to-child transmission of HIV? A systematic review. Sex Transm Infect. 2017;93 (8):535-542. doi: 10.1136/sextrans-2016-052921. PubMed PMID:28600331 .
  7. Knox, DC, Anderson, PL, Harrigan, PR, Tan, DH. Multidrug-Resistant HIV-1 Infection despite Preexposure Prophylaxis. N. Engl. J. Med. 2017;376 (5):501-502. doi: 10.1056/NEJMc1611639. PubMed PMID:28146652 .
  8. Tan, DH, Raboud, J, Szadkowski, L, Szabo, E, Hu, H, Wong, Q et al.. Novel imaging modalities for the comparison of bone microarchitecture among HIV+ patients with and without fractures: a pilot study. HIV Clin Trials. 2017;18 (1):28-38. doi: 10.1080/15284336.2016.1266074. PubMed PMID:27951753 .
  9. MacFadden, DR, Tan, DH, Mishra, S. Optimizing HIV pre-exposure prophylaxis implementation among men who have sex with men in a large urban centre: a dynamic modelling study. J Int AIDS Soc. ;19 (1):20791. . PubMed PMID:27665722 PubMed Central PMC5035769.
  10. Money, DM, Moses, E, Blitz, S, Vandriel, SM, Lipsky, N, Walmsley, SL et al.. HIV viral suppression results in higher antibody responses in HIV-positive women vaccinated with the quadrivalent human papillomavirus vaccine. Vaccine. 2016;34 (40):4799-806. doi: 10.1016/j.vaccine.2016.08.016. PubMed PMID:27544584 .
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Affiliations & Other Activities

  • Clinician-Scientist, Department of Medicine, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Assistant Professor, Institute of Health Policy, Management & Evaluation, University of Toronto
  • Director, HIV Prevention Clinical Research Unit, University of Toronto
  • Affiliate Scientist, Toronto General Research Institute
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