Darrell Tan

MD, FRCPC, PhD

Scientist

Biography

Dr. Darrell Tan is an infectious diseases physician, clinician-scientist and Canadian Institutes of Health Research (CIHR) New Investigator whose research focuses on clinical trials in human immunodeficiency virus (HIV) prevention and HIV/sexual transmitted infection (STI) co-infection. As Director of the University of Toronto Clinical Research Unit on HIV Prevention and co-leader of the CIHR Canadian HIV Trials Network Biomedical Prevention Working Group, he is leading multiple efforts to optimize the implementation of HIV pre- and post-exposure prophylaxis (PrEP and PEP) in Canada. These include Canada’s first demonstration project of daily oral TDF/FTC-based PrEP in Toronto MSM, the development of national Clinical Practice Guidelines on PEP & PrEP use, exploration of the relationship between syndemic health problems and clinical outcomes of PEP & PrEP, studies of nurse-led PEP & PrEP, and evaluations of novel antiretroviral PEP regimens.

Additional research interests are in the interaction between HIV and common co-infections such as herpes simplex virus type 2 (HSV-2) and syphilis, and the role of systemic inflammation in driving clinical outcomes in people living with HIV. He is also Co-Principle Investigator on two CIHR-supported multicentre randomized control trials including the a trial of anti-herpes medication for attenuating HIV disease progression, and a trial of enhanced syphilis screening in HIV-positive men.

Recent Publications

  1. Orkin, C, Oka, S, Philibert, P, Brinson, C, Bassa, A, Gusev, D et al.. Long-acting cabotegravir plus rilpivirine for treatment in adults with HIV-1 infection: 96-week results of the randomised, open-label, phase 3 FLAIR study. Lancet HIV. 2021;8 (4):e185-e196. doi: 10.1016/S2352-3018(20)30340-4. PubMed PMID:33794181 .
  2. Tan, DHS, Chan, AK, Jüni, P, Tomlinson, G, Daneman, N, Walmsley, S et al.. Post-exposure prophylaxis against SARS-CoV-2 in close contacts of confirmed COVID-19 cases (CORIPREV): study protocol for a cluster-randomized trial. Trials. 2021;22 (1):224. doi: 10.1186/s13063-021-05134-7. PubMed PMID:33752741 PubMed Central PMC7982877.
  3. Charest, M, Sharma, M, Chris, A, Schnubb, A, Knox, DC, Wilton, J et al.. Decentralizing PrEP delivery: Implementation and dissemination strategies to increase PrEP uptake among MSM in Toronto, Canada. PLoS One. 2021;16 (3):e0248626. doi: 10.1371/journal.pone.0248626. PubMed PMID:33735209 PubMed Central PMC7971529.
  4. Hughes, JM, Tan, DH, Anderson, P, Bodhinayake, J, MacPherson, PA. Infection with antiretroviral-susceptible HIV in an individual adherent to pre-exposure prophylaxis: strategies for treatment initiation. Int J STD AIDS. 2021; :956462420971125. doi: 10.1177/0956462420971125. PubMed PMID:33663292 .
  5. Sinno, J, Doria, N, Cochkanoff, N, Numer, M, Neyedli, H, Tan, D et al.. Attitudes and Practices of a Sample of Nova Scotian Physicians for the Implementation of HIV Pre-Exposure Prophylaxis. HIV AIDS (Auckl). 2021;13 :157-170. doi: 10.2147/HIV.S287201. PubMed PMID:33574712 PubMed Central PMC7872901.
  6. Feld, JJ, Kandel, C, Biondi, MJ, Kozak, RA, Zahoor, MA, Lemieux, C et al.. Peginterferon lambda for the treatment of outpatients with COVID-19: a phase 2, placebo-controlled randomised trial. Lancet Respir Med. 2021; :. doi: 10.1016/S2213-2600(20)30566-X. PubMed PMID:33556319 PubMed Central PMC7906707.
  7. Wang, L, Moqueet, N, Simkin, A, Knight, J, Ma, H, Lachowsky, NJ et al.. Mathematical modelling of the influence of serosorting on the population-level HIV transmission impact of pre-exposure prophylaxis. AIDS. 2021; :. doi: 10.1097/QAD.0000000000002826. PubMed PMID:33534205 .
  8. Cheng, MP, Lee, TC, Tan, DHS, Murthy, S. CMAJ. 2020;192 (42):E1296-E1298. doi: 10.1503/cmaj.200438-f. PubMed PMID:33077531 PubMed Central PMC7588204.
  9. Rana, J, Guiang, CB, Lisk, R, Shahin, R, Brunetta, J, Mitterni, L et al.. Survey of Health Care Providers' Practices and Opinions Regarding Bacterial Sexually Transmitted Infection Testing Among Gay, Bisexual, and Other Men Who Have Sex With Men. Sex Transm Dis. 2021;48 (2):94-102. doi: 10.1097/OLQ.0000000000001287. PubMed PMID:33003183 .
  10. Tan, DHS, Agrawal, R, Barnabas, RV, Giles, JT, Dull, P. Moving fast but going slow: coordination challenges for trials of COVID-19 post-exposure prophylaxis. Trials. 2020;21 (1):815. doi: 10.1186/s13063-020-04754-9. PubMed PMID:32993804 PubMed Central PMC7523255.
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Affiliations & Other Activities

  • Clinician-Scientist, Department of Medicine, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Assistant Professor, Institute of Health Policy, Management & Evaluation, University of Toronto
  • Director, HIV Prevention Clinical Research Unit, University of Toronto
  • Affiliate Scientist, Toronto General Research Institute
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