Darrell Tan

MD, FRCPC, PhD

Scientist, Li Ka Shing Knowledge Institute

Biography

Dr. Darrell Tan is an infectious diseases physician, clinician-scientist and Canadian Institutes of Health Research (CIHR) New Investigator whose research focuses on clinical trials in human immunodeficiency virus (HIV) prevention and HIV/sexual transmitted infection (STI) co-infection. As Director of the University of Toronto Clinical Research Unit on HIV Prevention and co-leader of the CIHR Canadian HIV Trials Network Biomedical Prevention Working Group, he is leading multiple efforts to optimize the implementation of HIV pre- and post-exposure prophylaxis (PrEP and PEP) in Canada. These include Canada’s first demonstration project of daily oral TDF/FTC-based PrEP in Toronto MSM, the development of national Clinical Practice Guidelines on PEP & PrEP use, exploration of the relationship between syndemic health problems and clinical outcomes of PEP & PrEP, studies of nurse-led PEP & PrEP, and evaluations of novel antiretroviral PEP regimens.

Additional research interests are in the interaction between HIV and common co-infections such as herpes simplex virus type 2 (HSV-2) and syphilis, and the role of systemic inflammation in driving clinical outcomes in people living with HIV. He is also Co-Principle Investigator on two CIHR-supported multicentre randomized control trials including the a trial of anti-herpes medication for attenuating HIV disease progression, and a trial of enhanced syphilis screening in HIV-positive men.

Recent Publications

  1. Rana, J, Wilton, J, Fowler, S, Hart, TA, Bayoumi, AM, Tan, DHS et al.. Trends in the awareness, acceptability, and usage of HIV pre-exposure prophylaxis among at-risk men who have sex with men in Toronto. Can J Public Health. 2018; :. doi: 10.17269/s41997-018-0064-3. PubMed PMID:29981088 .
  2. Sharma, M, Chris, A, Chan, A, Knox, DC, Wilton, J, McEwen, O et al.. Decentralizing the delivery of HIV pre-exposure prophylaxis (PrEP) through family physicians and sexual health clinic nurses: a dissemination and implementation study protocol. BMC Health Serv Res. 2018;18 (1):513. doi: 10.1186/s12913-018-3324-2. PubMed PMID:29970087 PubMed Central PMC6029110.
  3. Morrison, SA, Yoong, D, Hart, TA, MacPherson, P, Bogoch, I, Sivarajah, V et al.. High prevalence of syndemic health problems in patients seeking post-exposure prophylaxis for sexual exposures to HIV. PLoS ONE. 2018;13 (5):e0197998. doi: 10.1371/journal.pone.0197998. PubMed PMID:29791514 PubMed Central PMC5965882.
  4. Thavorn, K, Kugathasan, H, Tan, DHS, Moqueet, N, Baral, SD, Skidmore, B et al.. Economic evaluation of HIV pre-exposure prophylaxis strategies: protocol for a methodological systematic review and quantitative synthesis. Syst Rev. 2018;7 (1):47. doi: 10.1186/s13643-018-0710-0. PubMed PMID:29544530 PubMed Central PMC5855998.
  5. Wilton, J, Noor, SW, Schnubb, A, Lawless, J, Hart, TA, Grennan, T et al.. High HIV risk and syndemic burden regardless of referral source among MSM screening for a PrEP demonstration project in Toronto, Canada. BMC Public Health. 2018;18 (1):292. doi: 10.1186/s12889-018-5180-8. PubMed PMID:29486737 PubMed Central PMC5830065.
  6. Gesink, D, Wang, S, Guimond, T, Kimura, L, Connell, J, Salway, T et al.. Conceptualizing Geosexual Archetypes: Mapping the Sexual Travels and Egocentric Sexual Networks of Gay and Bisexual Men in Toronto, Canada. Sex Transm Dis. 2018;45 (6):368-373. doi: 10.1097/OLQ.0000000000000752. PubMed PMID:29465690 PubMed Central PMC5959212.
  7. Tumarkin, E, Heendeniya, A, Murphy, P, Placido, T, Tan, DHS, Bogoch, II et al.. Brief Report: HIV Postexposure Prophylaxis-in-Pocket ("PIP") for Individuals With Low-Frequency, High-Risk HIV Exposures. J. Acquir. Immune Defic. Syndr. 2018;78 (1):20-22. doi: 10.1097/QAI.0000000000001639. PubMed PMID:29419570 .
  8. Naccarato, MJ, Yoong, DM, Fong, IW, Gough, KA, Ostrowski, MA, Tan, DHS et al.. Combination Therapy with Tenofovir Disoproxil Fumarate/Emtricitabine/Elvitegravir/Cobicistat Plus Darunavir Once Daily in Antiretroviral-Naive and Treatment-Experienced Patients: A Retrospective Review. J Int Assoc Provid AIDS Care. ;17 :2325957417752260. doi: 10.1177/2325957417752260. PubMed PMID:29385867 .
  9. Yanagawa, B, Bahji, A, Lamba, W, Tan, DH, Cheema, A, Syed, I et al.. Endocarditis in the setting of IDU: multidisciplinary management. Curr. Opin. Cardiol. 2018;33 (2):140-147. doi: 10.1097/HCO.0000000000000493. PubMed PMID:29232248 .
  10. Grace, D, Jollimore, J, MacPherson, P, Strang, MJP, Tan, DHS. The Pre-Exposure Prophylaxis-Stigma Paradox: Learning from Canada's First Wave of PrEP Users. AIDS Patient Care STDS. 2018;32 (1):24-30. doi: 10.1089/apc.2017.0153. PubMed PMID:29185801 PubMed Central PMC5756933.
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Affiliations & Other Activities

  • Clinician-Scientist, Department of Medicine, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Assistant Professor, Institute of Health Policy, Management & Evaluation, University of Toronto
  • Director, HIV Prevention Clinical Research Unit, University of Toronto
  • Affiliate Scientist, Toronto General Research Institute
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