Darrell Tan

MD, FRCPC, PhD

Scientist

Biography

Dr. Darrell Tan is an infectious diseases physician, clinician-scientist and Canadian Institutes of Health Research (CIHR) New Investigator whose research focuses on clinical trials in human immunodeficiency virus (HIV) prevention and HIV/sexual transmitted infection (STI) co-infection. As Director of the University of Toronto Clinical Research Unit on HIV Prevention and co-leader of the CIHR Canadian HIV Trials Network Biomedical Prevention Working Group, he is leading multiple efforts to optimize the implementation of HIV pre- and post-exposure prophylaxis (PrEP and PEP) in Canada. These include Canada’s first demonstration project of daily oral TDF/FTC-based PrEP in Toronto MSM, the development of national Clinical Practice Guidelines on PEP & PrEP use, exploration of the relationship between syndemic health problems and clinical outcomes of PEP & PrEP, studies of nurse-led PEP & PrEP, and evaluations of novel antiretroviral PEP regimens.

Additional research interests are in the interaction between HIV and common co-infections such as herpes simplex virus type 2 (HSV-2) and syphilis, and the role of systemic inflammation in driving clinical outcomes in people living with HIV. He is also Co-Principle Investigator on two CIHR-supported multicentre randomized control trials including the a trial of anti-herpes medication for attenuating HIV disease progression, and a trial of enhanced syphilis screening in HIV-positive men.

Recent Publications

  1. Christensen, BL, Tan, DH. An up-to-date evaluation of dolutegravir/abacavir/lamivudine for the treatment of HIV. Expert Opin Pharmacother. 2022; :1-8. doi: 10.1080/14656566.2022.2029409. PubMed PMID:35073817 .
  2. Ali, K, Azher, T, Baqi, M, Binnie, A, Borgia, S, Carrier, FM et al.. Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial. CMAJ. 2022; :. doi: 10.1503/cmaj.211698. PubMed PMID:35045989 .
  3. Costiniuk, CT, Singer, J, Langlois, MA, Kulic, I, Needham, J, Burchell, A et al.. CTN 328: immunogenicity outcomes in people living with HIV in Canada following vaccination for COVID-19 (HIV-COV): protocol for an observational cohort study. BMJ Open. 2021;11 (12):e054208. doi: 10.1136/bmjopen-2021-054208. PubMed PMID:34916326 PubMed Central PMC8678543.
  4. Tan, DHS, Rana, J, Tengra, Z, Hart, TA, Wilton, J, Bayoumi, AM et al.. Preferences regarding emerging HIV prevention technologies among Toronto men who have sex with men: a discrete choice experiment. Sci Rep. 2021;11 (1):22252. doi: 10.1038/s41598-021-01634-3. PubMed PMID:34782691 PubMed Central PMC8592986.
  5. Orkin, C, Bernal Morell, E, Tan, DHS, Katner, H, Stellbrink, HJ, Belonosova, E et al.. Initiation of long-acting cabotegravir plus rilpivirine as direct-to-injection or with an oral lead-in in adults with HIV-1 infection: week 124 results of the open-label phase 3 FLAIR study. Lancet HIV. 2021;8 (11):e668-e678. doi: 10.1016/S2352-3018(21)00184-3. PubMed PMID:34656207 .
  6. Suri, S, Yoong, D, Short, D, Tan, DH, Naccarato, M, Crane, HM et al.. Feasibility of implementing a same-day electronic screening tool for clinical assessment to measure patient-reported outcomes for eliciting actionable information on adherence to HIV medication and related factors in a busy Canadian urban HIV clinic. Int J STD AIDS. 2021; :9564624211032796. doi: 10.1177/09564624211032796. PubMed PMID:34293990 .
  7. MacKinnon, KR, Grewal, R, Tan, DH, Rousseau, R, Maxwell, J, Walmsley, S et al.. Patient perspectives on the implementation of routinised syphilis screening with HIV viral load testing: Qualitative process evaluation of the Enhanced Syphilis Screening Among HIV-positive Men trial. BMC Health Serv Res. 2021;21 (1):625. doi: 10.1186/s12913-021-06602-1. PubMed PMID:34193138 PubMed Central PMC8243864.
  8. Burchell, AN, Tan, DHS, Grewal, R, MacPherson, PA, Walmsley, S, Anita, R et al.. Routinised Syphilis Screening among Men Living with HIV: A stepped wedge cluster randomised controlled trial. Clin Infect Dis. 2021; :. doi: 10.1093/cid/ciab582. PubMed PMID:34175944 .
  9. Hart, TA, Moore, DM, Noor, SW, Lachowsky, N, Grace, D, Cox, J et al.. Prevalence of HIV and sexually transmitted and blood-borne infections, and related preventive and risk behaviours, among gay, bisexual and other men who have sex with men in Montreal, Toronto and Vancouver: results from the Engage Study. Can J Public Health. 2021;112 (6):1020-1029. doi: 10.17269/s41997-021-00546-z. PubMed PMID:34142353 PubMed Central PMC8210738.
  10. Cox, J, Apelian, H, Moodie, EEM, Messier-Peet, M, Hart, TA, Grace, D et al.. Use of HIV pre-exposure prophylaxis among urban Canadian gay, bisexual and other men who have sex with men: a cross-sectional analysis of the Engage cohort study. CMAJ Open. ;9 (2):E529-E538. doi: 10.9778/cmajo.20200198. PubMed PMID:34021010 PubMed Central PMC8177951.
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Affiliations & Other Activities

  • Clinician-Scientist, Department of Medicine, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Assistant Professor, Institute of Health Policy, Management & Evaluation, University of Toronto
  • Director, HIV Prevention Clinical Research Unit, University of Toronto
  • Affiliate Scientist, Toronto General Research Institute
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