Darrell Tan

MD, FRCPC, PhD

Scientist, Li Ka Shing Knowledge Institute

Biography

Dr. Darrell Tan is an infectious diseases physician, clinician-scientist and Canadian Institutes of Health Research (CIHR) New Investigator whose research focuses on clinical trials in human immunodeficiency virus (HIV) prevention and HIV/sexual transmitted infection (STI) co-infection. As Director of the University of Toronto Clinical Research Unit on HIV Prevention and co-leader of the CIHR Canadian HIV Trials Network Biomedical Prevention Working Group, he is leading multiple efforts to optimize the implementation of HIV pre- and post-exposure prophylaxis (PrEP and PEP) in Canada. These include Canada’s first demonstration project of daily oral TDF/FTC-based PrEP in Toronto MSM, the development of national Clinical Practice Guidelines on PEP & PrEP use, exploration of the relationship between syndemic health problems and clinical outcomes of PEP & PrEP, studies of nurse-led PEP & PrEP, and evaluations of novel antiretroviral PEP regimens.

Additional research interests are in the interaction between HIV and common co-infections such as herpes simplex virus type 2 (HSV-2) and syphilis, and the role of systemic inflammation in driving clinical outcomes in people living with HIV. He is also Co-Principle Investigator on two CIHR-supported multicentre randomized control trials including the a trial of anti-herpes medication for attenuating HIV disease progression, and a trial of enhanced syphilis screening in HIV-positive men.

Recent Publications

  1. Strike, C, Robinson, S, Guta, A, Tan, DH, O'Leary, B, Cooper, C et al.. Illicit drug use while admitted to hospital: Patient and health care provider perspectives. PLoS ONE. 2020;15 (3):e0229713. doi: 10.1371/journal.pone.0229713. PubMed PMID:32134973 PubMed Central PMC7058273.
  2. Tan, DHS, Lee, T, Raboud, J, Qamar, A, Cheung, AM, Walmsley, S et al.. Alendronate/Vitamin D for attenuating bone mineral density loss during antiretroviral initiation: a pilot randomized controlled trial. HIV Res Clin Pract. 2019;20 (6):140-150. doi: 10.1080/25787489.2020.1730114. PubMed PMID:32106792 .
  3. Baranek, B, Wang, S, Cheung, AM, Mishra, S, Tan, DH. The effect of tenofovir disoproxil fumarate on bone mineral density: a systematic review and meta-analysis. Antivir. Ther. (Lond.). 2020; :. doi: 10.3851/IMP3346. PubMed PMID:32077867 .
  4. Alghamdi, A, Hempel, A, Heendeniya, A, Clifford-Rashotte, M, Tan, DHS, Bogoch, II et al.. HIV postexposure prophylaxis-in-pocket: long-term follow-up of individuals with low-frequency, high-risk HIV exposures. AIDS. 2020;34 (3):433-437. doi: 10.1097/QAD.0000000000002441. PubMed PMID:31996594 .
  5. Fusca, L, Hull, M, Ross, P, Grennan, T, Burchell, AN, Bayoumi, AM et al.. High Interest in Syphilis Pre-exposure and Post-exposure Prophylaxis Among Gay, Bisexual and Other Men Who Have Sex With Men in Vancouver and Toronto. Sex Transm Dis. 2020;47 (4):224-231. doi: 10.1097/OLQ.0000000000001130. PubMed PMID:31977974 PubMed Central PMC7077973.
  6. Alghamdi, A, Hempel, A, Heendeniya, A, Clifford-Rashotte, M, Tan, DHS, Bogoch, II et al.. HIV post-exposure prophylaxis-in-pocket ("PIP"): long-term follow-up of individuals with low-frequency, high-risk HIV exposures. AIDS. 2019; :. doi: 10.1097/QAD.0000000000002441. PubMed PMID:31764075 .
  7. Wang, L, Moqueet, N, Lambert, G, Grace, D, Rodrigues, R, Cox, J et al.. Population-Level Sexual Mixing By HIV Status and Pre-exposure Prophylaxis Use Among Men Who Have Sex with Men in Montreal, Canada: Implications for HIV Prevention. Am. J. Epidemiol. 2019; :. doi: 10.1093/aje/kwz231. PubMed PMID:31612213 .
  8. Tan, DHS, Rolon, MJ, Figueroa, MI, Sued, O, Gun, A, Kaul, R et al.. Inflammatory biomarker levels over 48 weeks with dual vs triple lopinavir/ritonavir-based therapy: Substudy of a randomized trial. PLoS ONE. 2019;14 (9):e0221653. doi: 10.1371/journal.pone.0221653. PubMed PMID:31490959 PubMed Central PMC6730918.
  9. Walmsley, B, Gallant, D, Naccarato, M, Hull, M, Smith, A, Tan, DH et al.. The PrEP You Want: A Web-Based Survey of Online Cross-Border Shopping for HIV Prophylaxis Medications. J. Med. Internet Res. 2019;21 (7):e12076. doi: 10.2196/12076. PubMed PMID:31333200 PubMed Central PMC6681640.
  10. Burchell, AN, Lisk, R, Yeung, A, Rana, J, Bacon, J, Brunetta, J et al.. Community-Directed Bacterial Sexually Transmitted Infection Testing Interventions Among Men Who Have Sex With Men: Protocol for an E-Delphi Study in Toronto, Canada. JMIR Res Protoc. 2019;8 (7):e13801. doi: 10.2196/13801. PubMed PMID:31274111 PubMed Central PMC6637728.
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Affiliations & Other Activities

  • Clinician-Scientist, Department of Medicine, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Assistant Professor, Institute of Health Policy, Management & Evaluation, University of Toronto
  • Director, HIV Prevention Clinical Research Unit, University of Toronto
  • Affiliate Scientist, Toronto General Research Institute
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