Darren Yuen

MD, FRCPC, PhD

Scientist

Biography

My lab is interested in understanding novel mechanisms of fibrovascular injury in the kidney, using both cell and animal models of disease, with the goal of using the knowledge gained to develop innovative new therapies for kidney disease. Research projects span the spectrum from basic cell biology to clinical studies, including the investigation of cellular processes underlying fibroblast and endothelial cell behaviour, the testing of potential new treatments in animal models of disease, and the examination of structure-function relationships in patients with kidney disease.

Recent Publications

  1. Hysi, E, Yuen, DA. Imaging of renal fibrosis. Curr Opin Nephrol Hypertens. 2020;29 (6):599-607. doi: 10.1097/MNH.0000000000000650. PubMed PMID:33009130 .
  2. Gilbert, RE, Caldwell, L, Misra, PS, Chan, K, Burns, KD, Wrana, JL et al.. Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019. Can J Diabetes. 2020; :. doi: 10.1016/j.jcjd.2020.07.003. PubMed PMID:32917504 PubMed Central PMC7368650.
  3. Misra, PS, Szeto, SG, Krizova, A, Gilbert, RE, Yuen, DA. Renal histology in diabetic nephropathy predicts progression to end-stage kidney disease but not the rate of renal function decline. BMC Nephrol. 2020;21 (1):285. doi: 10.1186/s12882-020-01943-1. PubMed PMID:32682403 PubMed Central PMC7368674.
  4. Hashim, E, Yuen, DA, Kirpalani, A. Reduced Flow in Delayed Graft Function as Assessed by IVIM Is Associated With Time to Recovery Following Kidney Transplantation. J Magn Reson Imaging. 2021;53 (1):108-117. doi: 10.1002/jmri.27245. PubMed PMID:32602206 .
  5. Tangri, N, Ferguson, TW, Wiebe, C, Eng, F, Nash, M, Astor, BC et al.. Validation of the Kidney Failure Risk Equation in Kidney Transplant Recipients. Can J Kidney Health Dis. 2020;7 :2054358120922627. doi: 10.1177/2054358120922627. PubMed PMID:32549052 PubMed Central PMC7249550.
  6. Abdalla, M, Abdalla, M, Siddiqi, FS, Geldenhuys, L, Batchu, SN, Tolosa, MF et al.. A common glomerular transcriptomic signature distinguishes diabetic kidney disease from other kidney diseases in humans and mice. Curr Res Transl Med. 2020;68 (4):225-236. doi: 10.1016/j.retram.2020.05.001. PubMed PMID:32499177 .
  7. Hysi, E, He, X, Fadhel, MN, Zhang, T, Krizova, A, Ordon, M et al.. Photoacoustic imaging of kidney fibrosis for assessing pretransplant organ quality. JCI Insight. 2020;5 (10):. doi: 10.1172/jci.insight.136995. PubMed PMID:32298239 PubMed Central PMC7259526.
  8. He, X, Zhang, T, Tolosa, M, Goru, SK, Chen, X, Misra, PS et al.. A new, easily generated mouse model of diabetic kidney fibrosis. Sci Rep. 2019;9 (1):12549. doi: 10.1038/s41598-019-49012-4. PubMed PMID:31467329 PubMed Central PMC6715679.
  9. Yamamura, K, Yuen, D, Hickey, EJ, He, X, Chaturvedi, RR, Friedberg, MK et al.. Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement. Heart. 2019;105 (11):855-863. doi: 10.1136/heartjnl-2018-313961. PubMed PMID:30514732 .
  10. Kepecs, DM, Glick, L, Silver, SA, Yuen, DA. Does Chronic Kidney Disease-Induced Cognitive Impairment Affect Driving Safety?. Can J Kidney Health Dis. 2018;5 :2054358118777133. doi: 10.1177/2054358118777133. PubMed PMID:29977582 PubMed Central PMC6024330.
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Affiliations & Other Activities

  • Staff Physician, Division of Nephrology, Department of Medicine, St. Michael’s Hospital
  • Assistant Professor, Medicine, University of Toronto
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