Darren Yuen


Scientist, Keenan Research Centre for Biomedical Science


My lab is interested in understanding novel mechanisms of fibrovascular injury in the kidney, using both cell and animal models of disease, with the goal of using the knowledge gained to develop innovative new therapies for kidney disease. Research projects span the spectrum from basic cell biology to clinical studies, including the investigation of cellular processes underlying fibroblast and endothelial cell behaviour, the testing of potential new treatments in animal models of disease, and the examination of structure-function relationships in patients with kidney disease.

Recent Publications

  1. Hysi, E, He, X, Fadhel, MN, Zhang, T, Krizova, A, Ordon, M et al.. Photoacoustic imaging of kidney fibrosis for assessing pretransplant organ quality. JCI Insight. 2020;5 (10):. doi: 10.1172/jci.insight.136995. PubMed PMID:32298239 .
  2. He, X, Zhang, T, Tolosa, M, Goru, SK, Chen, X, Misra, PS et al.. A new, easily generated mouse model of diabetic kidney fibrosis. Sci Rep. 2019;9 (1):12549. doi: 10.1038/s41598-019-49012-4. PubMed PMID:31467329 PubMed Central PMC6715679.
  3. Yamamura, K, Yuen, D, Hickey, EJ, He, X, Chaturvedi, RR, Friedberg, MK et al.. Right ventricular fibrosis is associated with cardiac remodelling after pulmonary valve replacement. Heart. 2019;105 (11):855-863. doi: 10.1136/heartjnl-2018-313961. PubMed PMID:30514732 .
  4. Kepecs, DM, Glick, L, Silver, SA, Yuen, DA. Does Chronic Kidney Disease-Induced Cognitive Impairment Affect Driving Safety?. Can J Kidney Health Dis. 2018;5 :2054358118777133. doi: 10.1177/2054358118777133. PubMed PMID:29977582 PubMed Central PMC6024330.
  5. Kirpalani, A, Hashim, E, Leung, G, Kim, JK, Krizova, A, Jothy, S et al.. Magnetic Resonance Elastography to Assess Fibrosis in Kidney Allografts. Clin J Am Soc Nephrol. 2017;12 (10):1671-1679. doi: 10.2215/CJN.01830217. PubMed PMID:28855238 PubMed Central PMC5628708.
  6. Misra, P, Kirpalani, A, Leung, G, Vlachou, PA, Lee, JY, Jothy, S et al.. The role of thrombectomy and diffusion-weighted imaging with MRI in post-transplant renal vein thrombosis: a case report. BMC Nephrol. 2017;18 (1):224. doi: 10.1186/s12882-017-0618-2. PubMed PMID:28693502 PubMed Central PMC5504730.
  7. Sarak, B, Wald, R, Goldstein, MB, Deva, DP, Leipsic, J, Kiaii, M et al.. Relationship between changes in blood pressure and left ventricular mass over 1 year in end-stage renal disease. J. Hypertens. 2017;35 (8):1709-1716. doi: 10.1097/HJH.0000000000001353. PubMed PMID:28319597 .
  8. Leung, G, Kirpalani, A, Szeto, SG, Deeb, M, Foltz, W, Simmons, CA et al.. Could MRI Be Used To Image Kidney Fibrosis? A Review of Recent Advances and Remaining Barriers. Clin J Am Soc Nephrol. 2017;12 (6):1019-1028. doi: 10.2215/CJN.07900716. PubMed PMID:28298435 PubMed Central PMC5460707.
  9. Ross, BA, Wald, R, Goldstein, MB, Yuen, DA, Leipsic, J, Kiaii, M et al.. Relationships Between Left Ventricular Structure and Function According to Cardiac MRI and Cardiac Biomarkers in End-Stage Renal Disease. Can J Cardiol. 2017;33 (4):501-507. doi: 10.1016/j.cjca.2016.11.021. PubMed PMID:28222921 .
  10. Kepecs, DM, Yuen, DA, Zhang, Y, Thai, K, Connelly, KA, Gilbert, RE et al.. Progenitor cell secretory products exert additive renoprotective effects when combined with ace inhibitors in experimental CKD. J Renin Angiotensin Aldosterone Syst. 2016;17 (3):. doi: 10.1177/1470320316668434. PubMed PMID:27638853 PubMed Central PMC5843926.
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Affiliations & Other Activities

  • Staff Physician, Division of Nephrology, Department of Medicine, St. Michael’s Hospital
  • Assistant Professor, Medicine, University of Toronto