Darren Yuen

MD, FRCPC, PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

My lab is interested in understanding novel mechanisms of fibrovascular injury in the kidney, using both cell and animal models of disease, with the goal of using the knowledge gained to develop innovative new therapies for kidney disease. Research projects span the spectrum from basic cell biology to clinical studies, including the investigation of cellular processes underlying fibroblast and endothelial cell behaviour, the testing of potential new treatments in animal models of disease, and the examination of structure-function relationships in patients with kidney disease.

Recent Publications

  1. Sarak, B, Wald, R, Goldstein, MB, Deva, DP, Leipsic, J, Kiaii, M et al.. Relationship between changes in blood pressure and left ventricular mass over 1 year in end-stage renal disease. J. Hypertens. 2017; :. doi: 10.1097/HJH.0000000000001353. PubMed PMID:28319597 .
  2. Leung, G, Kirpalani, A, Szeto, SG, Deeb, M, Foltz, W, Simmons, CA et al.. Could MRI Be Used To Image Kidney Fibrosis? A Review of Recent Advances and Remaining Barriers. Clin J Am Soc Nephrol. 2017;12 (6):1019-1028. doi: 10.2215/CJN.07900716. PubMed PMID:28298435 PubMed Central PMC5460707.
  3. Ross, BA, Wald, R, Goldstein, MB, Yuen, DA, Leipsic, J, Kiaii, M et al.. Relationships Between Left Ventricular Structure and Function According to Cardiac MRI and Cardiac Biomarkers in End-Stage Renal Disease. Can J Cardiol. 2017;33 (4):501-507. doi: 10.1016/j.cjca.2016.11.021. PubMed PMID:28222921 .
  4. Kepecs, DM, Yuen, DA, Zhang, Y, Thai, K, Connelly, KA, Gilbert, RE et al.. Progenitor cell secretory products exert additive renoprotective effects when combined with ace inhibitors in experimental CKD. J Renin Angiotensin Aldosterone Syst. 2016;17 (3):. doi: 10.1177/1470320316668434. PubMed PMID:27638853 .
  5. Auguste, BL, Yuen, D, Chan, CT. Conventional hemodialysis is associated with greater bone loss than nocturnal hemodialysis: a retrospective observational study of a convenience cohort. Can J Kidney Health Dis. 2016;3 :27. doi: 10.1186/s40697-016-0118-5. PubMed PMID:27252880 PubMed Central PMC4888502.
  6. Szeto, SG, Narimatsu, M, Lu, M, He, X, Sidiqi, AM, Tolosa, MF et al.. YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis. J. Am. Soc. Nephrol. 2016;27 (10):3117-3128. doi: 10.1681/ASN.2015050499. PubMed PMID:26961347 PubMed Central PMC5042658.
  7. Yuen, DA, Huang, YW, Liu, GY, Patel, S, Fang, F, Zhou, J et al.. Recombinant N-Terminal Slit2 Inhibits TGF-β-Induced Fibroblast Activation and Renal Fibrosis. J. Am. Soc. Nephrol. 2016;27 (9):2609-15. doi: 10.1681/ASN.2015040356. PubMed PMID:26869008 PubMed Central PMC5004640.
  8. Yuen, DA, Kepecs, DM, Zhang, Y, Advani, S, Thai, K, Connelly, KA et al.. Repeated treatment with bone marrow cell secretory products maintains long-term renoprotection in experimental chronic kidney disease: a placebo-controlled trial. Can J Kidney Health Dis. 2015;2 :44. doi: 10.1186/s40697-015-0082-5. PubMed PMID:26568839 PubMed Central PMC4644292.
  9. Rozycki, M, Bialik, JF, Speight, P, Dan, Q, Knudsen, TE, Szeto, SG et al.. Myocardin-related Transcription Factor Regulates Nox4 Protein Expression: LINKING CYTOSKELETAL ORGANIZATION TO REDOX STATE. J. Biol. Chem. 2016;291 (1):227-43. doi: 10.1074/jbc.M115.674606. PubMed PMID:26555261 PubMed Central PMC4697158.
  10. Wald, R, Goldstein, MB, Perl, J, Kiaii, M, Yuen, D, Wald, RM et al.. The Association Between Conversion to In-centre Nocturnal Hemodialysis and Left Ventricular Mass Regression in Patients With End-Stage Renal Disease. Can J Cardiol. 2016;32 (3):369-77. doi: 10.1016/j.cjca.2015.07.004. PubMed PMID:26386732 .
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Affiliations & Other Activities

  • Staff Physician, Medicine/Nephrology, St. Michael’s Hospital
  • Assistant Professor, Medicine, University of Toronto