David Jenkins

OC, MD, FRSC, FRCP, FRCPC, PhD, DSc

Scientist

Biography

Educated at Oxford University, Dr. David Jenkins is currently a Professor in both the Departments of Nutritional Sciences and Medicine, Faculty of Medicine, University of Toronto, a Staff Physician in the Division of Endocrinology and Metabolism, the Director of the Clinical Nutrition and Risk Factor Modification Center, and a Scientist in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital. He has served on committees in Canada and the United States that have formulated nutritional guidelines for the treatment of diabetes and recommendations for fibre and macronutrient intake (fat protein and carbohydrates) for the general population (including the Dietary Reference intake or DRIs) under the joint United States-Canada DRI system (RDAs) of the National Academy of Sciences (Washington, DC). He led the team that first defined and explored the concept of the glycemic index of foods. He was the first to demonstrate the breadth of metabolic effects of viscous soluble fiber (as found in fruit, certain beans, oats barley) on blood glucose and cholesterol lowering of relevance to prevention and treatment of diabetes and heart disease. His studies on combining cholesterol lowering food components (dietary portfolio) have been recognized as creating an effective dietary alternative to drug therapy (statins) for lower risk people. In an important study, he compared a dietary portfolio with all food provided with a statin in the same people and demonstrated that the effects of both were comparable. The dietary portfolio, on the basis of this and other studies including a major cross Canada real world study, was the only dietary approach referenced in 2004 Guidelines update of the US National Cholesterol Education Program (ATP III) and recommended in the Canadian Cardiovascular Society (CCS) guidelines for 2012 and the European Atherosclerosis Society consensus statement (2015). He has received many National and International awards in recognition of his contribution to nutrition research. He believes in the value of plant based diets, and that a major effort is required to mount large studies to determine the extent of their health benefits. He also believes that diets have to be environmentally sustainable.

Please note: Dr. Jenkins is currently accepting volunteer students.

Recent Publications

  1. Nishi, SK, Viguiliouk, E, Blanco Mejia, S, Kendall, CWC, Bazinet, RP, Hanley, AJ et al.. Are fatty nuts a weighty concern? A systematic review and meta-analysis and dose-response meta-regression of prospective cohorts and randomized controlled trials. Obes Rev. 2021; :e13330. doi: 10.1111/obr.13330. PubMed PMID:34494363 .
  2. Glenn, AJ, Boucher, BA, Kavcic, CC, Khan, TA, Paquette, M, Kendall, CWC et al.. Development of a Portfolio Diet Score and Its Concurrent and Predictive Validity Assessed by a Food Frequency Questionnaire. Nutrients. 2021;13 (8):. doi: 10.3390/nu13082850. PubMed PMID:34445009 PubMed Central PMC8398786.
  3. de Perrot, M, Gopalan, D, Jenkins, D, Lang, IM, Fadel, E, Delcroix, M et al.. Evaluation and management of patients with chronic thromboembolic pulmonary hypertension - consensus statement from the ISHLT. J Heart Lung Transplant. 2021; :. doi: 10.1016/j.healun.2021.07.020. PubMed PMID:34420851 .
  4. Jenkins, DJA, Kendall, CWC, Sievenpiper, JL. Plant Polyphenols Lignans and Cardiovascular Disease. J Am Coll Cardiol. 2021;78 (7):679-682. doi: 10.1016/j.jacc.2021.06.014. PubMed PMID:34384549 .
  5. Chiavaroli, L, Lee, D, Ahmed, A, Cheung, A, Khan, TA, Blanco, S et al.. Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials. BMJ. 2021;374 :n1651. doi: 10.1136/bmj.n1651. PubMed PMID:34348965 PubMed Central PMC8336013.
  6. Glenn, AJ, Lo, K, Jenkins, DJA, Boucher, BA, Hanley, AJ, Kendall, CWC et al.. Relationship Between a Plant-Based Dietary Portfolio and Risk of Cardiovascular Disease: Findings From the Women's Health Initiative Prospective Cohort Study. J Am Heart Assoc. 2021;10 (16):e021515. doi: 10.1161/JAHA.121.021515. PubMed PMID:34346245 .
  7. Jenkins, DJA, Dehghan, M, Yusuf, S. Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality. Reply. N Engl J Med. 2021;385 (4):379-380. doi: 10.1056/NEJMc2107926. PubMed PMID:34289286 .
  8. Ayoub-Charette, S, Chiavaroli, L, Liu, Q, Khan, TA, Zurbau, A, Au-Yeung, F et al.. Different Food Sources of Fructose-Containing Sugars and Fasting Blood Uric Acid Levels: A Systematic Review and Meta-Analysis of Controlled Feeding Trials. J Nutr. 2021;151 (8):2409-2421. doi: 10.1093/jn/nxab144. PubMed PMID:34087940 PubMed Central PMC8349131.
  9. Semnani-Azad, Z, Connelly, PW, Bazinet, RP, Retnakaran, R, Jenkins, DJA, Harris, SB et al.. Adipose Tissue Insulin Resistance Is Longitudinally Associated With Adipose Tissue Dysfunction, Circulating Lipids, and Dysglycemia: The PROMISE Cohort. Diabetes Care. 2021; :. doi: 10.2337/dc20-1918. PubMed PMID:34001534 .
  10. Glenn, AJ, Hernández-Alonso, P, Kendall, CWC, Martínez-González, MÁ, Corella, D, Fitó, M et al.. Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study. Clin Nutr. 2021;40 (5):2825-2836. doi: 10.1016/j.clnu.2021.03.016. PubMed PMID:33933749 .
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Affiliations & Other Activities

  • Director, Clinical Nutrition and Risk Factor Modification Centre, St. Michael’s Hospital
  • Staff Physician, Division of Endocrinology, Department of Medicine, St. Michael’s Hospital
  • Professor and Canada Research Chair in Nutrition and Metabolism, Dept. of Medicine and Nutritional Sciences, Faculty of Medicine, University of Toronto
  • Canada Research Chair in Nutrition and Metabolism
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