David Klein


Associate Scientist, Li Ka Shing Knowledge Institute


Currently, I work in conjunction with Dr. A. Romaschin of the Department of Laboratory Medicine on the development and clinical application of novel biomarkers to acute care and critical care. I also am involved in the development of novel therapeutics targeting endotoxin in critical illness as well as the linkage of diagnostics and therapeutics. Separately, I lead business strategy and partnerships for the Applied Health Research Center and serve in a number of advisory roles to government and other policy makers on healthcare system and business strategy.

Recent Publications

  1. Howard, M, Day, AG, Bernard, C, Tan, A, You, J, Klein, D et al.. Development and psychometric properties of a survey to assess barriers to implementing advance care planning in primary care. J Pain Symptom Manage. 2017; :. doi: 10.1016/j.jpainsymman.2017.08.003. PubMed PMID:28803079 .
  2. Klein, D, Jeejeebhoy, K, Tremblay, A, Kallio, M, Rheaume, C, Humphries, S et al.. The CHANGE program: Exercise intervention in primary care. Can Fam Physician. 2017;63 (7):546-552. . PubMed PMID:28701449 PubMed Central PMC5507234.
  3. Romaschin, AD, Obiezu-Forster, CV, Shoji, H, Klein, DJ. Novel Insights into the Direct Removal of Endotoxin by Polymyxin B Hemoperfusion. Blood Purif. 2017;44 (3):193-197. doi: 10.1159/000475982. PubMed PMID:28601867 .
  4. Klein, DJ, Brown, AD, Detsky, AS. Investing Wisely in Health Care Capital. JAMA. 2016;316 (15):1543-1544. doi: 10.1001/jama.2016.10605. PubMed PMID:27684645 .
  5. Ip, CW, Isaias, IU, Kusche-Tekin, BB, Klein, D, Groh, J, O'Leary, A et al.. Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury. Acta Neuropathol Commun. 2016;4 (1):108. doi: 10.1186/s40478-016-0375-7. PubMed PMID:27716431 PubMed Central PMC5048687.
  6. Charbonney, E, Tsang, JY, Li, Y, Klein, D, Duque, P, Romaschin, A et al.. Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications. Crit. Care Med. 2016;44 (2):335-41. doi: 10.1097/CCM.0000000000001404. PubMed PMID:26509322 .
  7. Rewa, O, Wald, R, Adhikari, NK, Hladunewich, M, Lapinsky, S, Muscedere, J et al.. Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study. J Crit Care. 2015;30 (6):1359-64. doi: 10.1016/j.jcrc.2015.08.019. PubMed PMID:26421697 .
  8. Howard, M, Bernard, C, Tan, A, Slaven, M, Klein, D, Heyland, DK et al.. Advance care planning: Let's start sooner. Can Fam Physician. 2015;61 (8):663-5. . PubMed PMID:26273075 PubMed Central PMC4541424.
  9. Kitchlu, A, Adhikari, N, Burns, KE, Friedrich, JO, Garg, AX, Klein, D et al.. Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study. BMC Nephrol. 2015;16 :127. doi: 10.1186/s12882-015-0123-4. PubMed PMID:26238520 PubMed Central PMC4522955.
  10. Wald, R, Adhikari, NK, Smith, OM, Weir, MA, Pope, K, Cohen, A et al.. Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kidney Int. 2015;88 (4):897-904. doi: 10.1038/ki.2015.184. PubMed PMID:26154928 .
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Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health