David Klein

MD, MBA

Investigator

Biography

My research follows two major themes: (1) health policy and (2) sepsis and critical illness.   In the area of health policy, I co-lead the Centre for the Evaluation and Optimization of Public Healthcare Finance at IHPME with Dr. Adalsteinn Brown.  We are focused on improving healthcare capital investment and evaluation with a multidisciplinary group of collaborators.   In the area of sepsis and critical illness, I lead several efforts to develop novel diagnostics and therapeutics.  I have particular expertise in healthcare innovation and commercialization in addition to clinical development strategy.

Please note: Dr. Klein is not taking any summer students.

Recent Publications

  1. Arabi, YM, Gordon, AC, Derde, LPG, Nichol, AD, Murthy, S, Beidh, FA et al.. Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med. 2021;47 (8):867-886. doi: 10.1007/s00134-021-06448-5. PubMed PMID:34251506 PubMed Central PMC8274471.
  2. REMAP-CAP Investigators, Gordon, AC, Mouncey, PR, Al-Beidh, F, Rowan, KM, Nichol, AD et al.. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021;384 (16):1491-1502. doi: 10.1056/NEJMoa2100433. PubMed PMID:33631065 PubMed Central PMC7953461.
  3. Bao, EL, Nandakumar, SK, Liao, X, Bick, AG, Karjalainen, J, Tabaka, M et al.. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020;586 (7831):769-775. doi: 10.1038/s41586-020-2786-7. PubMed PMID:33057200 PubMed Central PMC7606745.
  4. STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, United Kingdom Critical Care Research Group, Canadian Nephrology Trials Network, Irish Critical Care Trials Group et al.. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N Engl J Med. 2020;383 (3):240-251. doi: 10.1056/NEJMoa2000741. PubMed PMID:32668114 .
  5. Teja, B, Daniel, I, Pink, GH, Brown, A, Klein, DJ. Ensuring adequate capital investment in Canadian health care. CMAJ. 2020;192 (25):E677-E683. doi: 10.1503/cmaj.191126. PubMed PMID:32571884 PubMed Central PMC7828857.
  6. Rachoin, JS, Foster, D, Giese, R, Weisberg, LS, Klein, DJ. Importance of Endotoxin Clearance in Endotoxemic Septic Shock: An Analysis From the Evaluating Use of PolymyxinB Hemoperfusion in a Randomized Controlled Trial of Adults Treated for Endotoxemic Septic Shock (EUPHRATES) Trial. Crit Care Explor. 2020;2 (2):e0083. doi: 10.1097/CCE.0000000000000083. PubMed PMID:32211615 PubMed Central PMC7069594.
  7. Lowry, DE, Feng, Z, Jeejeebhoy, K, Dhaliwal, R, Brauer, P, Royall, D et al.. Prediction modelling of 1-year outcomes to a personalized lifestyle intervention for Canadians with metabolic syndrome. Appl Physiol Nutr Metab. 2020;45 (6):621-627. doi: 10.1139/apnm-2019-0375. PubMed PMID:31738589 .
  8. Howard, M, Langevin, J, Bernard, C, Tan, A, Klein, D, Slaven, M et al.. Primary care clinicians' confidence, willingness participation and perceptions of roles in advance care planning discussions with patients: a multi-site survey. Fam Pract. 2020;37 (2):219-226. doi: 10.1093/fampra/cmz050. PubMed PMID:31536615 .
  9. Iba, T, Klein, DJ. The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS. J Intensive Care. 2019;7 :31. doi: 10.1186/s40560-019-0386-0. PubMed PMID:31131109 PubMed Central PMC6521478.
  10. Heyland, DK, van Zanten, ARH, Grau-Carmona, T, Evans, D, Beishuizen, A, Schouten, J et al.. A multicenter, randomized, double-blind study of ulimorelin and metoclopramide in the treatment of critically ill patients with enteral feeding intolerance: PROMOTE trial. Intensive Care Med. 2019;45 (5):647-656. doi: 10.1007/s00134-019-05593-2. PubMed PMID:31062046 .
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Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health
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