David Klein


Associate Scientist, Li Ka Shing Knowledge Institute


Currently, I work in conjunction with Dr. A. Romaschin of the Department of Laboratory Medicine on the development and clinical application of novel biomarkers to acute care and critical care. I also am involved in the development of novel therapeutics targeting endotoxin in critical illness as well as the linkage of diagnostics and therapeutics. Separately, I lead business strategy and partnerships for the Applied Health Research Center and serve in a number of advisory roles to government and other policy makers on healthcare system and business strategy.

Recent Publications

  1. Klein, DJ, Brown, AD, Detsky, AS. Investing Wisely in Health Care Capital. JAMA. 2016;316 (15):1543-1544. doi: 10.1001/jama.2016.10605. PubMed PMID:27684645 .
  2. Ip, CW, Isaias, IU, Kusche-Tekin, BB, Klein, D, Groh, J, O'Leary, A et al.. Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury. Acta Neuropathol Commun. 2016;4 (1):108. doi: 10.1186/s40478-016-0375-7. PubMed PMID:27716431 PubMed Central PMC5048687.
  3. Charbonney, E, Tsang, JY, Li, Y, Klein, D, Duque, P, Romaschin, A et al.. Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications. Crit. Care Med. 2016;44 (2):335-41. doi: 10.1097/CCM.0000000000001404. PubMed PMID:26509322 .
  4. Rewa, O, Wald, R, Adhikari, NK, Hladunewich, M, Lapinsky, S, Muscedere, J et al.. Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study. J Crit Care. 2015;30 (6):1359-64. doi: 10.1016/j.jcrc.2015.08.019. PubMed PMID:26421697 .
  5. Howard, M, Bernard, C, Tan, A, Slaven, M, Klein, D, Heyland, DK et al.. Advance care planning: Let's start sooner. Can Fam Physician. 2015;61 (8):663-5. . PubMed PMID:26273075 PubMed Central PMC4541424.
  6. Kitchlu, A, Adhikari, N, Burns, KE, Friedrich, JO, Garg, AX, Klein, D et al.. Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study. BMC Nephrol. 2015;16 :127. doi: 10.1186/s12882-015-0123-4. PubMed PMID:26238520 PubMed Central PMC4522955.
  7. Wald, R, Adhikari, NK, Smith, OM, Weir, MA, Pope, K, Cohen, A et al.. Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kidney Int. 2015;88 (4):897-904. doi: 10.1038/ki.2015.184. PubMed PMID:26154928 .
  8. Royall, D, Brauer, P, Bjorklund, L, O'Young, O, Tremblay, A, Jeejeebhoy, K et al.. Development of a Dietary Management Care Map for Metabolic Syndrome. Can J Diet Pract Res. 2014;75 (3):132-9. doi: 10.3148/cjdpr-2014-005. PubMed PMID:26066817 .
  9. Aad, G, Abbott, B, Abdallah, J, Abdinov, O, Aben, R, Abolins, M et al.. Combined Measurement of the Higgs Boson Mass in pp Collisions at sqrt[s]=7 and 8 TeV with the ATLAS and CMS Experiments. Phys. Rev. Lett. 2015;114 (19):191803. doi: 10.1103/PhysRevLett.114.191803. PubMed PMID:26024162 .
  10. Kudlow, P, Burns, KE, Adhikari, NK, Bell, B, Klein, DJ, Xie, B et al.. Inter-hospital transfers and outcomes of critically ill patients with severe acute kidney injury: a multicenter cohort study. Crit Care. 2014;18 (5):513. doi: 10.1186/s13054-014-0513-1. PubMed PMID:25228166 PubMed Central PMC4189586.
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Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health