David Klein

MD, MBA

Associate Scientist, Li Ka Shing Knowledge Institute

Biography

I currently work in conjunction with Dr. Alexander Romaschin in the Department of Laboratory Medicine at St. Michael’s Hospital on the development and clinical application of novel biomarkers to acute care and critical care. I am also involved in the development of novel therapeutics targeting endotoxin in critical illness, as well as the linkage of diagnostics and therapeutics. Separately, I lead business strategy and partnerships for the Applied Health Research Centre (AHRC) and hold advisory roles to government and other policy makers regarding the healthcare system and business strategy.

Please note: Dr. Klein is not taking any summer students in 2018.

Recent Publications

  1. Lowry, DE, Fenwick, PH, Roke, K, Jeejeebhoy, K, Dhaliwal, R, Brauer, P et al.. Variants in APOA5 and ADIPOQ Moderate Improvements in Metabolic Syndrome during a One-Year Lifestyle Intervention. Lifestyle Genom. 2018; :1-10. doi: 10.1159/000494331. PubMed PMID:30472712 .
  2. Klein, DJ, Foster, D, Walker, PM, Bagshaw, SM, Mekonnen, H, Antonelli, M et al.. Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial. Intensive Care Med. 2018;44 (12):2205-2212. doi: 10.1007/s00134-018-5463-7. PubMed PMID:30470853 .
  3. Shashi, V, Magiera, MM, Klein, D, Zaki, M, Schoch, K, Rudnik-Schöneborn, S et al.. Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. EMBO J. 2018;37 (23):. doi: 10.15252/embj.2018100540. PubMed PMID:30420557 PubMed Central PMC6276871.
  4. Dellinger, RP, Bagshaw, SM, Antonelli, M, Foster, DM, Klein, DJ, Marshall, JC et al.. Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial. JAMA. 2018;320 (14):1455-1463. doi: 10.1001/jama.2018.14618. PubMed PMID:30304428 PubMed Central PMC6233793.
  5. Klein, J, Brauer, P, Royall, D, Israeloff-Smith, M, Klein, D, Tremblay, A et al.. Patient experiences of a lifestyle program for metabolic syndrome offered in family medicine clinics: a mixed methods study. BMC Fam Pract. 2018;19 (1):148. doi: 10.1186/s12875-018-0837-z. PubMed PMID:30170544 PubMed Central PMC6119314.
  6. Howard, M, Bernard, C, Klein, D, Tan, A, Slaven, M, Barwich, D et al.. Older patient engagement in advance care planning in Canadian primary care practices: Results of a multisite survey. Can Fam Physician. 2018;64 (5):371-377. . PubMed PMID:29760260 PubMed Central PMC5951655.
  7. Howard, M, Bernard, C, Klein, D, Elston, D, Tan, A, Slaven, M et al.. Barriers to and enablers of advance care planning with patients in primary care: Survey of health care providers. Can Fam Physician. 2018;64 (4):e190-e198. . PubMed PMID:29650621 PubMed Central PMC5897087.
  8. Fenwick, PH, Jeejeebhoy, K, Dhaliwal, R, Royall, D, Brauer, P, Tremblay, A et al.. Lifestyle genomics and the metabolic syndrome: A review of genetic variants that influence response to diet and exercise interventions. Crit Rev Food Sci Nutr. 2018; :1-12. doi: 10.1080/10408398.2018.1437022. PubMed PMID:29400991 .
  9. Howard, M, Bansback, N, Tan, A, Klein, D, Bernard, C, Barwich, D et al.. Recognizing difficult trade-offs: values and treatment preferences for end-of-life care in a multi-site survey of adult patients in family practices. BMC Med Inform Decis Mak. 2017;17 (1):164. doi: 10.1186/s12911-017-0570-x. PubMed PMID:29212487 PubMed Central PMC5719577.
  10. Howard, M, Day, AG, Bernard, C, Tan, A, You, J, Klein, D et al.. Development and Psychometric Properties of a Survey to Assess Barriers to Implementing Advance Care Planning in Primary Care. J Pain Symptom Manage. 2018;55 (1):12-21. doi: 10.1016/j.jpainsymman.2017.08.003. PubMed PMID:28803079 .
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Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health
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