David Klein


Associate Scientist, Li Ka Shing Knowledge Institute


I currently work in conjunction with Dr. Alexander Romaschin in the Department of Laboratory Medicine at St. Michael’s Hospital on the development and clinical application of novel biomarkers to acute care and critical care. I am also involved in the development of novel therapeutics targeting endotoxin in critical illness, as well as the linkage of diagnostics and therapeutics. Separately, I lead business strategy and partnerships for the Applied Health Research Centre (AHRC) and hold advisory roles to government and other policy makers regarding the healthcare system and business strategy.

Recent Publications

  1. Howard, M, Bansback, N, Tan, A, Klein, D, Bernard, C, Barwich, D et al.. Recognizing difficult trade-offs: values and treatment preferences for end-of-life care in a multi-site survey of adult patients in family practices. BMC Med Inform Decis Mak. 2017;17 (1):164. doi: 10.1186/s12911-017-0570-x. PubMed PMID:29212487 PubMed Central PMC5719577.
  2. Howard, M, Day, AG, Bernard, C, Tan, A, You, J, Klein, D et al.. Development and Psychometric Properties of a Survey to Assess Barriers to Implementing Advance Care Planning in Primary Care. J Pain Symptom Manage. 2017; :. doi: 10.1016/j.jpainsymman.2017.08.003. PubMed PMID:28803079 .
  3. Klein, D, Jeejeebhoy, K, Tremblay, A, Kallio, M, Rheaume, C, Humphries, S et al.. The CHANGE program: Exercise intervention in primary care. Can Fam Physician. 2017;63 (7):546-552. . PubMed PMID:28701449 PubMed Central PMC5507234.
  4. Romaschin, AD, Obiezu-Forster, CV, Shoji, H, Klein, DJ. Novel Insights into the Direct Removal of Endotoxin by Polymyxin B Hemoperfusion. Blood Purif. 2017;44 (3):193-197. doi: 10.1159/000475982. PubMed PMID:28601867 .
  5. Klein, DJ, Brown, AD, Detsky, AS. Investing Wisely in Health Care Capital. JAMA. 2016;316 (15):1543-1544. doi: 10.1001/jama.2016.10605. PubMed PMID:27684645 .
  6. Ip, CW, Isaias, IU, Kusche-Tekin, BB, Klein, D, Groh, J, O'Leary, A et al.. Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury. Acta Neuropathol Commun. 2016;4 (1):108. doi: 10.1186/s40478-016-0375-7. PubMed PMID:27716431 PubMed Central PMC5048687.
  7. Charbonney, E, Tsang, JY, Li, Y, Klein, D, Duque, P, Romaschin, A et al.. Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications. Crit. Care Med. 2016;44 (2):335-41. doi: 10.1097/CCM.0000000000001404. PubMed PMID:26509322 .
  8. Rewa, O, Wald, R, Adhikari, NK, Hladunewich, M, Lapinsky, S, Muscedere, J et al.. Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study. J Crit Care. 2015;30 (6):1359-64. doi: 10.1016/j.jcrc.2015.08.019. PubMed PMID:26421697 .
  9. Howard, M, Bernard, C, Tan, A, Slaven, M, Klein, D, Heyland, DK et al.. Advance care planning: Let's start sooner. Can Fam Physician. 2015;61 (8):663-5. . PubMed PMID:26273075 PubMed Central PMC4541424.
  10. Kitchlu, A, Adhikari, N, Burns, KE, Friedrich, JO, Garg, AX, Klein, D et al.. Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study. BMC Nephrol. 2015;16 :127. doi: 10.1186/s12882-015-0123-4. PubMed PMID:26238520 PubMed Central PMC4522955.
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Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health