David Klein




I currently work in conjunction with Dr. Alexander Romaschin in the Department of Laboratory Medicine at St. Michael’s Hospital on the development and clinical application of novel biomarkers to acute care and critical care. I am also involved in the development of novel therapeutics targeting endotoxin in critical illness, as well as the linkage of diagnostics and therapeutics. Separately, I lead business strategy and partnerships for the Applied Health Research Centre (AHRC) and hold advisory roles to government and other policy makers regarding the healthcare system and business strategy.

Please note: Dr. Klein is not taking any summer students.

Recent Publications

  1. Bao, EL, Nandakumar, SK, Liao, X, Bick, AG, Karjalainen, J, Tabaka, M et al.. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020;586 (7831):769-775. doi: 10.1038/s41586-020-2786-7. PubMed PMID:33057200 PubMed Central PMC7606745.
  2. STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, United Kingdom Critical Care Research Group, Canadian Nephrology Trials Network, Irish Critical Care Trials Group et al.. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N Engl J Med. 2020;383 (3):240-251. doi: 10.1056/NEJMoa2000741. PubMed PMID:32668114 .
  3. Teja, B, Daniel, I, Pink, GH, Brown, A, Klein, DJ. Ensuring adequate capital investment in Canadian health care. CMAJ. 2020;192 (25):E677-E683. doi: 10.1503/cmaj.191126. PubMed PMID:32571884 PubMed Central PMC7828857.
  4. Rachoin, JS, Foster, D, Giese, R, Weisberg, LS, Klein, DJ. Importance of Endotoxin Clearance in Endotoxemic Septic Shock: An Analysis From the Evaluating Use of PolymyxinB Hemoperfusion in a Randomized Controlled Trial of Adults Treated for Endotoxemic Septic Shock (EUPHRATES) Trial. Crit Care Explor. 2020;2 (2):e0083. doi: 10.1097/CCE.0000000000000083. PubMed PMID:32211615 PubMed Central PMC7069594.
  5. Lowry, DE, Feng, Z, Jeejeebhoy, K, Dhaliwal, R, Brauer, P, Royall, D et al.. Prediction modelling of 1-year outcomes to a personalized lifestyle intervention for Canadians with metabolic syndrome. Appl Physiol Nutr Metab. 2020;45 (6):621-627. doi: 10.1139/apnm-2019-0375. PubMed PMID:31738589 .
  6. Howard, M, Langevin, J, Bernard, C, Tan, A, Klein, D, Slaven, M et al.. Primary care clinicians' confidence, willingness participation and perceptions of roles in advance care planning discussions with patients: a multi-site survey. Fam Pract. 2020;37 (2):219-226. doi: 10.1093/fampra/cmz050. PubMed PMID:31536615 .
  7. Iba, T, Klein, DJ. The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS. J Intensive Care. 2019;7 :31. doi: 10.1186/s40560-019-0386-0. PubMed PMID:31131109 PubMed Central PMC6521478.
  8. Heyland, DK, van Zanten, ARH, Grau-Carmona, T, Evans, D, Beishuizen, A, Schouten, J et al.. A multicenter, randomized, double-blind study of ulimorelin and metoclopramide in the treatment of critically ill patients with enteral feeding intolerance: PROMOTE trial. Intensive Care Med. 2019;45 (5):647-656. doi: 10.1007/s00134-019-05593-2. PubMed PMID:31062046 .
  9. Brauer, P, Royall, D, Li, A, Rodrigues, A, Green, J, Macklin, S et al.. Nutrient intake and dietary quality changes within a personalized lifestyle intervention program for metabolic syndrome in primary care. Appl Physiol Nutr Metab. 2019;44 (12):1297-1304. doi: 10.1139/apnm-2019-0070. PubMed PMID:31039319 .
  10. You, JJ, Allatt, P, Howard, M, Robinson, CA, Simon, J, Sudore, R et al.. Short Graphic Values History Tool for decision making during serious illness. BMJ Support Palliat Care. 2019; :. doi: 10.1136/bmjspcare-2018-001698. PubMed PMID:30733208 .
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Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health