David Klein


Associate Scientist, Li Ka Shing Knowledge Institute


I currently work in conjunction with Dr. Alexander Romaschin in the Department of Laboratory Medicine at St. Michael’s Hospital on the development and clinical application of novel biomarkers to acute care and critical care. I am also involved in the development of novel therapeutics targeting endotoxin in critical illness, as well as the linkage of diagnostics and therapeutics. Separately, I lead business strategy and partnerships for the Applied Health Research Centre (AHRC) and hold advisory roles to government and other policy makers regarding the healthcare system and business strategy.

Please note: Dr. Klein is not taking any summer students in 2018.

Recent Publications

  1. Iba, T, Klein, DJ. The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS. J Intensive Care. 2019;7 :31. doi: 10.1186/s40560-019-0386-0. PubMed PMID:31131109 PubMed Central PMC6521478.
  2. Heyland, DK, van Zanten, ARH, Grau-Carmona, T, Evans, D, Beishuizen, A, Schouten, J et al.. A multicenter, randomized, double-blind study of ulimorelin and metoclopramide in the treatment of critically ill patients with enteral feeding intolerance: PROMOTE trial. Intensive Care Med. 2019;45 (5):647-656. doi: 10.1007/s00134-019-05593-2. PubMed PMID:31062046 .
  3. Brauer, P, Royall, D, Li, A, Rodrigues, A, Green, J, Macklin, S et al.. Nutrient Intake and Dietary Quality Changes within a Personalized Lifestyle Intervention Program for Metabolic Syndrome in Primary Care. Appl Physiol Nutr Metab. 2019; :. doi: 10.1139/apnm-2019-0070. PubMed PMID:31039319 .
  4. You, JJ, Allatt, P, Howard, M, Robinson, CA, Simon, J, Sudore, R et al.. Short Graphic Values History Tool for decision making during serious illness. BMJ Support Palliat Care. 2019; :. doi: 10.1136/bmjspcare-2018-001698. PubMed PMID:30733208 .
  5. McNeil, J, Brenner, DR, Stone, CR, O'Reilly, R, Ruan, Y, Vallance, JK et al.. Activity Tracker to Prescribe Various Exercise Intensities in Breast Cancer Survivors. Med Sci Sports Exerc. 2019;51 (5):930-940. doi: 10.1249/MSS.0000000000001890. PubMed PMID:30694978 .
  6. Althoff, KN, Gebo, KA, Moore, RD, Boyd, CM, Justice, AC, Wong, C et al.. Contributions of traditional and HIV-related risk factors on non-AIDS-defining cancer, myocardial infarction, and end-stage liver and renal diseases in adults with HIV in the USA and Canada: a collaboration of cohort studies. Lancet HIV. 2019;6 (2):e93-e104. doi: 10.1016/S2352-3018(18)30295-9. PubMed PMID:30683625 PubMed Central PMC6589140.
  7. Lowry, DE, Fenwick, PH, Roke, K, Jeejeebhoy, K, Dhaliwal, R, Brauer, P et al.. Variants in APOA5 and ADIPOQ Moderate Improvements in Metabolic Syndrome during a One-Year Lifestyle Intervention. Lifestyle Genom. 2018;11 (2):80-89. doi: 10.1159/000494331. PubMed PMID:30472712 .
  8. Klein, DJ, Foster, D, Walker, PM, Bagshaw, SM, Mekonnen, H, Antonelli, M et al.. Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial. Intensive Care Med. 2018;44 (12):2205-2212. doi: 10.1007/s00134-018-5463-7. PubMed PMID:30470853 PubMed Central PMC6280819.
  9. Shashi, V, Magiera, MM, Klein, D, Zaki, M, Schoch, K, Rudnik-Schöneborn, S et al.. Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. EMBO J. 2018;37 (23):. doi: 10.15252/embj.2018100540. PubMed PMID:30420557 PubMed Central PMC6276871.
  10. Dellinger, RP, Bagshaw, SM, Antonelli, M, Foster, DM, Klein, DJ, Marshall, JC et al.. Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial. JAMA. 2018;320 (14):1455-1463. doi: 10.1001/jama.2018.14618. PubMed PMID:30304428 PubMed Central PMC6233793.
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Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health