David Munoz


Project Investigator, Keenan Research Centre for Biomedical Science

Research Programs


Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Reasearch) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students.

Recent Publications

  1. Fornazzari, L, Haladyn, J, Toledo, T, Leggieri, M, Friszberg, I, Barfett, J et al.. Do painters need their whole brain to excel?. Neurocase. 2020; :1-6. doi: 10.1080/13554794.2020.1764055. PubMed PMID:32420807 .
  2. Antel, J, Bar-Or, A, Munoz, D. Samuel Ludwin: Obituary. Mult. Scler. 2020;26 (6):622-623. doi: 10.1177/1352458520915815. PubMed PMID:32412378 .
  3. Abdollahi, M, Gao, AF, Munoz, DG. A case of disseminated microscopic demyelination with multifocal dystrophic calcification. Neuropathology. 2020; :. doi: 10.1111/neup.12642. PubMed PMID:32128889 .
  4. Atayde, AL, Fischer, CE, Schweizer, TA, Munoz, DG. Neuropsychiatric Inventory-Assessed Nighttime Behavior Accompanies, but Does Not Precede, Progressive Cognitive Decline Independent of Alzheimer's Disease Histopathology. J. Alzheimers Dis. 2020;74 (3):839-850. doi: 10.3233/JAD-190907. PubMed PMID:32116249 .
  5. Han, S, Sharma, RA, Sekhon, H, Munoz, D, Albreiki, DH. Aquaporin-4 immunoglobulin-G-positive neuromyelitis optica spectrum disorder associated with small cell lung carcinoma. Can. J. Ophthalmol. 2020; :. doi: 10.1016/j.jcjo.2020.01.005. PubMed PMID:32115187 .
  6. Suthiphosuwan, S, Sasikumar, S, Munoz, DG, Chan, DK, Montanera, WJ, Bharatha, A et al.. MRI diagnosis of neuronal intranuclear inclusion disease leukoencephalopathy. Neurol Clin Pract. 2019;9 (6):497-499. doi: 10.1212/CPJ.0000000000000664. PubMed PMID:32042489 PubMed Central PMC6927451.
  7. Bells, S, Isabella, SL, Brien, DC, Coe, BC, Munoz, DP, Mabbott, DJ et al.. Mapping neural dynamics underlying saccade preparation and execution and their relation to reaction time and direction errors. Hum Brain Mapp. 2020;41 (7):1934-1949. doi: 10.1002/hbm.24922. PubMed PMID:31916374 .
  8. Azarpazhooh, MR, Avan, A, Cipriano, LE, Munoz, DG, Erfanian, M, Amiri, A et al.. A third of community-dwelling elderly with intermediate and high level of Alzheimer's neuropathologic changes are not demented: A meta-analysis. Ageing Res. Rev. 2020;58 :101002. doi: 10.1016/j.arr.2019.101002. PubMed PMID:31899366 .
  9. Karimi, S, Zuccato, JA, Mamatjan, Y, Mansouri, S, Suppiah, S, Nassiri, F et al.. The central nervous system tumor methylation classifier changes neuro-oncology practice for challenging brain tumor diagnoses and directly impacts patient care. Clin Epigenetics. 2019;11 (1):185. doi: 10.1186/s13148-019-0766-2. PubMed PMID:31806041 PubMed Central PMC6896594.
  10. Boronat, A, Mateus, J, Soldevila-Domenech, N, Guerra, M, Rodríguez-Morató, J, Varon, C et al.. Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans. Data Brief. 2019;27 :104787. doi: 10.1016/j.dib.2019.104787. PubMed PMID:31788516 PubMed Central PMC6880089.
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Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto