David Munoz


Project Investigator, Keenan Research Centre for Biomedical Science

Research Programs


Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Reasearch) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students in 2018.

Recent Publications

  1. Karameh, WK, Murari, G, Schweizer, TA, Munoz, DG, Fischer, CE. Psychosis in neurodegenerative disorders: recent developments. Curr Opin Psychiatry. 2018; :. doi: 10.1097/YCO.0000000000000476. PubMed PMID:30520740 .
  2. Qian, W, Schweizer, TA, Churchill, NW, Millikin, C, Ismail, Z, Smith, EE et al.. Gray Matter Changes Associated With the Development of Delusions in Alzheimer Disease. Am J Geriatr Psychiatry. 2018; :. doi: 10.1016/j.jagp.2018.09.016. PubMed PMID:30503703 .
  3. Goulam-Houssein, S, Grenville, JL, Mastrocostas, K, Munoz, DG, Lin, A, Bharatha, A et al.. IgG4-related intracranial disease. Neuroradiol J. 2018; :1971400918806323. doi: 10.1177/1971400918806323. PubMed PMID:30320530 .
  4. Beach, TG, Serrano, GE, Kremer, T, Canamero, M, Dziadek, S, Sade, H et al.. Immunohistochemical Method and Histopathology Judging for the Systemic Synuclein Sampling Study (S4). J. Neuropathol. Exp. Neurol. 2018;77 (9):793-802. doi: 10.1093/jnen/nly056. PubMed PMID:30107604 PubMed Central PMC6097838.
  5. Maralani, PJ, Das, S, Mainprize, T, Phan, N, Bharatha, A, Keith, J et al.. Hypoxia Detection in Infiltrative Astrocytoma: Ferumoxytol-based Quantitative BOLD MRI with Intraoperative and Histologic Validation. Radiology. 2018;288 (3):821-829. doi: 10.1148/radiol.2018172601. PubMed PMID:29944077 .
  6. Kim, J, Schweizer, TA, Fischer, CE, Munoz, DG. Psychosis in "Cognitively Asymptomatic" Elderly Subjects is Associated With Neuritic Plaque Load, Not Neurofibrillary Tangles. Alzheimer Dis Assoc Disord. ;32 (3):185-189. doi: 10.1097/WAD.0000000000000250. PubMed PMID:29553944 PubMed Central PMC6107422.
  7. Munoz, DG, Fujioka, S. Caffeine and Parkinson disease: A possible diagnostic and pathogenic breakthrough. Neurology. 2018;90 (5):205-206. doi: 10.1212/WNL.0000000000004898. PubMed PMID:29298853 .
  8. Mathieu, F, Morgan, E, So, J, Munoz, DG, Mason, W, Kongkham, P et al.. Oculoleptomeningeal Amyloidosis Secondary to the Rare Transthyretin c.381T>G (p.Ile127Met) Mutation. World Neurosurg. 2018;111 :190-193. doi: 10.1016/j.wneu.2017.12.096. PubMed PMID:29277593 .
  9. Visanji, NP, Lang, AE, Munoz, DG. Lymphatic vasculature in human dural superior sagittal sinus: Implications for neurodegenerative proteinopathies. Neurosci. Lett. 2018;665 :18-21. doi: 10.1016/j.neulet.2017.11.001. PubMed PMID:29133178 .
  10. Gao, AF, Saleh, PA, Kassardjian, CD, Vinik, O, Munoz, DG. Brachio-cervical inflammatory myopathy with associated scleroderma phenotype and lupus serology. Neurol Neuroimmunol Neuroinflamm. 2018;5 (1):e410. doi: 10.1212/NXI.0000000000000410. PubMed PMID:29114565 PubMed Central PMC5663630.
Search PubMed

Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto