David Munoz


Project Investigator, Keenan Research Centre for Biomedical Science

Research Programs


Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Reasearch) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students in 2018.

Recent Publications

  1. Showraki, A, Murari, G, Ismail, Z, Barfett, JJ, Fornazzari, L, Munoz, DG et al.. Cerebrospinal Fluid Correlates of Neuropsychiatric Symptoms in Patients with Alzheimer's Disease/Mild Cognitive Impairment: A Systematic Review. J. Alzheimers Dis. 2019; :. doi: 10.3233/JAD-190365. PubMed PMID:31424398 .
  2. Sachdeva, R, Wu, M, Smiljanic, S, Kaskun, O, Ghannad-Zadeh, K, Celebre, A et al.. ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma. Cancer Res. 2019;79 (16):4057-4071. doi: 10.1158/0008-5472.CAN-18-1357. PubMed PMID:31292163 .
  3. Yoon, J, Cusimano, M, Munoz, DG. Pilocytic astrocytoma vs. ganglioglioma: Progression vs. misdiagnosis, and implications in BRAF testing. J Clin Neurosci. 2019;66 :231-234. doi: 10.1016/j.jocn.2019.05.002. PubMed PMID:31147230 .
  4. Gunness, VRN, Munoz, D, González-López, P, Alshafai, N, Mikhalkova, A, Spears, J et al.. Ipsilateral brain cavernoma under scleroderma plaque: a case report. Pan Afr Med J. 2019;32 :13. doi: 10.11604/pamj.2019.32.13.15288. PubMed PMID:31143318 PubMed Central PMC6522175.
  5. Sunderland, KM, Beaton, D, Fraser, J, Kwan, D, McLaughlin, PM, Montero-Odasso, M et al.. The utility of multivariate outlier detection techniques for data quality evaluation in large studies: an application within the ONDRI project. BMC Med Res Methodol. 2019;19 (1):102. doi: 10.1186/s12874-019-0737-5. PubMed PMID:31092212 PubMed Central PMC6521365.
  6. Leggieri, M, Thaut, MH, Fornazzari, L, Schweizer, TA, Barfett, J, Munoz, DG et al.. Music Intervention Approaches for Alzheimer's Disease: A Review of the Literature. Front Neurosci. 2019;13 :132. doi: 10.3389/fnins.2019.00132. PubMed PMID:30930728 PubMed Central PMC6424022.
  7. Woolman, M, Kuzan-Fischer, CM, Ferry, I, Kiyota, T, Luu, B, Wu, M et al.. Picosecond Infrared Laser Desorption Mass Spectrometry Identifies Medulloblastoma Subgroups on Intrasurgical Timescales. Cancer Res. 2019;79 (9):2426-2434. doi: 10.1158/0008-5472.CAN-18-3411. PubMed PMID:30890619 .
  8. Ing, EB, Lahaie Luna, G, Pagnoux, C, Baer, PA, Wang, D, Benard-Seguin, E et al.. The incidence of giant cell arteritis in Ontario, Canada. Can. J. Ophthalmol. 2019;54 (1):119-124. doi: 10.1016/j.jcjo.2018.03.002. PubMed PMID:30851765 .
  9. Gao, AF, Vinik, O, Munoz, DG. A 45-Year-Old Woman with Rash and Severe Weakness. Brain Pathol. 2019;29 (2):303-304. doi: 10.1111/bpa.12705. PubMed PMID:30821028 .
  10. Fischer, CE, Kortebi, I, Karameh, WK, Kumar, S, Gallagher, D, Golas, A et al.. Examining the Link Between Cardiovascular Risk Factors and Neuropsychiatric Symptoms in Mild Cognitive Impairment and Major Depressive Disorder in Remission. J. Alzheimers Dis. 2019;67 (4):1305-1311. doi: 10.3233/JAD-181099. PubMed PMID:30741676 .
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Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto