David Munoz


Project Investigator, Keenan Research Centre for Biomedical Science

Research Programs


Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Reasearch) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students in 2018.

Recent Publications

  1. Munoz, DG, Fujioka, S. Caffeine and Parkinson disease: A possible diagnostic and pathogenic breakthrough. Neurology. 2018;90 (5):205-206. doi: 10.1212/WNL.0000000000004898. PubMed PMID:29298853 .
  2. Mathieu, F, Morgan, E, So, J, Munoz, DG, Mason, W, Kongkham, P et al.. Oculoleptomeningeal Amyloidosis Secondary to the Rare Transthyretin c.381T>G (p.Ile127Met) Mutation. World Neurosurg. 2018;111 :190-193. doi: 10.1016/j.wneu.2017.12.096. PubMed PMID:29277593 .
  3. Visanji, NP, Lang, AE, Munoz, DG. Lymphatic vasculature in human dural superior sagittal sinus: Implications for neurodegenerative proteinopathies. Neurosci. Lett. 2018;665 :18-21. doi: 10.1016/j.neulet.2017.11.001. PubMed PMID:29133178 .
  4. Gao, AF, Saleh, PA, Kassardjian, CD, Vinik, O, Munoz, DG. Brachio-cervical inflammatory myopathy with associated scleroderma phenotype and lupus serology. Neurol Neuroimmunol Neuroinflamm. 2018;5 (1):e410. doi: 10.1212/NXI.0000000000000410. PubMed PMID:29114565 PubMed Central PMC5663630.
  5. Fischer, CE, Qian, W, Schweizer, TA, Ismail, Z, Smith, EE, Millikin, CP et al.. Determining the impact of psychosis on rates of false-positive and false-negative diagnosis in Alzheimer's disease. Alzheimers Dement (N Y). 2017;3 (3):385-392. doi: 10.1016/j.trci.2017.06.001. PubMed PMID:29067344 PubMed Central PMC5651446.
  6. Azarpazhooh, MR, Avan, A, Cipriano, LE, Munoz, DG, Sposato, LA, Hachinski, V et al.. Concomitant vascular and neurodegenerative pathologies double the risk of dementia. Alzheimers Dement. 2018;14 (2):148-156. doi: 10.1016/j.jalz.2017.07.755. PubMed PMID:28974416 .
  7. Qian, W, Fischer, CE, Schweizer, TA, Munoz, DG. Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease. Curr Alzheimer Res. 2018;15 (2):187-194. doi: 10.2174/1567205014666170829114346. PubMed PMID:28847281 .
  8. Gao, AF, Faust-Socher, A, Al-Murshed, M, Del Bigio, MR, Lang, AE, Munoz, DG et al.. Progressive ataxia and palatal tremor: Two autopsy cases of a novel tauopathy. Mov. Disord. 2017;32 (10):1465-1473. doi: 10.1002/mds.27074. PubMed PMID:28736850 .
  9. Montero-Odasso, M, Pieruccini-Faria, F, Bartha, R, Black, SE, Finger, E, Freedman, M et al.. Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). J. Alzheimers Dis. 2017;59 (2):707-721. doi: 10.3233/JAD-170149. PubMed PMID:28671116 PubMed Central PMC5523841.
  10. Yoon, JY, Gao, A, Das, S, Munoz, DG. Epidemiology and clinical characteristics of hemangioblastomas in the elderly: An update. J Clin Neurosci. 2017;43 :264-266. doi: 10.1016/j.jocn.2017.05.029. PubMed PMID:28651893 .
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Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto