Diana Elizabeth Tullis

MD, FRCPC

Associate Scientist, Li Ka Shing Knowledge Institute

Biography

As the Director of the Toronto Adult Cystic Fibrosis (CF) Clinic at St. Michael’s Hospital, Dr. Tullis is responsible for the care of 450 adults with CF. Dr. Tullis is a Professor of Medicine at the University of Toronto, the Respirology Division Head at St. Michael’s Hospital, and an Associate Scientist in the Li Ka Shing Knowledge Institute. She is the Cystic Fibrosis Canada Chair in Adult CF Research.

Dr. Tullis has published over 100 articles and book chapters and has lectured nationally and internationally on issues related to CF in adults. She has had 25 years of experience with CF clinical care. She was the Chair of the Clinic Subcommittee of the Medical/Scientific Advisory Board of Cystic Fibrosis Canada from 2005-2011 and in 2010 was a Coach for the Adult Quality Improvement Program run by the American Cystic Fibrosis Foundation.

Recent Publications

  1. Gupta, S, Batt, J, Bourbeau, J, Chapman, KR, Gershon, A, Granton, J et al.. Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge: Key Highlights From the Canadian Thoracic Society (CTS) Position Statement. Chest. 2020; :. doi: 10.1016/j.chest.2020.07.018. PubMed PMID:32693101 PubMed Central PMC7368654.
  2. Langawi, MA, Byrnes, C, Davies, JC, Hamouda, S, Kabra, M, Rached, SZ et al.. 'Go for it, dream big, work hard and persist': A message to the next generation of CF leaders in recognition of International Women's Day 2020. J Cyst Fibros. 2020;19 (2):184-193. doi: 10.1016/j.jcf.2020.02.021. PubMed PMID:32156627 .
  3. Middleton, PG, Mall, MA, Dřevínek, P, Lands, LC, McKone, EF, Polineni, D et al.. Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele. N Engl J Med. 2019;381 (19):1809-1819. doi: 10.1056/NEJMoa1908639. PubMed PMID:31697873 PubMed Central PMC7282384.
  4. Heijerman, HGM, McKone, EF, Downey, DG, Van Braeckel, E, Rowe, SM, Tullis, E et al.. Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial. Lancet. 2019;394 (10212):1940-1948. doi: 10.1016/S0140-6736(19)32597-8. PubMed PMID:31679946 PubMed Central PMC7571408.
  5. Mejia, JF, Hirschi, KM, Tsai, KYF, Long, MG, Tullis, BC, Bitter, EEK et al.. Differential placental ceramide levels during gestational diabetes mellitus (GDM). Reprod Biol Endocrinol. 2019;17 (1):81. doi: 10.1186/s12958-019-0523-6. PubMed PMID:31647034 PubMed Central PMC6813062.
  6. Singh, AN, Oehler, J, Torrecilla, I, Kilgas, S, Li, S, Vaz, B et al.. The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8. EMBO J. 2019;38 (21):e102361. doi: 10.15252/embj.2019102361. PubMed PMID:31613024 PubMed Central PMC6826192.
  7. Bell, SC, Mall, MA, Gutierrez, H, Macek, M, Madge, S, Davies, JC et al.. The future of cystic fibrosis care: a global perspective. Lancet Respir Med. 2020;8 (1):65-124. doi: 10.1016/S2213-2600(19)30337-6. PubMed PMID:31570318 .
  8. Couroux, P, Farias, P, Rizvi, L, Griffin, K, Hudson, C, Crowder, T et al.. First clinical trials of novel ENaC targeting therapy, SPX-101, in healthy volunteers and adults with cystic fibrosis. Pulm Pharmacol Ther. 2019;58 :101819. doi: 10.1016/j.pupt.2019.101819. PubMed PMID:31302339 .
  9. Klingel, M, Stanojevic, S, Tullis, E, Ratjen, F, Waters, V. Oral Azithromycin and Response to Pulmonary Exacerbations Treated with Intravenous Tobramycin in Children with Cystic Fibrosis. Ann Am Thorac Soc. 2019;16 (7):861-867. doi: 10.1513/AnnalsATS.201811-774OC. PubMed PMID:30874447 .
  10. Clark, ST, Sinha, U, Zhang, Y, Wang, PW, Donaldson, SL, Coburn, B et al.. Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams. Int J Antimicrob Agents. 2019;53 (5):620-628. doi: 10.1016/j.ijantimicag.2019.01.009. PubMed PMID:30664925 .
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Affiliations & Other Activities

  • Head, Division of Respirology, St. Michael’s Hospital
  • The Cystic Fibrosis Canada Chair in Adult Cystic Fibrosis Research, St. Michael’s Hospital
  • Professor, Department of Medicine, University of Toronto
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