Gaspard Montandon

PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Gaspard Montandon is a Scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is also an Assistant Professor in the Division of Respirology, Department of Medicine at the University of Toronto.

Dr. Montandon combines biomedical and clinical research to understand the neural control of breathing and disorders such as respiratory depression by opioid drugs and sleep-disordered breathing. His main research focuses on understanding how opioid drugs affect breathing and to find novel therapies to prevent respiratory depression without reducing opioid analgesia.

As a Parker B. Francis Fellow, along with support from the Canadian Lung Association, the Ontario Thoracic Society and CIHR, Dr. Montandon has developed a strategic research program that aims to understand opioid-induced respiratory depression and to identify new therapies to prevent it.

Recent Publications

  1. Satkunendrarajah, K, Karadimas, SK, Laliberte, AM, Montandon, G, Fehlings, MG. Cervical excitatory neurons sustain breathing after spinal cord injury. Nature. 2018; :. doi: 10.1038/s41586-018-0595-z. PubMed PMID:30305735 .
  2. Nagappa, M, Weingarten, TN, Montandon, G, Sprung, J, Chung, F. Opioids, respiratory depression, and sleep-disordered breathing. Best Pract Res Clin Anaesthesiol. 2017;31 (4):469-485. doi: 10.1016/j.bpa.2017.05.004. PubMed PMID:29739536 .
  3. Montandon, G, Wu, H, Liu, H, Vu, MT, Orser, BA, Horner, RL et al.. δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks. Sci Rep. 2017;7 (1):18105. doi: 10.1038/s41598-017-17379-x. PubMed PMID:29273726 PubMed Central PMC5741762.
  4. Salam, MT, Montandon, G, Genov, R, Devinsky, O, Del Campo, M, Carlen, PL et al.. Mortality with brainstem seizures from focal 4-aminopyridine-induced recurrent hippocampal seizures. Epilepsia. 2017;58 (9):1637-1644. doi: 10.1111/epi.13846. PubMed PMID:28691204 .
  5. Horton, GA, Fraigne, JJ, Torontali, ZA, Snow, MB, Lapierre, JL, Liu, H et al.. Activation of the Hypoglossal to Tongue Musculature Motor Pathway by Remote Control. Sci Rep. 2017;7 :45860. doi: 10.1038/srep45860. PubMed PMID:28383527 PubMed Central PMC5382915.
  6. Montandon, G, Cushing, SL, Campbell, F, Propst, EJ, Horner, RL, Narang, I et al.. Distinct Cortical Signatures Associated with Sedation and Respiratory Rate Depression by Morphine in a Pediatric Population. Anesthesiology. 2016;125 (5):889-903. doi: 10.1097/ALN.0000000000001303. PubMed PMID:27541315 .
  7. Montandon, G, Liu, H, Horner, RL. Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors. Sci Rep. 2016;6 :32707. doi: 10.1038/srep32707. PubMed PMID:27599866 PubMed Central PMC5013327.
  8. Montandon, G, Ren, J, Victoria, NC, Liu, H, Wickman, K, Greer, JJ et al.. G-protein-gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids. Anesthesiology. 2016;124 (3):641-50. doi: 10.1097/ALN.0000000000000984. PubMed PMID:26675532 PubMed Central PMC4755838.
  9. Poublanc, J, Crawley, AP, Sobczyk, O, Montandon, G, Sam, K, Mandell, DM et al.. Measuring cerebrovascular reactivity: the dynamic response to a step hypercapnic stimulus. J. Cereb. Blood Flow Metab. 2015;35 (11):1746-56. doi: 10.1038/jcbfm.2015.114. PubMed PMID:26126862 PubMed Central PMC4635229.
  10. Montandon, G, Horner, RL. State-dependent contribution of the hyperpolarization-activated Na+/K+ and persistent Na+ currents to respiratory rhythmogenesis in vivo. J. Neurosci. 2013;33 (20):8716-28. doi: 10.1523/JNEUROSCI.5066-12.2013. PubMed PMID:23678115 .
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Affiliations & Other Activities

  • Assistant Professor, Division of Respirology, Department of Medicine, University of Toronto
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