George Yousef

MD, PhD, FRCPC, MSc

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Yousef is an anatomical pathologist and the division head of Molecular Diagnostics at St. Michael’s hospital. He is a Professor at the University of Toronto and a Full Scientist at the Li Ka Shing Knowledge Institute of St. Michael’s Hospital. He is also the director of postgraduate research of the Department of Laboratory Medicine and Pathobiology and the director of the CELIC Centre for molecular innovation at St. Michael’s hospital.

His research laboratory is one of the leading laboratories focusing on the cancer biomarkers in renal cell carcinoma and prostate cancer using an integrated genomic, quantitative proteomic, transcriptomic and miRNA approaches with extensive bioinformatics analysis. His laboratory is also internationally recognized in miRNA research. In addition, he also published extensively about the discovery of kallikrein family of tumor markers and their roles as cancer biomarkers.

Dr. Yousef is a founding member of the International Scientific Committee of Kallikreins and was the chair of the 5th international symposium on Kallikreins in 2013. He is also the Vice President of the International Society of Enzymology.

He has over 200 published research papers and review articles and 15 book chapters. He is the editor-in-Chief of the Canadian Journal of Pathology and serves as a reviewer for over 40 journals. He is also the editor of a book on “Molecular Pathology in Cancer”. He serves as a reviewer for many national and international granting agencies.

He has served on numerous academic and governmental advisory committees, including the international kallikrein nomenclature Committee and the International Society of Urologic Pathology Kidney Cancer Classification in 2012. He is also a co-leader of the Kidney Cancer Research Network of Canada personalized medicine initiative; and member of the steering committee for prostate cancer management in Ontario.

At the pathology education frontier, he is a member of the Royal College Examination Board in Anatomical pathology and is leading the committee to digitalize the Royal College exam in Pathology. He is also a founding member and Chair of Pathology Informatics at the Canadian Association of Pathologists; His research was recognized by prestigious awards from the Royal College of Physicians, Canadian Association of Pathologists, and the United States National Academy of Clinical Chemistry.

Recent Publications

  1. Matin, F, Jeet, V, Clements, JA, Yousef, GM, Batra, J. MicroRNA Theranostics in Prostate Cancer Precision Medicine. Clin. Chem. 2016; :. doi: 10.1373/clinchem.2015.242800. PubMed PMID:27540032 .
  2. Prud'homme, GJ, Glinka, Y, Lichner, Z, Yousef, GM. Neuropilin-1 is a receptor for extracellular miRNA and AGO2/miRNA complexes and mediates the internalization of miRNAs that modulate cell function. Oncotarget. 2016; :. doi: 10.18632/oncotarget.10929. PubMed PMID:27486976 .
  3. Mirham, L, Naugler, C, Hayes, M, Ismiil, N, Belisle, A, Sade, S et al.. Performance of residents using digital images versus glass slides on certification examination in anatomical pathology: a mixed methods pilot study. CMAJ Open. ;4 (1):E88-94. Epub 2016/2/25. doi: 10.9778/cmajo.20140075. PubMed PMID:27280119 PubMed Central PMC4866926.
  4. Markou, A, Zavridou, M, Sourvinou, I, Yousef, G, Kounelis, S, Malamos, N et al.. Direct Comparison of Metastasis-Related miRNAs Expression Levels in Circulating Tumor Cells, Corresponding Plasma, and Primary Tumors of Breast Cancer Patients. Clin. Chem. 2016;62 (7):1002-11. doi: 10.1373/clinchem.2015.253716. PubMed PMID:27197674 .
  5. Di Meo, A, Pasic, MD, Yousef, GM. Proteomics and peptidomics: moving toward precision medicine in urological malignancies. Oncotarget. 2016; :. doi: 10.18632/oncotarget.8931. PubMed PMID:27119500 .
  6. Sidiropoulos, KG, Ding, Q, Pampalakis, G, White, NM, Boulos, P, Sotiropoulou, G et al.. KLK6-regulated miRNA networks activate oncogenic pathways in breast cancer subtypes. Mol Oncol. 2016;10 (7):993-1007. doi: 10.1016/j.molonc.2016.03.008. PubMed PMID:27093921 .
  7. Kuczynski, EA, Yin, M, Bar-Zion, A, Lee, CR, Butz, H, Man, S et al.. Co-option of Liver Vessels and Not Sprouting Angiogenesis Drives Acquired Sorafenib Resistance in Hepatocellular Carcinoma. J. Natl. Cancer Inst. 2016;108 (8):. doi: 10.1093/jnci/djw030. PubMed PMID:27059374 .
  8. Ibrahim, R, Pasic, M, Yousef, GM. Omics for personalized medicine: defining the current we swim in. Expert Rev. Mol. Diagn. 2016;16 (7):719-22. doi: 10.1586/14737159.2016.1164601. PubMed PMID:26959799 .
  9. Nofech-Mozes, R, Khella, HW, Scorilas, A, Youssef, L, Krylov, SN, Lianidou, E et al.. MicroRNA-194 is a Marker for Good Prognosis in Clear Cell Renal Cell Carcinoma. Cancer Med. 2016;5 (4):656-64. doi: 10.1002/cam4.631. PubMed PMID:26860079 PubMed Central PMC4831284.
  10. Rotondo, F, Butz, H, Syro, LV, Yousef, GM, Di Ieva, A, Restrepo, LM et al.. Arginine vasopressin (AVP): a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system. Pituitary. 2016;19 (4):345-55. doi: 10.1007/s11102-015-0703-0. PubMed PMID:26762848 .
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Affiliations & Other Activities

  • Division Head, Molecular Diagnostics, St. Michael’s Hospital
  • Anatomical Pathologist, Laboratory Medicine, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto
  • Professor, School of Graduate Studies, University of Toronto
  • Member, Institute of Medical Science, University of Toronto