George Yousef

MD, FRCPC, PhD, MSc

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Yousef is an anatomical pathologist and the division head of Molecular Diagnostics at St. Michael’s Hospital. He is a Professor at the University of Toronto and a Full Scientist at the Li Ka Shing Knowledge Institute of St. Michael’s Hospital. He is also the director of postgraduate research of the Department of Laboratory Medicine and Pathobiology and the director of the CELIC Centre for molecular innovation at St. Michael’s Hospital.

His research laboratory is one of the leading laboratories focusing on the cancer biomarkers in renal cell carcinoma and prostate cancer using an integrated genomic, quantitative proteomic, transcriptomic and miRNA approaches with extensive bioinformatics analysis. His laboratory is also internationally recognized in miRNA research. In addition, he also published extensively about the discovery of kallikrein family of tumor markers and their roles as cancer biomarkers.

Dr. Yousef is a founding member of the International Scientific Committee of Kallikreins and was the chair of the 5th international symposium on Kallikreins in 2013. He is also the Vice President of the International Society of Enzymology.

He has over 200 published research papers and review articles and 15 book chapters. He is the editor-in-Chief of the Canadian Journal of Pathology and serves as a reviewer for over 40 journals. He is also the editor of a book on “Molecular Pathology in Cancer”. He serves as a reviewer for many national and international granting agencies.

He has served on numerous academic and governmental advisory committees, including the international kallikrein nomenclature Committee and the International Society of Urologic Pathology Kidney Cancer Classification in 2012. He is also a co-leader of the Kidney Cancer Research Network of Canada personalized medicine initiative; and member of the steering committee for prostate cancer management in Ontario.

At the pathology education frontier, he is a member of the Royal College Examination Board in Anatomical pathology and is leading the committee to digitalize the Royal College exam in Pathology. He is also a founding member and Chair of Pathology Informatics at the Canadian Association of Pathologists; His research was recognized by prestigious awards from the Royal College of Physicians, Canadian Association of Pathologists, and the United States National Academy of Clinical Chemistry.

Recent Publications

  1. Di Meo, A, Bartlett, J, Cheng, Y, Pasic, MD, Yousef, GM. Liquid biopsy: a step forward towards precision medicine in urologic malignancies. Mol. Cancer. 2017;16 (1):80. doi: 10.1186/s12943-017-0644-5. PubMed PMID:28410618 PubMed Central PMC5391592.
  2. Khella, HW, Daniel, N, Youssef, L, Scorilas, A, Nofech-Mozes, R, Mirham, L et al.. miR-10b is a prognostic marker in clear cell renal cell carcinoma. J. Clin. Pathol. 2017; :. doi: 10.1136/jclinpath-2017-204341. PubMed PMID:28360191 .
  3. Hu, L, Stasheuski, AS, Wegman, DW, Wu, N, Yang, BB, Hayder, H et al.. Accurate MicroRNA Analysis in Crude Cell Lysate by Capillary Electrophoresis-Based Hybridization Assay in Comparison with Quantitative Reverse Transcription-Polymerase Chain Reaction. Anal. Chem. 2017;89 (8):4743-4748. doi: 10.1021/acs.analchem.7b00707. PubMed PMID:28339187 .
  4. Kapur, R, Kim, M, Aslam, R, McVey, MJ, Tabuchi, A, Luo, A et al.. T Regulatory Cells and Dendritic Cells Protect Against Transfusion-Related Acute Lung Injury via IL-10. Blood. 2017; :. doi: 10.1182/blood-2016-12-758185. PubMed PMID:28202460 .
  5. Di Michele, J, Rotondo, F, Kovacs, K, Syro, LV, Yousef, GM, Cusimano, MD et al.. Vasculogenic Mimicry in Clinically Non-functioning Pituitary Adenomas: a Histologic Study. Pathol. Oncol. Res. 2017; :. doi: 10.1007/s12253-017-0196-4. PubMed PMID:28084580 .
  6. Wang, C, Zhang, W, Zhang, L, Chen, X, Liu, F, Zhang, J et al.. miR-146a-5p mediates epithelial-mesenchymal transition of oesophageal squamous cell carcinoma via targeting Notch2. Br. J. Cancer. 2016;115 (12):1548-1554. doi: 10.1038/bjc.2016.367. PubMed PMID:27832663 PubMed Central PMC5155362.
  7. Fendler, A, Stephan, C, Yousef, GM, Kristiansen, G, Jung, K. The translational potential of microRNAs as biofluid markers of urological tumours. Nat Rev Urol. 2016;13 (12):734-752. doi: 10.1038/nrurol.2016.193. PubMed PMID:27804986 .
  8. White Al-Habeeb, N, Kulasingam, V, Diamandis, EP, Yousef, GM, Tsongalis, GJ, Vermeulen, L et al.. The Use of Targeted Therapies for Precision Medicine in Oncology. Clin. Chem. 2016;62 (12):1556-1564. doi: 10.1373/clinchem.2015.247882. PubMed PMID:27679436 .
  9. Matin, F, Jeet, V, Clements, JA, Yousef, GM, Batra, J. MicroRNA Theranostics in Prostate Cancer Precision Medicine. Clin. Chem. 2016;62 (10):1318-33. doi: 10.1373/clinchem.2015.242800. PubMed PMID:27540032 .
  10. Prud'homme, GJ, Glinka, Y, Lichner, Z, Yousef, GM. Neuropilin-1 is a receptor for extracellular miRNA and AGO2/miRNA complexes and mediates the internalization of miRNAs that modulate cell function. Oncotarget. 2016;7 (42):68057-68071. doi: 10.18632/oncotarget.10929. PubMed PMID:27486976 PubMed Central PMC5356539.
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Affiliations & Other Activities

  • Division Head, Molecular Diagnostics, St. Michael’s Hospital
  • Anatomical Pathologist, Laboratory Medicine, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto
  • Professor, School of Graduate Studies, University of Toronto
  • Member, Institute of Medical Science, University of Toronto