George Yousef


Affiliate Scientist, Keenan Research Centre for Biomedical Science


Dr. George Yousef is an anatomical pathologist and the Division Head of Molecular Diagnostics at St. Michael’s Hospital. He is a Professor at the University of Toronto and a Scientist at the Li Ka Shing Knowledge Institute of St. Michael’s Hospital. He is also the Director of Postgraduate Research of the Department of Laboratory Medicine and Pathobiology and the Director of the CELIC Centre for Molecular Innovation at St. Michael’s Hospital.

Dr. Yousef’s research laboratory is internationally recognized in miRNA research. It is one of the leading laboratories focusing on the cancer biomarkers in renal cell carcinoma and prostate cancer using an integrated genomic, quantitative proteomic, transcriptomic and miRNA approaches with extensive bioinformatics analysis. He has published extensively about the discovery of the kallikrein family of tumor markers and their roles as cancer biomarkers.

Dr. Yousef is a founding member of the International Scientific Committee of Kallikreins and was the Chair of the 5th International Symposium on Kallikreins in 2013. He is also the Vice President of the International Society of Enzymology.

He has over 200 published research papers and review articles and 15 book chapters. He is the Editor-in-Chief of the Canadian Journal of Pathology and serves as a reviewer for over 40 journals. He is also the Editor of a book on “Molecular Pathology in Cancer”. He serves as a reviewer for many national and international granting agencies.

He has served on numerous academic and governmental advisory committees, including the International Kallikrein Nomenclature Committee and the International Society of Urologic Pathology Kidney Cancer Classification in 2012. He is also a co-leader of the Kidney Cancer Research Network of Canada personalized medicine initiative; and member of the steering committee for prostate cancer management in Ontario.

At the pathology education frontier, he is a member of the Royal College Examination Board in Anatomical Pathology and is leading the committee to digitalize the Royal College Exam in Pathology. He is also a founding member and Chair of Pathology Informatics at the Canadian Association of Pathologists. His research has been recognized by prestigious awards from the Royal College of Physicians, Canadian Association of Pathologists, and the United States National Academy of Clinical Chemistry.

Please note: Dr. Yousef is not taking any summer students in 2018.

Recent Publications

  1. Di Meo, A, Batruch, I, Brown, MD, Yang, C, Finelli, A, Jewett, MA et al.. Searching for Prognostic Biomarkers for Small Renal Masses in the Urinary Proteome. Int. J. Cancer. 2019; :. doi: 10.1002/ijc.32650. PubMed PMID:31465112 .
  2. Saleeb, RM, Farag, M, Ding, Q, Downes, M, Bjarnason, G, Brimo, F et al.. Integrated Molecular Analysis of Papillary Renal Cell Carcinoma and Precursor Lesions Unfolds Evolutionary Process from Kidney Progenitor-Like Cells. Am. J. Pathol. 2019;189 (10):2046-2060. doi: 10.1016/j.ajpath.2019.07.002. PubMed PMID:31381885 .
  3. Kaldas, M, Michael, S, Hanna, J, Yousef, GM. Journal impact factor: a bumpy ride in an open space. J. Investig. Med. 2019; :. doi: 10.1136/jim-2019-001009. PubMed PMID:31248943 .
  4. Pampalakis, G, Zingkou, E, Sidiropoulos, KG, Diamandis, EP, Zoumpourlis, V, Yousef, GM et al.. Biochemical pathways mediated by KLK6 protease in breast cancer. Mol Oncol. 2019; :. doi: 10.1002/1878-0261.12493. PubMed PMID:30980596 .
  5. Wang, C, Ding, Q, Plant, P, Basheer, M, Yang, C, Tawedrous, E et al.. Droplet digital PCR improves urinary exosomal miRNA detection compared to real-time PCR. Clin. Biochem. 2019;67 :54-59. doi: 10.1016/j.clinbiochem.2019.03.008. PubMed PMID:30905583 .
  6. Barsoum, I, Tawedrous, E, Faragalla, H, Yousef, GM. Histo-genomics: digital pathology at the forefront of precision medicine. Diagnosis (Berl). 2019;6 (3):203-212. doi: 10.1515/dx-2018-0064. PubMed PMID:30827078 .
  7. Hu, L, Anand, M, Krylova, SM, Yang, BB, Liu, SK, Yousef, GM et al.. Direct Quantitative Analysis of Multiple microRNAs (DQAMmiR) with Peptide Nucleic Acid Hybridization Probes. Anal. Chem. 2018;90 (24):14610-14615. doi: 10.1021/acs.analchem.8b04793. PubMed PMID:30451492 .
  8. Khella, HWZ, Yousef, GM. Translational research: Empowering the role of pathologists and cytopathologists. Cancer Cytopathol. 2018;126 (10):831-838. doi: 10.1002/cncy.22046. PubMed PMID:30281935 .
  9. Lichner, Z, Saleeb, R, Butz, H, Ding, Q, Nofech-Mozes, R, Riad, S et al.. Sunitinib induces early histomolecular changes in a subset of renal cancer cells that contribute to resistance. FASEB J. 2019;33 (1):1347-1359. doi: 10.1096/fj.201800596R. PubMed PMID:30148679 .
  10. Damayanti, NP, Budka, JA, Khella, HWZ, Ferris, MW, Ku, SY, Kauffman, E et al.. Therapeutic Targeting of TFE3/IRS-1/PI3K/mTOR Axis in Translocation Renal Cell Carcinoma. Clin. Cancer Res. 2018;24 (23):5977-5989. doi: 10.1158/1078-0432.CCR-18-0269. PubMed PMID:30061365 PubMed Central PMC6279468.
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Affiliations & Other Activities

  • Division Head, Molecular Diagnostics, St. Michael’s Hospital
  • Anatomical Pathologist, Laboratory Medicine, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto
  • Professor, School of Graduate Studies, University of Toronto
  • Member, Institute of Medical Science, University of Toronto