Autoimmune diseases, DNA vaccination, gene therapy, diabetes, tumour immunology
My main research interests are in the areas of autoimmune diseases, tumour immunotherapy and gene therapy. My laboratory has developed a method of non-viral gene transfer that can be utilized for intra-muscular transfer of genes or DNA vaccination. We are currently studying the role of neuropilins in TGF-beta activation, immune regulation and cancer biology. In addition, we are investigating the aryl hydrocarbon receptor as a drug target for the therapy of breast cancer, the inhibition of cancer stem cells, and the prevention of metastatic disease.