Gerard Curley

MB, PhD, MSc

Associate Scientist, Keenan Research Centre for Biomedical Science

Biography

Research Interests

Mesenchymal stem/stromal cell therapy for sepsis and Acute Respiratory Distress Syndrome, macrophage biology, ex-vivo lung perfusion, carbon dioxide and critical illness, systematic review/meta-analysis of interventions in anesthesia and intensive care

Selected Research

1. Curley GF, Ansari B, Hayes M, Devaney J, O’Toole D, O’Brien T, Laffey JG. Effects of intra-tracheal Mesenchymal Stem Cells therapy during recovery and resolution following Ventilator Induced Lung Injury. Anesthesiology 2013 Apr;118(4):924-932

2. Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O’Brien T, O’Toole D, Laffey JG. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax. 2012 Jun;67(6):496-501

3. Curley G, Contreras M, O’Toole B, Higgins B, O’Kane C, McAuley D, Laffey JG. Evolution of the inflammatory and fibroproliferative responses during resolution and repair following Ventilator Induced Lung Injury. Anesthesiology 2011 Nov;115(5):1022-32

4. Curley G, Kavanagh BP, Laffey JG. Hypocapnia and the injured brain: More harm than benefit. Crit Care Med. 2010 May;38(5):1348-59.2010 Mar 11

5. Curley GF, Laffey JG, Kavanagh BP. Point-Counterpoint Series: There IS added benefit to providing permissive hypercapnia in the treatment of ARDS. Journal of Physiology, Jun 1;591(Pt 11):2763-5

Recent Publications

  1. Jerkic, M, Gagnon, S, Rabani, R, Ward-Able, T, Masterson, C, Otulakowski, G et al.. Human Umbilical Cord Mesenchymal Stromal Cells Attenuate Systemic Sepsis in Part by Enhancing Peritoneal Macrophage Bacterial Killing via Heme Oxygenase-1 Induction in Rats. Anesthesiology. 2019; :. doi: 10.1097/ALN.0000000000003018. PubMed PMID:31764154 .
  2. McNicholas, BA, Rezoagli, E, Pham, T, Madotto, F, Guiard, E, Fanelli, V et al.. Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study. Crit. Care Med. 2019;47 (9):1216-1225. doi: 10.1097/CCM.0000000000003832. PubMed PMID:31162201 .
  3. Kei, T, Mistry, N, Curley, G, Pavenski, K, Shehata, N, Tanzini, RM et al.. Efficacy and safety of erythropoietin and iron therapy to reduce red blood cell transfusion in surgical patients: a systematic review and meta-analysis. Can J Anaesth. 2019;66 (6):716-731. doi: 10.1007/s12630-019-01351-6. PubMed PMID:30924000 .
  4. Varkouhi, AK, Jerkic, M, Ormesher, L, Gagnon, S, Goyal, S, Rabani, R et al.. Extracellular Vesicles from Interferon-γ-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats. Anesthesiology. 2019;130 (5):778-790. doi: 10.1097/ALN.0000000000002655. PubMed PMID:30870158 .
  5. Pham, T, Serpa Neto, A, Pelosi, P, Laffey, JG, De Haro, C, Lorente, JA et al.. Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study. Anesthesiology. 2019;130 (2):263-283. doi: 10.1097/ALN.0000000000002508. PubMed PMID:30499850 .
  6. van Haren, F, Pham, T, Brochard, L, Bellani, G, Laffey, J, Dres, M et al.. Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study. Crit. Care Med. 2019;47 (2):229-238. doi: 10.1097/CCM.0000000000003519. PubMed PMID:30379668 PubMed Central PMC6336491.
  7. Boyle, AJ, Madotto, F, Laffey, JG, Bellani, G, Pham, T, Pesenti, A et al.. Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database. Crit Care. 2018;22 (1):268. doi: 10.1186/s13054-018-2158-y. PubMed PMID:30367670 PubMed Central PMC6203969.
  8. Abe, T, Madotto, F, Pham, T, Nagata, I, Uchida, M, Tamiya, N et al.. Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries. Crit Care. 2018;22 (1):195. doi: 10.1186/s13054-018-2126-6. PubMed PMID:30115127 PubMed Central PMC6097245.
  9. Shehata, N, Mistry, N, da Costa, BR, Pereira, TV, Whitlock, R, Curley, GF et al.. Restrictive compared with liberal red cell transfusion strategies in cardiac surgery: a meta-analysis. Eur. Heart J. 2019;40 (13):1081-1088. doi: 10.1093/eurheartj/ehy435. PubMed PMID:30107514 PubMed Central PMC6441852.
  10. Cortegiani, A, Madotto, F, Gregoretti, C, Bellani, G, Laffey, JG, Pham, T et al.. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Crit Care. 2018;22 (1):157. doi: 10.1186/s13054-018-2079-9. PubMed PMID:29895331 PubMed Central PMC5998562.
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Affiliations & Other Activities

  • Associate Professor, Department of Anesthesia, University of Toronto

 

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