Gerard Curley

MB, PhD, MSc

Affiliate Scientist

Biography

Research Interests

Mesenchymal stem/stromal cell therapy for sepsis and Acute Respiratory Distress Syndrome, macrophage biology, ex-vivo lung perfusion, carbon dioxide and critical illness, systematic review/meta-analysis of interventions in anesthesia and intensive care

Selected Research

1. Curley GF, Ansari B, Hayes M, Devaney J, O’Toole D, O’Brien T, Laffey JG. Effects of intra-tracheal Mesenchymal Stem Cells therapy during recovery and resolution following Ventilator Induced Lung Injury. Anesthesiology 2013 Apr;118(4):924-932

2. Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O’Brien T, O’Toole D, Laffey JG. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax. 2012 Jun;67(6):496-501

3. Curley G, Contreras M, O’Toole B, Higgins B, O’Kane C, McAuley D, Laffey JG. Evolution of the inflammatory and fibroproliferative responses during resolution and repair following Ventilator Induced Lung Injury. Anesthesiology 2011 Nov;115(5):1022-32

4. Curley G, Kavanagh BP, Laffey JG. Hypocapnia and the injured brain: More harm than benefit. Crit Care Med. 2010 May;38(5):1348-59.2010 Mar 11

5. Curley GF, Laffey JG, Kavanagh BP. Point-Counterpoint Series: There IS added benefit to providing permissive hypercapnia in the treatment of ARDS. Journal of Physiology, Jun 1;591(Pt 11):2763-5

Recent Publications

  1. REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher, EC, Bradbury, CA, McVerry, BJ et al.. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):777-789. doi: 10.1056/NEJMoa2103417. PubMed PMID:34351722 PubMed Central PMC8362592.
  2. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler, PR, Goligher, EC, Berger, JS et al.. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):790-802. doi: 10.1056/NEJMoa2105911. PubMed PMID:34351721 PubMed Central PMC8362594.
  3. Arabi, YM, Gordon, AC, Derde, LPG, Nichol, AD, Murthy, S, Beidh, FA et al.. Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med. 2021;47 (8):867-886. doi: 10.1007/s00134-021-06448-5. PubMed PMID:34251506 PubMed Central PMC8274471.
  4. Masterson, CH, Tabuchi, A, Hogan, G, Fitzpatrick, G, Kerrigan, SW, Jerkic, M et al.. Intra-vital imaging of mesenchymal stromal cell kinetics in the pulmonary vasculature during infection. Sci Rep. 2021;11 (1):5265. doi: 10.1038/s41598-021-83894-7. PubMed PMID:33664277 PubMed Central PMC7933415.
  5. REMAP-CAP Investigators, Gordon, AC, Mouncey, PR, Al-Beidh, F, Rowan, KM, Nichol, AD et al.. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021;384 (16):1491-1502. doi: 10.1056/NEJMoa2100433. PubMed PMID:33631065 PubMed Central PMC7953461.
  6. Pham, T, Pesenti, A, Bellani, G, Rubenfeld, G, Fan, E, Bugedo, G et al.. Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study. Eur Respir J. 2021;57 (6):. doi: 10.1183/13993003.03317-2020. PubMed PMID:33334944 .
  7. Madotto, F, Rezoagli, E, Pham, T, Schmidt, M, McNicholas, B, Protti, A et al.. Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study. Crit Care. 2020;24 (1):125. doi: 10.1186/s13054-020-2826-6. PubMed PMID:32234077 PubMed Central PMC7110678.
  8. Jerkic, M, Gagnon, S, Rabani, R, Ward-Able, T, Masterson, C, Otulakowski, G et al.. Human Umbilical Cord Mesenchymal Stromal Cells Attenuate Systemic Sepsis in Part by Enhancing Peritoneal Macrophage Bacterial Killing via Heme Oxygenase-1 Induction in Rats. Anesthesiology. 2020;132 (1):140-154. doi: 10.1097/ALN.0000000000003018. PubMed PMID:31764154 .
  9. McNicholas, BA, Rezoagli, E, Pham, T, Madotto, F, Guiard, E, Fanelli, V et al.. Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study. Crit Care Med. 2019;47 (9):1216-1225. doi: 10.1097/CCM.0000000000003832. PubMed PMID:31162201 .
  10. Kei, T, Mistry, N, Curley, G, Pavenski, K, Shehata, N, Tanzini, RM et al.. Efficacy and safety of erythropoietin and iron therapy to reduce red blood cell transfusion in surgical patients: a systematic review and meta-analysis. Can J Anaesth. 2019;66 (6):716-731. doi: 10.1007/s12630-019-01351-6. PubMed PMID:30924000 .
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Affiliations & Other Activities

  • Associate Professor, Department of Anesthesia, University of Toronto

 

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