Dr. Greg Fairn is a Staff Scientist in the Keenan Research Centre for Biomedical Science at St. Michael’s Hospital. Dr. Fairn is trained in a variety of disciplines including Cell Biology, Immunology, Genetics and Biochemistry. He is an Associate Professor at the University of Toronto in both the Department of Surgery and the Department of Biochemistry. He is also a Member of the Institute of Medical Science, University of Toronto, iBEST and Yeates School of Graduate Studies, Ryerson University.

His research interests are broad but tend to focus on novel aspects of lipid metabolism and cellular signaling in a variety of physiological settings. As such, he has published ~60 peer-reviewed articles, covering a variety of topics including cancer biology, innate immunity and inflammation as well as fundamental studies on cell dynamics, organelle biology, lipid metabolism and chemical biology. Since beginning his lab at St. Michael’s Hospital in the summer of 2012, he has contributed to the training of over 30 students, post-doctoral fellows and visiting medical residents.

Dr. Fairn serves on several academic and governmental review committees, including project grant and graduate student scholarship committees for the Canadian Institutes of Health Research (CIHR) and Alberta Innovates Health Solutions. He also is an editorial board member for the journals Cellular MicrobiologyScientific Reports, and Traffic. Dr. Fairn has received a New Investigator Award from CIHR and an Early Researcher Award from the Government of Ontario to support the establishment of his laboratory. He also holds research grants from CIHR, the JP Bickell Foundation and Natural Sciences and Engineering Research Council of Canada.

For more information on the Fairn lab and for anyone interested in graduate studies please visit his Department of Biochemistry webpage. Publications can be found on PubMed by searching Fairn GD or Fairn G.





Recent Publications

  1. Dixon, CL, Fairn, GD. S-palmitoylation of NOD2 controls its localization to the plasma membrane. J Lipid Res. 2021;62 :100097. doi: 10.1016/j.jlr.2021.100097. PubMed PMID:34293401 PubMed Central PMC8385166.
  2. Borges, JP, Mekhail, K, Fairn, GD, Antonescu, CN, Steinberg, BE. Modulation of Pathological Pain by Epidermal Growth Factor Receptor. Front Pharmacol. 2021;12 :642820. doi: 10.3389/fphar.2021.642820. PubMed PMID:34054523 PubMed Central PMC8149758.
  3. Dixon, CL, Mekhail, K, Fairn, GD. Examining the Underappreciated Role of S-Acylated Proteins as Critical Regulators of Phagocytosis and Phagosome Maturation in Macrophages. Front Immunol. 2021;12 :659533. doi: 10.3389/fimmu.2021.659533. PubMed PMID:33868308 PubMed Central PMC8047069.
  4. Lu, Y, Zheng, Y, Coyaud, É, Zhang, C, Selvabaskaran, A, Yu, Y et al.. Palmitoylation of NOD1 and NOD2 is required for bacterial sensing. Science. 2019;366 (6464):460-467. doi: 10.1126/science.aau6391. PubMed PMID:31649195 .
  5. Yang, Y, Park, M, Maekawa, M, Fairn, GD. Enforced expression of phosphatidylinositol 4-phosphate 5-kinase homolog alters PtdIns(4,5)P2 distribution and the localization of small G-proteins. Sci Rep. 2019;9 (1):14789. doi: 10.1038/s41598-019-51272-z. PubMed PMID:31616009 PubMed Central PMC6794296.
  6. Kay, JG, Fairn, GD. Distribution, dynamics and functional roles of phosphatidylserine within the cell. Cell Commun Signal. 2019;17 (1):126. doi: 10.1186/s12964-019-0438-z. PubMed PMID:31615534 PubMed Central PMC6792266.
  7. Levin-Konigsberg, R, Montaño-Rendón, F, Keren-Kaplan, T, Li, R, Ego, B, Mylvaganam, S et al.. Phagolysosome resolution requires contacts with the endoplasmic reticulum and phosphatidylinositol-4-phosphate signalling. Nat Cell Biol. 2019;21 (10):1234-1247. doi: 10.1038/s41556-019-0394-2. PubMed PMID:31570833 PubMed Central PMC8340083.
  8. Sugiyama, MG, Fairn, GD, Antonescu, CN. Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling. Front Cell Dev Biol. 2019;7 :70. doi: 10.3389/fcell.2019.00070. PubMed PMID:31131274 PubMed Central PMC6509475.
  9. Westman, J, Hube, B, Fairn, GD. Integrity under stress: Host membrane remodelling and damage by fungal pathogens. Cell Microbiol. 2019;21 (4):e13016. doi: 10.1111/cmi.13016. PubMed PMID:30740852 .
  10. Tan, JMJ, Mellouk, N, Osborne, SE, Ammendolia, DA, Dyer, DN, Li, R et al.. An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread. Nat Microbiol. 2018;3 (12):1472-1485. doi: 10.1038/s41564-018-0293-5. PubMed PMID:30478389 .
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Affiliations & Other Activities

  • Associate Professor, Department of Surgery, University of Toronto
  • Associate Professor, Department of Biochemistry, University of Toronto