Haibo Zhang


Scientist, Keenan Research Centre for Biomedical Science


Dr. Haibo Zhang is a Staff Scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor of Anesthesia, Medicine and Physiology at the University of Toronto. His translational research program focuses on the mechanisms and therapy of acute lung injury and sepsis. He has published over 200 peer-reviewed articles, and is the recipient of enormous research grants and a number of research awards, including Premier’s Research Excellence Award (Ontario), a New Investigator Award from the Canadian Institutes of Health Research (CIHR), and Chang Jiang Scholar supported by Li Ka Shing Foundation. He serves on a number of academic and appointment committees at the Institute of Medical Sciences (IMS), University of Toronto and at St. Michael’s Hospital. He has trained over 80 MSc and PhD students, and post-doctoral fellows.

He has served on the Standing Committee of Critical Care Assembly, the American Thoracic Society in 2005-2006, Associate Editor, Intensive Care Medicine in 2007-2013, Chairman of Final Review Panel of Respiration System and the Natural Science Foundation of China (NSFC) in 2010-2011. He was a member of grant and award committees of CIHR in 2014-2016, and an external grant reviewer for European nations (Austria, Belgium, Germany, Holland, Israel and Italy) in 2010-2015.

Recent Publications

  1. Li, Y, Jerkic, M, Slutsky, AS, Zhang, H. Molecular mechanisms of sex bias differences in COVID-19 mortality. Crit Care. 2020;24 (1):405. doi: 10.1186/s13054-020-03118-8. PubMed PMID:32646459 PubMed Central PMC7347256.
  2. Monteil, V, Kwon, H, Prado, P, Hagelkrüys, A, Wimmer, RA, Stahl, M et al.. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell. 2020;181 (4):905-913.e7. doi: 10.1016/j.cell.2020.04.004. PubMed PMID:32333836 PubMed Central PMC7181998.
  3. Maron, DJ, Hochman, JS, Reynolds, HR, Bangalore, S, O'Brien, SM, Boden, WE et al.. Initial Invasive or Conservative Strategy for Stable Coronary Disease. N. Engl. J. Med. 2020;382 (15):1395-1407. doi: 10.1056/NEJMoa1915922. PubMed PMID:32227755 PubMed Central PMC7263833.
  4. Zhang, H, Penninger, JM, Li, Y, Zhong, N, Slutsky, AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020;46 (4):586-590. doi: 10.1007/s00134-020-05985-9. PubMed PMID:32125455 PubMed Central PMC7079879.
  5. Dai, Q, Morita, Y, Huang, Y, Liaw, PC, Wu, J, Khang, J et al.. Modulation of Human Neutrophil Peptides on P. aeruginosa Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles. J Inflamm Res. 2019;12 :335-343. doi: 10.2147/JIR.S219276. PubMed PMID:31908518 PubMed Central PMC6927223.
  6. Henzler, D, Schmidt, A, Xu, Z, Ismaiel, N, Zhang, H, Slutsky, AS et al.. Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury. Intensive Care Med Exp. 2019;7 (1):60. doi: 10.1186/s40635-019-0272-z. PubMed PMID:31691042 PubMed Central PMC6831786.
  7. Liang, H, Ding, X, Yu, Y, Zhang, H, Wang, L, Kan, Q et al.. Adipose-derived mesenchymal stem cells ameliorate acute liver injury in rat model of CLP induced-sepsis via sTNFR1. Exp. Cell Res. 2019;383 (1):111465. doi: 10.1016/j.yexcr.2019.06.010. PubMed PMID:31201811 .
  8. Jerkic, M, Masterson, C, Ormesher, L, Gagnon, S, Goyal, S, Rabani, R et al.. Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis. J Clin Med. 2019;8 (6):. doi: 10.3390/jcm8060847. PubMed PMID:31200579 PubMed Central PMC6616885.
  9. Zhang, H, Li, Y, Slutsky, AS. Precision medicine for cell therapy in acute respiratory distress syndrome. Lancet Respir Med. 2019;7 (4):e13. doi: 10.1016/S2213-2600(19)30089-X. PubMed PMID:30926050 .
  10. Islam, D, Huang, Y, Fanelli, V, Delsedime, L, Wu, S, Khang, J et al.. Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury. Am. J. Respir. Crit. Care Med. 2019;199 (10):1214-1224. doi: 10.1164/rccm.201802-0356OC. PubMed PMID:30521764 .
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Affiliations & Other Activities

  • Professor, Department of Anesthesia, University of Toronto
  • Professor, Department of Medicine, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Faculty Member, Institute of Medical Sciences, School of Graduate Studies, University of Toronto