Haibo Zhang


Scientist, Keenan Research Centre for Biomedical Science


Dr. Haibo Zhang is a Staff Scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor of Anesthesia, Medicine and Physiology at the University of Toronto. His translational research program focuses on the mechanisms and therapy of acute lung injury and sepsis. He has published over 200 peer-reviewed articles, and is the recipient of enormous research grants and a number of research awards, including Premier’s Research Excellence Award (Ontario), a New Investigator Award from the Canadian Institutes of Health Research (CIHR), and Chang Jiang Scholar supported by Li Ka Shing Foundation. He serves on a number of academic and appointment committees at the Institute of Medical Sciences (IMS), University of Toronto and at St. Michael’s Hospital. He has trained over 80 MSc and PhD students, and post-doctoral fellows.

He has served on the Standing Committee of Critical Care Assembly, the American Thoracic Society in 2005-2006, Associate Editor, Intensive Care Medicine in 2007-2013, Chairman of Final Review Panel of Respiration System and the Natural Science Foundation of China (NSFC) in 2010-2011. He was a member of grant and award committees of CIHR in 2014-2016, and an external grant reviewer for European nations (Austria, Belgium, Germany, Holland, Israel and Italy) in 2010-2015.

Recent Publications

  1. Dai, Q, Morita, Y, Huang, Y, Liaw, PC, Wu, J, Khang, J et al.. Modulation of Human Neutrophil Peptides on P. aeruginosa Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles. J Inflamm Res. 2019;12 :335-343. doi: 10.2147/JIR.S219276. PubMed PMID:31908518 PubMed Central PMC6927223.
  2. Henzler, D, Schmidt, A, Xu, Z, Ismaiel, N, Zhang, H, Slutsky, AS et al.. Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury. Intensive Care Med Exp. 2019;7 (1):60. doi: 10.1186/s40635-019-0272-z. PubMed PMID:31691042 PubMed Central PMC6831786.
  3. Liang, H, Ding, X, Yu, Y, Zhang, H, Wang, L, Kan, Q et al.. Adipose-derived mesenchymal stem cells ameliorate acute liver injury in rat model of CLP induced-sepsis via sTNFR1. Exp. Cell Res. 2019;383 (1):111465. doi: 10.1016/j.yexcr.2019.06.010. PubMed PMID:31201811 .
  4. Jerkic, M, Masterson, C, Ormesher, L, Gagnon, S, Goyal, S, Rabani, R et al.. Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis. J Clin Med. 2019;8 (6):. doi: 10.3390/jcm8060847. PubMed PMID:31200579 PubMed Central PMC6616885.
  5. Zhang, H, Li, Y, Slutsky, AS. Precision medicine for cell therapy in acute respiratory distress syndrome. Lancet Respir Med. 2019;7 (4):e13. doi: 10.1016/S2213-2600(19)30089-X. PubMed PMID:30926050 .
  6. Islam, D, Huang, Y, Fanelli, V, Delsedime, L, Wu, S, Khang, J et al.. Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury. Am. J. Respir. Crit. Care Med. 2019;199 (10):1214-1224. doi: 10.1164/rccm.201802-0356OC. PubMed PMID:30521764 .
  7. Zhang, H. Introduction to Journal of Thoracic Disease new column: Critical Care Frontier and Horizon. J Thorac Dis. 2018;10 (9):5605-5606. doi: 10.21037/jtd.2018.09.09. PubMed PMID:30416811 PubMed Central PMC6196186.
  8. Villar, J, Zhang, H, Slutsky, AS. Lung Repair and Regeneration in ARDS: Role of PECAM1 and Wnt Signaling. Chest. 2019;155 (3):587-594. doi: 10.1016/j.chest.2018.10.022. PubMed PMID:30392791 PubMed Central PMC6435939.
  9. Xu, Z, Li, Y, Zhou, J, Li, X, Huang, Y, Liu, X et al.. High-flow nasal cannula in adults with acute respiratory failure and after extubation: a systematic review and meta-analysis. Respir. Res. 2018;19 (1):202. doi: 10.1186/s12931-018-0908-7. PubMed PMID:30326893 PubMed Central PMC6192218.
  10. Zheng, J, Huang, Y, Islam, D, Wen, XY, Wu, S, Streutker, C et al.. Dual effects of human neutrophil peptides in a mouse model of pneumonia and ventilator-induced lung injury. Respir. Res. 2018;19 (1):190. doi: 10.1186/s12931-018-0869-x. PubMed PMID:30268129 PubMed Central PMC6162902.
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Affiliations & Other Activities

  • Professor, Department of Anesthesia, University of Toronto
  • Professor, Department of Medicine, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Faculty Member, Institute of Medical Sciences, School of Graduate Studies, University of Toronto