Biography

Dr. Haibo Zhang is a Staff Scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor of Anesthesia, Medicine and Physiology at the University of Toronto. His translational research program focuses on the mechanisms and therapy of acute lung injury and sepsis. He has published over 250 peer-reviewed articles, and is the recipient of enormous research grants and a number of research awards, including Premier’s Research Excellence Award (Ontario), a New Investigator Award from the Canadian Institutes of Health Research (CIHR), and Fellow of Canadian Academy of Health Science. He serves on a number of academic and appointment committees at the Institute of Medical Sciences (IMS), University of Toronto and at St. Michael’s Hospital. He has trained over 90 MSc and PhD students, and post-doctoral fellows.

He has served on the Standing Committee of Critical Care Assembly, the American Thoracic Society in 2005-2006, Associate Editor, Intensive Care Medicine in 2007-2013, and Editorial Boards on a number of medical journals. He was a member of grant and award committees of CIHR since 2012 and is a member of College of Reviewer since 2016, a guest grant reviewer for European nations (Austria, Belgium, Germany, Holland, Israel, UK and Italy) since 2010. He is Theme Lead of Biomaterial, Tissue Injury and Repair at the Institute of Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael’s Hospital since 2017.

Recent Publications

  1. Khateeb, J, Li, Y, Zhang, H. Emerging SARS-CoV-2 variants of concern and potential intervention approaches. Crit Care. 2021;25 (1):244. doi: 10.1186/s13054-021-03662-x. PubMed PMID:34253247 PubMed Central PMC8274962.
  2. Fuller, S, Kumar, SR, Roy, N, Mahle, WT, Romano, JC, Nelson, JS et al.. The American Association for Thoracic Surgery Congenital Cardiac Surgery Working Group 2021 consensus document on a comprehensive perioperative approach to enhanced recovery after pediatric cardiac surgery. J Thorac Cardiovasc Surg. 2021; :. doi: 10.1016/j.jtcvs.2021.04.072. PubMed PMID:34059337 .
  3. Gabarin, RS, Li, M, Zimmel, PA, Marshall, JC, Li, Y, Zhang, H et al.. Intracellular and Extracellular Lipopolysaccharide Signaling in Sepsis: Avenues for Novel Therapeutic Strategies. J Innate Immun. 2021; :1-10. doi: 10.1159/000515740. PubMed PMID:34004605 .
  4. Zhang, X, Cui, Y, Ding, X, Liu, S, Han, B, Duan, X et al.. Analysis of mRNA‑lncRNA and mRNA‑lncRNA-pathway co‑expression networks based on WGCNA in developing pediatric sepsis. Bioengineered. 2021;12 (1):1457-1470. doi: 10.1080/21655979.2021.1908029. PubMed PMID:33949285 .
  5. Jerkic, M, Litvack, ML, Gagnon, S, Otulakowski, G, Zhang, H, Rotstein, O et al.. Embryonic-Derived Myb- Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis. Int J Mol Sci. 2021;22 (6):. doi: 10.3390/ijms22063190. PubMed PMID:33804806 PubMed Central PMC8004006.
  6. Mendelson, AA, Lansdell, C, Fox-Robichaud, AE, Liaw, P, Arora, J, Cailhier, JF et al.. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Med Exp. 2021;9 (1):14. doi: 10.1186/s40635-020-00366-4. PubMed PMID:33738642 PubMed Central PMC7973346.
  7. McGinn, R, Fergusson, DA, Stewart, DJ, Kristof, AS, Barron, CC, Thebaud, B et al.. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021;49 (2):311-323. doi: 10.1097/CCM.0000000000004734. PubMed PMID:33332817 .
  8. Amatullah, H, Maron-Gutierrez, T, Shan, Y, Gupta, S, Tsoporis, JN, Varkouhi, AK et al.. Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury. Redox Biol. 2021;38 :101796. doi: 10.1016/j.redox.2020.101796. PubMed PMID:33246293 PubMed Central PMC7695876.
  9. Stebbing, J, Sánchez Nievas, G, Falcone, M, Youhanna, S, Richardson, P, Ottaviani, S et al.. JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Sci Adv. 2021;7 (1):. doi: 10.1126/sciadv.abe4724. PubMed PMID:33187978 PubMed Central PMC7775747.
  10. Monteil, V, Dyczynski, M, Lauschke, VM, Kwon, H, Wirnsberger, G, Youhanna, S et al.. Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection. EMBO Mol Med. 2021;13 (1):e13426. doi: 10.15252/emmm.202013426. PubMed PMID:33179852 PubMed Central PMC7799356.
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Affiliations & Other Activities

  • Professor, Department of Anesthesia, University of Toronto
  • Professor, Department of Medicine, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Faculty Member, Institute of Medical Sciences, School of Graduate Studies, University of Toronto
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