Dr. Haibo Zhang is a Staff Scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor of Anesthesia, Medicine and Physiology at the University of Toronto. His translational research program focuses on the mechanisms and therapy of acute lung injury and sepsis. He has published over 200 peer-reviewed articles, and is the recipient of enormous research grants and a number of research awards, including Premier’s Research Excellence Award (Ontario), a New Investigator Award from the Canadian Institutes of Health Research (CIHR), and Chang Jiang Scholar supported by Li Ka Shing Foundation. He serves on a number of academic and appointment committees at the Institute of Medical Sciences (IMS), University of Toronto and at St. Michael’s Hospital. He has trained over 80 MSc and PhD students, and post-doctoral fellows.

He has served on the Standing Committee of Critical Care Assembly, the American Thoracic Society in 2005-2006, Associate Editor, Intensive Care Medicine in 2007-2013, Chairman of Final Review Panel of Respiration System and the Natural Science Foundation of China (NSFC) in 2010-2011. He was a member of grant and award committees of CIHR in 2014-2016, and an external grant reviewer for European nations (Austria, Belgium, Germany, Holland, Israel and Italy) in 2010-2015.

Recent Publications

  1. Jerkic, M, Litvack, ML, Gagnon, S, Otulakowski, G, Zhang, H, Rotstein, O et al.. Embryonic-Derived Myb- Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis. Int J Mol Sci. 2021;22 (6):. doi: 10.3390/ijms22063190. PubMed PMID:33804806 PubMed Central PMC8004006.
  2. Mendelson, AA, Lansdell, C, Fox-Robichaud, AE, Liaw, P, Arora, J, Cailhier, JF et al.. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Med Exp. 2021;9 (1):14. doi: 10.1186/s40635-020-00366-4. PubMed PMID:33738642 PubMed Central PMC7973346.
  3. McGinn, R, Fergusson, DA, Stewart, DJ, Kristof, AS, Barron, CC, Thebaud, B et al.. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021;49 (2):311-323. doi: 10.1097/CCM.0000000000004734. PubMed PMID:33332817 .
  4. Amatullah, H, Maron-Gutierrez, T, Shan, Y, Gupta, S, Tsoporis, JN, Varkouhi, AK et al.. Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury. Redox Biol. 2021;38 :101796. doi: 10.1016/j.redox.2020.101796. PubMed PMID:33246293 PubMed Central PMC7695876.
  5. Stebbing, J, Sánchez Nievas, G, Falcone, M, Youhanna, S, Richardson, P, Ottaviani, S et al.. JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Sci Adv. 2021;7 (1):. doi: 10.1126/sciadv.abe4724. PubMed PMID:33187978 PubMed Central PMC7775747.
  6. Monteil, V, Dyczynski, M, Lauschke, VM, Kwon, H, Wirnsberger, G, Youhanna, S et al.. Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection. EMBO Mol Med. 2021;13 (1):e13426. doi: 10.15252/emmm.202013426. PubMed PMID:33179852 PubMed Central PMC7799356.
  7. Zoufaly, A, Poglitsch, M, Aberle, JH, Hoepler, W, Seitz, T, Traugott, M et al.. Human recombinant soluble ACE2 in severe COVID-19. Lancet Respir Med. 2020;8 (11):1154-1158. doi: 10.1016/S2213-2600(20)30418-5. PubMed PMID:33131609 PubMed Central PMC7515587.
  8. Li, Y, Jerkic, M, Slutsky, AS, Zhang, H. Molecular mechanisms of sex bias differences in COVID-19 mortality. Crit Care. 2020;24 (1):405. doi: 10.1186/s13054-020-03118-8. PubMed PMID:32646459 PubMed Central PMC7347256.
  9. Monteil, V, Kwon, H, Prado, P, Hagelkrüys, A, Wimmer, RA, Stahl, M et al.. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell. 2020;181 (4):905-913.e7. doi: 10.1016/j.cell.2020.04.004. PubMed PMID:32333836 PubMed Central PMC7181998.
  10. Maron, DJ, Hochman, JS, Reynolds, HR, Bangalore, S, O'Brien, SM, Boden, WE et al.. Initial Invasive or Conservative Strategy for Stable Coronary Disease. N Engl J Med. 2020;382 (15):1395-1407. doi: 10.1056/NEJMoa1915922. PubMed PMID:32227755 PubMed Central PMC7263833.
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Affiliations & Other Activities

  • Professor, Department of Anesthesia, University of Toronto
  • Professor, Department of Medicine, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Faculty Member, Institute of Medical Sciences, School of Graduate Studies, University of Toronto