Howard Leong-Poi


Associate Scientist, Keenan Research Centre for Biomedical Science


Dr. Howard Leong-Poi is a Clinician Scientist in the Keenan Research Centre for Biomedical Science and Head of the Division of Cardiology at St. Michael’s Hospital, Associate Professor of Medicine at the University of Toronto. He holds the Brazilian Ball Chair in Cardiovascular Research. His research has been funded by the Canadian Institutes for Health Research (CIHR), Heart and Stroke Foundation of Canada (HSFC) and the Canadian Foundation for Innovation. He has held personnel support from the CIHR (New Investigator), HSFC (Clinician Scientist – Phase II Award) and the Ministry of Research and Innovation (Early Researcher Award). He has published over 100 articles in peer-reviewed journals, and serves on the editorial board of the Canadian Journal of Cardiology. Dr. Howard Leong-Poi has served on numerous grant review panels, including the Canadian Institutes of Health Research (CIHR) Cardiovascular B (CSB) – Chair 2012-2015, and Heart & Stroke Foundation of Canada (Committees I and II). His basic biomedical research focuses on ultrasound-targeted gene- and cell-based therapies for cardiovascular disease and cancer. His clinical research interests revolve around cardiac imaging, predominantly echocardiography, in ischemic heart disease, heart failure and valvular heart disease.

Recent Publications

  1. Quan, A, Pan, Y, Singh, KK, Polemidiotis, J, Teoh, H, Leong-Poi, H et al.. Cardiovascular inflammation is reduced with methotrexate in diabetes. Mol. Cell. Biochem. 2017; :. doi: 10.1007/s11010-017-3006-0. PubMed PMID:28303409 .
  2. Ross, BA, Wald, R, Goldstein, MB, Yuen, DA, Leipsic, J, Kiaii, M et al.. Relationships Between Left Ventricular Structure and Function According to Cardiac MRI and Cardiac Biomarkers in End-Stage Renal Disease. Can J Cardiol. 2017;33 (4):501-507. doi: 10.1016/j.cjca.2016.11.021. PubMed PMID:28222921 .
  3. Mofid, A, Newman, NS, Lee, PJ, Abbasi, C, Matkar, PN, Rudenko, D et al.. Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia-Reperfusion. J Am Heart Assoc. 2017;6 (2):. doi: 10.1161/JAHA.116.004738. PubMed PMID:28174168 .
  4. Connelly, KA, Ho, EC, Leong-Poi, H. Controversies in quantification of mitral valve regurgitation: role of cardiac magnetic resonance imaging. Curr. Opin. Cardiol. 2017;32 (2):152-160. doi: 10.1097/HCO.0000000000000363. PubMed PMID:27861188 .
  5. Matkar, PN, Singh, KK, Rudenko, D, Kim, YJ, Kuliszewski, MA, Prud'homme, GJ et al.. Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma. Oncotarget. 2016;7 (43):69489-69506. doi: 10.18632/oncotarget.11060. PubMed PMID:27542226 PubMed Central PMC5342493.
  6. Leong-Poi, H. Contrast Ultrasound Ischemic Memory Imaging: Path to Clinical Translation. JACC Cardiovasc Imaging. 2016;9 (8):947-9. doi: 10.1016/j.jcmg.2015.12.021. PubMed PMID:27318721 .
  7. Chen, HH, Matkar, PN, Afrasiabi, K, Kuliszewski, MA, Leong-Poi, H. Prospect of ultrasound-mediated gene delivery in cardiovascular applications. Expert Opin Biol Ther. 2016;16 (6):815-26. doi: 10.1517/14712598.2016.1169268. PubMed PMID:27063021 .
  8. Michler, RE, Smith, PK, Parides, MK, Ailawadi, G, Thourani, V, Moskowitz, AJ et al.. Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation. N. Engl. J. Med. 2016;374 (20):1932-41. doi: 10.1056/NEJMoa1602003. PubMed PMID:27040451 PubMed Central PMC4908820.
  9. Cao, WJ, Matkar, PN, Chen, HH, Mofid, A, Leong-Poi, H. Microbubbles and Ultrasound: Therapeutic Applications in Diabetic Nephropathy. Adv. Exp. Med. Biol. 2016;880 :309-30. doi: 10.1007/978-3-319-22536-4_17. PubMed PMID:26486345 .
  10. Wald, R, Goldstein, MB, Perl, J, Kiaii, M, Yuen, D, Wald, RM et al.. The Association Between Conversion to In-centre Nocturnal Hemodialysis and Left Ventricular Mass Regression in Patients With End-Stage Renal Disease. Can J Cardiol. 2016;32 (3):369-77. doi: 10.1016/j.cjca.2015.07.004. PubMed PMID:26386732 .
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Affiliations & Other Activities

  • Associate Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • The Brazilian Ball Endowed Research Chair in Cardiology Research, St. Michael’s Hospital
  • Head, Division of Cardiology, St. Michael’s Hospital
  • Associate Professor of Medicine, Medicine/Cardiology, St. Michael’s Hospital
  • Adjunct Scientist, Ryerson University