Howard Leong-Poi


Scientist, Keenan Research Centre for Biomedical Science


Dr. Howard Leong-Poi is a Clinician Scientist in the Keenan Research Centre for Biomedical Science and Head of the Division of Cardiology at St. Michael’s Hospital. He is also an Associate Professor of Medicine at the University of Toronto. He is the current incumbent of the Brazilian Ball Chair in Cardiology at St. Michael’s Hospital. His research has been funded by the Canadian Institutes for Health Research (CIHR), Heart and Stroke Foundation of Canada (HSFC) and the Canadian Foundation for Innovation. He has held personnel support from the CIHR (New Investigator), HSFC (Clinician Scientist – Phase II Award) and the Ministry of Research and Innovation (Early Researcher Award). He has published over 100 articles in peer-reviewed journals, and serves on the editorial board of the Canadian Journal of Cardiology. Dr. Leong-Poi has served on numerous grant review panels, including the Canadian Institutes of Health Research (CIHR) Cardiovascular B (CSB) – Chair 2012-2015, and Heart & Stroke Foundation of Canada (Committees I and II). His basic biomedical research focuses on ultrasound-targeted gene- and cell-based therapies for cardiovascular disease and cancer. His clinical research interests revolve around cardiac imaging, predominantly echocardiography, in ischemic heart disease, heart failure and valvular heart disease.

Recent Publications

  1. Ong, G, Redfors, B, Crowley, A, Abdel-Qadir, H, Harrington, A, Liu, Y et al.. Evaluation of left ventricular reverse remodeling in patients with severe aortic regurgitation undergoing aortic valve replacement: Comparison between diameters and volumes. Echocardiography. 2017; :. doi: 10.1111/echo.13750. PubMed PMID:29193376 .
  2. Matkar, PN, Ariyagunarajah, R, Leong-Poi, H, Singh, KK. Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis. Biomolecules. 2017;7 (4):. doi: 10.3390/biom7040074. PubMed PMID:28974056 .
  3. Yougbaré, I, Tai, WS, Zdravic, D, Oswald, BE, Lang, S, Zhu, G et al.. Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia. Nat Commun. 2017;8 (1):224. doi: 10.1038/s41467-017-00269-1. PubMed PMID:28794456 PubMed Central PMC5550461.
  4. Chan, V, Chu, MWA, Leong-Poi, H, Latter, DA, Hall, J, Thorpe, KE et al.. Randomised trial of mitral valve repair with leaflet resection versus leaflet preservation on functional mitral stenosis (The CAMRA CardioLink-2 Trial). BMJ Open. 2017;7 (5):e015032. doi: 10.1136/bmjopen-2016-015032. PubMed PMID:28566364 .
  5. Ong, G, Connelly, KA, Goodman, J, Leong-Poi, H, Evangelista, V, Levitt, K et al.. Echocardiographic Assessment of Young Male Draft-Eligible Elite Hockey Players Invited to the Medical and Fitness Combine by the National Hockey League. Am. J. Cardiol. 2017;119 (12):2088-2092. doi: 10.1016/j.amjcard.2017.03.042. PubMed PMID:28477859 .
  6. Quan, A, Pan, Y, Singh, KK, Polemidiotis, J, Teoh, H, Leong-Poi, H et al.. Cardiovascular inflammation is reduced with methotrexate in diabetes. Mol. Cell. Biochem. 2017;432 (1-2):159-167. doi: 10.1007/s11010-017-3006-0. PubMed PMID:28303409 .
  7. Ross, BA, Wald, R, Goldstein, MB, Yuen, DA, Leipsic, J, Kiaii, M et al.. Relationships Between Left Ventricular Structure and Function According to Cardiac MRI and Cardiac Biomarkers in End-Stage Renal Disease. Can J Cardiol. 2017;33 (4):501-507. doi: 10.1016/j.cjca.2016.11.021. PubMed PMID:28222921 .
  8. Mofid, A, Newman, NS, Lee, PJ, Abbasi, C, Matkar, PN, Rudenko, D et al.. Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia-Reperfusion. J Am Heart Assoc. 2017;6 (2):. doi: 10.1161/JAHA.116.004738. PubMed PMID:28174168 PubMed Central PMC5523770.
  9. Connelly, KA, Ho, EC, Leong-Poi, H. Controversies in quantification of mitral valve regurgitation: role of cardiac magnetic resonance imaging. Curr. Opin. Cardiol. 2017;32 (2):152-160. doi: 10.1097/HCO.0000000000000363. PubMed PMID:27861188 .
  10. Matkar, PN, Singh, KK, Rudenko, D, Kim, YJ, Kuliszewski, MA, Prud'homme, GJ et al.. Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma. Oncotarget. 2016;7 (43):69489-69506. doi: 10.18632/oncotarget.11060. PubMed PMID:27542226 PubMed Central PMC5342493.
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Affiliations & Other Activities

  • Chair, The Brazilian Ball Chair in Cardiology Research, St. Michael’s Hospital
  • Head, Division of Cardiology, St. Michael’s Hospital
  • Associate Professor of Medicine, Medicine/Cardiology, St. Michael’s Hospital
  • Adjunct Scientist, Ryerson University