Howard Leong-Poi


Scientist, Keenan Research Centre for Biomedical Science


Dr. Howard Leong-Poi is a Clinician Scientist in the Keenan Research Centre for Biomedical Science and Head of the Division of Cardiology at St. Michael’s Hospital. He is also an Associate Professor of Medicine at the University of Toronto. He is the current incumbent of the Brazilian Ball Chair in Cardiology at St. Michael’s Hospital. His research has been funded by the Canadian Institutes for Health Research (CIHR), Heart and Stroke Foundation of Canada (HSFC) and the Canadian Foundation for Innovation. He has held personnel support from the CIHR (New Investigator), HSFC (Clinician Scientist – Phase II Award) and the Ministry of Research and Innovation (Early Researcher Award). He has published over 100 articles in peer-reviewed journals, and serves on the editorial board of the Canadian Journal of Cardiology. Dr. Leong-Poi has served on numerous grant review panels, including the Canadian Institutes of Health Research (CIHR) Cardiovascular B (CSB) – Chair 2012-2015, and Heart & Stroke Foundation of Canada (Committees I and II). His basic biomedical research focuses on ultrasound-targeted gene- and cell-based therapies for cardiovascular disease and cancer. His clinical research interests revolve around cardiac imaging, predominantly echocardiography, in ischemic heart disease, heart failure and valvular heart disease.

Recent Publications

  1. Moulson, N, Bewick, D, Selway, T, Harris, J, Suskin, N, Oh, P et al.. Cardiac Rehabilitation during the COVID-19 Era: Guidance on Implementing Virtual Care. Can J Cardiol. 2020; :. doi: 10.1016/j.cjca.2020.06.006. PubMed PMID:32553606 PubMed Central PMC7293761.
  2. Virani, A, Singh, G, Bewick, D, Chow, CM, Clarke, B, Cowan, S et al.. Guiding Cardiac Care during the COVID-19 Pandemic: How Ethics Shapes Our Health System Response. Can J Cardiol. 2020; :. doi: 10.1016/j.cjca.2020.06.002. PubMed PMID:32505633 PubMed Central PMC7270812.
  3. Turgeon, RD, Zieroth, S, Bewick, D, Chow, CM, Clarke, B, Cowan, S et al.. Use of Renin-Angiotensin System Blockers During the COVID-19 Pandemic: Early Guidance and Evolving Evidence. Can J Cardiol. 2020; :. doi: 10.1016/j.cjca.2020.05.033. PubMed PMID:32502522 PubMed Central PMC7265831.
  4. Bami, K, Gandhi, S, Leong-Poi, H, Yan, AT, Ho, E, Zahrani, M et al.. Effects of Empagliflozin on Left Ventricular Remodeling in Patients with Type 2 Diabetes and Coronary Artery Disease: Echocardiographic Substudy of the EMPA-HEART CardioLink-6 Randomized Clinical Trial. J Am Soc Echocardiogr. 2020;33 (5):644-646. doi: 10.1016/j.echo.2020.02.005. PubMed PMID:32199780 .
  5. Angaran, P, Dorian, P, Ha, ACT, Thavendiranathan, P, Tsang, W, Leong-Poi, H et al.. Association of Left Ventricular Ejection Fraction with Mortality and Hospitalizations. J Am Soc Echocardiogr. 2020;33 (7):802-811.e6. doi: 10.1016/j.echo.2019.12.016. PubMed PMID:32164977 .
  6. Singh, S, Adam, M, Matkar, PN, Bugyei-Twum, A, Desjardins, JF, Chen, HH et al.. Endothelial-specific Loss of IFT88 Promotes Endothelial-to-Mesenchymal Transition and Exacerbates Bleomycin-induced Pulmonary Fibrosis. Sci Rep. 2020;10 (1):4466. doi: 10.1038/s41598-020-61292-9. PubMed PMID:32161282 PubMed Central PMC7066128.
  7. Paterson, DI, Wells, G, Erthal, F, Mielniczuk, L, O'Meara, E, White, J et al.. OUTSMART HF: A Randomized Controlled Trial of Routine Versus Selective Cardiac Magnetic Resonance for Patients With Nonischemic Heart Failure (IMAGE-HF 1B). Circulation. 2020;141 (10):818-827. doi: 10.1161/CIRCULATIONAHA.119.043964. PubMed PMID:31910649 .
  8. Connolly, K, Ong, G, Kuhlmann, M, Ho, E, Levitt, K, Abdel-Qadir, H et al.. Use of the Valve Visualization on Echocardiography Grade Tool Improves Sensitivity and Negative Predictive Value of Transthoracic Echocardiogram for Exclusion of Native Valvular Vegetation. J Am Soc Echocardiogr. 2019;32 (12):1551-1557.e1. doi: 10.1016/j.echo.2019.08.018. PubMed PMID:31679901 .
  9. Ge, Y, Leong-Poi, H. Ischemic Memory Imaging: The Quest for the Holy Grail Continues. J Am Soc Echocardiogr. 2019;32 (11):1487-1490. doi: 10.1016/j.echo.2019.09.003. PubMed PMID:31679582 .
  10. Keith, M, Quach, S, Ahmed, M, Azizi-Namini, P, Al-Hesayen, A, Azevedo, E et al.. Thiamin supplementation does not improve left ventricular ejection fraction in ambulatory heart failure patients: a randomized controlled trial. Am. J. Clin. Nutr. 2019;110 (6):1287-1295. doi: 10.1093/ajcn/nqz192. PubMed PMID:31504093 .
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Affiliations & Other Activities

  • Chair, The Brazilian Ball Chair in Cardiology Research, St. Michael’s Hospital
  • Head, Division of Cardiology, St. Michael’s Hospital
  • Associate Professor of Medicine, Medicine/Cardiology, St. Michael’s Hospital
  • Adjunct Scientist, Ryerson University