Howard Leong-Poi

MD, FRCPC, FACC, FASE

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Howard Leong-Poi is a Clinician Scientist in the Keenan Research Centre for Biomedical Science and Head of the Division of Cardiology at St. Michael’s Hospital. He is also an Associate Professor of Medicine at the University of Toronto. He is the current incumbent of the Brazilian Ball Chair in Cardiology at St. Michael’s Hospital. His research has been funded by the Canadian Institutes for Health Research (CIHR), Heart and Stroke Foundation of Canada (HSFC) and the Canadian Foundation for Innovation. He has held personnel support from the CIHR (New Investigator), HSFC (Clinician Scientist – Phase II Award) and the Ministry of Research and Innovation (Early Researcher Award). He has published over 100 articles in peer-reviewed journals, and serves on the editorial board of the Canadian Journal of Cardiology. Dr. Leong-Poi has served on numerous grant review panels, including the Canadian Institutes of Health Research (CIHR) Cardiovascular B (CSB) – Chair 2012-2015, and Heart & Stroke Foundation of Canada (Committees I and II). His basic biomedical research focuses on ultrasound-targeted gene- and cell-based therapies for cardiovascular disease and cancer. His clinical research interests revolve around cardiac imaging, predominantly echocardiography, in ischemic heart disease, heart failure and valvular heart disease.

Recent Publications

  1. Matkar, PN, Jong, ED, Ariyagunarajah, R, Prud'homme, GJ, Singh, KK, Leong-Poi, H et al.. Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer. Cancer Med. 2018;7 (10):5036-5046. doi: 10.1002/cam4.1715. PubMed PMID:30216699 PubMed Central PMC6198212.
  2. Murugavel, S, Bugyei-Twum, A, Matkar, PN, Al-Mubarak, H, Chen, HH, Adam, M et al.. Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching. Front Pharmacol. 2018;9 :737. doi: 10.3389/fphar.2018.00737. PubMed PMID:30050438 PubMed Central PMC6050396.
  3. Sugiyama, MG, Mintsopoulos, V, Raheel, H, Goldenberg, NM, Batt, JE, Brochard, L et al.. Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli-induced Pneumonia and Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2018;198 (3):404-408. doi: 10.1164/rccm.201711-2259LE. PubMed PMID:29638143 .
  4. Porter, TR, Mulvagh, SL, Abdelmoneim, SS, Becher, H, Belcik, JT, Bierig, M et al.. Clinical Applications of Ultrasonic Enhancing Agents in Echocardiography: 2018 American Society of Echocardiography Guidelines Update. J Am Soc Echocardiogr. 2018;31 (3):241-274. doi: 10.1016/j.echo.2017.11.013. PubMed PMID:29502588 .
  5. Ong, G, Redfors, B, Crowley, A, Abdel-Qadir, H, Harrington, A, Liu, Y et al.. Evaluation of left ventricular reverse remodeling in patients with severe aortic regurgitation undergoing aortic valve replacement: Comparison between diameters and volumes. Echocardiography. 2018;35 (2):142-147. doi: 10.1111/echo.13750. PubMed PMID:29193376 .
  6. Matkar, PN, Ariyagunarajah, R, Leong-Poi, H, Singh, KK. Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis. Biomolecules. 2017;7 (4):. doi: 10.3390/biom7040074. PubMed PMID:28974056 PubMed Central PMC5745456.
  7. Yougbaré, I, Tai, WS, Zdravic, D, Oswald, BE, Lang, S, Zhu, G et al.. Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia. Nat Commun. 2017;8 (1):224. doi: 10.1038/s41467-017-00269-1. PubMed PMID:28794456 PubMed Central PMC5550461.
  8. Chan, V, Chu, MWA, Leong-Poi, H, Latter, DA, Hall, J, Thorpe, KE et al.. Randomised trial of mitral valve repair with leaflet resection versus leaflet preservation on functional mitral stenosis (The CAMRA CardioLink-2 Trial). BMJ Open. 2017;7 (5):e015032. doi: 10.1136/bmjopen-2016-015032. PubMed PMID:28566364 PubMed Central PMC5729977.
  9. Ong, G, Connelly, KA, Goodman, J, Leong-Poi, H, Evangelista, V, Levitt, K et al.. Echocardiographic Assessment of Young Male Draft-Eligible Elite Hockey Players Invited to the Medical and Fitness Combine by the National Hockey League. Am. J. Cardiol. 2017;119 (12):2088-2092. doi: 10.1016/j.amjcard.2017.03.042. PubMed PMID:28477859 .
  10. Quan, A, Pan, Y, Singh, KK, Polemidiotis, J, Teoh, H, Leong-Poi, H et al.. Cardiovascular inflammation is reduced with methotrexate in diabetes. Mol. Cell. Biochem. 2017;432 (1-2):159-167. doi: 10.1007/s11010-017-3006-0. PubMed PMID:28303409 .
Search PubMed

Affiliations & Other Activities

  • Chair, The Brazilian Ball Chair in Cardiology Research, St. Michael’s Hospital
  • Head, Division of Cardiology, St. Michael’s Hospital
  • Associate Professor of Medicine, Medicine/Cardiology, St. Michael’s Hospital
  • Adjunct Scientist, Ryerson University
X