Howard Leong-Poi


Scientist, Keenan Research Centre for Biomedical Science


Dr. Howard Leong-Poi is a Clinician Scientist in the Keenan Research Centre for Biomedical Science and Head of the Division of Cardiology at St. Michael’s Hospital. He is also an Associate Professor of Medicine at the University of Toronto. He is the current incumbent of the Brazilian Ball Chair in Cardiology at St. Michael’s Hospital. His research has been funded by the Canadian Institutes for Health Research (CIHR), Heart and Stroke Foundation of Canada (HSFC) and the Canadian Foundation for Innovation. He has held personnel support from the CIHR (New Investigator), HSFC (Clinician Scientist – Phase II Award) and the Ministry of Research and Innovation (Early Researcher Award). He has published over 100 articles in peer-reviewed journals, and serves on the editorial board of the Canadian Journal of Cardiology. Dr. Leong-Poi has served on numerous grant review panels, including the Canadian Institutes of Health Research (CIHR) Cardiovascular B (CSB) – Chair 2012-2015, and Heart & Stroke Foundation of Canada (Committees I and II). His basic biomedical research focuses on ultrasound-targeted gene- and cell-based therapies for cardiovascular disease and cancer. His clinical research interests revolve around cardiac imaging, predominantly echocardiography, in ischemic heart disease, heart failure and valvular heart disease.

Recent Publications

  1. Connolly, K, Ong, G, Kuhlmann, M, Ho, E, Levitt, K, Abdel-Qadir, H et al.. Use of the Valve Visualization on Echocardiography Grade Tool Improves Sensitivity and Negative Predictive Value of Transthoracic Echocardiogram for Exclusion of Native Valvular Vegetation. J Am Soc Echocardiogr. 2019;32 (12):1551-1557.e1. doi: 10.1016/j.echo.2019.08.018. PubMed PMID:31679901 .
  2. Ge, Y, Leong-Poi, H. Ischemic Memory Imaging: The Quest for the Holy Grail Continues. J Am Soc Echocardiogr. 2019;32 (11):1487-1490. doi: 10.1016/j.echo.2019.09.003. PubMed PMID:31679582 .
  3. Keith, M, Quach, S, Ahmed, M, Azizi-Namini, P, Al-Hesayen, A, Azevedo, E et al.. Thiamin supplementation does not improve left ventricular ejection fraction in ambulatory heart failure patients: a randomized controlled trial. Am. J. Clin. Nutr. 2019;110 (6):1287-1295. doi: 10.1093/ajcn/nqz192. PubMed PMID:31504093 .
  4. Braga, JR, Leong-Poi, H, Rac, VE, Austin, PC, Ross, HJ, Lee, DS et al.. Trends in the Use of Cardiac Imaging for Patients With Heart Failure in Canada. JAMA Netw Open. 2019;2 (8):e198766. doi: 10.1001/jamanetworkopen.2019.8766. PubMed PMID:31397858 PubMed Central PMC6692835.
  5. Gandhi, S, Ho, EC, Ong, G, Zahrani, M, Lu, J, Leong-Poi, H et al.. A Physician Education Tool to Improve Appropriate Use Criteria for Stress Echocardiography: Long-Term Follow-Up of a Single-Center Study. J Am Soc Echocardiogr. 2019;32 (9):1255-1257. doi: 10.1016/j.echo.2019.05.017. PubMed PMID:31311701 .
  6. Gong, IY, Al-Amro, B, Prasad, GVR, Connelly, PW, Wald, RM, Wald, R et al.. Cardiovascular magnetic resonance left ventricular strain in end-stage renal disease patients after kidney transplantation. J Cardiovasc Magn Reson. 2018;20 (1):83. doi: 10.1186/s12968-018-0504-5. PubMed PMID:30554567 PubMed Central PMC6296102.
  7. Matkar, PN, Jong, ED, Ariyagunarajah, R, Prud'homme, GJ, Singh, KK, Leong-Poi, H et al.. Jack of many trades: Multifaceted role of neuropilins in pancreatic cancer. Cancer Med. 2018;7 (10):5036-5046. doi: 10.1002/cam4.1715. PubMed PMID:30216699 PubMed Central PMC6198212.
  8. Murugavel, S, Bugyei-Twum, A, Matkar, PN, Al-Mubarak, H, Chen, HH, Adam, M et al.. Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching. Front Pharmacol. 2018;9 :737. doi: 10.3389/fphar.2018.00737. PubMed PMID:30050438 PubMed Central PMC6050396.
  9. Sugiyama, MG, Mintsopoulos, V, Raheel, H, Goldenberg, NM, Batt, JE, Brochard, L et al.. Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli-induced Pneumonia and Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2018;198 (3):404-408. doi: 10.1164/rccm.201711-2259LE. PubMed PMID:29638143 .
  10. Porter, TR, Mulvagh, SL, Abdelmoneim, SS, Becher, H, Belcik, JT, Bierig, M et al.. Clinical Applications of Ultrasonic Enhancing Agents in Echocardiography: 2018 American Society of Echocardiography Guidelines Update. J Am Soc Echocardiogr. 2018;31 (3):241-274. doi: 10.1016/j.echo.2017.11.013. PubMed PMID:29502588 .
Search PubMed

Affiliations & Other Activities

  • Chair, The Brazilian Ball Chair in Cardiology Research, St. Michael’s Hospital
  • Head, Division of Cardiology, St. Michael’s Hospital
  • Associate Professor of Medicine, Medicine/Cardiology, St. Michael’s Hospital
  • Adjunct Scientist, Ryerson University