Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students in 2017.

Recent Publications

  1. Wilcox, ME, Lim, AS, McAndrews, MP, Wennberg, RA, Pinto, RL, Black, SE et al.. A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study. BMJ Open. 2017;7 (7):e015600. doi: 10.1136/bmjopen-2016-015600. PubMed PMID:28710215 .
  2. Smith, OM, Chant, C, Burns, KEA, Kaur, M, Ashraf, S, DosSantos, CC et al.. Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study. PLoS ONE. 2017;12 (6):e0179207. doi: 10.1371/journal.pone.0179207. PubMed PMID:28604792 PubMed Central PMC5467852.
  3. Burns, KEA, Soliman, I, Adhikari, NKJ, Zwein, A, Wong, JTY, Gomez-Builes, C et al.. Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis. Crit Care. 2017;21 (1):127. doi: 10.1186/s13054-017-1698-x. PubMed PMID:28576127 PubMed Central PMC5455092.
  4. Verma, S, Goldenberg, RM, Bhatt, DL, Farkouh, ME, Quan, A, Teoh, H et al.. Dipeptidyl peptidase-4 inhibitors and the risk of heart failure: a systematic review and meta-analysis. CMAJ Open. ;5 (1):E152-E177. doi: 10.9778/cmajo.20160058. PubMed PMID:28459046 PubMed Central PMC5403656.
  5. Huang, HW, Sun, XM, Shi, ZH, Chen, GQ, Chen, L, Friedrich, JO et al.. Effect of High-Flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy and Noninvasive Ventilation on Reintubation Rate in Adult Patients After Extubation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Intensive Care Med. 2017; :885066617705118. doi: 10.1177/0885066617705118. PubMed PMID:28429603 .
  6. Chen, L, Chen, GQ, Shore, K, Shklar, O, Martins, C, Devenyi, B et al.. Implementing a bedside assessment of respiratory mechanics in patients with acute respiratory distress syndrome. Crit Care. 2017;21 (1):84. doi: 10.1186/s13054-017-1671-8. PubMed PMID:28372575 PubMed Central PMC5379641.
  7. Yanagawa, B, Verma, S, Mazine, A, Tam, DY, Jüni, P, Puskas, JD et al.. Impact of total arterial revascularization on long term survival: A systematic review and meta-analysis of 130,305 patients. Int. J. Cardiol. 2017;233 :29-36. doi: 10.1016/j.ijcard.2017.02.010. PubMed PMID:28185702 .
  8. Yanagawa, B, Verma, S, Jüni, P, Tam, DY, Mazine, A, Puskas, JD et al.. A systematic review and meta-analysis of in situ versus composite bilateral internal thoracic artery grafting. J. Thorac. Cardiovasc. Surg. 2017;153 (5):1108-1116.e16. doi: 10.1016/j.jtcvs.2016.11.027. PubMed PMID:28017369 .
  9. Sklar, MC, Burns, K, Rittayamai, N, Lanys, A, Rauseo, M, Chen, L et al.. Effort to Breathe with Various Spontaneous Breathing Trial Techniques. A Physiologic Meta-analysis. Am. J. Respir. Crit. Care Med. 2017;195 (11):1477-1485. doi: 10.1164/rccm.201607-1338OC. PubMed PMID:27768396 .
  10. Brooks, SC, Scales, DC, Pinto, R, Dainty, KN, Racz, EM, Gaudio, M et al.. The Postcardiac Arrest Consult Team: Impact on Hospital Care Processes for Out-of-Hospital Cardiac Arrest Patients. Crit. Care Med. 2016;44 (11):2037-2044. doi: 10.1097/CCM.0000000000001863. PubMed PMID:27509389 .
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Affiliations & Other Activities

  • Medical Director MSICU, Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto