Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students in 2018.

Recent Publications

  1. Elbatarny, M, Tam, DY, Edelman, JJ, Rocha, RV, Chu, MWA, Peterson, MD et al.. Valve-Sparing Root Replacement vs Composite Valve Grafting in Aortic Root Dilation: A Meta-Analysis. Ann. Thorac. Surg. 2020; :. doi: 10.1016/j.athoracsur.2019.11.054. PubMed PMID:31981499 .
  2. Ribeiro, RVP, Friedrich, JO, Ouzounian, M, Yau, T, Lee, J, Yanagawa, B et al.. Supplemental Cardioplegia During Donor Heart Implantation: A Systematic Review and Meta-Analysis. Ann. Thorac. Surg. 2020; :. doi: 10.1016/j.athoracsur.2019.10.094. PubMed PMID:31972127 .
  3. Angriman, F, Pinto, R, Friedrich, JO, Ferguson, ND, Rubenfeld, G, Amaral, ACK et al.. Compliance With Evidence-Based Processes of Care After Transitions Between Staff Intensivists. Crit. Care Med. 2020;48 (3):e227-e232. doi: 10.1097/CCM.0000000000004201. PubMed PMID:31913986 .
  4. Li, DH, Wald, R, Blum, D, McArthur, E, James, MT, Burns, KEA et al.. Predicting mortality among critically ill patients with acute kidney injury treated with renal replacement therapy: Development and validation of new prediction models. J Crit Care. 2019;56 :113-119. doi: 10.1016/j.jcrc.2019.12.015. PubMed PMID:31896444 .
  5. Rocha, RV, Friedrich, JO, Hong, K, Lee, J, Cheema, A, Bagai, A et al.. Aortic valve replacement with pulmonary hypertension: Meta-analysis of 70 676 patients. J Card Surg. 2019;34 (12):1617-1625. doi: 10.1111/jocs.14309. PubMed PMID:31794128 .
  6. Hemilä, H, Friedrich, JO. Many continuous variables should be analyzed using the relative scale: a case study of β2-agonists for preventing exercise-induced bronchoconstriction. Syst Rev. 2019;8 (1):282. doi: 10.1186/s13643-019-1183-5. PubMed PMID:31744533 PubMed Central PMC6865024.
  7. Ribeiro, RVP, Yanagawa, B, Légaré, JF, Hassan, A, Ouzounian, M, Verma, S et al.. Clinical outcomes of mitral valve intervention in patients with mitral annular calcification: A systematic review and meta-analysis. J Card Surg. 2020;35 (1):66-74. doi: 10.1111/jocs.14325. PubMed PMID:31692124 .
  8. Rocha, RV, Lindsay, TF, Friedrich, JO, Shan, S, Sinha, S, Yanagawa, B et al.. Systematic review of contemporary outcomes of endovascular and open thoracoabdominal aortic aneurysm repair. J. Vasc. Surg. 2019; :. doi: 10.1016/j.jvs.2019.06.216. PubMed PMID:31690525 .
  9. Friedrich, JO, Burns, KEA. Spontaneous Breathing Trials and Successful Extubation. JAMA. 2019;322 (17):1716. doi: 10.1001/jama.2019.14217. PubMed PMID:31688876 .
  10. Yanagawa, B, An, KR, Ouzounian, M, Gaudino, M, Puskas, JD, Asaoka, N et al.. Management of Less-Than-Severe Aortic Stenosis During Coronary Bypass: A Systematic Review and Meta-Analysis. Innovations (Phila). 2019;14 (4):291-298. doi: 10.1177/1556984519849639. PubMed PMID:31185776 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto