Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students in 2018.

Recent Publications

  1. Mazine, A, Rocha, RV, El-Hamamsy, I, Ouzounian, M, Yanagawa, B, Bhatt, DL et al.. Ross Procedure vs Mechanical Aortic Valve Replacement in Adults: A Systematic Review and Meta-analysis. JAMA Cardiol. 2018;3 (10):978-987. doi: 10.1001/jamacardio.2018.2946. PubMed PMID:30326489 .
  2. Tam, DY, Yanagawa, B, Verma, S, Ruel, M, Fremes, SE, Mazine, A et al.. Early vs Late Surgery for Patients With Endocarditis and Neurological Injury: A Systematic Review and Meta-analysis. Can J Cardiol. 2018;34 (9):1185-1199. doi: 10.1016/j.cjca.2018.05.010. PubMed PMID:30170674 .
  3. Tam, DY, Vo, TX, Wijeysundera, HC, Dvir, D, Friedrich, JO, Fremes, SE et al.. Transcatheter valve-in-valve versus redo surgical aortic valve replacement for the treatment of degenerated bioprosthetic aortic valve: A systematic review and meta-analysis. Catheter Cardiovasc Interv. 2018; :. doi: 10.1002/ccd.27686. PubMed PMID:30024102 .
  4. Pai, M, Adhikari, NKJ, Ostermann, M, Heels-Ansdell, D, Douketis, JD, Skrobik, Y et al.. Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial. PLoS ONE. 2018;13 (6):e0198285. doi: 10.1371/journal.pone.0198285. PubMed PMID:29856817 PubMed Central PMC5983525.
  5. Yanagawa, B, Elbatarny, M, Verma, S, Hill, S, Mazine, A, Puskas, JD et al.. Surgical Management of Tricuspid Valve Infective Endocarditis: A Systematic Review and Meta-Analysis. Ann. Thorac. Surg. 2018;106 (3):708-714. doi: 10.1016/j.athoracsur.2018.04.012. PubMed PMID:29750928 .
  6. Tirupakuzhi Vijayaraghavan, BK, Hamed, S, Jain, A, Chimunda, T, Telias, I, Friedrich, JO et al.. Evidence Supporting Clinical Use of Proportional Assist Ventilation: A Systematic Review and Meta-Analysis of Clinical Trials. J Intensive Care Med. 2018; :885066618769021. doi: 10.1177/0885066618769021. PubMed PMID:29724123 .
  7. Tam, DY, Nedadur, R, Yu, M, Yanagawa, B, Fremes, SE, Friedrich, JO et al.. Rigid Plate Fixation Versus Wire Cerclage for Sternotomy After Cardiac Surgery: A Meta-Analysis. Ann. Thorac. Surg. 2018;106 (1):298-304. doi: 10.1016/j.athoracsur.2018.02.043. PubMed PMID:29577921 .
  8. Charidimou, A, Friedrich, JO, Greenberg, SM, Viswanathan, A. Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis. Neurology. 2018;90 (9):e754-e762. doi: 10.1212/WNL.0000000000005030. PubMed PMID:29386280 PubMed Central PMC5837868.
  9. Mazine, A, Friedrich, JO, Nedadur, R, Verma, S, Ouzounian, M, Jüni, P et al.. Systematic review and meta-analysis of chordal replacement versus leaflet resection for posterior mitral leaflet prolapse. J. Thorac. Cardiovasc. Surg. 2018;155 (1):120-128.e10. doi: 10.1016/j.jtcvs.2017.07.078. PubMed PMID:28967416 .
  10. Manyevitch, R, Protas, M, Scarpiello, S, Deliso, M, Bass, B, Nanajian, A et al.. Evaluation of Metabolic and Synaptic Dysfunction Hypotheses of Alzheimer's Disease (AD): A Meta-Analysis of CSF Markers. Curr Alzheimer Res. 2018;15 (2):164-181. doi: 10.2174/1567205014666170921122458. PubMed PMID:28933272 PubMed Central PMC5769087.
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto