Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Recent Publications

  1. Mazine, A, Friedrich, JO, Nedadur, R, Verma, S, Ouzounian, M, Jüni, P et al.. Systematic review and meta-analysis of chordal replacement versus leaflet resection for posterior mitral leaflet prolapse. J. Thorac. Cardiovasc. Surg. 2017; :. doi: 10.1016/j.jtcvs.2017.07.078. PubMed PMID:28967416 .
  2. Manyevitch, R, Protas, M, Scarpiello, S, Deliso, M, Bass, B, Nanajian, A et al.. Evaluation Of Metabolic And Synaptic Dysfunction Hypotheses Of Alzheimer's Disease (Ad): A Meta-Analysis Of Csf Markers. Curr Alzheimer Res. 2017; :. doi: 10.2174/1567205014666170921122458. PubMed PMID:28933272 .
  3. Duan, EH, Adhikari, NK, D'Aragon, F, Cook, DJ, Mehta, S, Alhazzani, W et al.. Management of ARDS and Refractory Hypoxemia: A Multicenter Observational Study. Ann Am Thorac Soc. 2017; :. doi: 10.1513/AnnalsATS.201612-1042OC. PubMed PMID:28910146 .
  4. Tam, DY, Vo, TX, Wijeysundera, HC, Ko, DT, Rocha, RV, Friedrich, J et al.. Transcatheter vs Surgical Aortic Valve Replacement for Aortic Stenosis in Low-Intermediate Risk Patients: A Meta-analysis. Can J Cardiol. 2017;33 (9):1171-1179. doi: 10.1016/j.cjca.2017.06.005. PubMed PMID:28843328 .
  5. Wilcox, ME, Lim, AS, McAndrews, MP, Wennberg, RA, Pinto, RL, Black, SE et al.. A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study. BMJ Open. 2017;7 (7):e015600. doi: 10.1136/bmjopen-2016-015600. PubMed PMID:28710215 .
  6. Smith, OM, Chant, C, Burns, KEA, Kaur, M, Ashraf, S, DosSantos, CC et al.. Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study. PLoS ONE. 2017;12 (6):e0179207. doi: 10.1371/journal.pone.0179207. PubMed PMID:28604792 PubMed Central PMC5467852.
  7. Burns, KEA, Soliman, I, Adhikari, NKJ, Zwein, A, Wong, JTY, Gomez-Builes, C et al.. Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis. Crit Care. 2017;21 (1):127. doi: 10.1186/s13054-017-1698-x. PubMed PMID:28576127 PubMed Central PMC5455092.
  8. Verma, S, Goldenberg, RM, Bhatt, DL, Farkouh, ME, Quan, A, Teoh, H et al.. Dipeptidyl peptidase-4 inhibitors and the risk of heart failure: a systematic review and meta-analysis. CMAJ Open. ;5 (1):E152-E177. doi: 10.9778/cmajo.20160058. PubMed PMID:28459046 PubMed Central PMC5403656.
  9. Huang, HW, Sun, XM, Shi, ZH, Chen, GQ, Chen, L, Friedrich, JO et al.. Effect of High-Flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy and Noninvasive Ventilation on Reintubation Rate in Adult Patients After Extubation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Intensive Care Med. 2017; :885066617705118. doi: 10.1177/0885066617705118. PubMed PMID:28429603 .
  10. Chen, L, Chen, GQ, Shore, K, Shklar, O, Martins, C, Devenyi, B et al.. Implementing a bedside assessment of respiratory mechanics in patients with acute respiratory distress syndrome. Crit Care. 2017;21 (1):84. doi: 10.1186/s13054-017-1671-8. PubMed PMID:28372575 PubMed Central PMC5379641.
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto