Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students in 2018.

Recent Publications

  1. Detsky, ME, Jivraj, N, Adhikari, NK, Friedrich, JO, Pinto, R, Simel, DL et al.. Will This Patient Be Difficult to Intubate?: The Rational Clinical Examination Systematic Review. JAMA. 2019;321 (5):493-503. doi: 10.1001/jama.2018.21413. PubMed PMID:30721300 .
  2. Wu, JH, Langford, BJ, Daneman, N, Friedrich, JO, Garber, G. Antimicrobial Stewardship Programs in Long-Term Care Settings: A Meta-Analysis and Systematic Review. J Am Geriatr Soc. 2019;67 (2):392-399. doi: 10.1111/jgs.15675. PubMed PMID:30517765 .
  3. Rocha, RV, Friedrich, JO, Elbatarny, M, Yanagawa, B, Al-Omran, M, Forbes, TL et al.. A systematic review and meta-analysis of early outcomes after endovascular versus open repair of thoracoabdominal aortic aneurysms. J. Vasc. Surg. 2018;68 (6):1936-1945.e5. doi: 10.1016/j.jvs.2018.08.147. PubMed PMID:30470373 .
  4. Mazine, A, Rocha, RV, El-Hamamsy, I, Ouzounian, M, Yanagawa, B, Bhatt, DL et al.. Ross Procedure vs Mechanical Aortic Valve Replacement in Adults: A Systematic Review and Meta-analysis. JAMA Cardiol. 2018;3 (10):978-987. doi: 10.1001/jamacardio.2018.2946. PubMed PMID:30326489 PubMed Central PMC6233830.
  5. Tam, DY, Yanagawa, B, Verma, S, Ruel, M, Fremes, SE, Mazine, A et al.. Early vs Late Surgery for Patients With Endocarditis and Neurological Injury: A Systematic Review and Meta-analysis. Can J Cardiol. 2018;34 (9):1185-1199. doi: 10.1016/j.cjca.2018.05.010. PubMed PMID:30170674 .
  6. Tam, DY, Vo, TX, Wijeysundera, HC, Dvir, D, Friedrich, JO, Fremes, SE et al.. Transcatheter valve-in-valve versus redo surgical aortic valve replacement for the treatment of degenerated bioprosthetic aortic valve: A systematic review and meta-analysis. Catheter Cardiovasc Interv. 2018;92 (7):1404-1411. doi: 10.1002/ccd.27686. PubMed PMID:30024102 .
  7. Pai, M, Adhikari, NKJ, Ostermann, M, Heels-Ansdell, D, Douketis, JD, Skrobik, Y et al.. Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial. PLoS ONE. 2018;13 (6):e0198285. doi: 10.1371/journal.pone.0198285. PubMed PMID:29856817 PubMed Central PMC5983525.
  8. Yanagawa, B, Elbatarny, M, Verma, S, Hill, S, Mazine, A, Puskas, JD et al.. Surgical Management of Tricuspid Valve Infective Endocarditis: A Systematic Review and Meta-Analysis. Ann. Thorac. Surg. 2018;106 (3):708-714. doi: 10.1016/j.athoracsur.2018.04.012. PubMed PMID:29750928 .
  9. Tirupakuzhi Vijayaraghavan, BK, Hamed, S, Jain, A, Chimunda, T, Telias, I, Friedrich, JO et al.. Evidence Supporting Clinical Use of Proportional Assist Ventilation: A Systematic Review and Meta-Analysis of Clinical Trials. J Intensive Care Med. 2018; :885066618769021. doi: 10.1177/0885066618769021. PubMed PMID:29724123 .
  10. Tam, DY, Nedadur, R, Yu, M, Yanagawa, B, Fremes, SE, Friedrich, JO et al.. Rigid Plate Fixation Versus Wire Cerclage for Sternotomy After Cardiac Surgery: A Meta-Analysis. Ann. Thorac. Surg. 2018;106 (1):298-304. doi: 10.1016/j.athoracsur.2018.02.043. PubMed PMID:29577921 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto