Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students in 2018.

Recent Publications

  1. Wu, JH, Langford, BJ, Daneman, N, Friedrich, JO, Garber, G. Antimicrobial stewardship programs in long-term care settings: a meta-analysis and systematic review. J Am Geriatr Soc. 2018; :. doi: 10.1111/jgs.15675. PubMed PMID:30517765 .
  2. Rocha, RV, Friedrich, JO, Elbatarny, M, Yanagawa, B, Al-Omran, M, Forbes, TL et al.. A systematic review and meta-analysis of early outcomes after endovascular versus open repair of thoracoabdominal aortic aneurysms. J. Vasc. Surg. 2018;68 (6):1936-1945.e5. doi: 10.1016/j.jvs.2018.08.147. PubMed PMID:30470373 .
  3. Mazine, A, Rocha, RV, El-Hamamsy, I, Ouzounian, M, Yanagawa, B, Bhatt, DL et al.. Ross Procedure vs Mechanical Aortic Valve Replacement in Adults: A Systematic Review and Meta-analysis. JAMA Cardiol. 2018;3 (10):978-987. doi: 10.1001/jamacardio.2018.2946. PubMed PMID:30326489 PubMed Central PMC6233830.
  4. Tam, DY, Yanagawa, B, Verma, S, Ruel, M, Fremes, SE, Mazine, A et al.. Early vs Late Surgery for Patients With Endocarditis and Neurological Injury: A Systematic Review and Meta-analysis. Can J Cardiol. 2018;34 (9):1185-1199. doi: 10.1016/j.cjca.2018.05.010. PubMed PMID:30170674 .
  5. Tam, DY, Vo, TX, Wijeysundera, HC, Dvir, D, Friedrich, JO, Fremes, SE et al.. Transcatheter valve-in-valve versus redo surgical aortic valve replacement for the treatment of degenerated bioprosthetic aortic valve: A systematic review and meta-analysis. Catheter Cardiovasc Interv. 2018;92 (7):1404-1411. doi: 10.1002/ccd.27686. PubMed PMID:30024102 .
  6. Pai, M, Adhikari, NKJ, Ostermann, M, Heels-Ansdell, D, Douketis, JD, Skrobik, Y et al.. Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial. PLoS ONE. 2018;13 (6):e0198285. doi: 10.1371/journal.pone.0198285. PubMed PMID:29856817 PubMed Central PMC5983525.
  7. Yanagawa, B, Elbatarny, M, Verma, S, Hill, S, Mazine, A, Puskas, JD et al.. Surgical Management of Tricuspid Valve Infective Endocarditis: A Systematic Review and Meta-Analysis. Ann. Thorac. Surg. 2018;106 (3):708-714. doi: 10.1016/j.athoracsur.2018.04.012. PubMed PMID:29750928 .
  8. Tirupakuzhi Vijayaraghavan, BK, Hamed, S, Jain, A, Chimunda, T, Telias, I, Friedrich, JO et al.. Evidence Supporting Clinical Use of Proportional Assist Ventilation: A Systematic Review and Meta-Analysis of Clinical Trials. J Intensive Care Med. 2018; :885066618769021. doi: 10.1177/0885066618769021. PubMed PMID:29724123 .
  9. Tam, DY, Nedadur, R, Yu, M, Yanagawa, B, Fremes, SE, Friedrich, JO et al.. Rigid Plate Fixation Versus Wire Cerclage for Sternotomy After Cardiac Surgery: A Meta-Analysis. Ann. Thorac. Surg. 2018;106 (1):298-304. doi: 10.1016/j.athoracsur.2018.02.043. PubMed PMID:29577921 .
  10. Charidimou, A, Friedrich, JO, Greenberg, SM, Viswanathan, A. Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis. Neurology. 2018;90 (9):e754-e762. doi: 10.1212/WNL.0000000000005030. PubMed PMID:29386280 PubMed Central PMC5837868.
Search PubMed

Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto