Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students in 2018.

Recent Publications

  1. Tam, DY, Nedadur, R, Yu, M, Yanagawa, B, Fremes, SE, Friedrich, JO et al.. Rigid Plate Fixation Versus Wire Cerclage For Sternotomy After Cardiac Surgery: A Meta-Analysis. Ann. Thorac. Surg. 2018; :. doi: 10.1016/j.athoracsur.2018.02.043. PubMed PMID:29577921 .
  2. Charidimou, A, Friedrich, JO, Greenberg, SM, Viswanathan, A. Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis. Neurology. 2018;90 (9):e754-e762. doi: 10.1212/WNL.0000000000005030. PubMed PMID:29386280 PubMed Central PMC5837868.
  3. Mazine, A, Friedrich, JO, Nedadur, R, Verma, S, Ouzounian, M, Jüni, P et al.. Systematic review and meta-analysis of chordal replacement versus leaflet resection for posterior mitral leaflet prolapse. J. Thorac. Cardiovasc. Surg. 2018;155 (1):120-128.e10. doi: 10.1016/j.jtcvs.2017.07.078. PubMed PMID:28967416 .
  4. Manyevitch, R, Protas, M, Scarpiello, S, Deliso, M, Bass, B, Nanajian, A et al.. Evaluation of Metabolic and Synaptic Dysfunction Hypotheses of Alzheimer's Disease (AD): A Meta-Analysis of CSF Markers. Curr Alzheimer Res. 2018;15 (2):164-181. doi: 10.2174/1567205014666170921122458. PubMed PMID:28933272 PubMed Central PMC5769087.
  5. Duan, EH, Adhikari, NKJ, D'Aragon, F, Cook, DJ, Mehta, S, Alhazzani, W et al.. Management of Acute Respiratory Distress Syndrome and Refractory Hypoxemia. A Multicenter Observational Study. Ann Am Thorac Soc. 2017;14 (12):1818-1826. doi: 10.1513/AnnalsATS.201612-1042OC. PubMed PMID:28910146 .
  6. Tam, DY, Vo, TX, Wijeysundera, HC, Ko, DT, Rocha, RV, Friedrich, J et al.. Transcatheter vs Surgical Aortic Valve Replacement for Aortic Stenosis in Low-Intermediate Risk Patients: A Meta-analysis. Can J Cardiol. 2017;33 (9):1171-1179. doi: 10.1016/j.cjca.2017.06.005. PubMed PMID:28843328 .
  7. Wilcox, ME, Lim, AS, McAndrews, MP, Wennberg, RA, Pinto, RL, Black, SE et al.. A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study. BMJ Open. 2017;7 (7):e015600. doi: 10.1136/bmjopen-2016-015600. PubMed PMID:28710215 PubMed Central PMC5734403.
  8. Smith, OM, Chant, C, Burns, KEA, Kaur, M, Ashraf, S, DosSantos, CC et al.. Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study. PLoS ONE. 2017;12 (6):e0179207. doi: 10.1371/journal.pone.0179207. PubMed PMID:28604792 PubMed Central PMC5467852.
  9. Burns, KEA, Soliman, I, Adhikari, NKJ, Zwein, A, Wong, JTY, Gomez-Builes, C et al.. Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis. Crit Care. 2017;21 (1):127. doi: 10.1186/s13054-017-1698-x. PubMed PMID:28576127 PubMed Central PMC5455092.
  10. Verma, S, Goldenberg, RM, Bhatt, DL, Farkouh, ME, Quan, A, Teoh, H et al.. Dipeptidyl peptidase-4 inhibitors and the risk of heart failure: a systematic review and meta-analysis. CMAJ Open. ;5 (1):E152-E177. doi: 10.9778/cmajo.20160058. PubMed PMID:28459046 PubMed Central PMC5403656.
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto