Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students.

Recent Publications

  1. Hare, GMT, Cazorla-Bak, MP, Ku, SFM, Chin, K, Mistry, N, Sklar, MC et al.. When to transfuse your acute care patient? A narrative review of the risk of anemia and red blood cell transfusion based on clinical trial outcomes. Can J Anaesth. 2020; :. doi: 10.1007/s12630-020-01763-9. PubMed PMID:32770311 .
  2. Wilcox, ME, McAndrews, MP, Van, J, Jackson, JC, Pinto, R, Black, SE et al.. Sleep Fragmentation and Cognitive Trajectories after Critical Illness. Chest. 2020; :. doi: 10.1016/j.chest.2020.07.036. PubMed PMID:32717265 .
  3. STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, United Kingdom Critical Care Research Group, Canadian Nephrology Trials Network, Irish Critical Care Trials Group et al.. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N. Engl. J. Med. 2020;383 (3):240-251. doi: 10.1056/NEJMoa2000741. PubMed PMID:32668114 .
  4. Smith, OM, Metcalfe, K, Puts, M, McDonald, E, Sue-Chee, S, Friedrich, JO et al.. Role Incongruence and Psychological Stress Symptoms in Substitute Decision Makers of Intensive Care Patients. Am. J. Crit. Care. 2020;29 (4):301-310. doi: 10.4037/ajcc2020307. PubMed PMID:32607568 .
  5. Yanagawa, B, Ribeiro, R, Lee, J, Mazer, CD, Cheng, D, Martin, J et al.. Platelet Transfusion in Cardiac Surgery: A Systematic Review and Meta-Analysis. Ann. Thorac. Surg. 2020; :. doi: 10.1016/j.athoracsur.2020.04.139. PubMed PMID:32585201 .
  6. Yanagawa, B, Lee, J, Ouzounian, M, Bagai, A, Cheema, A, Verma, S et al.. Mitral valve prosthesis choice in patients <70 years: A systematic review and meta-analysis of 20 219 patients. J Card Surg. 2020;35 (4):818-825. doi: 10.1111/jocs.14478. PubMed PMID:32092191 .
  7. Elbatarny, M, Tam, DY, Edelman, JJ, Rocha, RV, Chu, MWA, Peterson, MD et al.. Valve-Sparing Root Replacement Versus Composite Valve Grafting in Aortic Root Dilation: A Meta-Analysis. Ann. Thorac. Surg. 2020;110 (1):296-306. doi: 10.1016/j.athoracsur.2019.11.054. PubMed PMID:31981499 .
  8. Ribeiro, RVP, Friedrich, JO, Ouzounian, M, Yau, T, Lee, J, Yanagawa, B et al.. Supplemental Cardioplegia During Donor Heart Implantation: A Systematic Review and Meta-Analysis. Ann. Thorac. Surg. 2020;110 (2):545-552. doi: 10.1016/j.athoracsur.2019.10.094. PubMed PMID:31972127 .
  9. Angriman, F, Pinto, R, Friedrich, JO, Ferguson, ND, Rubenfeld, G, Amaral, ACK et al.. Compliance With Evidence-Based Processes of Care After Transitions Between Staff Intensivists. Crit. Care Med. 2020;48 (3):e227-e232. doi: 10.1097/CCM.0000000000004201. PubMed PMID:31913986 .
  10. Li, DH, Wald, R, Blum, D, McArthur, E, James, MT, Burns, KEA et al.. Predicting mortality among critically ill patients with acute kidney injury treated with renal replacement therapy: Development and validation of new prediction models. J Crit Care. 2020;56 :113-119. doi: 10.1016/j.jcrc.2019.12.015. PubMed PMID:31896444 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto