Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students in 2018.

Recent Publications

  1. Charidimou, A, Friedrich, JO, Greenberg, SM, Viswanathan, A. Core CSF biomarker profile in cerebral amyloid angiopathy: A meta-analysis. Neurology. 2018; :. doi: 10.1212/WNL.0000000000005030. PubMed PMID:29386280 .
  2. Mazine, A, Friedrich, JO, Nedadur, R, Verma, S, Ouzounian, M, Jüni, P et al.. Systematic review and meta-analysis of chordal replacement versus leaflet resection for posterior mitral leaflet prolapse. J. Thorac. Cardiovasc. Surg. 2018;155 (1):120-128.e10. doi: 10.1016/j.jtcvs.2017.07.078. PubMed PMID:28967416 .
  3. Manyevitch, R, Protas, M, Scarpiello, S, Deliso, M, Bass, B, Nanajian, A et al.. Evaluation of Metabolic and Synaptic Dysfunction Hypotheses of Alzheimer's Disease (AD): A Meta-Analysis of CSF Markers. Curr Alzheimer Res. 2018;15 (2):164-181. doi: 10.2174/1567205014666170921122458. PubMed PMID:28933272 PubMed Central PMC5769087.
  4. Duan, EH, Adhikari, NKJ, D'Aragon, F, Cook, DJ, Mehta, S, Alhazzani, W et al.. Management of Acute Respiratory Distress Syndrome and Refractory Hypoxemia. A Multicenter Observational Study. Ann Am Thorac Soc. 2017;14 (12):1818-1826. doi: 10.1513/AnnalsATS.201612-1042OC. PubMed PMID:28910146 .
  5. Tam, DY, Vo, TX, Wijeysundera, HC, Ko, DT, Rocha, RV, Friedrich, J et al.. Transcatheter vs Surgical Aortic Valve Replacement for Aortic Stenosis in Low-Intermediate Risk Patients: A Meta-analysis. Can J Cardiol. 2017;33 (9):1171-1179. doi: 10.1016/j.cjca.2017.06.005. PubMed PMID:28843328 .
  6. Wilcox, ME, Lim, AS, McAndrews, MP, Wennberg, RA, Pinto, RL, Black, SE et al.. A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study. BMJ Open. 2017;7 (7):e015600. doi: 10.1136/bmjopen-2016-015600. PubMed PMID:28710215 PubMed Central PMC5734403.
  7. Smith, OM, Chant, C, Burns, KEA, Kaur, M, Ashraf, S, DosSantos, CC et al.. Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study. PLoS ONE. 2017;12 (6):e0179207. doi: 10.1371/journal.pone.0179207. PubMed PMID:28604792 PubMed Central PMC5467852.
  8. Burns, KEA, Soliman, I, Adhikari, NKJ, Zwein, A, Wong, JTY, Gomez-Builes, C et al.. Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis. Crit Care. 2017;21 (1):127. doi: 10.1186/s13054-017-1698-x. PubMed PMID:28576127 PubMed Central PMC5455092.
  9. Verma, S, Goldenberg, RM, Bhatt, DL, Farkouh, ME, Quan, A, Teoh, H et al.. Dipeptidyl peptidase-4 inhibitors and the risk of heart failure: a systematic review and meta-analysis. CMAJ Open. ;5 (1):E152-E177. doi: 10.9778/cmajo.20160058. PubMed PMID:28459046 PubMed Central PMC5403656.
  10. Huang, HW, Sun, XM, Shi, ZH, Chen, GQ, Chen, L, Friedrich, JO et al.. Effect of High-Flow Nasal Cannula Oxygen Therapy Versus Conventional Oxygen Therapy and Noninvasive Ventilation on Reintubation Rate in Adult Patients After Extubation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Intensive Care Med. 2017; :885066617705118. doi: 10.1177/0885066617705118. PubMed PMID:28429603 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto