Jan O. Friedrich

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students in 2018.

Recent Publications

  1. Burns, KEA, Wong, JTY, Dodek, P, Cook, DJ, Lamontagne, F, Cohen, A et al.. Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials. Crit. Care Med. 2019; :. doi: 10.1097/CCM.0000000000003722. PubMed PMID:30920411 .
  2. Tam, DY, Tran, A, Mazine, A, Tang, GHL, Gaudino, MFL, Calafiore, AM et al.. Tricuspid valve intervention at the time of mitral valve surgery: a meta-analysis. Interact Cardiovasc Thorac Surg. 2019; :. doi: 10.1093/icvts/ivz036. PubMed PMID:30848789 .
  3. Arabi, YM, Al-Hameed, F, Burns, KEA, Mehta, S, Alsolamy, SJ, Alshahrani, MS et al.. Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis. N. Engl. J. Med. 2019;380 (14):1305-1315. doi: 10.1056/NEJMoa1816150. PubMed PMID:30779530 .
  4. Detsky, ME, Jivraj, N, Adhikari, NK, Friedrich, JO, Pinto, R, Simel, DL et al.. Will This Patient Be Difficult to Intubate?: The Rational Clinical Examination Systematic Review. JAMA. 2019;321 (5):493-503. doi: 10.1001/jama.2018.21413. PubMed PMID:30721300 .
  5. Wu, JH, Langford, BJ, Daneman, N, Friedrich, JO, Garber, G. Antimicrobial Stewardship Programs in Long-Term Care Settings: A Meta-Analysis and Systematic Review. J Am Geriatr Soc. 2019;67 (2):392-399. doi: 10.1111/jgs.15675. PubMed PMID:30517765 .
  6. Rocha, RV, Friedrich, JO, Elbatarny, M, Yanagawa, B, Al-Omran, M, Forbes, TL et al.. A systematic review and meta-analysis of early outcomes after endovascular versus open repair of thoracoabdominal aortic aneurysms. J. Vasc. Surg. 2018;68 (6):1936-1945.e5. doi: 10.1016/j.jvs.2018.08.147. PubMed PMID:30470373 .
  7. Mazine, A, Rocha, RV, El-Hamamsy, I, Ouzounian, M, Yanagawa, B, Bhatt, DL et al.. Ross Procedure vs Mechanical Aortic Valve Replacement in Adults: A Systematic Review and Meta-analysis. JAMA Cardiol. 2018;3 (10):978-987. doi: 10.1001/jamacardio.2018.2946. PubMed PMID:30326489 PubMed Central PMC6233830.
  8. Tam, DY, Yanagawa, B, Verma, S, Ruel, M, Fremes, SE, Mazine, A et al.. Early vs Late Surgery for Patients With Endocarditis and Neurological Injury: A Systematic Review and Meta-analysis. Can J Cardiol. 2018;34 (9):1185-1199. doi: 10.1016/j.cjca.2018.05.010. PubMed PMID:30170674 .
  9. Tam, DY, Vo, TX, Wijeysundera, HC, Dvir, D, Friedrich, JO, Fremes, SE et al.. Transcatheter valve-in-valve versus redo surgical aortic valve replacement for the treatment of degenerated bioprosthetic aortic valve: A systematic review and meta-analysis. Catheter Cardiovasc Interv. 2018;92 (7):1404-1411. doi: 10.1002/ccd.27686. PubMed PMID:30024102 .
  10. Pai, M, Adhikari, NKJ, Ostermann, M, Heels-Ansdell, D, Douketis, JD, Skrobik, Y et al.. Low-molecular-weight heparin venous thromboprophylaxis in critically ill patients with renal dysfunction: A subgroup analysis of the PROTECT trial. PLoS ONE. 2018;13 (6):e0198285. doi: 10.1371/journal.pone.0198285. PubMed PMID:29856817 PubMed Central PMC5983525.
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto