Jane Batt

MD, PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Jane Batt is a Respirologist and Scientist at St. Michael’s Hospital. Her research focuses on delineating the molecular mechanisms underlying the development of skeletal muscle atrophy. In chronic respiratory illness such as Chronic Obstructive Pulmonary Disease, loss of muscle mass significantly decreases quality of life, and increases health resource utilization and costs. In the critically ill patient, Intensive Care Unit acquired weakness and Critical illness myopathy prevent weaning from the ventilator, increase in-hospital mortality and in the long term rob critical illness survivors of functional independence. We lack therapies that can prevent or achieve a sustainable reversal of muscle wasting in these patient populations. Her research program i) studies the molecular biology and signalling networks regulating muscle wasting in tissue culture and rodent models, with the aim of identifying novel mediators of atrophy and ii) evaluates the activity of signalling networks and biologic processes identified as being key regulators of muscle atrophy, in human disease.

Dr. Batt’s research has been consistently funded by several competitive sources including the Canadian Institutes of Health Research (CIHR), Ontario Thoracic Society and Physician Services Incorporation. She has served on several hospital and University of Toronto advisory committees including Co-Chair, Division of Respirology Research Day (2008 – 2014) and Chair, Division of Respirology Research Advisory Committee (2014 – present).

Dr. Batt’s clinical practice encompasses General Respirology and Tuberculosis. She is the Medical Director of the St Michaels Hospital Tuberculosis Program.

Recent Publications

  1. Lad, H, Saumur, TM, Herridge, MS, Dos Santos, CC, Mathur, S, Batt, J et al.. Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition. Int J Mol Sci. 2020;21 (21):. doi: 10.3390/ijms21217840. PubMed PMID:33105809 .
  2. Gupta, S, Batt, J, Bourbeau, J, Chapman, KR, Gershon, A, Granton, J et al.. Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge: Key Highlights From the Canadian Thoracic Society (CTS) Position Statement. Chest. 2020; :. doi: 10.1016/j.chest.2020.07.018. PubMed PMID:32693101 PubMed Central PMC7368654.
  3. Binnie, A, Walsh, CJ, Hu, P, Dwivedi, DJ, Fox-Robichaud, A, Liaw, PC et al.. Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness. Crit Care Med. 2020;48 (2):142-150. doi: 10.1097/CCM.0000000000004097. PubMed PMID:31939781 .
  4. Petch, J, Batt, J, Murray, J, Mamdani, M. Extracting Clinical Features From Dictated Ambulatory Consult Notes Using a Commercially Available Natural Language Processing Tool: Pilot, Retrospective, Cross-Sectional Validation Study. JMIR Med Inform. 2019;7 (4):e12575. doi: 10.2196/12575. PubMed PMID:31682579 PubMed Central PMC6913750.
  5. Batt, J, Herridge, MS, Dos Santos, CC. From skeletal muscle weakness to functional outcomes following critical illness: a translational biology perspective. Thorax. 2019;74 (11):1091-1098. doi: 10.1136/thoraxjnl-2016-208312. PubMed PMID:31431489 .
  6. Batt, J, Khan, K. Responsible use of rifampin for the treatment of latent tuberculosis infection. CMAJ. 2019;191 (25):E678-E679. doi: 10.1503/cmaj.190081. PubMed PMID:31235488 PubMed Central PMC6592804.
  7. Hamilton, M, Tomlinson, G, Chu, L, Robles, P, Matte, A, Burns, S et al.. Determinants of Depressive Symptoms at 1 Year Following ICU Discharge in Survivors of ≥ 7 Days of Mechanical Ventilation: Results From the RECOVER Program, a Secondary Analysis of a Prospective Multicenter Cohort Study. Chest. 2019;156 (3):466-476. doi: 10.1016/j.chest.2019.04.104. PubMed PMID:31102611 .
  8. Parotto, M, Batt, J, Herridge, M. The Pathophysiology of Neuromuscular Dysfunction in Critical Illness. Crit Care Clin. 2018;34 (4):549-556. doi: 10.1016/j.ccc.2018.06.010. PubMed PMID:30223993 .
  9. Chien, K, Seemangal, J, Batt, J, Vozoris, NT. Abdominal tuberculosis: a descriptive case series of the experience in a Canadian tuberculosis clinic. Int J Tuberc Lung Dis. 2018;22 (6):681-685. doi: 10.5588/ijtld.17.0685. PubMed PMID:29862954 .
  10. Sugiyama, MG, Mintsopoulos, V, Raheel, H, Goldenberg, NM, Batt, JE, Brochard, L et al.. Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in Escherichia coli-induced Pneumonia and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018;198 (3):404-408. doi: 10.1164/rccm.201711-2259LE. PubMed PMID:29638143 .
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Affiliations & Other Activities

  • Respirologist and Clinician Scientist, Division of Respirology, Department of Medicine, St. Michael’s Hospital
  • Medical Director, Tuberculosis Program, St. Michael’s Hospital
  • Associate Professor, Faculty of Medicine, University of Toronto
  • Cross appointed to the to the IDCCM
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