Jane Batt

MD, PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Jane Batt is a Respirologist and Scientist at St. Michael’s Hospital. Her research focuses on delineating the molecular mechanisms underlying the development of skeletal muscle atrophy. In chronic respiratory illness such as Chronic Obstructive Pulmonary Disease, loss of muscle mass significantly decreases quality of life, and increases health resource utilization and costs. In the critically ill patient, Intensive Care Unit acquired weakness and Critical illness myopathy prevent weaning from the ventilator, increase in-hospital mortality and in the long term rob critical illness survivors of functional independence. We lack therapies that can prevent or achieve a sustainable reversal of muscle wasting in these patient populations. Her research program i) studies the molecular biology and signalling networks regulating muscle wasting in tissue culture and rodent models, with the aim of identifying novel mediators of atrophy and ii) evaluates the activity of signalling networks and biologic processes identified as being key regulators of muscle atrophy, in human disease.

Dr. Batt’s research has been consistently funded by several competitive sources including the Canadian Institutes of Health Research (CIHR), Ontario Thoracic Society and Physician Services Incorporation. She has served on several hospital and University of Toronto advisory committees including Co-Chair, Division of Respirology Research Day (2008 – 2014) and Chair, Division of Respirology Research Advisory Committee (2014 – present).

Dr. Batt’s clinical practice encompasses General Respirology and Tuberculosis. She is the Medical Director of the St Michaels Hospital Tuberculosis Program.

Recent Publications

  1. Dos Santos, CC, Reynolds, S, Batt, J. Searching for the 'Spark' in Ventilator Induced Diaphragm Dysfunction. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201708-1716ED. PubMed PMID:28954198 .
  2. Batt, J, Herridge, M, Dos Santos, C. Mechanism of ICU-acquired weakness: skeletal muscle loss in critical illness. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4758-4. PubMed PMID:28283700 .
  3. Batt, J, Mathur, S, Katzberg, HD. Mechanism of ICU-acquired weakness: muscle contractility in critical illness. Intensive Care Med. 2017;43 (4):584-586. doi: 10.1007/s00134-017-4730-3. PubMed PMID:28255615 .
  4. Walsh, CJ, Hu, P, Batt, J, Dos Santos, CC. Discovering MicroRNA-Regulatory Modules in Multi-Dimensional Cancer Genomic Data: A Survey of Computational Methods. Cancer Inform. 2016;15 (Suppl 2):25-42. doi: 10.4137/CIN.S39369. PubMed PMID:27721651 PubMed Central PMC5051584.
  5. Dos Santos, CC, Herridge, M, Batt, J. Early goal directed mobility in the ICU: 'something in the way you move'. J Thorac Dis. 2016;8 (8):E784-7. doi: 10.21037/jtd.2016.05.96. PubMed PMID:27620874 PubMed Central PMC4999664.
  6. Vozoris, NT, Batt, J. Change in the Prevalence of Testing for Latent Tuberculosis Infection in the United States: 1999-2012. Can. Respir. J. 2016;2016 :1850879. doi: 10.1155/2016/1850879. PubMed PMID:27445519 PubMed Central PMC4904560.
  7. Walsh, CJ, Batt, J, Herridge, MS, Mathur, S, Bader, GD, Hu, P et al.. Transcriptomic analysis reveals abnormal muscle repair and remodeling in survivors of critical illness with sustained weakness. Sci Rep. 2016;6 :29334. doi: 10.1038/srep29334. PubMed PMID:27411715 PubMed Central PMC4944143.
  8. Cameron, JI, Chu, LM, Matte, A, Tomlinson, G, Chan, L, Thomas, C et al.. One-Year Outcomes in Caregivers of Critically Ill Patients. N. Engl. J. Med. 2016;374 (19):1831-41. doi: 10.1056/NEJMoa1511160. PubMed PMID:27168433 .
  9. Dos Santos, C, Hussain, SN, Mathur, S, Picard, M, Herridge, M, Correa, J et al.. Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study. Am. J. Respir. Crit. Care Med. 2016;194 (7):821-830. doi: 10.1164/rccm.201512-2344OC. PubMed PMID:27058306 .
  10. Herridge, MS, Chu, LM, Matte, A, Tomlinson, G, Chan, L, Thomas, C et al.. The RECOVER Program: Disability Risk Groups and 1-Year Outcome after 7 or More Days of Mechanical Ventilation. Am. J. Respir. Crit. Care Med. 2016;194 (7):831-844. doi: 10.1164/rccm.201512-2343OC. PubMed PMID:26974173 .
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Affiliations & Other Activities

  • Respirologist and Clinician Scientist, Division of Respirology, Department of Medicine, St. Michael’s Hospital
  • Interim Director, Tuberculosis Program, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
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