John J. Graham

MRCP, MB ChB, BSc

Associate Scientist, Li Ka Shing Knowledge Institute

Biography

Research Interests

Interventional cardiology, primary angioplasty, radial access Percutaneous Coronary Intervention (PCI), MRI assessment of PCI outcomes, renal denervation for resistant hypertension

Research Activities

Within interventional cardiology, my research interests include:

  1. chronically occluded coronary arteries (‘CTO’) and the potential benefits of percutaneously revascularising these;
  2. Fibromuscular dysplasia – an increasingly recognized cause of myocardial infarction in (predominantly) young females;
  3. Renal Denervation therapy for resistant hypertension.

In all of these, my interests include the use of MRI to assess outcomes and response to therapy.

Recent Publications

  1. Shuvy, M, Qiu, F, Chee-A-Tow, A, Graham, JJ, Abuzeid, W, Buller, C et al.. Management of Chronic Total Coronary Occlusion in Stable Ischemic Heart Disease by Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting Versus Medical Therapy. Am. J. Cardiol. 2017; :. doi: 10.1016/j.amjcard.2017.05.061. PubMed PMID:28716335 .
  2. Ellis, SG, Burke, MN, Murad, MB, Graham, JJ, Badawi, R, Toma, C et al.. Predictors of Successful Hybrid-Approach Chronic Total Coronary Artery Occlusion Stenting: An Improved Model With Novel Correlates. JACC Cardiovasc Interv. 2017;10 (11):1089-1098. doi: 10.1016/j.jcin.2017.03.016. PubMed PMID:28595879 .
  3. Ross, BA, Wald, R, Goldstein, MB, Yuen, DA, Leipsic, J, Kiaii, M et al.. Relationships Between Left Ventricular Structure and Function According to Cardiac MRI and Cardiac Biomarkers in End-Stage Renal Disease. Can J Cardiol. 2017;33 (4):501-507. doi: 10.1016/j.cjca.2016.11.021. PubMed PMID:28222921 .
  4. Rodés-Cabau, J, Jolly, SS, Cairns, J, Mansour, S, L'Allier, PL, Teefy, PJ et al.. Sealing Intermediate Nonobstructive Coronary Saphenous Vein Graft Lesions With Drug-Eluting Stents as a New Approach to Reducing Cardiac Events: A Randomized Controlled Trial. Circ Cardiovasc Interv. 2016;9 (11):. doi: 10.1161/CIRCINTERVENTIONS.116.004336. PubMed PMID:27815344 .
  5. Ting, R, Tejpal, A, Finken, L, Fisher, M, Lefkowitz, C, Parthasarathy, H et al.. Repatriation to referral hospital after reperfusion of STEMI patients transferred for primary percutaneous coronary intervention: Insights of a Canadian regional STEMI care system. Am. Heart J. 2016;177 :145-52. doi: 10.1016/j.ahj.2016.04.017. PubMed PMID:27297860 .
  6. Graham, JJ, Yan, AT, Tan, MK, Cantor, WJ, DiMario, C, Jolly, SS et al.. Radial versus femoral access for percutaneous coronary intervention in ST-elevation myocardial infarction patients treated with fibrinolysis: Results from the randomized routine early invasive clinical trials. Cardiovasc Revasc Med. ;17 (5):295-301. doi: 10.1016/j.carrev.2016.03.008. PubMed PMID:27116940 .
  7. Russo, JJ, Goodman, SG, Cantor, WJ, Tan, MK, Borgundvaag, B, Fitchett, D et al.. Efficacy and safety of a routine early invasive strategy in relation to time from symptom onset to fibrinolysis (a subgroup analysis of TRANSFER-AMI). Am. J. Cardiol. 2015;115 (8):1005-12. doi: 10.1016/j.amjcard.2015.01.533. PubMed PMID:25711435 .
  8. Madan, M, Halvorsen, S, Di Mario, C, Tan, M, Westerhout, CM, Cantor, WJ et al.. Relationship between time to invasive assessment and clinical outcomes of patients undergoing an early invasive strategy after fibrinolysis for ST-segment elevation myocardial infarction: a patient-level analysis of the randomized early routine invasive clinical trials. JACC Cardiovasc Interv. 2015;8 (1 Pt B):166-74. doi: 10.1016/j.jcin.2014.09.005. PubMed PMID:25616922 .
  9. Ward, MR, Connelly, KA, Vijayaraghavan, R, Vaags, AK, Graham, JJ, Foltz, W et al.. eNOS overexpressing bone marrow cells are safe and effective in a porcine model of myocardial regeneration following acute myocardial infarction. Cardiovasc Ther. 2013;31 (6):e72-8. doi: 10.1111/1755-5922.12037. PubMed PMID:23837864 .
  10. Yang, Y, Connelly, KA, Zeidan-Shwiri, T, Lu, Y, Paul, G, Roifman, I et al.. Multi-contrast late enhancement CMR determined gray zone and papillary muscle involvement predict appropriate ICD therapy in patients with ischemic heart disease. J Cardiovasc Magn Reson. 2013;15 :57. doi: 10.1186/1532-429X-15-57. PubMed PMID:23803259 PubMed Central PMC3702486.
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Affiliations & Other Activities

  • Staff Cardiologist, Division of Cardiology, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto