John Laffey


Co-Director, Critical Illness and Injury Research Centre


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Byrnes, D, Masterson, CH, Artigas, A, Laffey, JG. Mesenchymal Stem/Stromal Cells Therapy for Sepsis and Acute Respiratory Distress Syndrome. Semin Respir Crit Care Med. 2020; :. doi: 10.1055/s-0040-1713422. PubMed PMID:32767301 .
  2. van Haren, FMP, Page, C, Laffey, JG, Artigas, A, Camprubi-Rimblas, M, Nunes, Q et al.. Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence. Crit Care. 2020;24 (1):454. doi: 10.1186/s13054-020-03148-2. PubMed PMID:32698853 PubMed Central PMC7374660.
  3. McNicholas, B, Madden, MG, Laffey, J. Machine Learning Classifier Models: The Future for ARDS Phenotyping?. Am. J. Respir. Crit. Care Med. 2020; :. doi: 10.1164/rccm.202006-2388ED. PubMed PMID:32687397 .
  4. Horie, S, McNicholas, B, Rezoagli, E, Pham, T, Curley, G, McAuley, D et al.. Emerging pharmacological therapies for ARDS: COVID-19 and beyond. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06141-z. PubMed PMID:32654006 PubMed Central PMC7352097.
  5. Andrade, E, Quinlan, L, Harte, R, Byrne, D, Fallon, E, Kelly, M et al.. Novel Interface Designs for Patient Monitoring Applications in Critical Care Medicine: Human Factors Review. JMIR Hum Factors. 2020;7 (3):e15052. doi: 10.2196/15052. PubMed PMID:32618574 PubMed Central PMC7367533.
  6. Madotto, F, Rezoagli, E, McNicholas, BA, Pham, T, Slutsky, AS, Bellani, G et al.. Patterns and impact of arterial CO2 management in patients with Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE study. Chest. 2020; :. doi: 10.1016/j.chest.2020.05.605. PubMed PMID:32589951 .
  7. Saffaran, S, Das, A, Laffey, JG, Hardman, JG, Yehya, N, Bates, DG et al.. Utility of Driving Pressure and Mechanical Power to Guide Protective Ventilator Settings in Two Cohorts of Adult and Pediatric Patients With Acute Respiratory Distress Syndrome: A Computational Investigation. Crit. Care Med. 2020;48 (7):1001-1008. doi: 10.1097/CCM.0000000000004372. PubMed PMID:32574467 .
  8. McNicholas, B, Cosgrave, D, Giacomini, C, Brennan, A, Laffey, JG. Prone positioning in COVID-19 acute respiratory failure: just do it?. Br J Anaesth. 2020; :. doi: 10.1016/j.bja.2020.06.003. PubMed PMID:32571573 PubMed Central PMC7280095.
  9. WHO Working Group on the Clinical Characterisation and Management of COVID-19 infection. A minimal common outcome measure set for COVID-19 clinical research. Lancet Infect Dis. 2020;20 (8):e192-e197. doi: 10.1016/S1473-3099(20)30483-7. PubMed PMID:32539990 PubMed Central PMC7292605.
  10. Laffey, JG, Chikhani, M, Bates, DG, Hardman, JG. Supporting more than one patient with a single mechanical ventilator: useful last resort or unjustifiable risk?. Br J Anaesth. 2020; :. doi: 10.1016/j.bja.2020.05.029. PubMed PMID:32536443 PubMed Central PMC7262535.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto