John Laffey


Co-Director, Critical Illness and Injury Research Centre


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. de Prost, N, Pham, T, Carteaux, G, Mekontso Dessap, A, Brun-Buisson, C, Fan, E et al.. Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study. Ann Intensive Care. 2017;7 (1):69. doi: 10.1186/s13613-017-0281-6. PubMed PMID:28631088 .
  2. Laffey, JG, Madotto, F, Bellani, G, Pham, T, Fan, E, Brochard, L et al.. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. Lancet Respir Med. 2017; :. doi: 10.1016/S2213-2600(17)30213-8. PubMed PMID:28624388 .
  3. Curley, GF, Jerkic, M, Hogan, G, Masterson, C, O'Toole, D, Devaney, J et al.. The authors reply. Crit. Care Med. 2017;45 (7):e737-e738. doi: 10.1097/CCM.0000000000002480. PubMed PMID:28622234 .
  4. Laffey, JG, Matthay, MA. Fifty Years of Research in ARDS. Cell Based Therapy for ARDS: Biology and Potential Therapeutic Value. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201701-0107CP. PubMed PMID:28306336 .
  5. Bellani, G, Madotto, F, Pham, T, Fan, E, Laffey, JG. Reply to Coudroy et al. and Chertoff. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201702-2565LE. PubMed PMID:28231018 .
  6. Vargas, M, Pastore, A, Aloj, F, Laffey, JG, Servillo, G. A comparison of videolaryngoscopes for tracheal intubation in predicted difficult airway: a feasibility study. BMC Anesthesiol. 2017;17 (1):25. doi: 10.1186/s12871-017-0318-2. PubMed PMID:28219331 PubMed Central PMC5319085.
  7. Dreyfuss, D, Gaudry, S, Madotto, F, Laffey, JG. Some remaining important questions after LUNG SAFE : Discussion of "Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study". Intensive Care Med. 2017;43 (4):598-599. doi: 10.1007/s00134-017-4706-3. PubMed PMID:28213623 .
  8. Laffey, JG, Kavanagh, BP. Fifty Years of Research in ARDS. Insight into ARDS - From Models to Patients. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201612-2415CI. PubMed PMID:28146637 .
  9. Nagendran, M, McAuley, DF, Kruger, PS, Papazian, L, Truwit, JD, Laffey, JG et al.. Statin therapy for acute respiratory distress syndrome: an individual patient data meta-analysis of randomised clinical trials. Intensive Care Med. 2017;43 (5):663-671. doi: 10.1007/s00134-016-4649-0. PubMed PMID:28004129 .
  10. Laffey, JG, Pham, T, Bellani, G. Continued under-recognition of acute respiratory distress syndrome after the Berlin definition: what is the solution?. Curr Opin Crit Care. 2017;23 (1):10-17. doi: 10.1097/MCC.0000000000000381. PubMed PMID:27922845 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto