John Laffey


Co-Director, Critical Illness and Injury Research Centre


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Rezoagli, E, McNicholas, B, Moran, P, Laffey, JG. Recommended Reading from the Galway University Hospitals, Department of Anaesthesia and Intensive Care Medicine Fellows. Am. J. Respir. Crit. Care Med. 2018; :. doi: 10.1164/rccm.201804-0782RR. PubMed PMID:30277812 .
  2. Shologu, N, Scully, M, Laffey, JG, O'Toole, D. Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury. Int J Mol Sci. 2018;19 (10):. doi: 10.3390/ijms19102996. PubMed PMID:30274394 .
  3. Rezoagli, E, Masterson, CH, McCarthy, SD, Laffey, JG. Recommended Reading from the National University of Ireland Galway Regenerative Medicine Institute (REMEDI) Lung Biology Group Fellows. Am. J. Respir. Cell Mol. Biol. 2018; :. doi: 10.1165/rcmb.2018-0284RO. PubMed PMID:30230345 .
  4. Abe, T, Madotto, F, Pham, T, Nagata, I, Uchida, M, Tamiya, N et al.. Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries. Crit Care. 2018;22 (1):195. doi: 10.1186/s13054-018-2126-6. PubMed PMID:30115127 PubMed Central PMC6097245.
  5. Calfee, CS, Delucchi, KL, Sinha, P, Matthay, MA, Hackett, J, Shankar-Hari, M et al.. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial. Lancet Respir Med. 2018;6 (9):691-698. doi: 10.1016/S2213-2600(18)30177-2. PubMed PMID:30078618 .
  6. Laffey, JG, Kavanagh, BP. Negative trials in critical care: why most research is probably wrong. Lancet Respir Med. 2018;6 (9):659-660. doi: 10.1016/S2213-2600(18)30279-0. PubMed PMID:30061048 .
  7. Masterson, C, Devaney, J, Horie, S, O'Flynn, L, Deedigan, L, Elliman, S et al.. Syndecan-2-positive, Bone Marrow-derived Human Mesenchymal Stromal Cells Attenuate Bacterial-induced Acute Lung Injury and Enhance Resolution of Ventilator-induced Lung Injury in Rats. Anesthesiology. 2018;129 (3):502-516. doi: 10.1097/ALN.0000000000002327. PubMed PMID:29979191 .
  8. Cortegiani, A, Madotto, F, Gregoretti, C, Bellani, G, Laffey, JG, Pham, T et al.. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Crit Care. 2018;22 (1):157. doi: 10.1186/s13054-018-2079-9. PubMed PMID:29895331 PubMed Central PMC5998562.
  9. Madotto, F, Pham, T, Bellani, G, Bos, LD, Simonis, FD, Fan, E et al.. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Intensive Care Med. 2018;44 (5):564-577. doi: 10.1007/s00134-018-5152-6. PubMed PMID:29632996 .
  10. Rabani, R, Volchuk, A, Jerkic, M, Ormesher, L, Garces-Ramirez, L, Canton, J et al.. Mesenchymal stem cells enhance NOX2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis. Eur. Respir. J. 2018;51 (4):. doi: 10.1183/13993003.02021-2017. PubMed PMID:29519920 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto