John Laffey


Co-Director, Critical Illness and Injury Research Centre


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Jerkic, M, Masterson, C, Ormesher, L, Gagnon, S, Goyal, S, Rabani, R et al.. Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis. J Clin Med. 2019;8 (6):. doi: 10.3390/jcm8060847. PubMed PMID:31200579 .
  2. McNicholas, BA, Rezoagli, E, Pham, T, Madotto, F, Guiard, E, Fanelli, V et al.. Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study. Crit. Care Med. 2019; :. doi: 10.1097/CCM.0000000000003832. PubMed PMID:31162201 .
  3. Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology, Bluth, T, Serpa Neto, A, Schultz, MJ, Pelosi, P, Gama de Abreu, M et al.. Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial. JAMA. 2019; :. doi: 10.1001/jama.2019.7505. PubMed PMID:31157366 PubMed Central PMC6582260.
  4. Heunks, L, Bellani, G, Pham, T, Brochard, L, Laffey, JG. The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration. Eur. Respir. J. 2019;53 (3):. doi: 10.1183/13993003.02228-2018. PubMed PMID:30886021 .
  5. Varkouhi, AK, Jerkic, M, Ormesher, L, Gagnon, S, Goyal, S, Rabani, R et al.. Extracellular Vesicles from Interferon-γ-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats. Anesthesiology. 2019;130 (5):778-790. doi: 10.1097/ALN.0000000000002655. PubMed PMID:30870158 .
  6. Combes, A, Fanelli, V, Pham, T, Ranieri, VM, European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med. 2019;45 (5):592-600. doi: 10.1007/s00134-019-05567-4. PubMed PMID:30790030 .
  7. Zhang, Z, Spieth, PM, Chiumello, D, Goyal, H, Torres, A, Laffey, JG et al.. Declining Mortality in Patients With Acute Respiratory Distress Syndrome: An Analysis of the Acute Respiratory Distress Syndrome Network Trials. Crit. Care Med. 2019;47 (3):315-323. doi: 10.1097/CCM.0000000000003499. PubMed PMID:30779718 .
  8. Islam, D, Huang, Y, Fanelli, V, Delsedime, L, Wu, S, Khang, J et al.. Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury. Am. J. Respir. Crit. Care Med. 2019;199 (10):1214-1224. doi: 10.1164/rccm.201802-0356OC. PubMed PMID:30521764 .
  9. Pham, T, Serpa Neto, A, Pelosi, P, Laffey, JG, De Haro, C, Lorente, JA et al.. Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study. Anesthesiology. 2019;130 (2):263-283. doi: 10.1097/ALN.0000000000002508. PubMed PMID:30499850 .
  10. Horie, S, Gonzalez, HE, Laffey, JG, Masterson, CH. Cell therapy in acute respiratory distress syndrome. J Thorac Dis. 2018;10 (9):5607-5620. doi: 10.21037/jtd.2018.08.28. PubMed PMID:30416812 PubMed Central PMC6196176.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto