John Laffey


Co-Director, Critical Illness and Injury Research Centre


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Masterson, C, Devaney, J, Horie, S, O'Flynn, L, Deedigan, L, Elliman, S et al.. Syndecan-2-positive, Bone Marrow-derived Human Mesenchymal Stromal Cells Attenuate Bacterial-induced Acute Lung Injury and Enhance Resolution of Ventilator-induced Lung Injury in Rats. Anesthesiology. 2018; :. doi: 10.1097/ALN.0000000000002327. PubMed PMID:29979191 .
  2. Cortegiani, A, Madotto, F, Gregoretti, C, Bellani, G, Laffey, JG, Pham, T et al.. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Crit Care. 2018;22 (1):157. doi: 10.1186/s13054-018-2079-9. PubMed PMID:29895331 PubMed Central PMC5998562.
  3. Madotto, F, Pham, T, Bellani, G, Bos, LD, Simonis, FD, Fan, E et al.. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Intensive Care Med. 2018;44 (5):564-577. doi: 10.1007/s00134-018-5152-6. PubMed PMID:29632996 .
  4. Rabani, R, Volchuk, A, Jerkic, M, Ormesher, L, Garces-Ramirez, L, Canton, J et al.. Mesenchymal stem cells enhance NOX2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis. Eur. Respir. J. 2018;51 (4):. doi: 10.1183/13993003.02021-2017. PubMed PMID:29519920 .
  5. Goddard, SL, Rubenfeld, GD, Manoharan, V, Dev, SP, Laffey, J, Bellani, G et al.. The Randomized Educational Acute Respiratory Distress Syndrome Diagnosis Study: A Trial to Improve the Radiographic Diagnosis of Acute Respiratory Distress Syndrome. Crit. Care Med. 2018;46 (5):743-748. doi: 10.1097/CCM.0000000000003000. PubMed PMID:29438110 .
  6. Brodie, D, Vincent, JL, Brochard, LJ, Combes, A, Ferguson, ND, Hodgson, CL et al.. Research in Extracorporeal Life Support: A Call to Action. Chest. 2018;153 (4):788-791. doi: 10.1016/j.chest.2017.12.024. PubMed PMID:29355550 .
  7. Laffey, JG, Misak, C, Kavanagh, BP. Acute respiratory distress syndrome. BMJ. 2017;359 :j5055. . PubMed PMID:29146585 .
  8. Laffey, JG, Bellani, G, Pham, T, Fan, E, Madotto, F, Bajwa, EK et al.. Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. Intensive Care Med. 2018;44 (1):157-165. doi: 10.1007/s00134-017-4981-z. PubMed PMID:29138899 .
  9. McNicholas, BA, Rooney, GM, Laffey, JG. Lessons to learn from epidemiologic studies in ARDS. Curr Opin Crit Care. 2018;24 (1):41-48. doi: 10.1097/MCC.0000000000000473. PubMed PMID:29135617 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto