John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Writing Committee for the REMAP-CAP Investigators, Estcourt, LJ, Turgeon, AF, McQuilten, ZK, McVerry, BJ, Al-Beidh, F et al.. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2021; :. doi: 10.1001/jama.2021.18178. PubMed PMID:34606578 .
  2. Wildi, K, Li Bassi, G, Barnett, A, Panigada, M, Colombo, SM, Bandera, A et al.. Design and Rationale of a Prospective International Follow-Up Study on Intensive Care Survivors of COVID-19: The Long-Term Impact in Intensive Care Survivors of Coronavirus Disease-19-AFTERCOR. Front Med (Lausanne). 2021;8 :738086. doi: 10.3389/fmed.2021.738086. PubMed PMID:34568393 PubMed Central PMC8455846.
  3. Ehrmann, S, Li, J, Ibarra-Estrada, M, Perez, Y, Pavlov, I, McNicholas, B et al.. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Lancet Respir Med. 2021; :. doi: 10.1016/S2213-2600(21)00356-8. PubMed PMID:34425070 PubMed Central PMC8378833.
  4. Robba, C, Citerio, G, Taccone, FS, Galimberti, S, Rebora, P, Vargiolu, A et al.. Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol. BMJ Open. 2021;11 (8):e047100. doi: 10.1136/bmjopen-2020-047100. PubMed PMID:34380722 PubMed Central PMC8359464.
  5. Masterson, CH, O'Toole, D, Laffey, JG. Inhaled CO2 to Reduce Lung Ischemia and Reperfusion Injuries: Moving toward Clinical Translation?. Am J Respir Crit Care Med. 2021;204 (8):878-879. doi: 10.1164/rccm.202107-1665ED. PubMed PMID:34375575 .
  6. Laffey, J, Bellani, G, Russotto, V, INTUBE Investigators. Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients-Reply. JAMA. 2021;326 (6):569. doi: 10.1001/jama.2021.8532. PubMed PMID:34374723 .
  7. REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher, EC, Bradbury, CA, McVerry, BJ et al.. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):777-789. doi: 10.1056/NEJMoa2103417. PubMed PMID:34351722 PubMed Central PMC8362592.
  8. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler, PR, Goligher, EC, Berger, JS et al.. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):790-802. doi: 10.1056/NEJMoa2105911. PubMed PMID:34351721 PubMed Central PMC8362594.
  9. Pelosi, P, Ball, L, Barbas, CSV, Bellomo, R, Burns, KEA, Einav, S et al.. Personalized mechanical ventilation in acute respiratory distress syndrome. Crit Care. 2021;25 (1):250. doi: 10.1186/s13054-021-03686-3. PubMed PMID:34271958 PubMed Central PMC8284184.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto