John Laffey


Co-Director, Critical Illness and Injury Research Centre


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Russotto, V, Myatra, SN, Laffey, JG. What's new in airway management of the critically ill. Intensive Care Med. 2019; :. doi: 10.1007/s00134-019-05757-0. PubMed PMID:31529354 .
  2. Goligher, EC, Combes, A, Brodie, D, Ferguson, ND, Pesenti, AM, Ranieri, VM et al.. Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design. Intensive Care Med. 2019;45 (9):1219-1230. doi: 10.1007/s00134-019-05708-9. PubMed PMID:31432216 .
  3. Juffermans, NP, Schultz, M, Bos, LD, Penuelas, O, Laffey, J, Lorente, JA et al.. Why translational research matters: proceedings of the third international symposium on acute lung injury translational research (INSPIRES III). Intensive Care Med Exp. 2019;7 (Suppl 1):40. doi: 10.1186/s40635-019-0230-9. PubMed PMID:31346800 PubMed Central PMC6658622.
  4. Masterson, CH, Curley, GF, Laffey, JG. Modulating the distribution and fate of exogenously delivered MSCs to enhance therapeutic potential: knowns and unknowns. Intensive Care Med Exp. 2019;7 (Suppl 1):41. doi: 10.1186/s40635-019-0235-4. PubMed PMID:31346794 PubMed Central PMC6658643.
  5. McNicholas, BA, Madotto, F, Pham, T, Rezoagli, E, Masterson, CH, Horie, S et al.. Demographics, management and outcome of women and men with Acute Respiratory Distress Syndrome in the LUNG SAFE prospective cohort study. Eur. Respir. J. 2019; :. doi: 10.1183/13993003.00609-2019. PubMed PMID:31346004 .
  6. Jerkic, M, Masterson, C, Ormesher, L, Gagnon, S, Goyal, S, Rabani, R et al.. Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis. J Clin Med. 2019;8 (6):. doi: 10.3390/jcm8060847. PubMed PMID:31200579 PubMed Central PMC6616885.
  7. McNicholas, BA, Rezoagli, E, Pham, T, Madotto, F, Guiard, E, Fanelli, V et al.. Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study. Crit. Care Med. 2019;47 (9):1216-1225. doi: 10.1097/CCM.0000000000003832. PubMed PMID:31162201 .
  8. Heunks, L, Bellani, G, Pham, T, Brochard, L, Laffey, JG. The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration. Eur. Respir. J. 2019;53 (3):. doi: 10.1183/13993003.02228-2018. PubMed PMID:30886021 .
  9. Varkouhi, AK, Jerkic, M, Ormesher, L, Gagnon, S, Goyal, S, Rabani, R et al.. Extracellular Vesicles from Interferon-γ-primed Human Umbilical Cord Mesenchymal Stromal Cells Reduce Escherichia coli-induced Acute Lung Injury in Rats. Anesthesiology. 2019;130 (5):778-790. doi: 10.1097/ALN.0000000000002655. PubMed PMID:30870158 .
  10. Combes, A, Fanelli, V, Pham, T, Ranieri, VM, European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med. 2019;45 (5):592-600. doi: 10.1007/s00134-019-05567-4. PubMed PMID:30790030 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto