John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Maddali, MV, Churpek, M, Pham, T, Rezoagli, E, Zhuo, H, Zhao, W et al.. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Lancet Respir Med. 2022; :. doi: 10.1016/S2213-2600(21)00461-6. PubMed PMID:35026177 .
  2. van Haren, FMP, van Loon, LM, Steins, A, Smoot, TL, Sas, C, Staas, S et al.. Inhaled nebulised unfractionated heparin for the treatment of hospitalised patients with COVID-19: A multicentre case series of 98 patients. Br J Clin Pharmacol. 2022; :. doi: 10.1111/bcp.15212. PubMed PMID:34984714 .
  3. Singer, M, Young, PJ, Laffey, JG, Asfar, P, Taccone, FS, Skrifvars, MB et al.. Dangers of hyperoxia. Crit Care. 2021;25 (1):440. doi: 10.1186/s13054-021-03815-y. PubMed PMID:34924022 PubMed Central PMC8686263.
  4. Pisani, L, Algera, AG, Neto, AS, Azevedo, L, Pham, T, Paulus, F et al.. Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies. Lancet Glob Health. 2022;10 (2):e227-e235. doi: 10.1016/S2214-109X(21)00485-X. PubMed PMID:34914899 .
  5. Horie, S, Gonzalez, H, Brady, J, Devaney, J, Scully, M, O'Toole, D et al.. Fresh and Cryopreserved Human Umbilical-Cord-Derived Mesenchymal Stromal Cells Attenuate Injury and Enhance Resolution and Repair following Ventilation-Induced Lung Injury. Int J Mol Sci. 2021;22 (23):. doi: 10.3390/ijms222312842. PubMed PMID:34884645 PubMed Central PMC8657992.
  6. Murphy, EJ, Rezoagli, E, Pogue, R, Simonassi-Paiva, B, Abidin, IIZ, Fehrenbach, GW et al.. Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom - A potential treatment for inflammatory lung conditions. Sci Total Environ. 2022;809 :152177. doi: 10.1016/j.scitotenv.2021.152177. PubMed PMID:34875322 .
  7. Ibarra-Estrada, M, Li, J, Laffey, JG, Pavlov, I, Roca, O, Perez, Y et al.. Prone positioning might reduce the need for intubation in people with severe COVID-19 - Authors' reply. Lancet Respir Med. 2021;9 (12):e111. doi: 10.1016/S2213-2600(21)00449-5. PubMed PMID:34861160 PubMed Central PMC8631898.
  8. Dunbar, H, Weiss, DJ, Rolandsson Enes, S, Laffey, JG, English, K. The Inflammatory Lung Microenvironment; a Key Mediator in MSC Licensing. Cells. 2021;10 (11):. doi: 10.3390/cells10112982. PubMed PMID:34831203 PubMed Central PMC8616504.
  9. Russotto, V, Rahmani, LS, Parotto, M, Bellani, G, Laffey, JG. Tracheal intubation in the critically ill patient. Eur J Anaesthesiol. 2021; :. doi: 10.1097/EJA.0000000000001627. PubMed PMID:34799497 .
  10. Li Bassi, G, Suen, JY, White, N, Dalton, HJ, Fanning, J, Corley, A et al.. Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study. Crit Care Explor. 2021;3 (11):e0567. doi: 10.1097/CCE.0000000000000567. PubMed PMID:34765979 PubMed Central PMC8575423.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto