John Laffey


Co-Director, Critical Illness and Injury Research Centre


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Hussain, N, Goldar, G, Ragina, N, Banfield, L, Laffey, JG, Abdallah, FW et al.. Suprascapular and Interscalene Nerve Block for Shoulder Surgery: A Systematic Review and Meta-analysis. Anesthesiology. 2017; :. doi: 10.1097/ALN.0000000000001894. PubMed PMID:28968280 .
  2. Keane, C, Jerkic, M, Laffey, JG. Stem Cell-based Therapies for Sepsis. Anesthesiology. 2017; :. doi: 10.1097/ALN.0000000000001882. PubMed PMID:28872482 .
  3. Grassi, A, Foti, G, Laffey, JG, Bellani, G. Noninvasive mechanical ventilation in early acute respiratory distress syndrome. 2017;127 (9):614-620. doi: 10.20452/pamw.4088. PubMed PMID:28820175 .
  4. Jaber, S, Bellani, G, Blanch, L, Demoule, A, Esteban, A, Gattinoni, L et al.. The intensive care medicine research agenda for airways, invasive and noninvasive mechanical ventilation. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4896-8. PubMed PMID:28785882 .
  5. Brodie, D, Curtis, JR, Vincent, JL, Bakker, J, Brown, CE, Creteur, J et al.. Treatment limitations in the era of ECMO. Lancet Respir Med. 2017;5 (10):769-770. doi: 10.1016/S2213-2600(17)30263-1. PubMed PMID:28705688 .
  6. de Prost, N, Pham, T, Carteaux, G, Mekontso Dessap, A, Brun-Buisson, C, Fan, E et al.. Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study. Ann Intensive Care. 2017;7 (1):69. doi: 10.1186/s13613-017-0281-6. PubMed PMID:28631088 PubMed Central PMC5476531.
  7. Laffey, JG, Madotto, F, Bellani, G, Pham, T, Fan, E, Brochard, L et al.. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. Lancet Respir Med. 2017;5 (8):627-638. doi: 10.1016/S2213-2600(17)30213-8. PubMed PMID:28624388 .
  8. Curley, GF, Jerkic, M, Hogan, G, Masterson, C, O'Toole, D, Devaney, J et al.. The authors reply. Crit. Care Med. 2017;45 (7):e737-e738. doi: 10.1097/CCM.0000000000002480. PubMed PMID:28622234 .
  9. Laffey, JG, Matthay, MA. Fifty Years of Research in ARDS. Cell-based Therapy for Acute Respiratory Distress Syndrome. Biology and Potential Therapeutic Value. Am. J. Respir. Crit. Care Med. 2017;196 (3):266-273. doi: 10.1164/rccm.201701-0107CP. PubMed PMID:28306336 PubMed Central PMC5549868.
  10. Bellani, G, Madotto, F, Pham, T, Fan, E, Laffey, JG. Reply: "Could Noninvasive Ventilation Failure Rates Be Underestimated in the LUNG SAFE Study?" and "High-Flow Oxygen, Positive End-Expiratory Pressure, and the Berlin Definition of Acute Respiratory Distress Syndrome: Are They Mutually Exclusive?". Am. J. Respir. Crit. Care Med. 2017;196 (3):397-398. doi: 10.1164/rccm.201702-2565LE. PubMed PMID:28231018 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto