John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Pelosi, P, Ball, L, Barbas, CSV, Bellomo, R, Burns, KEA, Einav, S et al.. Personalized mechanical ventilation in acute respiratory distress syndrome. Crit Care. 2021;25 (1):250. doi: 10.1186/s13054-021-03686-3. PubMed PMID:34271958 PubMed Central PMC8284184.
  2. Weaver, L, Das, A, Saffaran, S, Yehya, N, Scott, TE, Chikhani, M et al.. High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study. Ann Intensive Care. 2021;11 (1):109. doi: 10.1186/s13613-021-00904-7. PubMed PMID:34255207 PubMed Central PMC8276227.
  3. Arabi, YM, Gordon, AC, Derde, LPG, Nichol, AD, Murthy, S, Beidh, FA et al.. Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med. 2021;47 (8):867-886. doi: 10.1007/s00134-021-06448-5. PubMed PMID:34251506 PubMed Central PMC8274471.
  4. Pavlov, I, He, H, McNicholas, B, Perez, Y, Tavernier, E, Trump, MW et al.. Awake prone positioning in non-intubated patients with acute hypoxemic respiratory failure due to COVID-19: A systematic review of proportional outcomes comparing observational studies with and without awake prone positioning in the setting of COVID-19. Respir Care. 2021; :. doi: 10.4187/respcare.09191. PubMed PMID:34234032 .
  5. ISARIC Clinical Characterisation Group. COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. Infection. 2021; :. doi: 10.1007/s15010-021-01599-5. PubMed PMID:34170486 PubMed Central PMC8231091.
  6. Li Bassi, G, Suen, JY, Dalton, HJ, White, N, Shrapnel, S, Fanning, JP et al.. An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients. Crit Care. 2021;25 (1):199. doi: 10.1186/s13054-021-03518-4. PubMed PMID:34108029 PubMed Central PMC8188162.
  7. De Marco Verissimo, C, O'Brien, C, López Corrales, J, Dorey, A, Cwiklinski, K, Lalor, R et al.. Improved diagnosis of SARS-CoV-2 by using nucleoprotein and spike protein fragment 2 in quantitative dual ELISA tests. Epidemiol Infect. 2021;149 :e140. doi: 10.1017/S0950268821001308. PubMed PMID:34099081 PubMed Central PMC8207563.
  8. Andrade, E, Quinlan, L, Harte, R, Byrne, D, Fallon, E, Kelly, M et al.. Augmenting Critical Care Patient Monitoring Using Wearable Technology: Review of Usability and Human Factors. JMIR Hum Factors. 2021;8 (2):e16491. doi: 10.2196/16491. PubMed PMID:34032574 PubMed Central PMC8188324.
  9. O'Connell, J, Abbas, M, Beecham, S, Buckley, J, Chochlov, M, Fitzgerald, B et al.. Best Practice Guidance for Digital Contact Tracing Apps: A Cross-disciplinary Review of the Literature. JMIR Mhealth Uhealth. 2021;9 (6):e27753. doi: 10.2196/27753. PubMed PMID:34003764 PubMed Central PMC8189288.
  10. Flynn, J, O'Connor, L, Hanlon, M, Bellani, G, Contreras, M, Doherty, A et al.. The identification of needs and development of best practice guidance for the psychological support of frontline healthcare workers during and after COVID-19: A protocol for the FLoWS project. HRB Open Res. 2020;3 :54. doi: 10.12688/hrbopenres.13117.2. PubMed PMID:33870088 PubMed Central PMC8030118.
Search PubMed

Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto