John Lee


Associate Scientist, Li Ka Shing Knowledge Institute


Dr. Lee is an Otolaryngologist-Head & Neck Surgeon and Assistant Professor in the Department of Otolaryngology-Head & Neck Surgery at the University of Toronto. He completed his residency training in Toronto before going on to do a fellowship in Endoscopic Sinus & Skull Base Surgery at the University of Pennsylvania. In 2009, Dr. Lee was recruited back to the University of Toronto based out of St. Michael’s Hospital. His main clinical focus is in the field of Rhinology (Diseases of the Nose and Sinuses) as well as working with Neurosurgeons in treating tumours of the skull base. As an Associate Scientist in the Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, Dr. Lee has research interests in the following areas:

1) Pathophysiology of chronic rhinosinusitis

2) Clinical outcomes of endoscopic sinus and skull base surgery

3) Clinical epidemiology

4) Surgical education

Currently, the main research focus has been on exploring the role of nasal nitric oxide in the pathophysiology of chronic rhinosinusitis. Additionally, he is developing a Nasal Physiology Laboratory to measure parameters such as airflow, resistance and olfaction in patients with various nasal and sinus conditions. Dr. Lee holds a Masters Degree in Health Research Methodology and accepts summer students as well as research volunteers.

Lists of publications:

Recent Publications

  1. Hatt, M, Lee, JA, Schmidtlein, CR, Naqa, IE, Caldwell, C, De Bernardi, E et al.. Classification and evaluation strategies of auto-segmentation approaches for PET: Report of AAPM task group No. 211. Med Phys. 2017;44 (6):e1-e42. doi: 10.1002/mp.12124. PubMed PMID:28120467 .
  2. Lee, JM, Derkinderen, P, Kordower, JH, Freeman, R, Munoz, DG, Kremer, T et al.. The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease. J. Neuropathol. Exp. Neurol. 2017;76 (1):2-15. doi: 10.1093/jnen/nlw103. PubMed PMID:28069931 .
  3. Belliveau, MJ, Wang, JC, Nijhawan, N, Latta, EK, Lee, JM. Staged endonasal-external resection of esthesioneuroblastoma involving the nasolacrimal duct and lacrimal sac. Can. J. Ophthalmol. 2016;51 (6):e173-e175. doi: 10.1016/j.jcjo.2016.06.012. PubMed PMID:27938977 .
  4. Chiu, LL, To, WT, Lee, JM, Waldman, SD. Scaffold-free cartilage tissue engineering with a small population of human nasoseptal chondrocytes. Laryngoscope. 2017;127 (3):E91-E99. doi: 10.1002/lary.26396. PubMed PMID:27861930 .
  5. Karnezis, TT, Baker, AB, Soler, ZM, Wise, SK, Rereddy, SK, Patel, ZM et al.. Factors impacting cerebrospinal fluid leak rates in endoscopic sellar surgery. Int Forum Allergy Rhinol. 2016;6 (11):1117-1125. doi: 10.1002/alr.21783. PubMed PMID:27552303 .
  6. Lee, JM, Au, M. Onodi cell mucocele: Case report and review of the literature. Ear Nose Throat J. 2016;95 (9):E4-8. . PubMed PMID:27657326 .
  7. Shahangian, A, Soler, ZM, Baker, A, Wise, SK, Rereddy, SK, Patel, ZM et al.. Successful repair of intraoperative cerebrospinal fluid leaks improves outcomes in endoscopic skull base surgery. Int Forum Allergy Rhinol. 2017;7 (1):80-86. doi: 10.1002/alr.21845. PubMed PMID:27579523 .
  8. Fathalla, H, Di Ieva, A, Lee, J, Anderson, J, Jing, R, Solarski, M et al.. Cerebrospinal fluid leaks in extended endoscopic transsphenoidal surgery: covering all the angles. Neurosurg Rev. 2017;40 (2):309-318. doi: 10.1007/s10143-016-0776-x. PubMed PMID:27558362 .
  9. le Nobel, GJ, Lin, VY, Iakovlev, V, Lee, JM. An Eustachian Tube Neuroendocrine Carcinoma: A Previously Undescribed Entity and Review of the Literature. Case Rep Surg. 2016;2016 :4643615. doi: 10.1155/2016/4643615. PubMed PMID:27429827 PubMed Central PMC4939327.
  10. Man, HS, Yan, MS, Lee, JJ, Marsden, PA. Epigenetic determinants of cardiovascular gene expression: vascular endothelium. Epigenomics. 2016;8 (7):959-79. doi: 10.2217/epi-2016-0012. PubMed PMID:27381277 .
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Affiliations & Other Activities

  • Assistant Professor, Dept. of Otolaryngology-Head and Neck Surgery, University of Toronto
  • Assistant Director of Undergraduate Medical Education, Department of Otolaryngology-Head & Neck Surgery, University of Toronto
  • Editorial Board, American Journal of Rhinology and Allergy
  • Faculty Member, F1000Prime, Section of Rhinology & Paranasal Sinus Disease
  • Information Technology Committee, American Rhinologic Societt
  • Awards Committee, American Rhinologic Society
  • Rhinology Working Group, Canadian Society of Otolaryngology-Head & Neck Surgery