John Marshall

MD, FRCSC, FACS, FCAHS

Co-Director, Critical Illness and Injury Research Centre

Biography

Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Rochwerg, B, Parke, R, Murthy, S, Fernando, SM, Leigh, JP, Marshall, J et al.. Misinformation During the Coronavirus Disease 2019 Outbreak: How Knowledge Emerges From Noise. Crit Care Explor. 2020;2 (4):e0098. doi: 10.1097/CCE.0000000000000098. PubMed PMID:32426740 PubMed Central PMC7188430.
  2. Angus, DC, Berry, S, Lewis, RJ, Al-Beidh, F, Arabi, Y, van Bentum-Puijk, W et al.. The Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia (REMAP-CAP) Study: Rationale and Design. Ann Am Thorac Soc. 2020; :. doi: 10.1513/AnnalsATS.202003-192SD. PubMed PMID:32267771 .
  3. Cook, DJ, Marshall, JC, Fowler, RA. Critical Illness in Patients With COVID-19: Mounting an Effective Clinical and Research Response. JAMA. 2020; :. doi: 10.1001/jama.2020.5775. PubMed PMID:32250408 .
  4. Baker, T, Schell, CO, Petersen, DB, Sawe, H, Khalid, K, Mndolo, S et al.. Essential care of critical illness must not be forgotten in the COVID-19 pandemic. Lancet. 2020;395 (10232):1253-1254. doi: 10.1016/S0140-6736(20)30793-5. PubMed PMID:32246914 .
  5. Vincent, JL, Sakr, Y, Singer, M, Martin-Loeches, I, Machado, FR, Marshall, JC et al.. Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017. JAMA. 2020; :. doi: 10.1001/jama.2020.2717. PubMed PMID:32207816 PubMed Central PMC7093816.
  6. Rose, L, Agar, M, Burry, L, Campbell, N, Clarke, M, Lee, J et al.. Reporting of Outcomes and Outcome Measures in Studies of Interventions to Prevent and/or Treat Delirium in the Critically Ill: A Systematic Review. Crit. Care Med. 2020;48 (4):e316-e324. doi: 10.1097/CCM.0000000000004238. PubMed PMID:32205622 .
  7. Thavarajah, T, Tucholska, M, Zhu, PH, Bowden, P, Marshall, JG. Re-evaluation of the 18 non-human protein standards used to create the empirical statistical model for decoy library searching. Anal. Biochem. 2020;599 :113680. doi: 10.1016/j.ab.2020.113680. PubMed PMID:32194076 .
  8. Rose, L, Agar, M, Burry, L, Campbell, N, Clarke, M, Lee, J et al.. Reporting of Outcomes and Outcome Measures in Studies of Interventions to Prevent and/or Treat Delirium in the Critically Ill: A Systematic Review. Crit. Care Med. 2020; :. doi: 10.1097/CCM.0000000000004238. PubMed PMID:32167491 .
  9. Liaw, PC, Fox-Robichaud, AE, Liaw, KL, McDonald, E, Dwivedi, DJ, Zamir, NM et al.. Mortality Risk Profiles for Sepsis: A Novel Longitudinal and Multivariable Approach. Crit Care Explor. 2019;1 (8):e0032. doi: 10.1097/CCE.0000000000000032. PubMed PMID:32166273 PubMed Central PMC7063956.
  10. Harhay, MO, Casey, JD, Clement, M, Collins, SP, Gayat, É, Gong, MN et al.. Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop. Intensive Care Med. 2020;46 (5):930-942. doi: 10.1007/s00134-020-05934-6. PubMed PMID:32072303 PubMed Central PMC7224097.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
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