John Marshall


Co-Director, Critical Illness and Injury Research Centre


Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Thavarajah, T, Dos Santos, CC, Slutsky, AS, Marshall, JC, Bowden, P, Romaschin, A et al.. The plasma peptides of sepsis. Clin Proteomics. 2020;17 :26. doi: 10.1186/s12014-020-09288-5. PubMed PMID:32636717 PubMed Central PMC7331219.
  2. Lau, VI, Cook, DJ, Fowler, R, Rochwerg, B, Johnstone, J, Lauzier, F et al.. Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol. BMJ Open. 2020;10 (6):e036047. doi: 10.1136/bmjopen-2019-036047. PubMed PMID:32595159 PubMed Central PMC7322334.
  3. Madani Kia, T, Marshall, JC, Murthy, S. Stakeholder perspectives on adaptive clinical trials: a scoping review. Trials. 2020;21 (1):539. doi: 10.1186/s13063-020-04466-0. PubMed PMID:32552852 PubMed Central PMC7301522.
  4. Pierrakos, C, Velissaris, D, Bisdorff, M, Marshall, JC, Vincent, JL. Biomarkers of sepsis: time for a reappraisal. Crit Care. 2020;24 (1):287. doi: 10.1186/s13054-020-02993-5. PubMed PMID:32503670 PubMed Central PMC7273821.
  5. Arabi, YM, Asseri, A, Webb, S, Marshall, J, Al Moamary, MS. Clinical trials for coronavirus disease 2019: What is being evaluated and what is not. Ann Thorac Med. ;15 (2):49-51. doi: 10.4103/atm.ATM_99_20. PubMed PMID:32489437 PubMed Central PMC7259392.
  6. Silversides, JA, McAuley, DF, Blackwood, B, Fan, E, Ferguson, AJ, Marshall, JC et al.. Fluid management and deresuscitation practices: A survey of critical care physicians. J Intensive Care Soc. 2020;21 (2):111-118. doi: 10.1177/1751143719846442. PubMed PMID:32489406 PubMed Central PMC7238475.
  7. Rochwerg, B, Parke, R, Murthy, S, Fernando, SM, Leigh, JP, Marshall, J et al.. Misinformation During the Coronavirus Disease 2019 Outbreak: How Knowledge Emerges From Noise. Crit Care Explor. 2020;2 (4):e0098. doi: 10.1097/CCE.0000000000000098. PubMed PMID:32426740 PubMed Central PMC7188430.
  8. Angus, DC, Berry, S, Lewis, RJ, Al-Beidh, F, Arabi, Y, van Bentum-Puijk, W et al.. The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design. Ann Am Thorac Soc. 2020;17 (7):879-891. doi: 10.1513/AnnalsATS.202003-192SD. PubMed PMID:32267771 PubMed Central PMC7328186.
  9. Cook, DJ, Marshall, JC, Fowler, RA. Critical Illness in Patients With COVID-19: Mounting an Effective Clinical and Research Response. JAMA. 2020; :. doi: 10.1001/jama.2020.5775. PubMed PMID:32250408 .
  10. Baker, T, Schell, CO, Petersen, DB, Sawe, H, Khalid, K, Mndolo, S et al.. Essential care of critical illness must not be forgotten in the COVID-19 pandemic. Lancet. 2020;395 (10232):1253-1254. doi: 10.1016/S0140-6736(20)30793-5. PubMed PMID:32246914 PubMed Central PMC7270584.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto