John Marshall




Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Piva, S, DiBlasi, RM, Slee, AE, Jobe, AH, Roccaro, AM, Filippini, M et al.. Surfactant therapy for COVID-19 related ARDS: a retrospective case-control pilot study. Respir Res. 2021;22 (1):20. doi: 10.1186/s12931-020-01603-w. PubMed PMID:33461535 PubMed Central PMC7812332.
  2. Zhen, J, Marshall, JK, Nguyen, GC, Atreja, A, Narula, N. Impact of Digital Health Monitoring in the Management of Inflammatory Bowel Disease. J Med Syst. 2021;45 (2):23. doi: 10.1007/s10916-021-01706-x. PubMed PMID:33449213 PubMed Central PMC7808932.
  3. Tong, A, Baumgart, A, Evangelidis, N, Viecelli, AK, Carter, SA, Azevedo, LC et al.. Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery. Crit Care Med. 2021;Publish Ahead of Print :. doi: 10.1097/CCM.0000000000004817. PubMed PMID:33400475 .
  4. Ektesabi, AM, Mori, K, Tsoporis, J, Vaswani, C, Gupta, S, Walsh, C et al.. Mesenchymal Stem/Stromal Cells Increase Cardiac MIR-187-3P Expression in Polymicrobial Animal Model of Sepsis. Shock. 2020;Publish Ahead of Print :. doi: 10.1097/SHK.0000000000001701. PubMed PMID:33378320 .
  5. Gupta, S, Tsoporis, JN, Jia, SH, Dos Santos, CC, Parker, TG, Marshall, JC et al.. Toll-Like Receptors, Associated Biochemical Signaling Networks, and S100 Ligands. Shock. 2020;Publish Ahead of Print :. doi: 10.1097/SHK.0000000000001704. PubMed PMID:33350801 .
  6. Marshall, JC, Murthy, S, Diaz, J, WHO Working Group on the Clinical Characterisation and Management of COVID-19 infection. Fungal infections should be part of the core outcome set for COVID-19 - Authors' reply. Lancet Infect Dis. 2020; :. doi: 10.1016/S1473-3099(20)30681-2. PubMed PMID:33301729 .
  7. Russell, JA, Marshall, JC, Slutsky, A, Murthy, S, Sweet, D, Lee, T et al.. Study protocol for a multicentre, prospective cohort study of the association of angiotensin II type 1 receptor blockers on outcomes of coronavirus infection. BMJ Open. 2020;10 (12):e040768. doi: 10.1136/bmjopen-2020-040768. PubMed PMID:33293316 PubMed Central PMC7722825.
  8. Amatullah, H, Maron-Gutierrez, T, Shan, Y, Gupta, S, Tsoporis, JN, Varkouhi, AK et al.. Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury. Redox Biol. 2021;38 :101796. doi: 10.1016/j.redox.2020.101796. PubMed PMID:33246293 PubMed Central PMC7695876.
  9. Cheng, N, Chen, ZZ, Florentinus-Mefailoski, A, Miao, M, Marshall, JG. Linear and Gaussian Analysis of a Single Enzyme Molecule by LC-MS. J Am Soc Mass Spectrom. 2021;32 (1):301-306. doi: 10.1021/jasms.0c00323. PubMed PMID:33196170 .
  10. Tsoporis, JN, Hatziagelaki, E, Gupta, S, Izhar, S, Salpeas, V, Tsiavou, A et al.. Circulating Ligands of the Receptor for Advanced Glycation End Products and the Soluble Form of the Receptor Modulate Cardiovascular Cell Apoptosis in Diabetes. Molecules. 2020;25 (22):. doi: 10.3390/molecules25225235. PubMed PMID:33182705 PubMed Central PMC7696395.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto