John Marshall




Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Rehm, HL, Page, AJH, Smith, L, Adams, JB, Alterovitz, G, Babb, LJ et al.. GA4GH: International policies and standards for data sharing across genomic research and healthcare. Cell Genom. 2021;1 (2):. doi: 10.1016/j.xgen.2021.100029. PubMed PMID:35072136 PubMed Central PMC8774288.
  2. Gardiner, E, Baumgart, A, Tong, A, Elliott, JH, Azevedo, LC, Bersten, A et al.. Perspectives of patients, family members, health professionals and the public on the impact of COVID-19 on mental health. J Ment Health. 2022; :1-10. doi: 10.1080/09638237.2021.2022637. PubMed PMID:34983279 .
  3. Soriano, JB, Murthy, S, Marshall, JC, Relan, P, Diaz, JV, WHO Clinical Case Definition Working Group on Post-COVID-19 Condition et al.. A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis. 2021; :. doi: 10.1016/S1473-3099(21)00703-9. PubMed PMID:34951953 PubMed Central PMC8691845.
  4. Silversides, JA, McMullan, R, Emerson, LM, Bradbury, I, Bannard-Smith, J, Szakmany, T et al.. Feasibility of conservative fluid administration and deresuscitation compared with usual care in critical illness: the Role of Active Deresuscitation After Resuscitation-2 (RADAR-2) randomised clinical trial. Intensive Care Med. 2021; :. doi: 10.1007/s00134-021-06596-8. PubMed PMID:34913089 .
  5. Diaz, JV, Herridge, M, Bertagnolio, S, Davis, HE, Dua, T, Kaushic, C et al.. Towards a universal understanding of post COVID-19 condition. Bull World Health Organ. 2021;99 (12):901-903. doi: 10.2471/BLT.21.286249. PubMed PMID:34866686 PubMed Central PMC8640686.
  6. Kiiza, P, Mullin, SI, Teo, K, Goodman, L, Perez, A, Pinto, R et al.. Establishing Healthcare Worker Performance and Safety in Providing Critical Care for Patients in a Simulated Ebola Treatment Unit: Non-Randomized Pilot Study. Viruses. 2021;13 (11):. doi: 10.3390/v13112205. PubMed PMID:34835011 PubMed Central PMC8622862.
  7. Losonczy, LI, Papali, A, Kivlehan, S, Calvello Hynes, EJ, Calderon, G, Laytin, A et al.. White Paper on Early Critical Care Services in Low Resource Settings. Ann Glob Health. 2021;87 (1):105. doi: 10.5334/aogh.3377. PubMed PMID:34786353 PubMed Central PMC8570193.
  8. Jones, JL, Benchimol, EI, Bernstein, CN, Huang, JG, Marshall, JK, Mukhtar, MS et al.. Crohn's and Colitis Canada's 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Health Care Delivery During the Pandemic and the Future Model of Inflammatory Bowel Disease Care. J Can Assoc Gastroenterol. 2021;4 (Suppl 2):S61-S67. doi: 10.1093/jcag/gwab034. PubMed PMID:34755041 PubMed Central PMC8570426.
  9. Kaplan, GG, Windsor, JW, Crain, J, Barrett, L, Bernstein, CN, Bitton, A et al.. Crohn's and Colitis Canada's 2021 Impact of COVID-19 & Inflammatory Bowel Disease in Canada: A Knowledge Translation Strategy. J Can Assoc Gastroenterol. 2021;4 (Suppl 2):S10-S19. doi: 10.1093/jcag/gwab028. PubMed PMID:34755034 PubMed Central PMC8570425.
  10. Ellen Kuenzig, M, Windsor, JW, Barrett, L, Bernstein, CN, Bitton, A, Carroll, MW et al.. Crohn's and Colitis Canada's 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: Executive Summary. J Can Assoc Gastroenterol. 2021;4 (Suppl 2):S1-S9. doi: 10.1093/jcag/gwab027. PubMed PMID:34755033 PubMed Central PMC8570424.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto