John Marshall


Co-Director, Critical Illness and Injury Research Centre


Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Daneman, N, Rishu, AH, Pinto, R, Aslanian, P, Bagshaw, SM, Carignan, A et al.. 7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial. Trials. 2018;19 (1):111. doi: 10.1186/s13063-018-2474-1. PubMed PMID:29452598 .
  2. Gupta, S, Lee, CM, Wang, JF, Parodo, J, Jia, SH, Hu, J et al.. Heat-shock protein-90 prolongs septic neutrophil survival by protecting c-Src kinase and caspase-8 from proteasomal degradation. J. Leukoc. Biol. 2018; :. doi: 10.1002/JLB.4A0816-354R. PubMed PMID:29393970 .
  3. Ziesmann, MT, Marshall, JC. Multiple Organ Dysfunction: The Defining Syndrome of Sepsis. Surg Infect (Larchmt). ;19 (2):184-190. doi: 10.1089/sur.2017.298. PubMed PMID:29360419 .
  4. Vincent, JL, Marshall, JC, Zimmerman, JL. The changing face of critical care: Task force on tropical diseases. J Crit Care. 2017; :. doi: 10.1016/j.jcrc.2017.12.019. PubMed PMID:29321100 .
  5. Dufresne, J, Florentinus-Mefailoski, A, Ajambo, J, Ferwa, A, Bowden, P, Marshall, J et al.. Random and independent sampling of endogenous tryptic peptides from normal human EDTA plasma by liquid chromatography micro electrospray ionization and tandem mass spectrometry. Clin Proteomics. 2017;14 :41. doi: 10.1186/s12014-017-9176-7. PubMed PMID:29234243 PubMed Central PMC5721679.
  6. Dufresne, J, Florentinus-Mefailoski, A, Ajambo, J, Ferwa, A, Bowden, P, Marshall, J et al.. The proteins cleaved by endogenous tryptic proteases in normal EDTA plasma by C18 collection of peptides for liquid chromatography micro electrospray ionization and tandem mass spectrometry. Clin Proteomics. 2017;14 :39. doi: 10.1186/s12014-017-9174-9. PubMed PMID:29213220 PubMed Central PMC5712186.
  7. Joly, P, Marshall, JC, Tessier, PA, Massé, C, Page, N, Frenette, AJ et al.. S100A8/A9 and sRAGE kinetic after polytrauma; an explorative observational study. Scand J Trauma Resusc Emerg Med. 2017;25 (1):114. doi: 10.1186/s13049-017-0455-0. PubMed PMID:29178941 PubMed Central PMC5702249.
  8. Marshall, JC. Sepsis Definitions: A Work in Progress. Crit Care Clin. 2018;34 (1):1-14. doi: 10.1016/j.ccc.2017.08.004. PubMed PMID:29149932 .
  9. Dufresne, J, Hoang, T, Ajambo, J, Florentinus-Mefailoski, A, Bowden, P, Marshall, J et al.. Freeze-dried plasma proteins are stable at room temperature for at least 1 year. Clin Proteomics. 2017;14 :35. doi: 10.1186/s12014-017-9170-0. PubMed PMID:29093647 PubMed Central PMC5659006.
  10. Jung, JJ, Pinto, R, Zarychanski, R, Cook, DJ, Jouvet, P, Marshall, JC et al.. 2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians. PLoS ONE. 2017;12 (10):e0184013. doi: 10.1371/journal.pone.0184013. PubMed PMID:29049285 PubMed Central PMC5648104.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto