John Marshall

MD, FRCSC, FACS, FCAHS

Scientist

Biography

Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Mendelson, AA, Lansdell, C, Fox-Robichaud, AE, Liaw, P, Arora, J, Cailhier, JF et al.. National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research. Intensive Care Med Exp. 2021;9 (1):14. doi: 10.1186/s40635-020-00366-4. PubMed PMID:33738642 PubMed Central PMC7973346.
  2. Leeies, M, Gershengorn, HB, Charbonney, E, Kumar, A, Fergusson, D, Turgeon, AF et al.. Correction to: Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians. Can J Anaesth. 2021; :. doi: 10.1007/s12630-021-01964-w. PubMed PMID:33694127 .
  3. Hughes, A, Marshall, JK, Moretti, ME, Ungar, WJ. A Cost-Utility Analysis of Switching from Reference to Biosimilar Infliximab Compared to Maintaining Reference Infliximab in Adult Patients with Crohn's Disease. J Can Assoc Gastroenterol. 2021;4 (1):48. doi: 10.1093/jcag/gwz045. PubMed PMID:33644677 PubMed Central PMC7898373.
  4. REMAP-CAP Investigators, Gordon, AC, Mouncey, PR, Al-Beidh, F, Rowan, KM, Nichol, AD et al.. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021; :. doi: 10.1056/NEJMoa2100433. PubMed PMID:33631065 PubMed Central PMC7953461.
  5. Benchimol, EI, Tse, F, Carroll, MW, deBruyn, JC, McNeil, SA, Pham-Huy, A et al.. TEMPORARY REMOVAL: Canadian Association of Gastroenterology CLINICAL Practice Guideline For Immunizations in Patients with Inflammatory Bowel Disease (IBD). Part 2: Inactivated Vaccines. Gastroenterology. 2021; :. doi: 10.1053/j.gastro.2020.12.079. PubMed PMID:33617891 .
  6. Aryal, D, Beane, A, Dondorp, AM, Green, C, Haniffa, R, Hashmi, M et al.. Operationalisation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 trials in a low and lower-middle income critical care learning health system. Wellcome Open Res. 2021;6 :14. doi: 10.12688/wellcomeopenres.16486.1. PubMed PMID:33604455 PubMed Central PMC7883321.
  7. Leeies, M, Gershengorn, HB, Charbonney, E, Kumar, A, Fergusson, D, Turgeon, AF et al.. Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians. Can J Anaesth. 2021; :. doi: 10.1007/s12630-021-01941-3. PubMed PMID:33598888 .
  8. DeMerle, KM, Angus, DC, Baillie, JK, Brant, E, Calfee, CS, Carcillo, J et al.. Sepsis Subclasses: A Framework for Development and Interpretation. Crit Care Med. 2021;49 (5):748-759. doi: 10.1097/CCM.0000000000004842. PubMed PMID:33591001 .
  9. Piva, S, DiBlasi, RM, Slee, AE, Jobe, AH, Roccaro, AM, Filippini, M et al.. Surfactant therapy for COVID-19 related ARDS: a retrospective case-control pilot study. Respir Res. 2021;22 (1):20. doi: 10.1186/s12931-020-01603-w. PubMed PMID:33461535 PubMed Central PMC7812332.
  10. Zhen, J, Marshall, JK, Nguyen, GC, Atreja, A, Narula, N. Impact of Digital Health Monitoring in the Management of Inflammatory Bowel Disease. J Med Syst. 2021;45 (2):23. doi: 10.1007/s10916-021-01706-x. PubMed PMID:33449213 PubMed Central PMC7808932.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
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