John Marshall

MD, FRCSC, FACS, FCAHS

Co-Director, Critical Illness and Injury Research Centre

Biography

Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Mack, DR, Benchimol, EI, Critch, J, deBruyn, J, Tse, F, Moayyedi, P et al.. Canadian Association of Gastroenterology Clinical Practice Guideline for the Medical Management of Pediatric Luminal Crohn's Disease. J Can Assoc Gastroenterol. 2019;2 (3):e35-e63. doi: 10.1093/jcag/gwz018. PubMed PMID:31294379 PubMed Central PMC6619414.
  2. Panaccione, R, Steinhart, AH, Bressler, B, Khanna, R, Marshall, JK, Targownik, L et al.. Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn's Disease. J Can Assoc Gastroenterol. 2019;2 (3):e1-e34. doi: 10.1093/jcag/gwz019. PubMed PMID:31294378 PubMed Central PMC6619415.
  3. Turpin, W, Espin-Garcia, O, Bedrani, L, Madsen, K, Meddings, JB, Raygoza Garay, JA et al.. Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease. Inflamm. Bowel Dis. 2019; :. doi: 10.1093/ibd/izz116. PubMed PMID:31251335 .
  4. Johnstone, J, Heels-Ansdell, D, Thabane, L, Meade, M, Marshall, J, Lauzier, F et al.. Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT. BMJ Open. 2019;9 (6):e025228. doi: 10.1136/bmjopen-2018-025228. PubMed PMID:31227528 .
  5. Prescott, HC, Iwashyna, TJ, Blackwood, B, Calandra, T, Chlan, LL, Choong, K et al.. Understanding and Enhancing Sepsis Survivorship: Priorities for Research and Practice. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201812-2383CP. PubMed PMID:31161771 .
  6. Jackson Chornenki, NL, Coke, R, Kwong, AC, Dwivedi, DJ, Xu, MK, McDonald, E et al.. Comparison of the source and prognostic utility of cfDNA in trauma and sepsis. Intensive Care Med Exp. 2019;7 (1):29. doi: 10.1186/s40635-019-0251-4. PubMed PMID:31119471 PubMed Central PMC6531595.
  7. Maslove, DM, Shapira, T, Tyryshkin, K, Veldhoen, RA, Marshall, JC, Muscedere, J et al.. Response to Letter to the Editor (Mangioni et al). J Crit Care. 2019;52 :269. doi: 10.1016/j.jcrc.2019.03.004. PubMed PMID:30922781 .
  8. Panaccione, R, Steinhart, AH, Bressler, B, Khanna, R, Marshall, JK, Targownik, L et al.. Clinical Practice Guideline for the Management of Luminal Crohn's Disease: The Toronto Consensus. Clin. Gastroenterol. Hepatol. 2019; :. doi: 10.1016/j.cgh.2019.02.043. PubMed PMID:30853616 .
  9. Marshall, JC, Walker, PM, Dellinger, RP. The Role of Endotoxin in Septic Shock-Reply. JAMA. 2019;321 (9):903. doi: 10.1001/jama.2018.20882. PubMed PMID:30835306 .
  10. Hoekstra, M, Maslove, DM, Veldhoen, RA, Marshall, JC, Muscedere, J. Insights Into a "Negative" ICU Trial Derived From Gene Expression Profiling. Crit. Care Med. 2019; :. doi: 10.1097/CCM.0000000000003693. PubMed PMID:30817329 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
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