John Marshall




Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Narula, N, Hu, A, Nguyen, GC, Rangrej, J, Marshall, JK. Periodic Colonoscopies Are Associated with Improved Survival and Prognosis of Colorectal Cancer in Ulcerative Colitis. Dig Dis Sci. 2021; :. doi: 10.1007/s10620-021-07151-7. PubMed PMID:34318355 .
  2. Beitler, JR, Thompson, BT, Baron, RM, Bastarache, JA, Denlinger, LC, Esserman, L et al.. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2021; :. doi: 10.1016/S2213-2600(21)00157-0. PubMed PMID:34310901 PubMed Central PMC8302189.
  3. Marshall, JC, Deutschman, CS. The Multiple Organ Dysfunction Syndrome: Syndrome, Metaphor, and Unsolved Clinical Challenge. Crit Care Med. 2021; :. doi: 10.1097/CCM.0000000000005139. PubMed PMID:34259449 .
  4. Arabi, YM, Gordon, AC, Derde, LPG, Nichol, AD, Murthy, S, Beidh, FA et al.. Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med. 2021;47 (8):867-886. doi: 10.1007/s00134-021-06448-5. PubMed PMID:34251506 PubMed Central PMC8274471.
  5. Narula, N, Wong, ECL, Colombel, JF, Riddell, R, Marshall, JK, Reinisch, W et al.. Early Change in Epithelial Neutrophilic Infiltrate Predicts Long-Term Response to Biologics in Ulcerative Colitis. Clin Gastroenterol Hepatol. 2021; :. doi: 10.1016/j.cgh.2021.07.005. PubMed PMID:34229037 .
  6. WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Shankar-Hari, M, Vale, CL, Godolphin, PJ, Fisher, D, Higgins, JPT et al.. Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis. JAMA. 2021; :. doi: 10.1001/jama.2021.11330. PubMed PMID:34228774 PubMed Central PMC8261689.
  7. Tsoporis, JN, Drosatos, IA, Gupta, S, Amatullah, H, Izhar, S, Dos Santos, CC et al.. Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology. Molecules. 2021;26 (13):. doi: 10.3390/molecules26133795. PubMed PMID:34206441 PubMed Central PMC8270312.
  8. Florentinus-Mefailoski, A, Bowden, P, Scheltens, P, Killestein, J, Teunissen, C, Marshall, JG et al.. The plasma peptides of Alzheimer's disease. Clin Proteomics. 2021;18 (1):17. doi: 10.1186/s12014-021-09320-2. PubMed PMID:34182925 PubMed Central PMC8240224.
  9. Rose, L, Burry, L, Agar, M, Blackwood, B, Campbell, NL, Clarke, M et al.. A core outcome set for studies evaluating interventions to prevent and/or treat delirium for adults requiring an acute care hospital admission: an international key stakeholder informed consensus study. BMC Med. 2021;19 (1):143. doi: 10.1186/s12916-021-02015-3. PubMed PMID:34140006 PubMed Central PMC8211534.
  10. Signorini, L, Moioli, G, Calza, S, Van Hauwermeiren, E, Lorenzotti, S, Del Fabro, G et al.. Epidemiological and Clinical Characterization of Superinfections in Critically Ill Coronavirus Disease 2019 Patients. Crit Care Explor. 2021;3 (6):e0430. doi: 10.1097/CCE.0000000000000430. PubMed PMID:34136819 PubMed Central PMC8202543.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto