John Marshall


Co-Director, Critical Illness and Injury Research Centre


Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Marshall, JC. Sepsis Definitions: A Work in Progress. Crit Care Clin. 2018;34 (1):1-14. doi: 10.1016/j.ccc.2017.08.004. PubMed PMID:29149932 .
  2. Dufresne, J, Hoang, T, Ajambo, J, Florentinus-Mefailoski, A, Bowden, P, Marshall, J et al.. Freeze-dried plasma proteins are stable at room temperature for at least 1 year. Clin Proteomics. 2017;14 :35. doi: 10.1186/s12014-017-9170-0. PubMed PMID:29093647 PubMed Central PMC5659006.
  3. Jung, JJ, Pinto, R, Zarychanski, R, Cook, DJ, Jouvet, P, Marshall, JC et al.. 2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians. PLoS ONE. 2017;12 (10):e0184013. doi: 10.1371/journal.pone.0184013. PubMed PMID:29049285 PubMed Central PMC5648104.
  4. McIntyre, LA, Stewart, DJ, Mei, SHJ, Courtman, D, Watpool, I, Granton, J et al.. Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201705-1006OC. PubMed PMID:28960096 .
  5. Marshall, JC. Steroids Redux: Targeting the Mineralocorticoid Axis in Sepsis. Crit. Care Med. 2017;45 (9):1582-1583. doi: 10.1097/CCM.0000000000002511. PubMed PMID:28816849 .
  6. Sebastián, UU, Ricardo, AVA, Alvarez, BC, Cubides, A, Luna, AF, Arroyo-Parejo, M et al.. Zika virus-induced neurological critical illness in Latin America: Severe Guillain-Barre Syndrome and encephalitis. J Crit Care. 2017;42 :275-281. doi: 10.1016/j.jcrc.2017.07.038. PubMed PMID:28806562 .
  7. Wong, HR, Marshall, JC. Leveraging Transcriptomics to Disentangle Sepsis Heterogeneity. Am. J. Respir. Crit. Care Med. 2017;196 (3):258-260. doi: 10.1164/rccm.201701-0143ED. PubMed PMID:28762788 PubMed Central PMC5549869.
  8. Philip, AM, Wang, Y, Mauro, A, El-Rass, S, Marshall, JC, Lee, WL et al.. Development of a zebrafish sepsis model for high-throughput drug discovery. Mol. Med. 2017;23 :. doi: 10.2119/molmed.2016.00188. PubMed PMID:28598490 PubMed Central PMC5522968.
  9. Lamontagne, F, Marshall, JC, Adhikari, NKJ. Permissive hypotension during shock resuscitation: equipoise in all patients?. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4849-2. PubMed PMID:28551721 .
  10. Perner, A, Gordon, AC, Angus, DC, Lamontagne, F, Machado, F, Russell, JA et al.. The intensive care medicine research agenda on septic shock. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4821-1. PubMed PMID:28500455 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto