John Marshall


Co-Director, Critical Illness and Injury Research Centre


Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Dos Santos, CC, Zehnbauer, BA, Trahtemberg, U, Marshall, J. Molecular Diagnosis of Coronavirus Disease 2019. Crit Care Explor. 2020;2 (9):e0184. doi: 10.1097/CCE.0000000000000184. PubMed PMID:33063040 PubMed Central PMC7515613.
  2. Turpin, W, Bedrani, L, Espin-Garcia, O, Xu, W, Silverberg, MS, Smith, MI et al.. Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn's disease subjects. BMC Med Genet. 2020;21 (1):204. doi: 10.1186/s12881-020-01115-w. PubMed PMID:33059653 PubMed Central PMC7566148.
  3. Sturdy, S, Miller, F, Hogarth, S, Armstrong, N, Chakraborty, P, Cressman, C et al.. Half a Century of Wilson & Jungner: Reflections on the Governance of Population Screening. Wellcome Open Res. 2020;5 :158. doi: 10.12688/wellcomeopenres.16057.2. PubMed PMID:32923689 PubMed Central PMC7468564.
  4. Tritschler, T, Mathieu, ME, Skeith, L, Rodger, M, Middeldorp, S, Brighton, T et al.. Anticoagulant interventions in hospitalized patients with COVID-19: A scoping review of randomized controlled trials and call for international collaboration. J Thromb Haemost. 2020; :. doi: 10.1111/jth.15094. PubMed PMID:32888372 .
  5. Writing Committee for the REMAP-CAP Investigators, Angus, DC, Derde, L, Al-Beidh, F, Annane, D, Arabi, Y et al.. Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial. JAMA. 2020;324 (13):1317-1329. doi: 10.1001/jama.2020.17022. PubMed PMID:32876697 PubMed Central PMC7489418.
  6. WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne, JAC, Murthy, S, Diaz, JV, Slutsky, AS, Villar, J et al.. Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis. JAMA. 2020;324 (13):1330-1341. doi: 10.1001/jama.2020.17023. PubMed PMID:32876694 PubMed Central PMC7489434.
  7. Martin-Loeches, I, Dickson, R, Torres, A, Hanberger, H, Lipman, J, Antonelli, M et al.. The importance of airway and lung microbiome in the critically ill. Crit Care. 2020;24 (1):537. doi: 10.1186/s13054-020-03219-4. PubMed PMID:32867808 PubMed Central PMC7457224.
  8. Sterne, JAC, Diaz, J, Villar, J, Murthy, S, Slutsky, AS, Perner, A et al.. Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials. Trials. 2020;21 (1):734. doi: 10.1186/s13063-020-04641-3. PubMed PMID:32831155 PubMed Central PMC7443535.
  9. Houston, BL, Lawler, PR, Goligher, EC, Farkouh, ME, Bradbury, C, Carrier, M et al.. Anti-Thrombotic Therapy to Ameliorate Complications of COVID-19 (ATTACC): Study design and methodology for an international, adaptive Bayesian randomized controlled trial. Clin Trials. 2020;17 (5):491-500. doi: 10.1177/1740774520943846. PubMed PMID:32815416 .
  10. Tong, A, Elliott, JH, Azevedo, LC, Baumgart, A, Bersten, A, Cervantes, L et al.. Core Outcomes Set for Trials in People With Coronavirus Disease 2019. Crit Care Med. 2020;48 (11):1622-1635. doi: 10.1097/CCM.0000000000004585. PubMed PMID:32804792 PubMed Central PMC7448717.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto