John Marshall


Co-Director, Critical Illness and Injury Research Centre


Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Osuchowski, MF, Ayala, A, Bahrami, S, Bauer, M, Boros, M, Cavaillon, JM et al.. Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis. Shock. 2018; :. doi: 10.1097/SHK.0000000000001212. PubMed PMID:30106875 .
  2. Zingarelli, B, Coopersmith, CM, Drechsler, S, Efron, P, Marshall, JC, Moldawer, L et al.. Part I: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) for Study Design And Humane Modeling Endpoints. Shock. 2018; :. doi: 10.1097/SHK.0000000000001243. PubMed PMID:30106874 .
  3. Osuchowski, MF, Ayala, A, Bahrami, S, Bauer, M, Boros, M, Cavaillon, JM et al.. Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection. 2018; :. doi: 10.1007/s15010-018-1183-8. PubMed PMID:30105433 .
  4. Steinhart, AH, Panaccione, R, Targownik, L, Bressler, B, Khanna, R, Marshall, JK et al.. Clinical Practice Guideline for the Medical Management of Perianal Fistulizing Crohn's Disease: The Toronto Consensus. Inflamm. Bowel Dis. 2018; :. doi: 10.1093/ibd/izy247. PubMed PMID:30099529 .
  5. Silversides, JA, Fitzgerald, E, Manickavasagam, US, Lapinsky, SE, Nisenbaum, R, Hemmings, N et al.. Deresuscitation of Patients With Iatrogenic Fluid Overload Is Associated With Reduced Mortality in Critical Illness. Crit. Care Med. 2018; :. doi: 10.1097/CCM.0000000000003276. PubMed PMID:29985214 .
  6. Wu, J, Han, B, Fanelli, V, Wen, X, Huang, Y, Luo, A et al.. Distinctive Roles and Mechanisms of Human Neutrophil Peptides in Experimental Sepsis and Acute Respiratory Distress Syndrome. Crit. Care Med. 2018;46 (9):e921-e927. doi: 10.1097/CCM.0000000000003265. PubMed PMID:29979223 .
  7. Gårdlund, B, Dmitrieva, NO, Pieper, CF, Finfer, S, Marshall, JC, Taylor Thompson, B et al.. Six subphenotypes in septic shock: Latent class analysis of the PROWESS Shock study. J Crit Care. 2018;47 :70-79. doi: 10.1016/j.jcrc.2018.06.012. PubMed PMID:29933169 .
  8. Marshall, JK, Bessette, L, Shear, NH, Lebovic, G, Glass, J, Millson, B et al.. Canada's Study of Adherence Outcomes in Patients Receiving Adalimumab: 3-year Results From the COMPANION Study. Clin Ther. 2018;40 (6):1024-1032. doi: 10.1016/j.clinthera.2018.04.017. PubMed PMID:29803532 .
  9. Xu, M, Li, J, Neves, MAD, Zhu, G, Carrim, N, Yu, R et al.. GPIbα is required for platelet-mediated hepatic thrombopoietin generation. Blood. 2018;132 (6):622-634. doi: 10.1182/blood-2017-12-820779. PubMed PMID:29794068 .
  10. Rezende-Neto, JB, Marcuzzi, D, Paskar, D, Sadler, E, Marshall, S, Nixon, K et al.. Multidisciplinary damage control management of life-threatening carotid blowout syndrome. Trauma Surg Acute Care Open. 2018;3 (1):e000166. doi: 10.1136/tsaco-2018-000166. PubMed PMID:29766140 PubMed Central PMC5887775.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto