John Marshall


Co-Director, Critical Illness and Injury Research Centre


Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Lamarche, D, Johnstone, J, Zytaruk, N, Clarke, F, Hand, L, Loukov, D et al.. Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study. Respir. Res. 2018;19 (1):245. doi: 10.1186/s12931-018-0950-5. PubMed PMID:30526610 .
  2. Dufresne, J, Bowden, P, Thavarajah, T, Florentinus-Mefailoski, A, Chen, ZZ, Tucholska, M et al.. The plasma peptidome. Clin Proteomics. 2018;15 :39. doi: 10.1186/s12014-018-9211-3. PubMed PMID:30519149 PubMed Central PMC6271647.
  3. Papp, KA, Haraoui, B, Kumar, D, Marshall, JK, Bissonnette, R, Bitton, A et al.. Vaccination Guidelines for Patients With Immune-Mediated Disorders on Immunosuppressive Therapies. J Cutan Med Surg. 2018; :1203475418811335. doi: 10.1177/1203475418811335. PubMed PMID:30463418 .
  4. McPeake, J, Hirshberg, EL, Christie, LM, Drumright, K, Haines, K, Hough, CL et al.. Models of Peer Support to Remediate Post-Intensive Care Syndrome: A Report Developed by the Society of Critical Care Medicine Thrive International Peer Support Collaborative. Crit. Care Med. 2018; :. doi: 10.1097/CCM.0000000000003497. PubMed PMID:30422863 .
  5. Maslove, DM, Shapira, T, Tyryshkin, K, Veldhoen, RA, Marshall, JC, Muscedere, J et al.. Validation of diagnostic gene sets to identify critically ill patients with sepsis. J Crit Care. 2019;49 :92-98. doi: 10.1016/j.jcrc.2018.10.028. PubMed PMID:30408726 .
  6. Dellinger, RP, Bagshaw, SM, Antonelli, M, Foster, DM, Klein, DJ, Marshall, JC et al.. Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial. JAMA. 2018;320 (14):1455-1463. doi: 10.1001/jama.2018.14618. PubMed PMID:30304428 PubMed Central PMC6233793.
  7. Baer, PA, Aumais, G, Ewara, EM, Khraishi, M, Marrache, AM, Panaccione, R et al.. Patterns and predictors of long-term retention of inflammatory bowel or rheumatoid disease patients on innovator infliximab: an analysis of a Canadian prescriptions claims database. Patient Prefer Adherence. 2018;12 :1805-1814. doi: 10.2147/PPA.S171363. PubMed PMID:30271124 PubMed Central PMC6154729.
  8. Taljaard, M, Weijer, C, Grimshaw, JM, Ali, A, Brehaut, JC, Campbell, MK et al.. Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol. Trials. 2018;19 (1):525. doi: 10.1186/s13063-018-2895-x. PubMed PMID:30261933 PubMed Central PMC6161426.
  9. Osuchowski, MF, Ayala, A, Bahrami, S, Bauer, M, Boros, M, Cavaillon, JM et al.. Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. Infection. 2018;46 (5):745-747. doi: 10.1007/s15010-018-1197-2. PubMed PMID:30225655 PubMed Central PMC6182465.
  10. Venkatesh, B, Mehta, S, Angus, DC, Finfer, S, Machado, FR, Marshall, J et al.. Women in Intensive Care study: a preliminary assessment of international data on female representation in the ICU physician workforce, leadership and academic positions. Crit Care. 2018;22 (1):211. doi: 10.1186/s13054-018-2139-1. PubMed PMID:30196796 PubMed Central PMC6130077.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto