Kalman Kovacs


Emeritus Scientist, Li Ka Shing Knowledge Institute


Dr. Kalman Thomas Kovacs is an Emeritus Professor of the Division of Pathology, Department of Laboratory Medicine at St. Michael’s Hospital.

Dr. Kovacs was born in Hungary. He received his MD from the University of Szeged, Hungary and his PhD from the University of Liverpool, England. He joined the Division of Pathology in 1971. At that time, apart from his duties as a diagnostic pathologist, his role was to develop research within the department, teach students, organize the electron microscopy laboratory, introduce immunohistochemistry methodology and be involved in the study of endocrine diseases-primarily diseases of the pituitary.

Dr. Kovacs has published several hundred peer-reviewed research papers, received several local and international awards, was invited to give lectures in many countries, and has supervised and mentored many students, residents and fellows. He has led various research projects and collaborated with research scientists at Cedar-Sinai Medical Center, Los Angeles, USA, Mayo Clinic, Rochester, MN, USA and Clinica Medellin, Colombia, as well as many other well recognized research centers in Brazil, Japan, Italy, and India.

Dr. Kovacs published and edited several books, wrote chapters, reviews and is active in teaching and research. He participated in several committees including the World Health Organization (WHO) classifying pituitary diseases. His research and contribution to pituitary disease and pathology has been recognized internationally. He is extensively involved in pituitary research and continues to be part of the Pathology and Neurosurgery team investigating pituitary diseases.

Dr. Kovacs’ research involved describing new pituitary tumor types, developing novel pituitary tumor classification and introducing new biomarkers which permit and simplify assessment of tumor cell proliferation, treatment options and therapeutic responsiveness.

Recent Publications

  1. Syro, LV, Rotondo, F, Camargo, M, Ortiz, LD, Serna, CA, Kovacs, K et al.. Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions. Front Endocrinol (Lausanne). 2018;9 :318. doi: 10.3389/fendo.2018.00318. PubMed PMID:29963012 PubMed Central PMC6013558.
  2. Syro, LV, Rotondo, F, Ortiz, LD, Kovacs, K. 65 YEARS OF THE DOUBLE HELIX: Treatment of pituitary tumors with temozolomide: an update. Endocr. Relat. Cancer. 2018;25 (8):T159-T169. doi: 10.1530/ERC-18-0015. PubMed PMID:29535142 .
  3. Solarski, M, Rotondo, F, Foulkes, WD, Priest, JR, Syro, LV, Butz, H et al.. DICER1 gene mutations in endocrine tumors. Endocr. Relat. Cancer. 2018;25 (3):R197-R208. doi: 10.1530/ERC-17-0509. PubMed PMID:29330195 .
  4. Solarski, M, Rotondo, F, Syro, LV, Cusimano, MD, Kovacs, K. Alpha subunit in clinically non-functioning pituitary adenomas: An immunohistochemical study. Pathol. Res. Pract. 2017;213 (9):1130-1133. doi: 10.1016/j.prp.2017.07.010. PubMed PMID:28780083 .
  5. Sav, A, Rotondo, F, Syro, LV, Altinoz, MA, Kovacs, K. Selective molecular biomarkers to predict biologic behavior in pituitary tumors. Expert Rev Endocrinol Metab. 2017;12 (3):177-185. doi: 10.1080/17446651.2017.1312341. PubMed PMID:30063456 .
  6. Rotondo, F, Qaddoura, A, Syro, LV, Karamchandani, J, Munoz, DG, Arroyave, MJ et al.. Immunoglobulin G4 (IgG4)-Related Hypophysitis. Endocr. Pathol. 2017;28 (4):308-314. doi: 10.1007/s12022-016-9464-1. PubMed PMID:28084610 .
  7. Di Michele, J, Rotondo, F, Kovacs, K, Syro, LV, Yousef, GM, Cusimano, MD et al.. Vasculogenic Mimicry in Clinically Non-functioning Pituitary Adenomas: a Histologic Study. Pathol. Oncol. Res. 2017;23 (4):803-809. doi: 10.1007/s12253-017-0196-4. PubMed PMID:28084580 .
  8. Syro, LV, Rotondo, F, Serna, CA, Ortiz, LD, Kovacs, K. Pathology of GH-producing pituitary adenomas and GH cell hyperplasia of the pituitary. Pituitary. 2017;20 (1):84-92. doi: 10.1007/s11102-016-0748-8. PubMed PMID:27586499 .
  9. Sav, A, Rotondo, F, Syro, LV, Di Ieva, A, Cusimano, MD, Kovacs, K et al.. Biomarkers of pituitary carcinomas. Expert Rev Endocrinol Metab. 2016;11 (3):253-261. doi: 10.1080/17446651.2016.1179110. PubMed PMID:30058931 .
  10. Rotondo, F, Butz, H, Syro, LV, Yousef, GM, Di Ieva, A, Restrepo, LM et al.. Arginine vasopressin (AVP): a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system. Pituitary. 2016;19 (4):345-55. doi: 10.1007/s11102-015-0703-0. PubMed PMID:26762848 .
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Affiliations & Other Activities

  • Professor, Division of Pathology, Department of Laboratory Medicine, University of Toronto