Karim Ladha


Associate Scientist, Li Ka Shing Knowledge Institute


Dr. Karim Ladha is a clinician-scientist and staff anesthesiologist at St. Michael’s Hospital and the University of Toronto. Dr. Ladha received his medical degree from the Johns Hopkins University School of Medicine. He then completed his anesthesia training at Massachusetts General Hospital and obtained a fellowship in cardiac anesthesia at Toronto General Hospital. He also holds a Master’s degree in clinical epidemiology from the Harvard School of Public Health. His program of research uses mixed methodologies to obtain a multifaceted view of pain and recovery after surgery including retrospective analyses of administrative databases, prospective observational studies, and multi-center randomized controlled trials. His research has been published in top-tier journals including JAMA, BMJ, British Journal of Anesthesia and Anesthesiology. He has received numerous awards for his work including the International Anesthesia Research Society Mentored Research Award, a new investigator award from the Canadian Anesthesiologists’ Society and the IMPACT award in anesthesia.

Please note: Dr. Ladha is not accepting any students at this time.

Recent Publications

  1. Zhang, DDQ, Dossa, F, Arora, A, Cusimano, MC, Speller, B, Little, T et al.. Recommendations for the Prescription of Opioids at Discharge After Abdominopelvic Surgery: A Systematic Review. JAMA Surg. 2020; :. doi: 10.1001/jamasurg.2019.5875. PubMed PMID:32159738 .
  2. Bethell, J, Neuman, MD, Bateman, BT, Hill, AD, Ladha, KS, Wijeysundera, DN et al.. Age and postoperative opioid prescriptions: a population-based cohort study of opioid-naïve adults. Pharmacoepidemiol Drug Saf. 2020; :. doi: 10.1002/pds.4964. PubMed PMID:32056336 .
  3. Little, B, Alshabrawy, O, Stow, D, Ferrier, IN, McNaney, R, Jackson, DG et al.. Deep learning-based automated speech detection as a marker of social functioning in late-life depression. Psychol Med. 2020; :1-10. doi: 10.1017/S0033291719003994. PubMed PMID:31944174 .
  4. Ladha, KS, Manoo, V, Virji, AF, Hanlon, JG, Mclaren-Blades, A, Goel, A et al.. The Impact of Perioperative Cannabis Use: A Narrative Scoping Review. Cannabis Cannabinoid Res. 2019;4 (4):219-230. doi: 10.1089/can.2019.0054. PubMed PMID:31872058 PubMed Central PMC6922064.
  5. Goel, A, McGuinness, B, Jivraj, NK, Wijeysundera, DN, Mittleman, MA, Bateman, BT et al.. Cannabis Use Disorder and Perioperative Outcomes in Major Elective Surgeries: A Retrospective Cohort Analysis. Anesthesiology. 2020;132 (4):625-635. doi: 10.1097/ALN.0000000000003067. PubMed PMID:31789638 .
  6. Khan, JS, Ladha, KS, Abdallah, F, Clarke, H. Treating Persistent Pain After Breast Cancer Surgery. Drugs. 2020;80 (1):23-31. doi: 10.1007/s40265-019-01227-5. PubMed PMID:31784873 .
  7. McNaney, R, Miller, N, Vines, J, Olivier, P, Ladha, K, Jackson, D et al.. The feasibility and acceptability of using a novel wrist worn cueing device to self-manage drooling problems in people with Parkinson's disease: A pilot study. J Rehabil Assist Technol Eng. ;6 :2055668319852529. doi: 10.1177/2055668319852529. PubMed PMID:31662884 PubMed Central PMC6796203.
  8. Wijeysundera, DN, Ladha, KS. Web Exclusive. Annals for Hospitalists Inpatient Notes - Rethinking the Role of Functional Capacity in Preoperative Risk Stratification. Ann. Intern. Med. 2019;171 (8):HO2-HO3. doi: 10.7326/M19-2846. PubMed PMID:31610575 .
  9. Lei Lei, E, Ladha, K, Mueller, B, Roche, L, Rao, V, Hickey, E et al.. Noncardiac determinants of death and intensive care morbidity in adult congenital heart disease surgery. J. Thorac. Cardiovasc. Surg. 2019; :. doi: 10.1016/j.jtcvs.2019.07.106. PubMed PMID:31585755 .
  10. Ladha, KS, Neuman, MD, Broms, G, Bethell, J, Bateman, BT, Wijeysundera, DN et al.. Opioid Prescribing After Surgery in the United States, Canada, and Sweden. JAMA Netw Open. 2019;2 (9):e1910734. doi: 10.1001/jamanetworkopen.2019.10734. PubMed PMID:31483475 PubMed Central PMC6727684.
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Affiliations & Other Activities

Department of Anesthesia and Pain Management – University of Toronto and St. Michael’s Hospital