Karim Ladha




Dr. Karim Ladha is a clinician-scientist and staff anesthesiologist at St. Michael’s Hospital and the University of Toronto. Dr. Ladha received his medical degree from the Johns Hopkins University School of Medicine. He then completed his anesthesia training at Massachusetts General Hospital and obtained a fellowship in cardiac anesthesia at Toronto General Hospital. He also holds a Master’s degree in clinical epidemiology from the Harvard School of Public Health. His program of research uses mixed methodologies to obtain a multifaceted view of pain and recovery after surgery including retrospective analyses of administrative databases, prospective observational studies, and multi-center randomized controlled trials. His research has been published in top-tier journals including JAMA, BMJ, British Journal of Anesthesia and Anesthesiology. He has received numerous awards for his work including the International Anesthesia Research Society Mentored Research Award, a new investigator award from the Canadian Anesthesiologists’ Society and the IMPACT award in anesthesia.

His current research interests include:

–       Exploring the use of anesthetic drugs such as ketamine and nitrous oxide to treat depression

–       Understanding the role of cannabis in mitigating pain

–       Using wearable technology and mobile applications to track recovery after surgery

Please note: Dr. Ladha is not accepting any students at this time.

Recent Publications

  1. Ladha, KS, McLaren-Blades, A, Clarke, H. Concerns about Recommendations for Perioperative Cannabis Use. JAMA Surg. 2021; :. doi: 10.1001/jamasurg.2021.2259. PubMed PMID:34132769 .
  2. Aternali, A, Slepian, PM, Clarke, H, Ladha, KS, Katznelson, R, McRae, K et al.. Presurgical distress about bodily sensations predicts chronic postsurgical pain intensity and disability 6 months after cardiothoracic surgery. Pain. 2021; :. doi: 10.1097/j.pain.0000000000002325. PubMed PMID:34086627 .
  3. Liu, CW, Page, MG, Weinrib, A, Wong, D, Huang, A, McRae, K et al.. Predictors of one year chronic post-surgical pain trajectories following thoracic surgery. J Anesth. 2021;35 (4):505-514. doi: 10.1007/s00540-021-02943-7. PubMed PMID:34002257 .
  4. Santa Mina, D, Sellers, D, Au, D, Alibhai, SMH, Clarke, H, Cuthbertson, BH et al.. A Pragmatic Non-Randomized Trial of Prehabilitation Prior to Cancer Surgery: Study Protocol and COVID-19-Related Adaptations. Front Oncol. 2021;11 :629207. doi: 10.3389/fonc.2021.629207. PubMed PMID:33777780 PubMed Central PMC7987917.
  5. COVIDSurg Collaborative, GlobalSurg Collaborative . SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. Br J Surg. 2021; :. doi: 10.1093/bjs/znab101. PubMed PMID:33761533 PubMed Central PMC7995808.
  6. COVIDSurg Collaborative, GlobalSurg Collaborative. Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study. Anaesthesia. 2021;76 (6):748-758. doi: 10.1111/anae.15458. PubMed PMID:33690889 PubMed Central PMC8206995.
  7. Diep, C, Bhat, V, Wijeysundera, DN, Clarke, HA, Ladha, KS. The Association between Recent Cannabis Use and Suicidal Ideation in Adults: A Population-based Analysis of the NHANES from 2005 to 2018: L'association Entre L'utilisation Récente de Cannabis et L'idéation Suicidaire Chez les Adultes: Une Analyse Dans la Population de la NHANES de 2005 à 2018. Can J Psychiatry. 2021; :706743721996112. doi: 10.1177/0706743721996112. PubMed PMID:33641436 .
  8. Meng, H, Page, MG, Ajrawat, P, Deshpande, A, Samman, B, Dominicis, M et al.. Patient-reported outcomes in those consuming medical cannabis: a prospective longitudinal observational study in chronic pain patients. Can J Anaesth. 2021;68 (5):633-644. doi: 10.1007/s12630-020-01903-1. PubMed PMID:33469735 .
  9. Ramos, RJ, Ladha, KS, Cuthbertson, BH, Shulman, MA, Myles, PS, Wijeysundera, DN et al.. Association of six-minute walk test distance with postoperative complications in non-cardiac surgery: a secondary analysis of a multicentre prospective cohort study. Can J Anaesth. 2021;68 (4):514-529. doi: 10.1007/s12630-020-01909-9. PubMed PMID:33442834 PubMed Central PMC7932965.
  10. Ladha, KS, McLaren-Blades, A, Goel, A, Buys, MJ, Farquhar-Smith, P, Haroutounian, S et al.. Perioperative Pain and Addiction Interdisciplinary Network (PAIN): consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users by a modified Delphi process. Br J Anaesth. 2021;126 (1):304-318. doi: 10.1016/j.bja.2020.09.026. PubMed PMID:33129489 .
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Affiliations & Other Activities

Department of Anesthesia and Pain Management – University of Toronto and St. Michael’s Hospital