Karim Ladha


Associate Scientist, Li Ka Shing Knowledge Institute


Dr. Karim Ladha is a clinician-scientist and staff anesthesiologist at St. Michael’s Hospital and the University of Toronto. Dr. Ladha received his medical degree from the Johns Hopkins University School of Medicine. He then completed his anesthesia training at Massachusetts General Hospital and obtained a fellowship in cardiac anesthesia at Toronto General Hospital. He also holds a Master’s degree in clinical epidemiology from the Harvard School of Public Health. His program of research uses mixed methodologies to obtain a multifaceted view of pain and recovery after surgery including retrospective analyses of administrative databases, prospective observational studies, and multi-center randomized controlled trials. His research has been published in top-tier journals including JAMA, BMJ, British Journal of Anesthesia and Anesthesiology. He has received numerous awards for his work including the International Anesthesia Research Society Mentored Research Award, a new investigator award from the Canadian Anesthesiologists’ Society and the IMPACT award in anesthesia.

Recent Publications

  1. Ladha, KS, Neuman, MD, Broms, G, Bethell, J, Bateman, BT, Wijeysundera, DN et al.. Opioid Prescribing After Surgery in the United States, Canada, and Sweden. JAMA Netw Open. 2019;2 (9):e1910734. doi: 10.1001/jamanetworkopen.2019.10734. PubMed PMID:31483475 .
  2. Thevathasan, T, Copeland, CC, Long, DR, Patrocínio, MD, Friedrich, S, Grabitz, SD et al.. The Impact of Postoperative Intensive Care Unit Admission on Postoperative Hospital Length of Stay and Costs: A Prespecified Propensity-Matched Cohort Study. Anesth. Analg. 2019;129 (3):753-761. doi: 10.1213/ANE.0000000000003946. PubMed PMID:31425217 .
  3. Zhang, DDQ, Sussman, J, Dossa, F, Jivraj, N, Ladha, K, Brar, S et al.. A Systematic Review of Behavioral Interventions to Decrease Opioid Prescribing After Surgery. Ann. Surg. 2019; :. doi: 10.1097/SLA.0000000000003483. PubMed PMID:31356268 .
  4. Ladha, KS, Wijeysundera, DN. Perioperative outcomes: easier to predict but harder to change. Can J Anaesth. 2019;66 (9):1014-1017. doi: 10.1007/s12630-019-01434-4. PubMed PMID:31267485 .
  5. Goel, A, Azargive, S, Weissman, JS, Shanthanna, H, Hanlon, JG, Samman, B et al.. Perioperative Pain and Addiction Interdisciplinary Network (PAIN) clinical practice advisory for perioperative management of buprenorphine: results of a modified Delphi process. Br J Anaesth. 2019;123 (2):e333-e342. doi: 10.1016/j.bja.2019.03.044. PubMed PMID:31153631 PubMed Central PMC6676043.
  6. Goel, A, Azargive, S, Weissman, JS, Shanthanna, H, Ladha, KS, Lamba, W et al.. Perioperative Pain and Addiction Interdisciplinary Network (PAIN): protocol of a practice advisory for the perioperative management of buprenorphine using a modified Delphi process. BMJ Open. 2019;9 (5):e027374. doi: 10.1136/bmjopen-2018-027374. PubMed PMID:31122990 PubMed Central PMC6538090.
  7. Au, D, Matthew, AG, Lopez, P, Hilton, WJ, Awasthi, R, Bousquet-Dion, G et al.. Prehabilitation and acute postoperative physical activity in patients undergoing radical prostatectomy: a secondary analysis from an RCT. Sports Med Open. 2019;5 (1):18. doi: 10.1186/s40798-019-0191-2. PubMed PMID:31119491 PubMed Central PMC6531507.
  8. Sniehotta, FF, Evans, EH, Sainsbury, K, Adamson, A, Batterham, A, Becker, F et al.. Behavioural intervention for weight loss maintenance versus standard weight advice in adults with obesity: A randomised controlled trial in the UK (NULevel Trial). PLoS Med. 2019;16 (5):e1002793. doi: 10.1371/journal.pmed.1002793. PubMed PMID:31063507 PubMed Central PMC6504043.
  9. Clarke, H, Ladha, K. Time for accountability and change: institutional gaps in pain care during the opioid crisis. Br J Anaesth. 2019;122 (6):e90-e93. doi: 10.1016/j.bja.2019.02.015. PubMed PMID:30916037 .
  10. Dhanju, S, Kennedy, SH, Abbey, S, Katz, J, Weinrib, A, Clarke, H et al.. The impact of comorbid pain and depression in the United States: results from a nationally representative survey. Scand J Pain. 2019;19 (2):319-325. doi: 10.1515/sjpain-2018-0323. PubMed PMID:30759071 .
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Affiliations & Other Activities

Department of Anesthesia and Pain Management – University of Toronto and St. Michael’s Hospital