Katharine Dunlop

PhD

Scientist, Keenan Research Centre for Biomedical Science

Research Programs

Biography

Dr. Katharine Dunlop is a scientist at the Centre for Depression and Suicide Studies, and an Assistant Professor of Psychiatry at the University of Toronto. Dr. Dunlop received her PhD in Medical Science in 2018 at the University of Toronto, Institute of Medical Science, as a CIHR Vanier Scholar. She also completed a postdoctoral fellowship in neuroscience as a CIHR Banting Fellow in the Department of Psychiatry at Weill Cornell Medicine in 2021.

Dr. Dunlop uses cognitive science, human structural and functional neuroimaging, and non-invasive brain stimulation (e.g., transcranial magnetic stimulation) to investigate the biological underpinnings of inter-individual variability in behaviour and symptomatology, treatment response, and predictors of symptom improvement. Her current research program aims: (1) to develop circuit-based models of symptom-specific antidepressant response, with a focus on glutamatergic modulation, psychosocial stress and reward processing; (2) to investigate the structural, functional and behavioural factors that influence non-invasive brain stimulation-evoked brain activity and plasticity; and (3) to translate this knowledge into clinical practice to aid in diagnosis and treatment selection.

Recent Publications

  1. Jaywant, A, Dunlop, K, Victoria, LW, Oberlin, L, Lynch, CJ, Respino, M et al.. Estimated Regional White Matter Hyperintensity Burden, Resting State Functional Connectivity, and Cognitive Functions in Older Adults. Am J Geriatr Psychiatry. 2021; :. doi: 10.1016/j.jagp.2021.07.015. PubMed PMID:34412936 .
  2. Woodside, DB, Dunlop, K, Sathi, C, Lam, E, McDonald, B, Downar, J et al.. A pilot trial of repetitive transcranial magnetic stimulation of the dorsomedial prefrontal cortex in anorexia nervosa: resting fMRI correlates of response. J Eat Disord. 2021;9 (1):52. doi: 10.1186/s40337-021-00411-x. PubMed PMID:33865456 PubMed Central PMC8052685.
  3. Dunlop, K, Victoria, LW, Downar, J, Gunning, FM, Liston, C. Accelerated brain aging predicts impulsivity and symptom severity in depression. Neuropsychopharmacology. 2021;46 (5):911-919. doi: 10.1038/s41386-021-00967-x. PubMed PMID:33495545 PubMed Central PMC8115107.
  4. Solomonov, N, Victoria, LW, Dunlop, K, Respino, M, Hoptman, MJ, Zilcha-Mano, S et al.. Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression. Am J Geriatr Psychiatry. 2020;28 (8):859-868. doi: 10.1016/j.jagp.2020.04.008. PubMed PMID:32376080 PubMed Central PMC7369214.
  5. Dunlop, K, Rizvi, SJ, Kennedy, SH, Hassel, S, Strother, SC, Harris, JK et al.. Clinical, behavioral, and neural measures of reward processing correlate with escitalopram response in depression: a Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report. Neuropsychopharmacology. 2020;45 (8):1390-1397. doi: 10.1038/s41386-020-0688-x. PubMed PMID:32349119 PubMed Central PMC7297974.
  6. Dunlop, K, Sheen, J, Schulze, L, Fettes, P, Mansouri, F, Feffer, K et al.. Dorsomedial prefrontal cortex repetitive transcranial magnetic stimulation for treatment-refractory major depressive disorder: A three-arm, blinded, randomized controlled trial. Brain Stimul. ;13 (2):337-340. doi: 10.1016/j.brs.2019.10.020. PubMed PMID:31711880 .
  7. Dunlop, K, Talishinsky, A, Liston, C. Intrinsic Brain Network Biomarkers of Antidepressant Response: a Review. Curr Psychiatry Rep. 2019;21 (9):87. doi: 10.1007/s11920-019-1072-6. PubMed PMID:31410661 PubMed Central PMC6692448.
  8. Dunlop, K, Liston, C. Stress response regulation and the hemodynamic response. Proc Natl Acad Sci U S A. 2018;115 (43):10827-10829. doi: 10.1073/pnas.1814592115. PubMed PMID:30309958 PubMed Central PMC6205467.
  9. Kolla, NJ, Dunlop, K, Meyer, JH, Downar, J. Corticostriatal Connectivity in Antisocial Personality Disorder by MAO-A Genotype and Its Relationship to Aggressive Behavior. Int J Neuropsychopharmacol. 2018;21 (8):725-733. doi: 10.1093/ijnp/pyy035. PubMed PMID:29746646 PubMed Central PMC6070029.
  10. Fettes, PW, Moayedi, M, Dunlop, K, Mansouri, F, Vila-Rodriguez, F, Giacobbe, P et al.. Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3 (4):337-347. doi: 10.1016/j.bpsc.2017.12.003. PubMed PMID:29628066 .
Search PubMed
X