Kim A. Connelly

FRACP, PhD, MBBS

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Kim Connelly is a Cardiologist and Scientist who is both nationally recognized as an expert in human and rodent echocardiography, cardiovascular MRI and the impact of diabetes upon cardiac function. His work has been recognized evident by winning the “Young Investigator of the Year Award” in 2012 by the Canadian Cardiovascular Society an Early Researcher Award in 2014, and a Canadian Institutes of Health Research (CIHR) New Investigator award in 2014.

Dr. Connelly runs a basic research laboratory at the Keenan Research Centre for Biomedical Science (KRCBS) at St. Michael’s Hospital where he focuses upon basic mechanisms of disease – primarily around the role of pathological extracellular matrix accumulation and the pro-sclerotic cytokine transforming growth factor beta, with a focus upon translating discoveries into therapies in humans. He is the Director of the Krembil Stem Cell Facility at St. Michael’s Hospital and uses stem cell based therapies to improve cardiac and renal dysfunction as a result of diabetes. He collaborates extensively not only locally in Toronto but also nationally and internationally – with research support from the Heart and Stroke Foundation (HSF) of Canada, CIHR and Canadian Foundation for Innovation along with significant research support from the pharmaceutical industry.

Locally, he sits on the executive of the University of Toronto Cardiovascular research network, and has been a reviewer for both the CIHR “CSB” panel, along with the Heart and Stroke Foundation of Canada (HSF). He was the national spokesperson for the HSF of Canada “heart healthy month” in February 2015.

Recent Publications

  1. Gandhi, S, Ho, EC, Ong, G, Zahrani, M, Lu, J, Leong-Poi, H et al.. A Physician Education Tool to Improve Appropriate Use Criteria for Stress Echocardiography: Long-Term Follow-Up of a Single-Center Study. J Am Soc Echocardiogr. 2019; :. doi: 10.1016/j.echo.2019.05.017. PubMed PMID:31311701 .
  2. Connelly, KA, Yan, AT, Amir, E, Thavendiranathan, P. CMR and Tissue Characterization: Don't Forget the Strain!. J. Am. Coll. Cardiol. 2019;73 (25):3359. doi: 10.1016/j.jacc.2019.03.521. PubMed PMID:31248561 .
  3. Roifman, I, Gutierrez, J, Wang, E, Biswas, L, Sparkes, J, Connelly, KA et al.. Evaluating a novel free-breathing accelerated cardiac MRI cine sequence in patients with cardiomyopathy. Magn Reson Imaging. 2019;61 :260-266. doi: 10.1016/j.mri.2019.06.008. PubMed PMID:31200025 .
  4. Dhir, V, Yan, AT, Nisenbaum, R, Sloninko, J, Connelly, KA, Barfett, J et al.. Assessment of left ventricular function by CMR versus MUGA scans in breast cancer patients receiving trastuzumab: a prospective observational study. Int J Cardiovasc Imaging. 2019; :. doi: 10.1007/s10554-019-01648-z. PubMed PMID:31197526 .
  5. Winther, S, Williams, LK, Keir, M, Connelly, KA, Bradley, TJ, Rakowski, H et al.. Cardiovascular Magnetic Resonance Provides Evidence of Abnormal Myocardial Strain and Primary Cardiomyopathy in Marfan syndrome. J Comput Assist Tomogr. 2019; :. doi: 10.1097/RCT.0000000000000863. PubMed PMID:31082985 .
  6. Winther, S, Williams, LK, Keir, M, Connelly, KA, Bradley, TJ, Rakowski, H et al.. Cardiovascular Magnetic Resonance Provides Evidence of Abnormal Myocardial Strain and Primary Cardiomyopathy in Marfan syndrome. J Comput Assist Tomogr. ;43 (3):410-415. doi: 10.1097/RCT.0000000000000863. PubMed PMID:31082946 .
  7. Connelly, KA, Zhang, Y, Visram, A, Advani, A, Batchu, SN, Desjardins, JF et al.. Empagliflozin Improves Diastolic Function in a Nondiabetic Rodent Model of Heart Failure With Preserved Ejection Fraction. JACC Basic Transl Sci. 2019;4 (1):27-37. doi: 10.1016/j.jacbts.2018.11.010. PubMed PMID:30847416 PubMed Central PMC6390677.
  8. Banks, L, Connelly, KA. Pre-exercise Stress Testing in Type 2 Diabetes: Another Case of Choosing Wisely?. Can J Cardiol. 2019;35 (2):150-152. doi: 10.1016/j.cjca.2018.12.008. PubMed PMID:30760420 .
  9. Song, L, Brezden-Masley, C, Ramanan, V, Ghugre, N, Barfett, JJ, Chan, KKW et al.. Serial Measurements of Left Ventricular Systolic and Diastolic Function by Cardiac Magnetic Resonance Imaging in Patients with Early Stage Breast Cancer on Trastuzumab. Am. J. Cardiol. 2019;123 (7):1173-1179. doi: 10.1016/j.amjcard.2018.12.046. PubMed PMID:30683420 .
  10. Gilbert, RE, Connelly, KA. Reduction in the incidence of myocardial infarction with sodium-glucose linked cotransporter-2 inhibitors: evident and plausible. Cardiovasc Diabetol. 2019;18 (1):6. doi: 10.1186/s12933-019-0812-6. PubMed PMID:30634959 PubMed Central PMC6329062.
Search PubMed

Affiliations & Other Activities

  • Director, Krembil Stem Cell Facility, St. Michael’s Hospital
  • Staff Cardiologist, Division of Cardiology, St. Michael’s Hospital
  • Member, Richard Lewar Center, University of Toronto
  • Cardiologist, Division of Cardiology, Sunnybrook Health Sciences Centre
X