Kim A. Connelly

FRACP, PhD, MBBS

Scientist

Biography

Dr. Kim Connelly is a Cardiologist and Scientist who is both nationally recognized as an expert in human and rodent echocardiography, cardiovascular MRI and the impact of diabetes upon cardiac function. His work has been recognized evident by winning the “Young Investigator of the Year Award” in 2012 by the Canadian Cardiovascular Society an Early Researcher Award in 2014, and a Canadian Institutes of Health Research (CIHR) New Investigator award in 2014.

Dr. Connelly runs a basic research laboratory at the Keenan Research Centre for Biomedical Science (KRCBS) at St. Michael’s Hospital where he focuses upon basic mechanisms of disease – primarily around the role of pathological extracellular matrix accumulation and the pro-sclerotic cytokine transforming growth factor beta, with a focus upon translating discoveries into therapies in humans. He is the Director of the Krembil Stem Cell Facility at St. Michael’s Hospital and uses stem cell based therapies to improve cardiac and renal dysfunction as a result of diabetes. He collaborates extensively not only locally in Toronto but also nationally and internationally – with research support from the Heart and Stroke Foundation (HSF) of Canada, CIHR and Canadian Foundation for Innovation along with significant research support from the pharmaceutical industry.

Locally, he sits on the executive of the University of Toronto Cardiovascular research network, and has been a reviewer for both the CIHR “CSB” panel, along with the Heart and Stroke Foundation of Canada (HSF). He was the national spokesperson for the HSF of Canada “heart healthy month” in February 2015.

Recent Publications

  1. Gordon, M, Meagher, P, Connelly, KA. Effect of Empagliflozin and Liraglutide on the Nucleotide-Binding and Oligomerization Domain-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome in a Rodent Model of Type 2 Diabetes Mellitus. Can J Diabetes. 2020; :. doi: 10.1016/j.jcjd.2020.11.003. PubMed PMID:33388277 .
  2. Banks, L, Randhawa, VK, Caterini, J, Colella, TJF, Dhanvantari, S, McMurtry, S et al.. Sex, Gender, and Equity in Cardiovascular Medicine, Surgery, and Science in Canada: Challenges, Successes, and Opportunities for Change. CJC Open. 2020;2 (6):522-529. doi: 10.1016/j.cjco.2020.06.016. PubMed PMID:33305212 PubMed Central PMC7711008.
  3. Ali, FM, Ong, G, Edwards, J, Connelly, KA, Fam, NP. Comparison of transcatheter tricuspid valve repair using the MitraClip NTR and XTR systems. Int J Cardiol. 2020; :. doi: 10.1016/j.ijcard.2020.11.073. PubMed PMID:33301831 .
  4. McKinney, J, Connelly, KA, Dorian, P, Fournier, A, Goodman, JM, Grubic, N et al.. COVID-19 - Myocarditis and Return-to-play: Reflections and Recommendations from a Canadian Working Group. Can J Cardiol. 2020; :. doi: 10.1016/j.cjca.2020.11.007. PubMed PMID:33248208 PubMed Central PMC7688421.
  5. Veitch, MR, Thai, K, Zhang, Y, Desjardins, JF, Kabir, G, Connelly, KA et al.. Late intervention in the remnant kidney model attenuates proteinuria but not glomerular filtration rate decline. Nephrology (Carlton). 2020; :. doi: 10.1111/nep.13828. PubMed PMID:33179827 .
  6. Chin, K, Cazorla-Bak, MP, Liu, E, Nghiem, L, Zhang, Y, Yu, J et al.. Renal microvascular oxygen tension during hyperoxia and acute hemodilution assessed by phosphorescence quenching and excitation with blue and red light. Can J Anaesth. 2020; :. doi: 10.1007/s12630-020-01848-5. PubMed PMID:33174162 .
  7. Banks, L, Al-Mousawy, S, Altaha, MA, Konieczny, KM, Osman, W, Currie, KD et al.. Cardiac remodeling in middle-aged endurance athletes: relation between signal-averaged electrocardiogram and LV mass. Am J Physiol Heart Circ Physiol. 2021;320 (1):H316-H322. doi: 10.1152/ajpheart.00602.2020. PubMed PMID:33124882 .
  8. Miura, M, Alessandrini, H, Alkhodair, A, Attinger-Toller, A, Biasco, L, Lurz, P et al.. Impact of Massive or Torrential Tricuspid Regurgitation in Patients Undergoing Transcatheter Tricuspid Valve Intervention. JACC Cardiovasc Interv. 2020;13 (17):1999-2009. doi: 10.1016/j.jcin.2020.05.011. PubMed PMID:32912460 .
  9. Huang, F, Connelly, PW, Prasad, GVR, Nash, MM, Gunaratnam, L, Deva, DP et al.. Evaluation of left atrial remodeling in kidney transplant patients using cardiac magnetic resonance imaging. J Nephrol. 2020; :. doi: 10.1007/s40620-020-00853-7. PubMed PMID:32910428 .
  10. Garg, V, Verma, S, Connelly, KA, Yan, AT, Sikand, A, Garg, A et al.. Does empagliflozin modulate the autonomic nervous system among individuals with type 2 diabetes and coronary artery disease? The EMPA-HEART CardioLink-6 Holter analysis. Metabol Open. 2020;7 :100039. doi: 10.1016/j.metop.2020.100039. PubMed PMID:32812924 PubMed Central PMC7424781.
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Affiliations & Other Activities

  • Director, Krembil Stem Cell Facility, St. Michael’s Hospital
  • Staff Cardiologist, Division of Cardiology, St. Michael’s Hospital
  • Member, Richard Lewar Center, University of Toronto
  • Cardiologist, Division of Cardiology, Sunnybrook Health Sciences Centre
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