Kim A. Connelly

FRACP, PhD, MBBS

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Kim Connelly is a Cardiologist and Scientist who is both nationally recognized as an expert in human and rodent echocardiography, cardiovascular MRI and the impact of diabetes upon cardiac function. His work has been recognized evident by winning the “Young Investigator of the Year Award” in 2012 by the Canadian Cardiovascular Society an Early Researcher Award in 2014, and a Canadian Institutes of Health Research (CIHR) New Investigator award in 2014.

Dr. Connelly runs a basic research laboratory at the Keenan Research Centre for Biomedical Science (KRCBS) at St. Michael’s Hospital where he focuses upon basic mechanisms of disease – primarily around the role of pathological extracellular matrix accumulation and the pro-sclerotic cytokine transforming growth factor beta, with a focus upon translating discoveries into therapies in humans. He is the Director of the Krembil Stem Cell Facility at St. Michael’s Hospital and uses stem cell based therapies to improve cardiac and renal dysfunction as a result of diabetes. He collaborates extensively not only locally in Toronto but also nationally and internationally – with research support from the Heart and Stroke Foundation (HSF) of Canada, CIHR and Canadian Foundation for Innovation along with significant research support from the pharmaceutical industry.

Locally, he sits on the executive of the University of Toronto Cardiovascular research network, and has been a reviewer for both the CIHR “CSB” panel, along with the Heart and Stroke Foundation of Canada (HSF). He was the national spokesperson for the HSF of Canada “heart healthy month” in February 2015.

Recent Publications

  1. Taramasso, M, Benfari, G, van der Bijl, P, Alessandrini, H, Attinger-Toller, A, Biasco, L et al.. Transcatheter versus medical treatment of symptomatic severe tricuspid regurgitation. J. Am. Coll. Cardiol. 2019; :. doi: 10.1016/j.jacc.2019.09.028. PubMed PMID:31568868 .
  2. Lee, CY, Soliman, H, Geraghty, BJ, Chen, AP, Connelly, KA, Endre, R et al.. Lactate topography of the human brain using hyperpolarized 13C-MRI. Neuroimage. 2019;204 :116202. doi: 10.1016/j.neuroimage.2019.116202. PubMed PMID:31557546 .
  3. Hess, DA, Terenzi, DC, Trac, JZ, Quan, A, Mason, T, Al-Omran, M et al.. SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus. Cell Metab. 2019;30 (4):609-613. doi: 10.1016/j.cmet.2019.08.015. PubMed PMID:31477497 .
  4. Verma, S, Mazer, CD, Yan, AT, Mason, T, Garg, V, Teoh, H et al.. Effect of Empagliflozin on Left Ventricular Mass in Patients with Type 2 Diabetes and Coronary Artery Disease: The EMPA-HEART CardioLink-6 Randomized Clinical Trial. Circulation. 2019; :. doi: 10.1161/CIRCULATIONAHA.119.042375. PubMed PMID:31434508 .
  5. Mehr, M, Taramasso, M, Besler, C, Ruf, T, Connelly, KA, Weber, M et al.. 1-Year Outcomes After Edge-to-Edge Valve Repair for Symptomatic Tricuspid Regurgitation: Results From the TriValve Registry. JACC Cardiovasc Interv. 2019;12 (15):1451-1461. doi: 10.1016/j.jcin.2019.04.019. PubMed PMID:31395215 .
  6. Konieczny, K, Banks, L, Osman, W, Glibbery, M, Connelly, KA, Yan, AT et al.. Prolonged P wave duration is associated with right atrial dimensions, but not atrial arrhythmias, in middle-aged endurance athletes. J Electrocardiol. ;56 :115-120. doi: 10.1016/j.jelectrocard.2019.07.002. PubMed PMID:31394411 .
  7. Gandhi, S, Ho, EC, Ong, G, Zahrani, M, Lu, J, Leong-Poi, H et al.. A Physician Education Tool to Improve Appropriate Use Criteria for Stress Echocardiography: Long-Term Follow-Up of a Single-Center Study. J Am Soc Echocardiogr. 2019;32 (9):1255-1257. doi: 10.1016/j.echo.2019.05.017. PubMed PMID:31311701 .
  8. Connelly, KA, Yan, AT, Amir, E, Thavendiranathan, P. CMR and Tissue Characterization: Don't Forget the Strain!. J. Am. Coll. Cardiol. 2019;73 (25):3359. doi: 10.1016/j.jacc.2019.03.521. PubMed PMID:31248561 .
  9. Roifman, I, Gutierrez, J, Wang, E, Biswas, L, Sparkes, J, Connelly, KA et al.. Evaluating a novel free-breathing accelerated cardiac MRI cine sequence in patients with cardiomyopathy. Magn Reson Imaging. 2019;61 :260-266. doi: 10.1016/j.mri.2019.06.008. PubMed PMID:31200025 .
  10. Dhir, V, Yan, AT, Nisenbaum, R, Sloninko, J, Connelly, KA, Barfett, J et al.. Assessment of left ventricular function by CMR versus MUGA scans in breast cancer patients receiving trastuzumab: a prospective observational study. Int J Cardiovasc Imaging. 2019; :. doi: 10.1007/s10554-019-01648-z. PubMed PMID:31197526 .
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Affiliations & Other Activities

  • Director, Krembil Stem Cell Facility, St. Michael’s Hospital
  • Staff Cardiologist, Division of Cardiology, St. Michael’s Hospital
  • Member, Richard Lewar Center, University of Toronto
  • Cardiologist, Division of Cardiology, Sunnybrook Health Sciences Centre
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