Kim A. Connelly

FRACP, PhD, MBBS

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Kim Connelly is a Cardiologist and Scientist who is both nationally recognized as an expert in human and rodent echocardiography, cardiovascular MRI and the impact of diabetes upon cardiac function. His work has been recognized evident by winning the “Young Investigator of the Year Award” in 2012 by the Canadian Cardiovascular Society an Early Researcher Award in 2014, and a Canadian Institutes of Health Research (CIHR) New Investigator award in 2014.

Dr. Connelly runs a basic research laboratory at the Keenan Research Centre for Biomedical Science (KRCBS) at St. Michael’s Hospital where he focuses upon basic mechanisms of disease – primarily around the role of pathological extracellular matrix accumulation and the pro-sclerotic cytokine transforming growth factor beta, with a focus upon translating discoveries into therapies in humans. He is the Director of the Krembil Stem Cell Facility at St. Michael’s Hospital and uses stem cell based therapies to improve cardiac and renal dysfunction as a result of diabetes. He collaborates extensively not only locally in Toronto but also nationally and internationally – with research support from the Heart and Stroke Foundation (HSF) of Canada, CIHR and Canadian Foundation for Innovation along with significant research support from the pharmaceutical industry.

Locally, he sits on the executive of the University of Toronto Cardiovascular research network, and has been a reviewer for both the CIHR “CSB” panel, along with the Heart and Stroke Foundation of Canada (HSF). He was the national spokesperson for the HSF of Canada “heart healthy month” in February 2015.

Recent Publications

  1. Roifman, I, Qiu, F, Connelly, KA, Wright, GA, Farkouh, M, Jimenez-Juan, L et al.. Validation of billing code combinations to identify cardiovascular magnetic resonance imaging scans in Ontario, Canada: a retrospective cohort study. BMJ Open. 2018;8 (10):e021370. doi: 10.1136/bmjopen-2017-021370. PubMed PMID:30297345 .
  2. Law, TK, Wald, R, Goldstein, M, Karur, GR, Ng, MY, Wang, AYM et al.. Left Atrial Remodeling Assessed by Cardiac MRI after Conversion from Conventional Hemodialysis to In-Centre Nocturnal Hemodialysis. J. Nephrol. 2018; :. doi: 10.1007/s40620-018-0522-2. PubMed PMID:30168083 .
  3. Batchu, SN, Thieme, K, Zadeh, FH, Alghamdi, TA, Yerra, VG, Hadden, MJ et al.. The Dipeptidyl Peptidase-4 Substrate CXCL12 has Opposing Cardiac Effects in Young Mice and Aged Diabetic Mice Mediated By Ca2+ Flux and Phosphoinositide 3-Kinase γ. Diabetes. 2018; :. doi: 10.2337/db18-0410. PubMed PMID:30150305 .
  4. Sherman, SE, Bell, GI, Teoh, H, Al-Omran, M, Connelly, KA, Bhatt, DL et al.. Canagliflozin Improves the Recovery of Blood Flow in an Experimental Model of Severe Limb Ischemia. JACC Basic Transl Sci. 2018;3 (2):327-329. doi: 10.1016/j.jacbts.2018.01.010. PubMed PMID:30062217 PubMed Central PMC6059819.
  5. Murugavel, S, Bugyei-Twum, A, Matkar, PN, Al-Mubarak, H, Chen, HH, Adam, M et al.. Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching. Front Pharmacol. 2018;9 :737. doi: 10.3389/fphar.2018.00737. PubMed PMID:30050438 PubMed Central PMC6050396.
  6. Connelly, KA, Roifman, I. STEMI, the Smoker's Paradox, and Cardiac Magnetic Resonance Imaging: It's All a Case of Smoke and Mirrors. JACC Cardiovasc Imaging. 2018; :. doi: 10.1016/j.jcmg.2018.04.029. PubMed PMID:30031703 .
  7. Connelly, KA, Zhang, Y, Desjardins, JF, Thai, K, Gilbert, RE. Dual inhibition of sodium-glucose linked cotransporters 1 and 2 exacerbates cardiac dysfunction following experimental myocardial infarction. Cardiovasc Diabetol. 2018;17 (1):99. doi: 10.1186/s12933-018-0741-9. PubMed PMID:29981571 PubMed Central PMC6035399.
  8. Katira, BH, Engelberts, D, Otulakowski, G, Giesinger, RE, Yoshida, T, Post, M et al.. Abrupt Deflation after Sustained Inflation Causes Lung Injury. Am. J. Respir. Crit. Care Med. 2018; :. doi: 10.1164/rccm.201801-0178OC. PubMed PMID:29902384 .
  9. Kotha, VK, Deva, DP, Connelly, KA, Freeman, MR, Yan, RT, Mangat, I et al.. Cardiac MRI and radionuclide ventriculography for measurement of left ventricular ejection fraction in ICD candidates. Magn Reson Imaging. 2018;52 :69-74. doi: 10.1016/j.mri.2018.05.012. PubMed PMID:29859946 .
  10. Goodman, JM, Banks, L, Connelly, KA, Yan, AT, Backx, PH, Dorian, P et al.. Excessive exercise in endurance athletes: Is atrial fibrillation a possible consequence?. Appl Physiol Nutr Metab. 2018;43 (9):973-976. doi: 10.1139/apnm-2017-0764. PubMed PMID:29842800 .
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Affiliations & Other Activities

  • Director, Krembil Stem Cell Facility, St. Michael’s Hospital
  • Staff Cardiologist, Division of Cardiology, St. Michael’s Hospital
  • Member, Richard Lewar Center, University of Toronto
  • Cardiologist, Division of Cardiology, Sunnybrook Health Sciences Centre
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