Kim A. Connelly


Scientist, Keenan Research Centre for Biomedical Science


Dr. Kim Connelly is a Cardiologist and Scientist who is both nationally recognized as an expert in human and rodent echocardiography, cardiovascular MRI and the impact of diabetes upon cardiac function. His work has been recognized evident by winning the “Young Investigator of the Year Award” in 2012 by the Canadian Cardiovascular Society an Early Researcher Award in 2014, and a Canadian Institutes of Health Research (CIHR) New Investigator award in 2014.

Dr. Connelly runs a basic research laboratory at the Keenan Research Centre for Biomedical Science (KRCBS) at St. Michael’s Hospital where he focuses upon basic mechanisms of disease – primarily around the role of pathological extracellular matrix accumulation and the pro-sclerotic cytokine transforming growth factor beta, with a focus upon translating discoveries into therapies in humans. He is the Director of the Krembil Stem Cell Facility at St. Michael’s Hospital and uses stem cell based therapies to improve cardiac and renal dysfunction as a result of diabetes. He collaborates extensively not only locally in Toronto but also nationally and internationally – with research support from the Heart and Stroke Foundation (HSF) of Canada, CIHR and Canadian Foundation for Innovation along with significant research support from the pharmaceutical industry.

Locally, he sits on the executive of the University of Toronto Cardiovascular research network, and has been a reviewer for both the CIHR “CSB” panel, along with the Heart and Stroke Foundation of Canada (HSF). He was the national spokesperson for the HSF of Canada “heart healthy month” in February 2015.

Recent Publications

  1. Connelly, KA, Zhang, Y, Visram, A, Advani, A, Batchu, SN, Desjardins, JF et al.. Empagliflozin Improves Diastolic Function in a Nondiabetic Rodent Model of Heart Failure With Preserved Ejection Fraction. JACC Basic Transl Sci. 2019;4 (1):27-37. doi: 10.1016/j.jacbts.2018.11.010. PubMed PMID:30847416 PubMed Central PMC6390677.
  2. Banks, L, Connelly, KA. Pre-exercise Stress Testing in Type 2 Diabetes: Another Case of Choosing Wisely?. Can J Cardiol. 2019;35 (2):150-152. doi: 10.1016/j.cjca.2018.12.008. PubMed PMID:30760420 .
  3. Song, L, Brezden-Masley, C, Ramanan, V, Ghugre, N, Barfett, JJ, Chan, KKW et al.. Serial Measurements of Left Ventricular Systolic and Diastolic Function by Cardiac Magnetic Resonance Imaging in Patients with Early Stage Breast Cancer on Trastuzumab. Am. J. Cardiol. 2019;123 (7):1173-1179. doi: 10.1016/j.amjcard.2018.12.046. PubMed PMID:30683420 .
  4. Gilbert, RE, Connelly, KA. Reduction in the incidence of myocardial infarction with sodium-glucose linked cotransporter-2 inhibitors: evident and plausible. Cardiovasc Diabetol. 2019;18 (1):6. doi: 10.1186/s12933-019-0812-6. PubMed PMID:30634959 PubMed Central PMC6329062.
  5. Ong, G, Yan, AT, Connelly, KA. Clinical application of echocardiographic-derived myocardial strain imaging in subclinical disease: a primer for cardiologists. Curr. Opin. Cardiol. 2019;34 (2):147-155. doi: 10.1097/HCO.0000000000000592. PubMed PMID:30633076 .
  6. Taramasso, M, Alessandrini, H, Latib, A, Asami, M, Attinger-Toller, A, Biasco, L et al.. Outcomes After Current Transcatheter Tricuspid Valve Intervention: Mid-Term Results From the International TriValve Registry. JACC Cardiovasc Interv. 2019;12 (2):155-165. doi: 10.1016/j.jcin.2018.10.022. PubMed PMID:30594510 .
  7. Gong, IY, Al-Amro, B, Prasad, GVR, Connelly, PW, Wald, RM, Wald, R et al.. Cardiovascular magnetic resonance left ventricular strain in end-stage renal disease patients after kidney transplantation. J Cardiovasc Magn Reson. 2018;20 (1):83. doi: 10.1186/s12968-018-0504-5. PubMed PMID:30554567 PubMed Central PMC6296102.
  8. Connelly, KA, Bhatt, DL, Verma, S. Can We DECLARE a Victory against Cardio-Renal Disease in Diabetes?. Cell Metab. 2018;28 (6):813-815. doi: 10.1016/j.cmet.2018.11.010. PubMed PMID:30517896 .
  9. Katira, BH, Kuebler, WM, Connelly, KA, Kavanagh, BP. Reply to Santini et al.: High Positive End-Expiratory Pressure: Only a Dam against Edema Formation? Probably Not (Again). Am. J. Respir. Crit. Care Med. 2019;199 (4):544. doi: 10.1164/rccm.201810-2000LE. PubMed PMID:30398892 .
  10. Gong, IY, Ong, G, Brezden-Masley, C, Dhir, V, Deva, DP, Chan, KKW et al.. Early diastolic strain rate measurements by cardiac MRI in breast cancer patients treated with trastuzumab: a longitudinal study. Int J Cardiovasc Imaging. 2018; :. doi: 10.1007/s10554-018-1482-2. PubMed PMID:30390170 .
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Affiliations & Other Activities

  • Director, Krembil Stem Cell Facility, St. Michael’s Hospital
  • Staff Cardiologist, Division of Cardiology, St. Michael’s Hospital
  • Member, Richard Lewar Center, University of Toronto
  • Cardiologist, Division of Cardiology, Sunnybrook Health Sciences Centre