Kim A. Connelly

FRACP, PhD, MBBS

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Kim Connelly is a Cardiologist and Scientist who is both nationally recognized as an expert in human and rodent echocardiography, cardiovascular MRI and the impact of diabetes upon cardiac function. His work has been recognized evident by winning the “Young Investigator of the Year Award” in 2012 by the Canadian Cardiovascular Society an Early Researcher Award in 2014, and a Canadian Institutes of Health Research (CIHR) New Investigator award in 2014.

Dr. Connelly runs a basic research laboratory at the Keenan Research Centre for Biomedical Science (KRCBS) at St. Michael’s Hospital where he focuses upon basic mechanisms of disease – primarily around the role of pathological extracellular matrix accumulation and the pro-sclerotic cytokine transforming growth factor beta, with a focus upon translating discoveries into therapies in humans. He is the Director of the Krembil Stem Cell Facility at St. Michael’s Hospital and uses stem cell based therapies to improve cardiac and renal dysfunction as a result of diabetes. He collaborates extensively not only locally in Toronto but also nationally and internationally – with research support from the Heart and Stroke Foundation (HSF) of Canada, CIHR and Canadian Foundation for Innovation along with significant research support from the pharmaceutical industry.

Locally, he sits on the executive of the University of Toronto Cardiovascular research network, and has been a reviewer for both the CIHR “CSB” panel, along with the Heart and Stroke Foundation of Canada (HSF). He was the national spokesperson for the HSF of Canada “heart healthy month” in February 2015.

Recent Publications

  1. Paterson, DI, Wells, G, Erthal, F, Mielniczuk, L, O'Meara, E, White, J et al.. OUTSMART HF: A Randomized Controlled Trial of Routine Versus Selective Cardiac Magnetic Resonance for Patients with Non-Ischemic Heart Failure (IMAGE-HF 1B). Circulation. 2020; :. doi: 10.1161/CIRCULATIONAHA.119.043964. PubMed PMID:31910649 .
  2. Altaha, MA, Nolan, M, Marwick, TH, Somerset, E, Houbois, C, Amir, E et al.. Can Quantitative CMR Tissue Characterization Adequately Identify Cardiotoxicity During Chemotherapy?: Impact of Temporal and Observer Variability. JACC Cardiovasc Imaging. 2019; :. doi: 10.1016/j.jcmg.2019.10.016. PubMed PMID:31864977 .
  3. Fam, NP, Braun, D, von Bardeleben, RS, Nabauer, M, Ruf, T, Connelly, KA et al.. Compassionate Use of the PASCAL Transcatheter Valve Repair System for Severe Tricuspid Regurgitation: A Multicenter, Observational, First-in-Human Experience. JACC Cardiovasc Interv. 2019;12 (24):2488-2495. doi: 10.1016/j.jcin.2019.09.046. PubMed PMID:31857018 .
  4. Banks, L, Bentley, RF, Currie, KD, Vecchiarelli, E, Aslam, A, Connelly, KA et al.. Cardiac Remodeling in Middle-Aged Endurance Athletes and Recreationally Active Individuals: Challenges in Defining the "Athlete's Heart". J Am Soc Echocardiogr. 2019; :. doi: 10.1016/j.echo.2019.09.014. PubMed PMID:31812548 .
  5. Mazer, CD, Arnaout, A, Connelly, KA, Gilbert, JD, Glazer, SA, Verma, S et al.. Sodium-glucose cotransporter 2 inhibitors and type 2 diabetes: clinical pearls for in-hospital initiation, in-hospital management, and postdischarge. Curr. Opin. Cardiol. 2019; :. doi: 10.1097/HCO.0000000000000704. PubMed PMID:31804229 .
  6. Cai, S, Wald, R, Deva, DP, Kiaii, M, Ng, MY, Karur, GR et al.. Cardiac MRI measurements of pericardial adipose tissue volumes in patients on in-centre nocturnal hemodialysis. J. Nephrol. 2019; :. doi: 10.1007/s40620-019-00665-4. PubMed PMID:31728837 .
  7. Mazer, CD, Hare, GMT, Connelly, PW, Gilbert, RE, Shehata, N, Quan, A et al.. Effect of Empagliflozin on Erythropoietin Levels, Iron Stores and Red Blood Cell Morphology in Patients with Type 2 Diabetes and Coronary Artery Disease. Circulation. 2019; :. doi: 10.1161/CIRCULATIONAHA.119.044235. PubMed PMID:31707794 .
  8. Connolly, K, Ong, G, Kuhlmann, M, Ho, E, Levitt, K, Abdel-Qadir, H et al.. Use of the Valve Visualization on Echocardiography Grade Tool Improves Sensitivity and Negative Predictive Value of Transthoracic Echocardiogram for Exclusion of Native Valvular Vegetation. J Am Soc Echocardiogr. 2019;32 (12):1551-1557.e1. doi: 10.1016/j.echo.2019.08.018. PubMed PMID:31679901 .
  9. Weissler-Snir, A, Allan, K, Cunningham, K, Connelly, KA, Lee, DS, Spears, DA et al.. Hypertrophic Cardiomyopathy-Related Sudden Cardiac Death in Young People in Ontario. Circulation. 2019;140 (21):1706-1716. doi: 10.1161/CIRCULATIONAHA.119.040271. PubMed PMID:31630535 .
  10. Taramasso, M, Benfari, G, van der Bijl, P, Alessandrini, H, Attinger-Toller, A, Biasco, L et al.. Transcatheter Versus Medical Treatment of Patients With Symptomatic Severe Tricuspid Regurgitation. J. Am. Coll. Cardiol. 2019;74 (24):2998-3008. doi: 10.1016/j.jacc.2019.09.028. PubMed PMID:31568868 .
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Affiliations & Other Activities

  • Director, Krembil Stem Cell Facility, St. Michael’s Hospital
  • Staff Cardiologist, Division of Cardiology, St. Michael’s Hospital
  • Member, Richard Lewar Center, University of Toronto
  • Cardiologist, Division of Cardiology, Sunnybrook Health Sciences Centre
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