Krishna K. Singh


Scientist, Keenan Research Centre for Biomedical Science


Dr. Krishna Singh’s research is mainly focused on the role of DNA damage/repair and autophagy in the development of cardiovascular diseases. He is also interested in understanding the relationship between autophagy and endothelial-to-mesenchymal transition, and its role in the organ fibrosis.

Recent Publications

  1. Richter, M, Murtaza, N, Scharrenberg, R, White, SH, Johanns, O, Walker, S et al.. Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling. Mol. Psychiatry. 2018; :. doi: 10.1038/s41380-018-0025-5. PubMed PMID:29467497 .
  2. Uddin, M, Unda, BK, Kwan, V, Holzapfel, NT, White, SH, Chalil, L et al.. OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome. Am. J. Hum. Genet. 2018;102 (2):278-295. doi: 10.1016/j.ajhg.2018.01.006. PubMed PMID:29395074 .
  3. Ramadan, A, Singh, KK, Quan, A, Plant, PJ, Al-Omran, M, Teoh, H et al.. Loss of vascular smooth muscle cell autophagy exacerbates angiotensin II-associated aortic remodeling. J. Vasc. Surg. 2017; :. doi: 10.1016/j.jvs.2017.08.086. PubMed PMID:29273297 .
  4. Matkar, PN, Ariyagunarajah, R, Leong-Poi, H, Singh, KK. Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis. Biomolecules. 2017;7 (4):. doi: 10.3390/biom7040074. PubMed PMID:28974056 PubMed Central PMC5745456.
  5. Mantella, LE, Singh, KK, Sandhu, P, Kantores, C, Ramadan, A, Khyzha, N et al.. Fingerprint of long non-coding RNA regulated by cyclic mechanical stretch in human aortic smooth muscle cells: implications for hypertension. Mol. Cell. Biochem. 2017;435 (1-2):163-173. doi: 10.1007/s11010-017-3065-2. PubMed PMID:28526936 .
  6. Yau, JW, Singh, KK, Hou, Y, Lei, X, Ramadan, A, Quan, A et al.. Endothelial-specific deletion of autophagy-related 7 (ATG7) attenuates arterial thrombosis in mice. J. Thorac. Cardiovasc. Surg. 2017;154 (3):978-988.e1. doi: 10.1016/j.jtcvs.2017.02.058. PubMed PMID:28400112 .
  7. Shi, X, Verma, S, Yun, J, Brand-Arzamendi, K, Singh, KK, Liu, X et al.. Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?. Mol. Cell. Biochem. 2017;433 (1-2):97-102. doi: 10.1007/s11010-017-3018-9. PubMed PMID:28391552 .
  8. Singh, KK, Matkar, PN, Pan, Y, Quan, A, Gupta, V, Teoh, H et al.. Endothelial long non-coding RNAs regulated by oxidized LDL. Mol. Cell. Biochem. 2017;431 (1-2):139-149. doi: 10.1007/s11010-017-2984-2. PubMed PMID:28316063 .
  9. Quan, A, Pan, Y, Singh, KK, Polemidiotis, J, Teoh, H, Leong-Poi, H et al.. Cardiovascular inflammation is reduced with methotrexate in diabetes. Mol. Cell. Biochem. 2017;432 (1-2):159-167. doi: 10.1007/s11010-017-3006-0. PubMed PMID:28303409 .
  10. Kwan, V, Meka, DP, White, SH, Hung, CL, Holzapfel, NT, Walker, S et al.. DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants. Cell Rep. 2016;17 (7):1892-1904. doi: 10.1016/j.celrep.2016.10.047. PubMed PMID:27829159 .
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Affiliations & Other Activities

  • Assistant Professor, Department of Surgery, University of Toronto