Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Rittayamai, N, Beloncle, F, Goligher, EC, Chen, L, Mancebo, J, Richard, JM et al.. Effect of inspiratory synchronization during pressure-controlled ventilation on lung distension and inspiratory effort. Ann Intensive Care. 2017;7 (1):100. doi: 10.1186/s13613-017-0324-z. PubMed PMID:28986852 .
  2. Del Sorbo, L, Goligher, E, McAuley, DF, Rubenfeld, GD, Brochard, LJ, Gattinoni, L et al.. Mechanical Ventilation in Adults with Acute Respiratory Distress Syndrome: Summary of the Experimental Evidence for the Clinical Practice Guideline. Ann Am Thorac Soc. 2017; :. doi: 10.1513/AnnalsATS.201704-345OT. PubMed PMID:28985479 .
  3. Vincent, JL, Brochard, LJ. Do we need randomized clinical trials in extracorporeal respiratory support? We are not sure. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4930-x. PubMed PMID:28948309 .
  4. Tanaka, T, Basoudan, N, Melo, LT, Wickerson, L, Brochard, LJ, Goligher, EC et al.. Deoxygenation of inspiratory muscles during cycling, hyperpnoea and loaded breathing in health and disease: a systematic review. Clin Physiol Funct Imaging. 2017; :. doi: 10.1111/cpf.12473. PubMed PMID:28940670 .
  5. Vivier, E, Roche-Campo, F, Brochard, L, Mekontso Dessap, A. Determinants of diaphragm thickening fraction during mechanical ventilation: an ancillary study of a randomised trial. Eur. Respir. J. 2017;50 (3):. doi: 10.1183/13993003.00783-2017. PubMed PMID:28931664 .
  6. Goligher, EC, Dres, M, Fan, E, Rubenfeld, GD, Scales, DC, Herridge, MS et al.. Mechanical Ventilation-induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201703-0536OC. PubMed PMID:28930478 .
  7. Dres, M, Goligher, EC, Heunks, LMA, Brochard, LJ. Critical illness-associated diaphragm weakness. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4928-4. PubMed PMID:28917004 .
  8. Chiumello, D, Brochard, L, Marini, JJ, Slutsky, AS, Mancebo, J, Ranieri, VM et al.. Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Crit Care. 2017;21 (1):240. doi: 10.1186/s13054-017-1820-0. PubMed PMID:28899408 PubMed Central PMC5596474.
  9. Pham, T, Brochard, LJ, Slutsky, AS. Mechanical Ventilation: State of the Art. Mayo Clin. Proc. 2017;92 (9):1382-1400. doi: 10.1016/j.mayocp.2017.05.004. PubMed PMID:28870355 .
  10. Rochwerg, B, Brochard, L, Elliott, MW, Hess, D, Hill, NS, Nava, S et al.. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur. Respir. J. 2017;50 (2):. doi: 10.1183/13993003.02426-2016. PubMed PMID:28860265 PubMed Central PMC5593345.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group