Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Béduneau, G, Pham, T, Brochard, L. Reply to Can the WIND Definition Classify All Invasively Ventilated Patients?. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201706-1213LE. PubMed PMID:28767269 .
  2. Yoshida, T, Engelberts, D, Otulakowski, G, Katira, BH, Post, M, Ferguson, ND et al.. Continuous Abdominal Negative Pressure Recruits Lungs at Lower Distending Pressures. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201705-0979LE. PubMed PMID:28742375 .
  3. Hantal, G, Brochard, L, Pellenq, RJ, Ulm, FJ, Coasne, B. Role of Interfaces in Elasticity and Failure of Clay-Organic Nanocomposites: Toughening upon Interface Weakening?. Langmuir. 2017; :. doi: 10.1021/acs.langmuir.7b01071. PubMed PMID:28728412 .
  4. Brodie, D, Curtis, JR, Vincent, JL, Bakker, J, Brown, CE, Creteur, J et al.. Treatment limitations in the era of ECMO. Lancet Respir Med. 2017; :. doi: 10.1016/S2213-2600(17)30263-1. PubMed PMID:28705688 .
  5. de Prost, N, Pham, T, Carteaux, G, Mekontso Dessap, A, Brun-Buisson, C, Fan, E et al.. Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study. Ann Intensive Care. 2017;7 (1):69. doi: 10.1186/s13613-017-0281-6. PubMed PMID:28631088 PubMed Central PMC5476531.
  6. Laffey, JG, Madotto, F, Bellani, G, Pham, T, Fan, E, Brochard, L et al.. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study. Lancet Respir Med. 2017;5 (8):627-638. doi: 10.1016/S2213-2600(17)30213-8. PubMed PMID:28624388 .
  7. Akoumianaki, E, Dousse, N, Lyazidi, A, Lefebvre, JC, Graf, S, Cordioli, RL et al.. Can proportional ventilation modes facilitate exercise in critically ill patients? A physiological cross-over study : Pressure support versus proportional ventilation during lower limb exercise in ventilated critically ill patients. Ann Intensive Care. 2017;7 (1):64. doi: 10.1186/s13613-017-0289-y. PubMed PMID:28608135 PubMed Central PMC5468357.
  8. Goligher, EC, Detsky, ME, Sklar, MC, Campbell, VT, Greco, P, Amaral, ACKB et al.. Rethinking Inspiratory Pressure Augmentation in Spontaneous Breathing Trials. Chest. 2017;151 (6):1399-1400. doi: 10.1016/j.chest.2017.02.033. PubMed PMID:28599934 .
  9. Burns, KEA, Soliman, I, Adhikari, NKJ, Zwein, A, Wong, JTY, Gomez-Builes, C et al.. Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis. Crit Care. 2017;21 (1):127. doi: 10.1186/s13054-017-1698-x. PubMed PMID:28576127 PubMed Central PMC5455092.
  10. Papazian, L, Brochard, L. Free Access to Costly Medical Resources: Provision of Extracorporeal Membrane Oxygenation for Profound Respiratory Failure in the French Health Care System. Ann Am Thorac Soc. 2017;14 (6):842-843. doi: 10.1513/AnnalsATS.201703-268ED. PubMed PMID:28570149 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group