Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Chen, L, Chen, GQ, Shore, K, Shklar, O, Martins, C, Devenyi, B et al.. Implementing a bedside assessment of respiratory mechanics in patients with acute respiratory distress syndrome. Crit Care. 2017;21 (1):84. doi: 10.1186/s13054-017-1671-8. PubMed PMID:28372575 PubMed Central PMC5379641.
  2. Henderson, WR, Chen, L, Amato, MB, Brochard, LJ. Fifty Years of Research in ARDS. Respiratory Mechanics in Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201612-2495CI. PubMed PMID:28306327 .
  3. Adler, D, Brochard, L. Reply: Selection Bias in Study Participants with Acute Hypercapnic Respiratory Failure. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201701-0044LE. PubMed PMID:28178424 .
  4. Beloncle, F, Piquilloud, L, Rittayamai, N, Sinderby, C, Rozé, H, Brochard, L et al.. A diaphragmatic electrical activity-based optimization strategy during pressure support ventilation improves synchronization but does not impact work of breathing. Crit Care. 2017;21 (1):21. doi: 10.1186/s13054-017-1599-z. PubMed PMID:28137269 PubMed Central PMC5282691.
  5. Nin, N, Muriel, A, Peñuelas, O, Brochard, L, Lorente, JA, Ferguson, ND et al.. Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome. Intensive Care Med. 2017;43 (2):200-208. doi: 10.1007/s00134-016-4611-1. PubMed PMID:28108768 .
  6. Brochard, L. Ventilation-induced lung injury exists in spontaneously breathing patients with acute respiratory failure: Yes. Intensive Care Med. 2017;43 (2):250-252. doi: 10.1007/s00134-016-4645-4. PubMed PMID:28074228 .
  7. Wang, ZH, Chen, H, Yang, YL, Shi, ZH, Guo, QH, Li, YW et al.. Bispectral Index Can Reliably Detect Deep Sedation in Mechanically Ventilated Patients: A Prospective Multicenter Validation Study. Anesth. Analg. 2016; :. doi: 10.1213/ANE.0000000000001786. PubMed PMID:28027085 .
  8. Adler, D, Pépin, JL, Dupuis-Lozeron, E, Espa-Cervena, K, Merlet-Violet, R, Muller, H et al.. Comorbidities and Subgroups of Patients Surviving Severe Acute Hypercapnic Respiratory Failure in the ICU. Am. J. Respir. Crit. Care Med. 2016; :. doi: 10.1164/rccm.201608-1666OC. PubMed PMID:27973930 .
  9. Grieco, DL, Chen, L, Dres, M, Brochard, L. Should we use driving pressure to set tidal volume?. Curr Opin Crit Care. 2017;23 (1):38-44. doi: 10.1097/MCC.0000000000000377. PubMed PMID:27875410 .
  10. Mahul, M, Jung, B, Galia, F, Molinari, N, de Jong, A, Coisel, Y et al.. Spontaneous breathing trial and post-extubation work of breathing in morbidly obese critically ill patients. Crit Care. 2016;20 (1):346. doi: 10.1186/s13054-016-1457-4. PubMed PMID:27784322 PubMed Central PMC5081985.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group