Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Rochwerg, B, Einav, S, Chaudhuri, D, Mancebo, J, Mauri, T, Helviz, Y et al.. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06312-y. PubMed PMID:33201321 PubMed Central PMC7670292.
  2. Mauri, T, Foti, G, Fornari, C, Grasselli, G, Pinciroli, R, Lovisari, F et al.. Sigh in patients with acute hypoxemic respiratory failure and acute respiratory distress syndrome: the PROTECTION pilot randomized clinical trial. Chest. 2020; :. doi: 10.1016/j.chest.2020.10.079. PubMed PMID:33197403 PubMed Central PMC7664474.
  3. Demoule, A, Brochard, L, Dres, M, Heunks, L, Jubran, A, Laghi, F et al.. How to ventilate obstructive and asthmatic patients. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06291-0. PubMed PMID:33169215 PubMed Central PMC7652057.
  4. Goligher, EC, Jonkman, AH, Dianti, J, Vaporidi, K, Beitler, JR, Patel, BK et al.. Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06288-9. PubMed PMID:33140181 PubMed Central PMC7605467.
  5. Yehya, N, Hodgson, CL, Amato, MBP, Richard, JC, Brochard, LJ, Mercat, A et al.. Response to Ventilator Adjustments for Predicting ARDS Mortality: Driving Pressure versus Oxygenation. Ann Am Thorac Soc. 2020; :. doi: 10.1513/AnnalsATS.202007-862OC. PubMed PMID:33112644 .
  6. Bastia, L, Engelberts, D, Osada, K, Katira, BH, Damiani, LF, Yoshida, T et al.. Role of PEEP and Regional Transpulmonary Pressure in Asymmetrical Lung Injury. Am J Respir Crit Care Med. 2020; :. doi: 10.1164/rccm.202005-1556OC. PubMed PMID:33091317 .
  7. Daou, M, Telias, I, Younes, M, Brochard, L, Wilcox, ME. Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?. Front Neurol. 2020;11 :549908. doi: 10.3389/fneur.2020.549908. PubMed PMID:33071941 PubMed Central PMC7530631.
  8. Rozé, H, Boisselier, C, Bonnardel, E, Perrier, V, Repusseau, B, Brochard, L et al.. Electrical Impedance Tomography to Detect Airway Closure Heterogeneity in Asymmetrical ARDS. Am J Respir Crit Care Med. 2020; :. doi: 10.1164/rccm.202007-2937LE. PubMed PMID:33030960 .
  9. Fernando, SM, Fan, E, Rochwerg, B, Burns, KEA, Brochard, LJ, Cook, DJ et al.. Lung-Protective Ventilation and Associated Outcomes and Costs Among Patients Receiving Invasive Mechanical Ventilation in the Emergency Department. Chest. 2020; :. doi: 10.1016/j.chest.2020.09.100. PubMed PMID:32966812 .
  10. Granton, D, Chaudhuri, D, Wang, D, Einav, S, Helviz, Y, Mauri, T et al.. High-Flow Nasal Cannula Compared With Conventional Oxygen Therapy or Noninvasive Ventilation Immediately Postextubation: A Systematic Review and Meta-Analysis. Crit Care Med. 2020;48 (11):e1129-e1136. doi: 10.1097/CCM.0000000000004576. PubMed PMID:32947472 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group