Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Dres, M, Younes, M, Brochard, L. Reply to: Pathological Sleep and Wakefulness in the ICU and Weaning Failure - a Causal Relationship?. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201905-0991LE. PubMed PMID:31106565 .
  2. Younes, M, Brochard, L. The Control of Breathing During Mechanical Ventilation. Clin. Chest Med. 2019;40 (2):259-267. doi: 10.1016/j.ccm.2019.02.009. PubMed PMID:31078208 .
  3. Coudroy, R, Chen, L, Pham, T, Piraino, T, Telias, I, Brochard, L et al.. Acute Respiratory Distress Syndrome: Respiratory Monitoring and Pulmonary Physiology. Semin Respir Crit Care Med. 2019;40 (1):66-80. doi: 10.1055/s-0039-1685159. PubMed PMID:31060089 .
  4. Burns, KEA, Wong, JTY, Dodek, P, Cook, DJ, Lamontagne, F, Cohen, A et al.. Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials. Crit. Care Med. 2019;47 (6):817-825. doi: 10.1097/CCM.0000000000003722. PubMed PMID:30920411 .
  5. Bezerra, FS, Ramos, CO, Castro, TF, Araújo, NPDS, de Souza, ABF, Bandeira, ACB et al.. Exogenous surfactant prevents hyperoxia-induced lung injury in adult mice. Intensive Care Med Exp. 2019;7 (1):19. doi: 10.1186/s40635-019-0233-6. PubMed PMID:30919149 PubMed Central PMC6437243.
  6. Heunks, L, Bellani, G, Pham, T, Brochard, L, Laffey, JG. The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration. Eur. Respir. J. 2019;53 (3):. doi: 10.1183/13993003.02228-2018. PubMed PMID:30886021 .
  7. Dres, M, Younes, M, Rittayamai, N, Kendzerska, T, Telias, I, Grieco, DL et al.. Sleep and Pathological Wakefulness at the Time of Liberation from Mechanical Ventilation (SLEEWE). A Prospective Multicenter Physiological Study. Am. J. Respir. Crit. Care Med. 2019;199 (9):1106-1115. doi: 10.1164/rccm.201811-2119OC. PubMed PMID:30818966 .
  8. Combes, A, Fanelli, V, Pham, T, Ranieri, VM, European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med. 2019;45 (5):592-600. doi: 10.1007/s00134-019-05567-4. PubMed PMID:30790030 .
  9. Grieco, DL, Brochard, L, Richard, JM. Reply to Rezoagli et al.: CO2 Oscillation during Cardiopulmonary Resuscitation: The Role of Respiratory System Compliance. Am. J. Respir. Crit. Care Med. 2019;199 (10):1291-1293. doi: 10.1164/rccm.201901-0044LE. PubMed PMID:30682258 .
  10. Rouze, A, Voiriot, G, Guivarch, E, Roux, F, Tran Van Nhieu, J, Isabey, D et al.. Inflammatory Cellular Response to Mechanical Ventilation in Elastase-Induced Experimental Emphysema: Role of Preexisting Alveolar Macrophages Infiltration. Biomed Res Int. 2018;2018 :5721293. doi: 10.1155/2018/5721293. PubMed PMID:30662910 PubMed Central PMC6313972.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group