Laurent J. Brochard

MD, HDR

Scientist, Keenan Research Centre for Biomedical Science

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Chaudhuri, D, Granton, D, Wang, DX, Einav, S, Helviz, Y, Mauri, T et al.. Moderate Certainty Evidence Suggests the Use of High-Flow Nasal Cannula Does Not Decrease Hypoxia When Compared With Conventional Oxygen Therapy in the Peri-Intubation Period: Results of a Systematic Review and Meta-Analysis. Crit. Care Med. 2020;48 (4):571-578. doi: 10.1097/CCM.0000000000004217. PubMed PMID:32205604 .
  2. Pan, C, Chen, L, Lu, C, Zhang, W, Xia, JA, Sklar, MC et al.. Lung Recruitability in SARS-CoV-2 Associated Acute Respiratory Distress Syndrome: A Single-center, Observational Study. Am. J. Respir. Crit. Care Med. 2020; :. doi: 10.1164/rccm.202003-0527LE. PubMed PMID:32200645 .
  3. Georgopoulos, D, Brochard, L. Dissociation between the brain target and respiratory capacity in critically ill patients. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-05983-x. PubMed PMID:32140735 .
  4. Telias, I, Junhasavasdikul, D, Rittayamai, N, Piquilloud, L, Chen, L, Ferguson, ND et al.. Airway Occlusion Pressure as an Estimate of Respiratory Drive and Inspiratory Effort During Assisted Ventilation. Am. J. Respir. Crit. Care Med. 2020; :. doi: 10.1164/rccm.201907-1425OC. PubMed PMID:32097569 .
  5. Dres, M, Dubé, BP, Goligher, E, Vorona, S, Demiri, S, Morawiec, E et al.. Usefulness of Parasternal Intercostal Muscle Ultrasound during Weaning from Mechanical Ventilation. Anesthesiology. 2020; :. doi: 10.1097/ALN.0000000000003191. PubMed PMID:32084029 .
  6. Sklar, MC, Dres, M, Fan, E, Rubenfeld, GD, Scales, DC, Herridge, MS et al.. Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults. JAMA Netw Open. 2020;3 (2):e1921520. doi: 10.1001/jamanetworkopen.2019.21520. PubMed PMID:32074293 .
  7. Zhang, B, Ratano, D, Brochard, LJ, Georgopoulos, D, Duffin, J, Long, M et al.. A physiology-based mathematical model for the selection of appropriate ventilator controls for lung and diaphragm protection. J Clin Monit Comput. 2020; :. doi: 10.1007/s10877-020-00479-x. PubMed PMID:32008149 .
  8. Derbakova, A, Khu, S, Ho, K, Lewis, C, Ma, T, Melo, LT et al.. Neck and Inspiratory Muscle Recruitment during Inspiratory Loading and Neck Flexion. Med Sci Sports Exerc. 2020; :. doi: 10.1249/MSS.0000000000002271. PubMed PMID:31977643 .
  9. Chaudhuri, D, Granton, D, Wang, DX, Einav, S, Helviz, Y, Mauri, T et al.. Moderate Certainty Evidence Suggests the Use of High-Flow Nasal Cannula Does Not Decrease Hypoxia When Compared With Conventional Oxygen Therapy in the Peri-Intubation Period: Results of a Systematic Review and Meta-Analysis. Crit. Care Med. 2020; :. doi: 10.1097/CCM.0000000000004217. PubMed PMID:31923025 .
  10. Yoshida, T, Grieco, DL, Brochard, L, Fujino, Y. Patient self-inflicted lung injury and positive end-expiratory pressure for safe spontaneous breathing. Curr Opin Crit Care. 2020;26 (1):59-65. doi: 10.1097/MCC.0000000000000691. PubMed PMID:31815775 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group
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