Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Dres, M, Younes, M, Rittayamai, N, Kendzerska, T, Telias, I, Grieco, DL et al.. Sleep and Pathological Wakefulness at Time of Liberation from Mechanical Ventilation (SLEEWE): A Prospective Multicenter Physiological Study. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201811-2119OC. PubMed PMID:30818966 .
  2. Combes, A, Fanelli, V, Pham, T, Ranieri, VM, European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med. 2019; :. doi: 10.1007/s00134-019-05567-4. PubMed PMID:30790030 .
  3. Grieco, DL, Brochard, L, Richard, JM. Reply to: CO2 Oscillation During Cardiopulmonary Resuscitation: The Role of Respiratory System Compliance. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201901-0044LE. PubMed PMID:30682258 .
  4. Rouze, A, Voiriot, G, Guivarch, E, Roux, F, Tran Van Nhieu, J, Isabey, D et al.. Inflammatory Cellular Response to Mechanical Ventilation in Elastase-Induced Experimental Emphysema: Role of Preexisting Alveolar Macrophages Infiltration. Biomed Res Int. 2018;2018 :5721293. doi: 10.1155/2018/5721293. PubMed PMID:30662910 PubMed Central PMC6313972.
  5. Abrams, D, Ferguson, ND, Brochard, L, Fan, E, Mercat, A, Combes, A et al.. ECMO for ARDS: from salvage to standard of care?. Lancet Respir Med. 2019;7 (2):108-110. doi: 10.1016/S2213-2600(18)30506-X. PubMed PMID:30642778 .
  6. Bourke, SC, Piraino, T, Pisani, L, Brochard, L, Elliott, MW. Beyond the guidelines for non-invasive ventilation in acute respiratory failure: implications for practice. Lancet Respir Med. 2018;6 (12):935-947. doi: 10.1016/S2213-2600(18)30388-6. PubMed PMID:30629932 .
  7. Grieco, DL, Brochard, L, Richard, JM. Reply to: Airway Pressure Monitoring May Improve Small Airway Flow, Hemodynamics, and Tissue Oxygenation. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201811-2234LE. PubMed PMID:30605345 .
  8. Coudroy, R, Lu, C, Chen, L, Demoule, A, Brochard, L. Mechanism of airway closure in acute respiratory distress syndrome: a possible role of surfactant depletion. Intensive Care Med. 2019;45 (2):290-291. doi: 10.1007/s00134-018-5501-5. PubMed PMID:30560279 .
  9. Yoshida, T, Grieco, DL, Brochard, L. Guiding ventilation with transpulmonary pressure. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5483-3. PubMed PMID:30506355 .
  10. Pham, T, Brochard, LJ. Editorial: Every breath you take…should be monitored. Curr Opin Crit Care. 2019;25 (1):1-2. doi: 10.1097/MCC.0000000000000576. PubMed PMID:30516589 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group