Laurent J. Brochard




Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Fernando, SM, Tran, A, Sadeghirad, B, Burns, KEA, Fan, E, Brodie, D et al.. Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis. Intensive Care Med. 2021; :. doi: 10.1007/s00134-021-06581-1. PubMed PMID:34825256 .
  2. Melo, LT, Rodrigues, A, Cabral, EE, Tanaka, T, Goligher, EC, Brochard, L et al.. Prefrontal cortex activation during incremental inspiratory loading in healthy participants. Respir Physiol Neurobiol. 2021;296 :103827. doi: 10.1016/j.resp.2021.103827. PubMed PMID:34808586 .
  3. Stavi, D, Goffi, A, Al Shalabi, M, Piraino, T, Chen, L, Jackson, R et al.. The Pressure Paradox: Abdominal Compression to Detect Lung Hyper-Inflation in COVID-19 ARDS. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202104-1062IM. PubMed PMID:34748470 .
  4. Lellouche, F, Lavoie-Bérard, CA, Rousseau, E, Bouchard, PA, Lefebvre, JC, Branson, R et al.. How to avoid an epidemic of endotracheal tube occlusion. Lancet Respir Med. 2021;9 (11):1215-1216. doi: 10.1016/S2213-2600(21)00404-5. PubMed PMID:34739886 PubMed Central PMC8563017.
  5. Schreiber, AF, Garlasco, J, Vieira, F, Lau, YH, Stavi, D, Lightfoot, D et al.. Separation from mechanical ventilation and survival after spinal cord injury: a systematic review and meta-analysis. Ann Intensive Care. 2021;11 (1):149. doi: 10.1186/s13613-021-00938-x. PubMed PMID:34693485 PubMed Central PMC8542415.
  6. Cavalot, G, Dounaevskaia, V, Vieira, F, Piraino, T, Coudroy, R, Smith, O et al.. One-Year Readmission Following Undifferentiated Acute Hypercapnic Respiratory Failure. COPD. 2021; :1-10. doi: 10.1080/15412555.2021.1990240. PubMed PMID:34657539 .
  7. Tran, A, Fernando, SM, Brochard, LJ, Fan, E, Inaba, K, Ferguson, ND et al.. Prognostic factors for development of acute respiratory distress syndrome following traumatic injury - a systematic review and meta-analysis. Eur Respir J. 2021; :. doi: 10.1183/13993003.00857-2021. PubMed PMID:34625477 .
  8. Writing Committee for the REMAP-CAP Investigators, Estcourt, LJ, Turgeon, AF, McQuilten, ZK, McVerry, BJ, Al-Beidh, F et al.. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2021;326 (17):1690-1702. doi: 10.1001/jama.2021.18178. PubMed PMID:34606578 PubMed Central PMC8491132.
  9. Ali, A, Wang, A, Ribeiro, RVP, Beroncal, EL, Baciu, C, Galasso, M et al.. Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function. Sci Transl Med. 2021;13 (611):eabf7601. doi: 10.1126/scitranslmed.abf7601. PubMed PMID:34524862 .
  10. Sakr, Y, Midega, T, Antoniazzi, J, Solé-Violán, J, Bauer, PR, Ostermann, M et al.. Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international, multicentre14-day inception cohort study. J Crit Care. 2021;66 :78-85. doi: 10.1016/j.jcrc.2021.08.008. PubMed PMID:34461380 PubMed Central PMC8394083.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group