Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Piquilloud, L, Beloncle, F, Richard, JM, Mancebo, J, Mercat, A, Brochard, L et al.. Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study. Ann Intensive Care. 2019;9 (1):89. doi: 10.1186/s13613-019-0564-1. PubMed PMID:31414251 .
  2. McNicholas, BA, Madotto, F, Pham, T, Rezoagli, E, Masterson, CH, Horie, S et al.. Demographics, management and outcome of women and men with Acute Respiratory Distress Syndrome in the LUNG SAFE prospective cohort study. Eur. Respir. J. 2019; :. doi: 10.1183/13993003.00609-2019. PubMed PMID:31346004 .
  3. Shi, ZH, Jonkman, A, de Vries, H, Jansen, D, Ottenheijm, C, Girbes, A et al.. Expiratory muscle dysfunction in critically ill patients: towards improved understanding. Intensive Care Med. 2019;45 (8):1061-1071. doi: 10.1007/s00134-019-05664-4. PubMed PMID:31236639 PubMed Central PMC6667683.
  4. Yoshida, T, Piraino, T, Lima, CAS, Kavanagh, BP, Amato, MBP, Brochard, L et al.. Regional Ventilation Displayed by Electrical Impedance Tomography as an Incentive to Decrease PEEP. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201904-0797LE. PubMed PMID:31225973 .
  5. Papazian, L, Aubron, C, Brochard, L, Chiche, JD, Combes, A, Dreyfuss, D et al.. Formal guidelines: management of acute respiratory distress syndrome. Ann Intensive Care. 2019;9 (1):69. doi: 10.1186/s13613-019-0540-9. PubMed PMID:31197492 PubMed Central PMC6565761.
  6. Dres, M, Younes, M, Brochard, L. Reply to: Pathological Sleep and Wakefulness in the ICU and Weaning Failure - a Causal Relationship?. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201905-0991LE. PubMed PMID:31106565 .
  7. Younes, M, Brochard, L. The Control of Breathing During Mechanical Ventilation. Clin. Chest Med. 2019;40 (2):259-267. doi: 10.1016/j.ccm.2019.02.009. PubMed PMID:31078208 .
  8. Coudroy, R, Chen, L, Pham, T, Piraino, T, Telias, I, Brochard, L et al.. Acute Respiratory Distress Syndrome: Respiratory Monitoring and Pulmonary Physiology. Semin Respir Crit Care Med. 2019;40 (1):66-80. doi: 10.1055/s-0039-1685159. PubMed PMID:31060089 .
  9. Burns, KEA, Wong, JTY, Dodek, P, Cook, DJ, Lamontagne, F, Cohen, A et al.. Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials. Crit. Care Med. 2019;47 (6):817-825. doi: 10.1097/CCM.0000000000003722. PubMed PMID:30920411 .
  10. Bezerra, FS, Ramos, CO, Castro, TF, Araújo, NPDS, de Souza, ABF, Bandeira, ACB et al.. Exogenous surfactant prevents hyperoxia-induced lung injury in adult mice. Intensive Care Med Exp. 2019;7 (1):19. doi: 10.1186/s40635-019-0233-6. PubMed PMID:30919149 PubMed Central PMC6437243.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group