Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Burns, KEA, Raptis, S MSc, Nisenbaum, R PhD, Rizvi, L, Jones, A, Bakshi, J et al.. International Practice Variation in Weaning Critically Ill Adults From Invasive Mechanical Ventilation. Ann Am Thorac Soc. 2018; :. doi: 10.1513/AnnalsATS.201705-410OC. PubMed PMID:29509509 .
  2. Telias, I, Brochard, L, Goligher, EC. Is my patient's respiratory drive (too) high?. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5091-2. PubMed PMID:29497778 .
  3. Brochard, L, Telias, I. Bedside Detection of Overassistance During Pressure Support Ventilation. Crit. Care Med. 2018;46 (3):488-490. doi: 10.1097/CCM.0000000000002913. PubMed PMID:29474334 .
  4. Junhasavasdikul, D, Telias, I, Grieco, DL, Chen, L, Gutierrez, CM, Piraino, T et al.. Expiratory Flow Limitation During Mechanical Ventilation. Chest. 2018; :. doi: 10.1016/j.chest.2018.01.046. PubMed PMID:29432712 .
  5. Brodie, D, Vincent, JL, Brochard, LJ, Combes, A, Ferguson, ND, Hodgson, CL et al.. Research in Extracorporeal Life Support: A Call to Action. Chest. 2018; :. doi: 10.1016/j.chest.2017.12.024. PubMed PMID:29355550 .
  6. Telias, I, Damiani, F, Brochard, L. The airway occlusion pressure (P) to monitor respiratory drive during mechanical ventilation: increasing awareness of a not-so-new problem. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5045-8. PubMed PMID:29350241 .
  7. Roche-Campo, F, Bedet, A, Vivier, E, Brochard, L, Mekontso Dessap, A. Cardiac function during weaning failure: the role of diastolic dysfunction. Ann Intensive Care. 2018;8 (1):2. doi: 10.1186/s13613-017-0348-4. PubMed PMID:29330683 PubMed Central PMC5768586.
  8. Yoshida, T, Amato, MBP, Grieco, DL, Chen, L, Lima, CAS, Roldan, R et al.. Esophageal Manometry and Regional Transpulmonary Pressure in Lung Injury. Am. J. Respir. Crit. Care Med. 2018; :. doi: 10.1164/rccm.201709-1806OC. PubMed PMID:29323931 .
  9. Charbonney, E, Delisle, S, Savary, D, Bronchti, G, Rigollot, M, Drouet, A et al.. A new physiological model for studying the effect of chest compression and ventilation during cardiopulmonary resuscitation: The Thiel cadaver. Resuscitation. 2018; :. doi: 10.1016/j.resuscitation.2018.01.012. PubMed PMID:29317351 .
  10. Li, HL, Chen, L, Brochard, L. Protecting lungs during spontaneous breathing: what can we do?. J Thorac Dis. 2017;9 (9):2777-2781. doi: 10.21037/jtd.2017.08.25. PubMed PMID:29221238 PubMed Central PMC5708397.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group