Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Chen, L, Del Sorbo, L, Grieco, DL, Junhasavasdikul, D, Rittayamai, N, Soliman, I et al.. Potential for Lung Recruitment Estimated by the Recruitment-to-Inflation Ratio in Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201902-0334OC. PubMed PMID:31577153 .
  2. Roesthuis, L, van der Hoeven, H, Sinderby, C, Frenzel, T, Ottenheijm, C, Brochard, L et al.. Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation. Intensive Care Med. 2019;45 (10):1372-1381. doi: 10.1007/s00134-019-05767-y. PubMed PMID:31576436 .
  3. Mancebo, J, Mercat, A, Brochard, L. Maximal Lung Recruitment in ARDS: A Nail in the Coffin. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201908-1615ED. PubMed PMID:31532227 .
  4. Brochard, L, Yoshida, T, Amato, M. Reply to: Simple Electrical Impedance Tomography Measures for the Assessment of Ventilation Distribution. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201908-1645LE. PubMed PMID:31526321 .
  5. Lewis, KA, Chaudhuri, D, Guyatt, G, Burns, KEA, Bosma, K, Ge, L et al.. Comparison of ventilatory modes to facilitate liberation from mechanical ventilation: protocol for a systematic review and network meta-analysis. BMJ Open. 2019;9 (9):e030407. doi: 10.1136/bmjopen-2019-030407. PubMed PMID:31492786 PubMed Central PMC6731837.
  6. Vaporidi, K, Akoumianaki, E, Telias, I, Goligher, EC, Brochard, L, Georgopoulos, D et al.. Respiratory Drive in Critically Ill Patients: Pathophysiology and Clinical Implications. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201903-0596SO. PubMed PMID:31437406 .
  7. Orser, BA, Brochard, L. In Memoriam: Brian Kavanagh, 1962 to 2019. Anesthesiology. 2019;131 (4):759-761. doi: 10.1097/ALN.0000000000002944. PubMed PMID:31436547 .
  8. Yoshida, T, Kavanagh, BP, Brochard, L. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N. Engl. J. Med. 2019;381 (8):786-787. doi: 10.1056/NEJMc1908874. PubMed PMID:31433933 .
  9. Goligher, EC, Combes, A, Brodie, D, Ferguson, ND, Pesenti, AM, Ranieri, VM et al.. Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design. Intensive Care Med. 2019;45 (9):1219-1230. doi: 10.1007/s00134-019-05708-9. PubMed PMID:31432216 .
  10. Piquilloud, L, Beloncle, F, Richard, JM, Mancebo, J, Mercat, A, Brochard, L et al.. Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study. Ann Intensive Care. 2019;9 (1):89. doi: 10.1186/s13613-019-0564-1. PubMed PMID:31414251 PubMed Central PMC6692797.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group