Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Chaudhuri, D, Granton, D, Wang, DX, Burns, KEA, Helviz, Y, Einav, S et al.. High flow nasal cannula in the immediate post-operative period: a systematic review and meta-analysis. Chest. 2020; :. doi: 10.1016/j.chest.2020.06.038. PubMed PMID:32615190 .
  2. Rittayamai, N, Chuaychoo, B, Tscheikuna, J, Dres, M, Goligher, EC, Brochard, L et al.. Ultrasound Evaluation of Diaphragm Force Reserve in Patients with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2020; :. doi: 10.1513/AnnalsATS.202002-129OC. PubMed PMID:32614240 .
  3. Mancebo, J, Richard, JC, Brochard, L. Ventilator Sharing During Shortages: A Siren's Song?. Am. J. Respir. Crit. Care Med. 2020; :. doi: 10.1164/rccm.202006-2438ED. PubMed PMID:32610021 .
  4. Pan, C, Chen, L, Lu, C, Du, B, Brochard, L, Qiu, H et al.. Reply by Pan et al to: Haouzi et al. Am. J. Respir. Crit. Care Med. 2020; :. doi: 10.1164/rccm.202005-2045LE. PubMed PMID:32579031 .
  5. Goligher, EC, Dres, M, Patel, BK, Sahetya, SK, Beitler, JR, Telias, I et al.. Lung and Diaphragm-Protective Ventilation. Am. J. Respir. Crit. Care Med. 2020; :. doi: 10.1164/rccm.202003-0655CP. PubMed PMID:32516052 .
  6. Abrams, D, Pesenti, A, Brochard, L, Brodie, D. Reply to: ECCO2R and the Alveolar Gas Equation. Am. J. Respir. Crit. Care Med. 2020; :. doi: 10.1164/rccm.202005-1923LE. PubMed PMID:32502355 .
  7. Hedenstierna, G, Chen, L, Brochard, L. Airway closure, more harmful than atelectasis in intensive care?. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06144-w. PubMed PMID:32500181 PubMed Central PMC7271133.
  8. Telias, I, Katira, BH, Brochard, L. Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19?. JAMA. 2020; :. doi: 10.1001/jama.2020.8539. PubMed PMID:32412579 .
  9. Chotirmall, SH, Martinez, FJ, Schumacker, PT, Cooke, CR, Seam, N, Brochard, L et al.. Life at the Editorial "COVID Frontline". The American Thoracic Society Journal Family. Am. J. Respir. Crit. Care Med. 2020;201 (12):1457-1459. doi: 10.1164/rccm.202005-1516ED. PubMed PMID:32356668 PubMed Central PMC7301742.
  10. Ali, A, Watanabe, Y, Galasso, M, Watanabe, T, Chen, M, Fan, E et al.. An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function. J. Heart Lung Transplant. 2020;39 (6):595-603. doi: 10.1016/j.healun.2020.03.027. PubMed PMID:32334946 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group