Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Sklar, MC, Dres, M, Rittayamai, N, West, B, Grieco, DL, Telias, I et al.. High-flow nasal oxygen versus noninvasive ventilation in adult patients with cystic fibrosis: a randomized crossover physiological study. Ann Intensive Care. 2018;8 (1):85. doi: 10.1186/s13613-018-0432-4. PubMed PMID:30187270 PubMed Central PMC6125258.
  2. Honorio, T, Brochard, L, Vandamme, M, Lebée, A. Flexibility of nanolayers and stacks: implications in the nanostructuration of clays. Soft Matter. 2018;14 (36):7354-7367. doi: 10.1039/c8sm01359d. PubMed PMID:30187051 .
  3. Brochard, L, Kavanagh, BP. Declaration of conflicts of interest: a 'crooked' line towards scientific integrity. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5358-7. PubMed PMID:30178137 .
  4. Mauri, T, Foti, G, Fornari, C, Constantin, JM, Guerin, C, Pelosi, P et al.. Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: study protocol for a pilot randomized controlled trial, the PROTECTION trial. Trials. 2018;19 (1):460. doi: 10.1186/s13063-018-2828-8. PubMed PMID:30157955 PubMed Central PMC6114230.
  5. Abe, T, Madotto, F, Pham, T, Nagata, I, Uchida, M, Tamiya, N et al.. Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries. Crit Care. 2018;22 (1):195. doi: 10.1186/s13054-018-2126-6. PubMed PMID:30115127 PubMed Central PMC6097245.
  6. Pham, T, Telias, I, Piraino, T, Yoshida, T, Brochard, LJ. Asynchrony Consequences and Management. Crit Care Clin. 2018;34 (3):325-341. doi: 10.1016/j.ccc.2018.03.008. PubMed PMID:29907268 .
  7. Cortegiani, A, Madotto, F, Gregoretti, C, Bellani, G, Laffey, JG, Pham, T et al.. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Crit Care. 2018;22 (1):157. doi: 10.1186/s13054-018-2079-9. PubMed PMID:29895331 PubMed Central PMC5998562.
  8. Combes, A, Hajage, D, Capellier, G, Demoule, A, Lavoué, S, Guervilly, C et al.. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N. Engl. J. Med. 2018;378 (21):1965-1975. doi: 10.1056/NEJMoa1800385. PubMed PMID:29791822 .
  9. Cordioli, RL, Brochard, L, Suppan, L, Lyazidi, A, Templier, F, Khoury, A et al.. How Ventilation Is Delivered During Cardiopulmonary Resuscitation: An International Survey. Respir Care. 2018;63 (10):1293-1301. doi: 10.4187/respcare.05964. PubMed PMID:29739857 .
  10. Yoshida, T, Engelberts, D, Otulakowski, G, Katira, B, Post, M, Ferguson, ND et al.. Continuous Negative Abdominal Pressure Reduces Ventilator-induced Lung Injury in a Porcine Model. Anesthesiology. 2018;129 (1):163-172. doi: 10.1097/ALN.0000000000002236. PubMed PMID:29708892 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group