Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Li, HL, Chen, L, Brochard, L. Protecting lungs during spontaneous breathing: what can we do?. J Thorac Dis. 2017;9 (9):2777-2781. doi: 10.21037/jtd.2017.08.25. PubMed PMID:29221238 PubMed Central PMC5708397.
  2. Guérin, C, Beuret, P, Constantin, JM, Bellani, G, Garcia-Olivares, P, Roca, O et al.. A prospective international observational prevalence study on prone positioning of ARDS patients: the APRONET (ARDS Prone Position Network) study. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4996-5. PubMed PMID:29218379 .
  3. Azoulay, E, Vincent, JL, Angus, DC, Arabi, YM, Brochard, L, Brett, SJ et al.. Recovery after critical illness: putting the puzzle together-a consensus of 29. Crit Care. 2017;21 (1):296. doi: 10.1186/s13054-017-1887-7. PubMed PMID:29208005 PubMed Central PMC5718148.
  4. Chen, L, Del Sorbo, L, Fan, E, Brochard, L. Reply to: The Plausibility of "Bronchiolotrauma". Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201710-2131LE. PubMed PMID:29186671 .
  5. Thille, AW, Córdoba-Izquierdo, A, Maitre, B, Boyer, L, Brochard, L, Drouot, X et al.. High prevalence of sleep apnea syndrome in patients admitted to ICU for acute hypercapnic respiratory failure: a preliminary study. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4998-3. PubMed PMID:29159561 .
  6. Laffey, JG, Bellani, G, Pham, T, Fan, E, Madotto, F, Bajwa, EK et al.. Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4981-z. PubMed PMID:29138899 .
  7. Sakr, Y, Ferrer, R, Reinhart, K, Beale, R, Rhodes, A, Moreno, R et al.. Correction to: The Intensive Care Global Study on Severe Acute Respiratory Infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-4979-6. PubMed PMID:29138898 .
  8. Frat, JP, Ragot, S, Coudroy, R, Constantin, JM, Girault, C, Prat, G et al.. Predictors of Intubation in Patients With Acute Hypoxemic Respiratory Failure Treated With a Noninvasive Oxygenation Strategy. Crit. Care Med. 2017; :. doi: 10.1097/CCM.0000000000002818. PubMed PMID:29099420 .
  9. Dres, M, Austin, PC, Pham, T, Aegerter, P, Guidet, B, Demoule, A et al.. Acute Respiratory Distress Syndrome Cases Volume and ICU Mortality in Medical Patients. Crit. Care Med. 2017; :. doi: 10.1097/CCM.0000000000002816. PubMed PMID:29095203 .
  10. Honorio, T, Brochard, L, Vandamme, M. Hydration Phase Diagram of Clay Particles from Molecular Simulations. Langmuir. 2017;33 (44):12766-12776. doi: 10.1021/acs.langmuir.7b03198. PubMed PMID:29035541 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group