Laurent J. Brochard

MD, HDR

Scientist

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Chen, L, Jonkman, A, Pereira, SM, Lu, C, Brochard, L. Driving pressure monitoring during acute respiratory failure in 2020. Curr Opin Crit Care. 2021;27 (3):303-310. doi: 10.1097/MCC.0000000000000827. PubMed PMID:33899820 .
  2. Dres, M, Similowski, T, Goligher, EC, Pham, T, Sergenyuk, L, Telias, I et al.. Dyspnea and respiratory muscles ultrasound to predict extubation failure. Eur Respir J. 2021; :. doi: 10.1183/13993003.00002-2021. PubMed PMID:33875492 .
  3. Madotto, F, McNicholas, B, Rezoagli, E, Pham, T, Laffey, JG, Bellani, G et al.. Death in hospital following ICU discharge: insights from the LUNG SAFE study. Crit Care. 2021;25 (1):144. doi: 10.1186/s13054-021-03465-0. PubMed PMID:33849625 PubMed Central PMC8043098.
  4. Costa, ELV, Slutsky, A, Brochard, LJ, Brower, R, Serpa-Neto, A, Cavalcanti, AB et al.. Ventilatory Variables and Mechanical Power in Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202009-3467OC. PubMed PMID:33784486 .
  5. Kolb, M, Dinh-Xuan, AT, Brochard, L. Guideline-directed management of COVID-19: Do's and Don'ts. Eur Respir J. 2021;57 (4):. doi: 10.1183/13993003.00753-2021. PubMed PMID:33766949 PubMed Central PMC7996221.
  6. Nasa, P, Azoulay, E, Khanna, AK, Jain, R, Gupta, S, Javeri, Y et al.. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. Crit Care. 2021;25 (1):106. doi: 10.1186/s13054-021-03491-y. PubMed PMID:33726819 PubMed Central PMC7962430.
  7. Tilmont, A, Coiffard, B, Yoshida, T, Daviet, F, Baumstarck, K, Brioude, G et al.. Oesophageal pressure as a surrogate of pleural pressure in mechanically ventilated patients. ERJ Open Res. 2021;7 (1):. doi: 10.1183/23120541.00646-2020. PubMed PMID:33718491 PubMed Central PMC7938048.
  8. Mellado Artigas, R, Damiani, LF, Piraino, T, Pham, T, Chen, L, Rauseo, M et al.. Reverse Triggering Dyssynchrony 24 h after Initiation of Mechanical Ventilation. Anesthesiology. 2021;134 (5):760-769. doi: 10.1097/ALN.0000000000003726. PubMed PMID:33662121 .
  9. Carteaux, G, Pons, M, Morin, F, Tuffet, S, Lesimple, A, Badat, B et al.. Continuous positive airway pressure for respiratory support during COVID-19 pandemic: a frugal approach from bench to bedside. Ann Intensive Care. 2021;11 (1):38. doi: 10.1186/s13613-021-00828-2. PubMed PMID:33655452 PubMed Central PMC7924341.
  10. REMAP-CAP Investigators, Gordon, AC, Mouncey, PR, Al-Beidh, F, Rowan, KM, Nichol, AD et al.. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021;384 (16):1491-1502. doi: 10.1056/NEJMoa2100433. PubMed PMID:33631065 PubMed Central PMC7953461.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group
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