Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Savary, D, Drennan, IR, Badat, B, Grieco, DL, Piraino, T, Lesimple, A et al.. GASTRIC INSUFFLATION DURING CARDIOPULMONARY RESUSCITATION: A STUDY IN HUMAN CADAVERS. Resuscitation. 2019; :. doi: 10.1016/j.resuscitation.2019.10.014. PubMed PMID:31730897 .
  2. Abrams, D, Schmidt, M, Pham, T, Beitler, JR, Fan, E, Goligher, EC et al.. Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201907-1283CI. PubMed PMID:31726013 .
  3. Bertoni, M, Telias, I, Urner, M, Long, M, Del Sorbo, L, Fan, E et al.. A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation. Crit Care. 2019;23 (1):346. doi: 10.1186/s13054-019-2617-0. PubMed PMID:31694692 PubMed Central PMC6836358.
  4. Mancebo, J, Goligher, E, Brochard, L. Spontaneous Breathing Trials and Successful Extubation. JAMA. 2019;322 (17):1716-1717. doi: 10.1001/jama.2019.14226. PubMed PMID:31688879 .
  5. Perren, A, Brochard, L. The importance of timing for the spontaneous breathing trial. Ann Transl Med. 2019;7 (Suppl 6):S210. doi: 10.21037/atm.2019.08.102. PubMed PMID:31656789 PubMed Central PMC6789354.
  6. Rittayamai, N, Phuangchoei, P, Tscheikuna, J, Praphruetkit, N, Brochard, L. Effects of high-flow nasal cannula and non-invasive ventilation on inspiratory effort in hypercapnic patients with chronic obstructive pulmonary disease: a preliminary study. Ann Intensive Care. 2019;9 (1):122. doi: 10.1186/s13613-019-0597-5. PubMed PMID:31641959 PubMed Central PMC6805835.
  7. Chen, L, Del Sorbo, L, Grieco, DL, Junhasavasdikul, D, Rittayamai, N, Soliman, I et al.. Potential for Lung Recruitment Estimated by the Recruitment-to-Inflation Ratio in Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201902-0334OC. PubMed PMID:31577153 .
  8. Roesthuis, L, van der Hoeven, H, Sinderby, C, Frenzel, T, Ottenheijm, C, Brochard, L et al.. Effects of levosimendan on respiratory muscle function in patients weaning from mechanical ventilation. Intensive Care Med. 2019;45 (10):1372-1381. doi: 10.1007/s00134-019-05767-y. PubMed PMID:31576436 PubMed Central PMC6773912.
  9. Mancebo, J, Mercat, A, Brochard, L. Maximal Lung Recruitment in Acute Respiratory Distress Syndrome: A Nail in the Coffin. Am. J. Respir. Crit. Care Med. 2019;200 (11):1331-1333. doi: 10.1164/rccm.201908-1615ED. PubMed PMID:31532227 PubMed Central PMC6884051.
  10. Brochard, L, Yoshida, T, Amato, M. Reply to: Simple Electrical Impedance Tomography Measures for the Assessment of Ventilation Distribution. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201908-1645LE. PubMed PMID:31526321 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group