Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Abrams, D, Ferguson, ND, Brochard, L, Fan, E, Mercat, A, Combes, A et al.. ECMO for ARDS: from salvage to standard of care?. Lancet Respir Med. 2019; :. doi: 10.1016/S2213-2600(18)30506-X. PubMed PMID:30642778 .
  2. Bourke, SC, Piraino, T, Pisani, L, Brochard, L, Elliott, MW. Beyond the guidelines for non-invasive ventilation in acute respiratory failure: implications for practice. Lancet Respir Med. 2018;6 (12):935-947. doi: 10.1016/S2213-2600(18)30388-6. PubMed PMID:30629932 .
  3. Grieco, DL, Brochard, L, Richard, JM. Reply to: Airway Pressure Monitoring May Improve Small Airway Flow, Hemodynamics, and Tissue Oxygenation. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201811-2234LE. PubMed PMID:30605345 .
  4. Coudroy, R, Lu, C, Chen, L, Demoule, A, Brochard, L. Mechanism of airway closure in acute respiratory distress syndrome: a possible role of surfactant depletion. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5501-5. PubMed PMID:30560279 .
  5. Yoshida, T, Grieco, DL, Brochard, L. Guiding ventilation with transpulmonary pressure. Intensive Care Med. 2018; :. doi: 10.1007/s00134-018-5483-3. PubMed PMID:30506355 .
  6. Pham, T, Brochard, LJ. Editorial: Every breath you take…should be monitored. Curr Opin Crit Care. 2019;25 (1):1-2. doi: 10.1097/MCC.0000000000000576. PubMed PMID:30516589 .
  7. Pham, T, Serpa Neto, A, Pelosi, P, Laffey, JG, De Haro, C, Lorente, JA et al.. Outcomes of Patients Presenting with Mild Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study. Anesthesiology. 2018; :. doi: 10.1097/ALN.0000000000002508. PubMed PMID:30499850 .
  8. Boyle, AJ, Sklar, MC, McNamee, JJ, Brodie, D, Slutsky, AS, Brochard, L et al.. Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future. Lancet Respir Med. 2018;6 (11):874-884. doi: 10.1016/S2213-2600(18)30326-6. PubMed PMID:30484429 .
  9. Goligher, EC, Brochard, LJ, Reid, WD, Fan, E, Saarela, O, Slutsky, AS et al.. Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure. Lancet Respir Med. 2019;7 (1):90-98. doi: 10.1016/S2213-2600(18)30366-7. PubMed PMID:30455078 .
  10. Brochard, L, Bersten, A. Mechanical Power: A Biomarker for the Lung?. Anesthesiology. 2019;130 (1):9-11. doi: 10.1097/ALN.0000000000002505. PubMed PMID:30383544 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group