Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Pham, T, Telias, I, Piraino, T, Yoshida, T, Brochard, LJ. Asynchrony Consequences and Management. Crit Care Clin. 2018;34 (3):325-341. doi: 10.1016/j.ccc.2018.03.008. PubMed PMID:29907268 .
  2. Cortegiani, A, Madotto, F, Gregoretti, C, Bellani, G, Laffey, JG, Pham, T et al.. Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database. Crit Care. 2018;22 (1):157. doi: 10.1186/s13054-018-2079-9. PubMed PMID:29895331 PubMed Central PMC5998562.
  3. Combes, A, Hajage, D, Capellier, G, Demoule, A, Lavoué, S, Guervilly, C et al.. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome. N. Engl. J. Med. 2018;378 (21):1965-1975. doi: 10.1056/NEJMoa1800385. PubMed PMID:29791822 .
  4. Cordioli, RL, Brochard, L, Suppan, L, Lyazidi, A, Templier, F, Khoury, A et al.. How Ventilation Is Delivered During Cardiopulmonary Resuscitation: An International Survey. Respir Care. 2018; :. doi: 10.4187/respcare.05964. PubMed PMID:29739857 .
  5. Yoshida, T, Engelberts, D, Otulakowski, G, Katira, B, Post, M, Ferguson, ND et al.. Continuous Negative Abdominal Pressure Reduces Ventilator-induced Lung Injury in a Porcine Model. Anesthesiology. 2018;129 (1):163-172. doi: 10.1097/ALN.0000000000002236. PubMed PMID:29708892 .
  6. Sugiyama, MG, Mintsopoulos, V, Raheel, H, Goldenberg, NM, Batt, JE, Brochard, L et al.. Lung Ultrasound and Microbubbles Enhance Aminoglycoside Efficacy and Delivery to the Lung in E. Coli-induced Pneumonia and ARDS. Am. J. Respir. Crit. Care Med. 2018; :. doi: 10.1164/rccm.201711-2259LE. PubMed PMID:29638143 .
  7. Madotto, F, Pham, T, Bellani, G, Bos, LD, Simonis, FD, Fan, E et al.. Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study. Intensive Care Med. 2018;44 (5):564-577. doi: 10.1007/s00134-018-5152-6. PubMed PMID:29632996 .
  8. Yoshida, T, Brochard, L. Esophageal pressure monitoring: why, when and how?. Curr Opin Crit Care. 2018;24 (3):216-222. doi: 10.1097/MCC.0000000000000494. PubMed PMID:29601320 .
  9. Yoshida, T, Engelberts, D, Otulakowski, G, Katira, B, Ferguson, ND, Brochard, L et al.. CONTINUOUS NEGATIVE ABDOMINAL PRESSURE: Mechanism of Action and Comparison with Prone Position. J. Appl. Physiol. 2018; :. doi: 10.1152/japplphysiol.01125.2017. PubMed PMID:29596015 .
  10. Vorona, S, Sabatini, U, Al-Maqbali, S, Bertoni, M, Dres, M, Bissett, B et al.. Inspiratory Muscle Rehabilitation in Critically Ill Adults. A Systematic Review and Meta-Analysis. Ann Am Thorac Soc. 2018;15 (6):735-744. doi: 10.1513/AnnalsATS.201712-961OC. PubMed PMID:29584447 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group