Lawrence A. Leiter

MDCM, FRCPC, FACP, FACE, FAHA

Associate Scientist, Li Ka Shing Knowledge Institute

Biography

Please note: Dr. Leiter is not taking any summer students.

Dr. Lawrence A. Leiter is Director of the Lipid Clinic, Associate Director of the Clinical Nutrition and Risk Factor Modification Centre and an Associate Scientist in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital in Toronto.  From 2000-2010, he was Head of the Division of Endocrinology and Metabolism. He is a Professor in the Departments of Medicine and Nutritional Sciences at the University of Toronto.

Dr. Leiter has several research interests including clinical trials on the prevention of atherosclerosis, especially in diabetes, and the dietary and pharmacologic treatment of diabetes mellitus, hyperlipidemia, hypertension, and obesity. He has over 500 publications in peer-reviewed journals. He was an investigator in many of the landmark diabetes trials including the Diabetes Control and Complications Trial (DCCT), Action to Control Cardiovascular Risk in Diabetes (ACCORD), and Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) and is on the Steering Committees of many ongoing outcome trials in both the diabetes and lipid areas.

Dr. Leiter is the past President of the Canadian Society of Endocrinology & Metabolism (CSEM) and is a past Chair of the Clinical and Scientific Section of the Canadian Diabetes Association (CDA). He has been involved in many national and international committees and consensus conferences including those of the International Diabetes Federation, CDA, Canadian Hypertension Education Program (CHEP), Canadian Cardiovascular Society (Dyslipidemia), and Obesity Canada.

For his work, he has received a number of awards including the CDA Frederick G. Banting Award and the American Diabetes Association Charles H Best Award (awarded to DCCT investigators), both for Distinguished Service. He also received the 2005 CSEM Educator of the Year Award, and the 2006 CDA Gerald S. Wong Award in recognition of significant contributions to the diabetes community. In 2016, Dr. Leiter received the Canadian Diabetes Association Long Term Achievement Award for Research and the Canadian Society of Endocrinology’s Robert Volpe Award. He was also the inaugural winner of the St. Michael’s Hospital Complete Physician Award in 2009.

 

Recent Publications

  1. Semnani-Azad, Z, Khan, TA, Blanco Mejia, S, de Souza, RJ, Leiter, LA, Kendall, CWC et al.. Association of Major Food Sources of Fructose-Containing Sugars With Incident Metabolic Syndrome: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020;3 (7):e209993. doi: 10.1001/jamanetworkopen.2020.9993. PubMed PMID:32644139 .
  2. Banach, M, Duell, PB, Gotto, AM Jr, Laufs, U, Leiter, LA, Mancini, GBJ et al.. Association of Bempedoic Acid Administration With Atherogenic Lipid Levels in Phase 3 Randomized Clinical Trials of Patients With Hypercholesterolemia. JAMA Cardiol. 2020; :. doi: 10.1001/jamacardio.2020.2314. PubMed PMID:32609313 PubMed Central PMC7330832.
  3. Cukierman-Yaffe, T, Gerstein, HC, Colhoun, HM, Diaz, R, García-Pérez, LE, Lakshmanan, M et al.. Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial. Lancet Neurol. 2020;19 (7):582-590. doi: 10.1016/S1474-4422(20)30173-3. PubMed PMID:32562683 .
  4. Rabi, DM, McBrien, KA, Sapir-Pichhadze, R, Nakhla, M, Ahmed, SB, Dumanski, SM et al.. Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children. Can J Cardiol. 2020;36 (5):596-624. doi: 10.1016/j.cjca.2020.02.086. PubMed PMID:32389335 .
  5. Leiter, LA, Bain, SC, Bhatt, DL, Buse, JB, Mazer, CD, Pratley, RE et al.. The effect of glucagon-like peptide-1 receptor agonists liraglutide and semaglutide on cardiovascular and renal outcomes across baseline blood pressure categories: Analysis of the LEADER and SUSTAIN 6 trials. Diabetes Obes Metab. 2020; :. doi: 10.1111/dom.14079. PubMed PMID:32372454 .
  6. Ghosh-Swaby, OR, Goodman, SG, Leiter, LA, Cheng, A, Connelly, KA, Fitchett, D et al.. Glucose-lowering drugs or strategies, atherosclerotic cardiovascular events, and heart failure in people with or at risk of type 2 diabetes: an updated systematic review and meta-analysis of randomised cardiovascular outcome trials. Lancet Diabetes Endocrinol. 2020;8 (5):418-435. doi: 10.1016/S2213-8587(20)30038-3. PubMed PMID:32333878 .
  7. Leiter, LA. Latest Evidence on Sulfonylureas: What's New?. Diabetes Ther. 2020;11 (Suppl 1):15-22. doi: 10.1007/s13300-020-00812-2. PubMed PMID:32323156 PubMed Central PMC7261305.
  8. Arnold, SV, Bhatt, DL, Barsness, GW, Beatty, AL, Deedwania, PC, Inzucchi, SE et al.. Clinical Management of Stable Coronary Artery Disease in Patients With Type 2 Diabetes Mellitus: A Scientific Statement From the American Heart Association. Circulation. 2020;141 (19):e779-e806. doi: 10.1161/CIR.0000000000000766. PubMed PMID:32279539 .
  9. Landmesser, U, Haghikia, A, Leiter, LA, Wright, RS, Kallend, D, Wijngaard, P et al.. Effect of inclisiran, the siRNA against PCSK9, on platelets, immune cells and immunological biomarkers - a pre-specified analysis from ORION-1. Cardiovasc. Res. 2020; :. doi: 10.1093/cvr/cvaa077. PubMed PMID:32243492 .
  10. Cahn, A, Raz, I, Bonaca, M, Mosenzon, O, Murphy, SA, Yanuv, I et al.. Safety of dapagliflozin in a broad population of patients with type 2 diabetes: Analyses from the DECLARE-TIMI 58 study. Diabetes Obes Metab. 2020;22 (8):1357-1368. doi: 10.1111/dom.14041. PubMed PMID:32239659 .
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Affiliations & Other Activities

  • Director, Lipid Clinic, St. Michael’s Hospital
  • Associate Director, Clinical Nutrition and Risk Factor Modification Centre, St. Michael’s Hospital
  • Professor, Departments of Medicine and Nutritional Sciences, University of Toronto
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