Mario Ostrowski

MD, FRCP

Scientist

Biography

My current research interests focus on the immunopathogenesis of Human Immunodeficiency Virus (HIV) /Acquired Immune Deficiency Syndrome (AIDS) and Hepatitis C Virus (HCV) and other virus infections including SARS-CoV-2. We are interested in understanding why chronic virus infections persist in the host. Current work is divided along the following lines:

  1. Examination of T cell immune response to HIV and HCV infection.
  2. Therapeutic and preventive vaccine strategies
  3. immunomodulation during virus infections

Recent Publications

  1. Yao, Z, Drecun, L, Aboualizadeh, F, Kim, SJ, Li, Z, Wood, H et al.. A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies. Nat Commun. 2021;12 (1):1806. doi: 10.1038/s41467-021-22102-6. PubMed PMID:33753733 .
  2. Kinloch, NN, Ren, Y, Conce Alberto, WD, Dong, W, Khadka, P, Huang, SH et al.. HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA). Nat Commun. 2021;12 (1):165. doi: 10.1038/s41467-020-20442-3. PubMed PMID:33420062 PubMed Central PMC7794580.
  3. Muir, RT, Suthiphosuwan, S, Bharatha, A, Lin, A, Munoz, D, Ostrowski, M et al.. Reversible Small Vessel Vasculitis and Encephalitis in HIV Antiretroviral Resistance. J Neuropathol Exp Neurol. 2021;80 (1):89-92. doi: 10.1093/jnen/nlaa106. PubMed PMID:33212472 PubMed Central PMC7749715.
  4. Isho, B, Abe, KT, Zuo, M, Jamal, AJ, Rathod, B, Wang, JH et al.. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol. 2020;5 (52):. doi: 10.1126/sciimmunol.abe5511. PubMed PMID:33033173 .
  5. Abe, KT, Li, Z, Samson, R, Samavarchi-Tehrani, P, Valcourt, EJ, Wood, H et al.. A simple protein-based surrogate neutralization assay for SARS-CoV-2. JCI Insight. 2020;5 (19):. doi: 10.1172/jci.insight.142362. PubMed PMID:32870820 PubMed Central PMC7566699.
  6. Zost, SJ, Gilchuk, P, Chen, RE, Case, JB, Reidy, JX, Trivette, A et al.. Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein. Nat Med. 2020;26 (9):1422-1427. doi: 10.1038/s41591-020-0998-x. PubMed PMID:32651581 .
  7. Jamal, AJ, Mozafarihashjin, M, Coomes, E, Powis, J, Li, AX, Paterson, A et al.. Sensitivity of Nasopharyngeal Swabs and Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2. Clin Infect Dis. 2021;72 (6):1064-1066. doi: 10.1093/cid/ciaa848. PubMed PMID:32584972 PubMed Central PMC7337630.
  8. Banerjee, A, Nasir, JA, Budylowski, P, Yip, L, Aftanas, P, Christie, N et al.. Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. Emerg Infect Dis. 2020;26 (9):2054-2063. doi: 10.3201/eid2609.201495. PubMed PMID:32558639 PubMed Central PMC7454076.
  9. Khan, S, Liu, Y, Ernst, LM, Leung, LYT, Budylowski, P, Dong, S et al.. Detection of Human CD38 Using Variable Lymphocyte Receptor (VLR) Tetramers. Cells. 2020;9 (4):. doi: 10.3390/cells9040950. PubMed PMID:32290546 PubMed Central PMC7226959.
  10. Liu, J, Clayton, K, Gao, W, Li, Y, Zealey, C, Budylowski, P et al.. Trimeric HIV-1 gp140 fused with APRIL, BAFF, and CD40L on the mucosal gp140-specific antibody responses in mice. Vaccine. 2020;38 (9):2149-2159. doi: 10.1016/j.vaccine.2020.01.050. PubMed PMID:32014267 .
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto
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