Mario Ostrowski

MD, FRCP

Scientist

Biography

My current research interests focus on the immunopathogenesis of Human Immunodeficiency Virus (HIV) /Acquired Immune Deficiency Syndrome (AIDS) and Hepatitis C Virus (HCV). We are interested in understanding why HIV and HCV persist in the host. Current work is divided along the following lines:

1. Examination of T cell immune response to HIV and HCV infection.
2. Investigation of new immune-based adjuvants for DNA or pox-based vaccines: Investigation of novel immune-based strategies to treat HIV- and HCV-infected individuals.

Recent Publications

  1. Kinloch, NN, Ren, Y, Conce Alberto, WD, Dong, W, Khadka, P, Huang, SH et al.. HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA). Nat Commun. 2021;12 (1):165. doi: 10.1038/s41467-020-20442-3. PubMed PMID:33420062 PubMed Central PMC7794580.
  2. Muir, RT, Suthiphosuwan, S, Bharatha, A, Lin, A, Munoz, D, Ostrowski, M et al.. Reversible Small Vessel Vasculitis and Encephalitis in HIV Antiretroviral Resistance. J Neuropathol Exp Neurol. 2021;80 (1):89-92. doi: 10.1093/jnen/nlaa106. PubMed PMID:33212472 PubMed Central PMC7749715.
  3. Isho, B, Abe, KT, Zuo, M, Jamal, AJ, Rathod, B, Wang, JH et al.. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol. 2020;5 (52):. doi: 10.1126/sciimmunol.abe5511. PubMed PMID:33033173 .
  4. Abe, KT, Li, Z, Samson, R, Samavarchi-Tehrani, P, Valcourt, EJ, Wood, H et al.. A simple protein-based surrogate neutralization assay for SARS-CoV-2. JCI Insight. 2020;5 (19):. doi: 10.1172/jci.insight.142362. PubMed PMID:32870820 PubMed Central PMC7566699.
  5. Zost, SJ, Gilchuk, P, Chen, RE, Case, JB, Reidy, JX, Trivette, A et al.. Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein. Nat Med. 2020;26 (9):1422-1427. doi: 10.1038/s41591-020-0998-x. PubMed PMID:32651581 .
  6. Banerjee, A, Nasir, JA, Budylowski, P, Yip, L, Aftanas, P, Christie, N et al.. Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. Emerg Infect Dis. 2020;26 (9):2054-2063. doi: 10.3201/eid2609.201495. PubMed PMID:32558639 PubMed Central PMC7454076.
  7. Khan, S, Liu, Y, Ernst, LM, Leung, LYT, Budylowski, P, Dong, S et al.. Detection of Human CD38 Using Variable Lymphocyte Receptor (VLR) Tetramers. Cells. 2020;9 (4):. doi: 10.3390/cells9040950. PubMed PMID:32290546 PubMed Central PMC7226959.
  8. Liu, J, Clayton, K, Gao, W, Li, Y, Zealey, C, Budylowski, P et al.. Trimeric HIV-1 gp140 fused with APRIL, BAFF, and CD40L on the mucosal gp140-specific antibody responses in mice. Vaccine. 2020;38 (9):2149-2159. doi: 10.1016/j.vaccine.2020.01.050. PubMed PMID:32014267 .
  9. Silva de Castro, I, Gordon, SN, Liu, J, Bissa, M, McKinnon, K, Trinh, HV et al.. Expression of CD40L by the ALVAC-Simian Immunodeficiency Virus Vector Abrogates T Cell Responses in Macaques. J Virol. 2020;94 (6):. doi: 10.1128/JVI.01933-19. PubMed PMID:31896599 PubMed Central PMC7158742.
  10. Wong, RW, Lingwood, CA, Ostrowski, MA, Cabral, T, Cochrane, A. Author Correction: Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling. Sci Rep. 2019;9 (1):18656. doi: 10.1038/s41598-019-54732-8. PubMed PMID:31796843 PubMed Central PMC6890798.
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto
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