Mario Ostrowski

MD, FRCP

Scientist, Keenan Research Centre for Biomedical Science

Biography

My current research interests focus on the immunopathogenesis of HIV/AIDS and HCV. We are interested in understanding why HIV and HCV persist in the host. Current work is divided along the following lines:

  1. Examination of T cell immune response to HIV and HCV infection.
  2. Investigation of new immune-based adjuvants for DNA or pox-based vaccines: Investigation of novel immune-based strategies to treat HIV- and HCV-infected individuals.

Recent Publications

  1. Naccarato, M, Hall, E, Wai, A, Ostrowski, M, Carvalhal, A. A case of a probable drug interaction between lurasidone and atazanavir-based antiretroviral therapy. Antivir. Ther. (Lond.). 2016; :. doi: 10.3851/IMP3059. PubMed PMID:27328703 .
  2. Ding, Y, Liu, J, Lu, S, Igweze, J, Xu, W, Kuang, D et al.. Self-assembling peptide for co-delivery of HIV-1 CD8+ T cells epitope and Toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell and augment polyfunctional cytotoxic T lymphocyte (CTL) response. J Control Release. 2016;236 :22-30. doi: 10.1016/j.jconrel.2016.06.019. PubMed PMID:27297778 .
  3. Yu, C, Liu, Y, Chan, JT, Tong, J, Li, Z, Shi, M et al.. Identification of human plasma cells with a lamprey monoclonal antibody. JCI Insight. ;1 (3):. Epub 2016/3/17. doi: 10.1172/jci.insight.84738. PubMed PMID:27152361 PubMed Central PMC4854299.
  4. MacParland, SA, Fadel, SM, Mihajlovic, V, Fawaz, A, Kim, C, Rahman, AK et al.. HCV Specific IL-21 Producing T Cells but Not IL-17A Producing T Cells Are Associated with HCV Viral Control in HIV/HCV Coinfection. PLoS ONE. 2016;11 (4):e0154433. Epub 2016/4/28. doi: 10.1371/journal.pone.0154433. PubMed PMID:27124305 PubMed Central PMC4849786.
  5. Jones, RB, Mueller, S, O'Connor, R, Rimpel, K, Sloan, DD, Karel, D et al.. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog. 2016;12 (4):e1005545. Epub 2016/4/15. doi: 10.1371/journal.ppat.1005545. PubMed PMID:27082643 PubMed Central PMC4833318.
  6. Chew, GM, Fujita, T, Webb, GM, Burwitz, BJ, Wu, HL, Reed, JS et al.. TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog. 2016;12 (1):e1005349. Epub 2016/1/7. doi: 10.1371/journal.ppat.1005349. PubMed PMID:26741490 PubMed Central PMC4704737.
  7. Ostrowski, M, Benko, E, Yue, FY, Kim, CJ, Huibner, S, Lee, T et al.. Intensifying Antiretroviral Therapy With Raltegravir and Maraviroc During Early Human Immunodeficiency Virus (HIV) Infection Does Not Accelerate HIV Reservoir Reduction. Open Forum Infect Dis. 2015;2 (4):ofv138. Epub 2015/9/22. doi: 10.1093/ofid/ofv138. PubMed PMID:26512359 PubMed Central PMC4621663.
  8. Anmole, G, Kuang, XT, Toyoda, M, Martin, E, Shahid, A, Le, AQ et al.. A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion. J. Immunol. Methods. 2015;426 :104-13. doi: 10.1016/j.jim.2015.08.010. PubMed PMID:26319395 .
  9. Ming, K, Kim, J, Biondi, MJ, Syed, A, Chen, K, Lam, A et al.. Integrated quantum dot barcode smartphone optical device for wireless multiplexed diagnosis of infected patients. ACS Nano. 2015;9 (3):3060-74. doi: 10.1021/nn5072792. PubMed PMID:25661584 .
  10. Clayton, KL, Douglas-Vail, MB, Nur-ur Rahman, AK, Medcalf, KE, Xie, IY, Chew, GM et al.. Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression. J. Virol. 2015;89 (7):3723-36. doi: 10.1128/JVI.00006-15. PubMed PMID:25609823 PubMed Central PMC4403393.
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto