Mario Ostrowski

MD, FRCP

Scientist, Keenan Research Centre for Biomedical Science

Biography

My current research interests focus on the immunopathogenesis of Human Immunodeficiency Virus (HIV) /Acquired Immune Deficiency Syndrome (AIDS) and Hepatitis C Virus (HCV). We are interested in understanding why HIV and HCV persist in the host. Current work is divided along the following lines:

1. Examination of T cell immune response to HIV and HCV infection.
2. Investigation of new immune-based adjuvants for DNA or pox-based vaccines: Investigation of novel immune-based strategies to treat HIV- and HCV-infected individuals.

Recent Publications

  1. Perciani, CT, Jaoko, W, Walmsley, S, Farah, B, Mahmud, SM, Ostrowski, M et al.. Protocol of a randomised controlled trial characterising the immune responses induced by varicella-zoster virus (VZV) vaccination in healthy Kenyan women: setting the stage for a potential VZV-based HIV vaccine. BMJ Open. 2017;7 (9):e017391. doi: 10.1136/bmjopen-2017-017391. PubMed PMID:28939581 PubMed Central PMC5623463.
  2. Liu, J, Ostrowski, M. Development of targeted adjuvants for HIV-1 vaccines. AIDS Res Ther. 2017;14 (1):43. doi: 10.1186/s12981-017-0165-8. PubMed PMID:28893282 PubMed Central PMC5594534.
  3. Mujib, S, Saiyed, A, Fadel, S, Bozorgzad, A, Aidarus, N, Yue, FY et al.. Pharmacologic HIV-1 Nef blockade promotes CD8 T cell-mediated elimination of latently HIV-1-infected cells in vitro. JCI Insight. 2017;2 (17):. doi: 10.1172/jci.insight.93684. PubMed PMID:28878119 PubMed Central PMC5621880.
  4. Mujib, S, Liu, J, Rahman, AKMN, Schwartz, JA, Bonner, P, Yue, FY et al.. Comprehensive Cross-Clade Characterization of Antibody-Mediated Recognition, Complement-Mediated Lysis, and Cell-Mediated Cytotoxicity of HIV-1 Envelope-Specific Antibodies toward Eradication of the HIV-1 Reservoir. J. Virol. 2017;91 (16):. doi: 10.1128/JVI.00634-17. PubMed PMID:28592534 PubMed Central PMC5533900.
  5. Kim, CJ, Rousseau, R, Huibner, S, Kovacs, C, Benko, E, Shahabi, K et al.. Impact of intensified antiretroviral therapy during early HIV infection on gut immunology and inflammatory blood biomarkers. AIDS. 2017;31 (11):1529-1534. doi: 10.1097/QAD.0000000000001515. PubMed PMID:28463882 .
  6. Schwartz, JA, Clayton, KL, Mujib, S, Zhang, H, Rahman, AK, Liu, J et al.. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. J. Immunol. 2017;198 (8):3181-3194. doi: 10.4049/jimmunol.1601298. PubMed PMID:28264968 .
  7. Yue, FY, Cohen, JC, Ho, M, Rahman, AK, Liu, J, Mujib, S et al.. HIV-Specific Granzyme B-Secreting but Not Gamma Interferon-Secreting T Cells Are Associated with Reduced Viral Reservoirs in Early HIV Infection. J. Virol. 2017;91 (8):. doi: 10.1128/JVI.02233-16. PubMed PMID:28179527 PubMed Central PMC5375660.
  8. MacParland, SA, Tsoi, KM, Ouyang, B, Ma, XZ, Manuel, J, Fawaz, A et al.. Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood. ACS Nano. 2017;11 (3):2428-2443. doi: 10.1021/acsnano.6b06245. PubMed PMID:28040885 .
  9. Tsoi, KM, MacParland, SA, Ma, XZ, Spetzler, VN, Echeverri, J, Ouyang, B et al.. Mechanism of hard-nanomaterial clearance by the liver. Nat Mater. 2016;15 (11):1212-1221. doi: 10.1038/nmat4718. PubMed PMID:27525571 PubMed Central PMC5132626.
  10. Naccarato, M, Hall, E, Wai, A, Ostrowski, M, Carvalhal, A. A case of a probable drug interaction between lurasidone and atazanavir-based antiretroviral therapy. Antivir. Ther. (Lond.). 2016;21 (8):735-738. doi: 10.3851/IMP3059. PubMed PMID:27328703 .
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto
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