Mario Ostrowski

MD, FRCP

Scientist, Keenan Research Centre for Biomedical Science

Biography

My current research interests focus on the immunopathogenesis of Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome(AIDS) and Hepatitis C Virus (HCV). We are interested in understanding why HIV and HCV persist in the host. Current work is divided along the following lines:

1. Examination of T cell immune response to HIV and HCV infection.
2. Investigation of new immune-based adjuvants for DNA or pox-based vaccines: Investigation of novel immune-based strategies to treat HIV- and HCV-infected individuals.

Recent Publications

  1. Mujib, S, Liu, J, Rahman, AKMN, Schwartz, JA, Bonner, P, Yue, FY et al.. Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir. J. Virol. 2017; :. doi: 10.1128/JVI.00634-17. PubMed PMID:28592534 .
  2. Kim, CJ, Rousseau, R, Huibner, S, Kovacs, C, Benko, E, Shahabi, K et al.. Impact of intensified antiretroviral therapy during early HIV infection on gut immunology and inflammatory blood biomarkers: a randomized controlled trial. AIDS. 2017; :. doi: 10.1097/QAD.0000000000001515. PubMed PMID:28463882 .
  3. Schwartz, JA, Clayton, KL, Mujib, S, Zhang, H, Rahman, AK, Liu, J et al.. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. J. Immunol. 2017;198 (8):3181-3194. doi: 10.4049/jimmunol.1601298. PubMed PMID:28264968 .
  4. Yue, FY, Cohen, JC, Ho, M, Rahman, AK, Liu, J, Mujib, S et al.. HIV-Specific Granzyme B-Secreting but Not Gamma Interferon-Secreting T Cells Are Associated with Reduced Viral Reservoirs in Early HIV Infection. J. Virol. 2017;91 (8):. doi: 10.1128/JVI.02233-16. PubMed PMID:28179527 PubMed Central PMC5375660.
  5. MacParland, SA, Tsoi, KM, Ouyang, B, Ma, XZ, Manuel, J, Fawaz, A et al.. Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood. ACS Nano. 2017;11 (3):2428-2443. doi: 10.1021/acsnano.6b06245. PubMed PMID:28040885 .
  6. Tsoi, KM, MacParland, SA, Ma, XZ, Spetzler, VN, Echeverri, J, Ouyang, B et al.. Mechanism of hard-nanomaterial clearance by the liver. Nat Mater. 2016;15 (11):1212-1221. doi: 10.1038/nmat4718. PubMed PMID:27525571 PubMed Central PMC5132626.
  7. Naccarato, M, Hall, E, Wai, A, Ostrowski, M, Carvalhal, A. A case of a probable drug interaction between lurasidone and atazanavir-based antiretroviral therapy. Antivir. Ther. (Lond.). 2016;21 (8):735-738. doi: 10.3851/IMP3059. PubMed PMID:27328703 .
  8. Ding, Y, Liu, J, Lu, S, Igweze, J, Xu, W, Kuang, D et al.. Self-assembling peptide for co-delivery of HIV-1 CD8+ T cells epitope and Toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell and augment polyfunctional cytotoxic T lymphocyte (CTL) response. J Control Release. 2016;236 :22-30. doi: 10.1016/j.jconrel.2016.06.019. PubMed PMID:27297778 .
  9. Yu, C, Liu, Y, Chan, JT, Tong, J, Li, Z, Shi, M et al.. Identification of human plasma cells with a lamprey monoclonal antibody. JCI Insight. ;1 (3):. doi: 10.1172/jci.insight.84738. PubMed PMID:27152361 PubMed Central PMC4854299.
  10. MacParland, SA, Fadel, SM, Mihajlovic, V, Fawaz, A, Kim, C, Rahman, AK et al.. HCV Specific IL-21 Producing T Cells but Not IL-17A Producing T Cells Are Associated with HCV Viral Control in HIV/HCV Coinfection. PLoS ONE. 2016;11 (4):e0154433. doi: 10.1371/journal.pone.0154433. PubMed PMID:27124305 PubMed Central PMC4849786.
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto