Mario Ostrowski

MD, FRCP

Scientist, Keenan Research Centre for Biomedical Science

Biography

My current research interests focus on the immunopathogenesis of HIV/AIDS and HCV. We are interested in understanding why HIV and HCV persist in the host. Current work is divided along the following lines:

  1. Examination of T cell immune response to HIV and HCV infection.
  2. Investigation of new immune-based adjuvants for DNA or pox-based vaccines: Investigation of novel immune-based strategies to treat HIV- and HCV-infected individuals.

Recent Publications

  1. Chew, GM, Fujita, T, Webb, GM, Burwitz, BJ, Wu, HL, Reed, JS et al.. TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog. 2016;12 (1):e1005349. Epub 2016/1/7. doi: 10.1371/journal.ppat.1005349. PubMed PMID:26741490 PubMed Central PMC4704737.
  2. Ostrowski, M, Benko, E, Yue, FY, Kim, CJ, Huibner, S, Lee, T et al.. Intensifying Antiretroviral Therapy With Raltegravir and Maraviroc During Early Human Immunodeficiency Virus (HIV) Infection Does Not Accelerate HIV Reservoir Reduction. Open Forum Infect Dis. 2015;2 (4):ofv138. Epub 2015/9/22. doi: 10.1093/ofid/ofv138. PubMed PMID:26512359 PubMed Central PMC4621663.
  3. Anmole, G, Kuang, XT, Toyoda, M, Martin, E, Shahid, A, Le, AQ et al.. A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion. J. Immunol. Methods. 2015;426 :104-13. doi: 10.1016/j.jim.2015.08.010. PubMed PMID:26319395 .
  4. Ming, K, Kim, J, Biondi, MJ, Syed, A, Chen, K, Lam, A et al.. Integrated quantum dot barcode smartphone optical device for wireless multiplexed diagnosis of infected patients. ACS Nano. 2015;9 (3):3060-74. doi: 10.1021/nn5072792. PubMed PMID:25661584 .
  5. Clayton, KL, Douglas-Vail, MB, Nur-ur Rahman, AK, Medcalf, KE, Xie, IY, Chew, GM et al.. Soluble T cell immunoglobulin mucin domain 3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression. J. Virol. 2015;89 (7):3723-36. doi: 10.1128/JVI.00006-15. PubMed PMID:25609823 PubMed Central PMC4403393.
  6. Huang, YH, Zhu, C, Kondo, Y, Anderson, AC, Gandhi, A, Russell, A et al.. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 2015;517 (7534):386-90. doi: 10.1038/nature13848. PubMed PMID:25363763 PubMed Central PMC4297519.
  7. Fujita, T, Burwitz, BJ, Chew, GM, Reed, JS, Pathak, R, Seger, E et al.. Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques. J. Immunol. 2014;193 (11):5576-83. doi: 10.4049/jimmunol.1400961. PubMed PMID:25348621 PubMed Central PMC4239185.
  8. Jones, RB, O'Connor, R, Mueller, S, Foley, M, Szeto, GL, Karel, D et al.. Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes. PLoS Pathog. 2014;10 (8):e1004287. Epub 2014/8/14. doi: 10.1371/journal.ppat.1004287. PubMed PMID:25122219 PubMed Central PMC4133386.
  9. Bitnun, A, Samson, L, Chun, TW, Kakkar, F, Brophy, J, Murray, D et al.. Early initiation of combination antiretroviral therapy in HIV-1-infected newborns can achieve sustained virologic suppression with low frequency of CD4+ T cells carrying HIV in peripheral blood. Clin. Infect. Dis. 2014;59 (7):1012-9. doi: 10.1093/cid/ciu432. PubMed PMID:24917662 PubMed Central PMC4184383.
  10. Sheppard, NC, Jones, RB, Burwitz, BJ, Nimityongskul, FA, Newman, LP, Buechler, MB et al.. Vaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replication. PLoS ONE. 2014;9 (3):e92012. Epub 2014/3/20. doi: 10.1371/journal.pone.0092012. PubMed PMID:24651676 PubMed Central PMC3961289.
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto