Matthew Muller


Associate Scientist, Li Ka Shing Knowledge Institute


Dr. Matthew Muller is an infectious diseases physician and the Medical Director of Infection Prevention and Control at St. Michael’s Hospital. He is an Assistant Professor at the University of Toronto in the Department of Medicine. His research interests are focused on the epidemiology and previous of hospital-acquired infections including C. difficile, infections due to common antibiotic-resistant organisms and emerging infectious threats such as MERS-CoV. Dr. Muller has a particular interest in hand hygiene measurement and improvement including the use of novel technological approaches to hand hygiene improvement. Dr. Muller chairs the Provincial Infectious Diseases Advisory Committee on Infection Prevention and Control, and is also interested in guideline and policy development with respect to infection prevention for Ontario hospitals.


Recent Publications

  1. Johnstone, J, Garber, G, Muller, M. Health care-associated infections in Canadian hospitals: still a major problem. CMAJ. 2019;191 (36):E977-E978. doi: 10.1503/cmaj.190948. PubMed PMID:32392482 PubMed Central PMC6733688.
  2. Leis, JA, Powis, JE, McGeer, A, Ricciuto, DR, Agnihotri, T, Coyle, N et al.. Introduction of Group Electronic Monitoring of Hand Hygiene on Inpatient Units: A Multicenter Cluster Randomized Quality Improvement Study. Clin. Infect. Dis. 2020; :. doi: 10.1093/cid/ciaa412. PubMed PMID:32270865 .
  3. Beauregard-Paultre, C, Abou Chakra, CN, McGeer, A, Labbé, AC, Simor, AE, Gold, W et al.. External validation of clinical prediction rules for complications and mortality following Clostridioides difficile infection. PLoS ONE. 2019;14 (12):e0226672. doi: 10.1371/journal.pone.0226672. PubMed PMID:31846487 PubMed Central PMC6917260.
  4. Grunebaum, E, Reid, B, Naqvi, A, Hershfield, MS, Kim, VH, Muller, MP et al.. Morbidity in an adenosine deaminase-deficient patient during 27 years of enzyme replacement therapy. Clin. Immunol. 2020;211 :108321. doi: 10.1016/j.clim.2019.108321. PubMed PMID:31812707 .
  5. Kandel, CE, Jenkinson, R, Daneman, N, Backstein, D, Hansen, BE, Muller, MP et al.. Predictors of Treatment Failure for Hip and Knee Prosthetic Joint Infections in the Setting of 1- and 2-Stage Exchange Arthroplasty: A Multicenter Retrospective Cohort. Open Forum Infect Dis. 2019;6 (11):ofz452. doi: 10.1093/ofid/ofz452. PubMed PMID:31737739 PubMed Central PMC6847009.
  6. Blanchard, AC, Tang, L, Tadros, M, Muller, M, Spilker, T, Waters, VJ et al.. Burkholderia cenocepacia ET12 transmission in adults with cystic fibrosis. Thorax. 2020;75 (1):88-90. doi: 10.1136/thoraxjnl-2019-214098. PubMed PMID:31732688 .
  7. Tadros, M, Cabrera, A, Matukas, LM, Muller, M. Evaluation of Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry and ClinPro Tools as a Rapid Tool for Typing Streptococcus pyogenes. Open Forum Infect Dis. 2019;6 (11):ofz441. doi: 10.1093/ofid/ofz441. PubMed PMID:31700941 PubMed Central PMC6825801.
  8. Jamal, AJ, Garcia-Jeldes, F, Baqi, M, Borgia, S, Johnstone, J, Katz, K et al.. Infection prevention and control practices related to carbapenemase-producing Enterobacteriaceae (CPE) in acute-care hospitals in Ontario, Canada. Infect Control Hosp Epidemiol. 2019;40 (9):1006-1012. doi: 10.1017/ice.2019.173. PubMed PMID:31244458 .
  9. Jiang, L, McGeer, A, McNeil, S, Katz, K, Loeb, M, Muller, MP et al.. Which healthcare workers work with acute respiratory illness? Evidence from Canadian acute-care hospitals during 4 influenza seasons: 2010-2011 to 2013-2014. Infect Control Hosp Epidemiol. 2019;40 (8):889-896. doi: 10.1017/ice.2019.141. PubMed PMID:31208477 .
  10. Garneau, JR, Abou Chakra, CN, Fortier, LC, Labbé, AC, Simor, AE, Gold, W et al.. Multilocus Variable-Number Tandem-Repeat Analysis of Clostridioides difficile Clusters in Ribotype 027 Isolates and Lack of Association with Clinical Outcomes. J. Clin. Microbiol. 2019;57 (5):. doi: 10.1128/JCM.01724-18. PubMed PMID:30760531 PubMed Central PMC6497997.
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Affiliations & Other Activities

  • Medical Director, Infection Prevention and Control, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto