Neeru Gupta


Scientist, Keenan Research Centre for Biomedical Science

Research Programs


Research Interests

Retinal disease, glaucoma, degeneration of vision pathways, neuroprotection and pharmacological treatment strategies, intraocular pressure regulation, the role of the lymphatic circulation in the eye, neuroimaging and clinical trials

Research Activities

I have a longstanding and broad interest in vision science, covering a variety of topics. These include retinal disease, the neuropharmacology of glaucoma, glaucoma as a neurodegenerative disease, the regulation of intraocular pressure, and the lymphatic circulation. Studies in the laboratory support and complement ongoing clinical studies and trials.

Recent Publications

  1. McKetton, L, Williams, J, Viviano, JD, Yücel, YH, Gupta, N, Schneider, KA et al.. High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem. J Vis Exp. 2015; (106):. doi: 10.3791/53309. PubMed PMID:26779880 .
  2. Yucel, Y, Gupta, N. Lymphatic drainage from the eye: A new target for therapy. Prog. Brain Res. 2015;220 :185-98. doi: 10.1016/bs.pbr.2015.07.028. PubMed PMID:26497791 .
  3. Yucel, YH, Gupta, N. A framework to explore the visual brain in glaucoma with lessons from models and man. Exp. Eye Res. 2015;141 :171-8. doi: 10.1016/j.exer.2015.07.004. PubMed PMID:26169795 .
  4. Gupta, N, Kocur, I. Chronic eye disease and the WHO Universal Eye Health Global Action Plan 2014-2019. Can. J. Ophthalmol. 2014;49 (5):403-5. doi: 10.1016/j.jcjo.2014.08.014. PubMed PMID:25284093 .
  5. Mathieu, E, Gupta, N, Macdonald, RL, Ai, J, Yücel, YH. In vivo imaging of lymphatic drainage of cerebrospinal fluid in mouse. Fluids Barriers CNS. 2013;10 (1):35. doi: 10.1186/2045-8118-10-35. PubMed PMID:24360130 PubMed Central PMC3879644.
  6. Tam, AL, Gupta, N, Zhang, Z, Yücel, YH. Latanoprost Stimulates Ocular Lymphatic Drainage: An In Vivo Nanotracer Study. Transl Vis Sci Technol. 2013;2 (5):3. Epub 2013/8/7. doi: 10.1167/tvst.2.5.3. PubMed PMID:24049723 PubMed Central PMC3763898.
  7. Khan, AM, Kagan, DB, Gupta, N, Navajas, EV, Jin, YP, Yücel, YH et al.. Ciliary body lymphangiogenesis in uveal melanoma with and without extraocular extension. Ophthalmology. 2013;120 (2):306-10. doi: 10.1016/j.ophtha.2012.07.064. PubMed PMID:23062649 .
  8. Tam, AL, Gupta, N, Zhang, Z, Yücel, YH. Quantum dots trace lymphatic drainage from the mouse eye. Nanotechnology. 2011;22 (42):425101. doi: 10.1088/0957-4484/22/42/425101. PubMed PMID:21934199 .
  9. Kim, M, Johnston, MG, Gupta, N, Moore, S, Yücel, YH. A model to measure lymphatic drainage from the eye. Exp. Eye Res. 2011;93 (5):586-91. doi: 10.1016/j.exer.2011.07.006. PubMed PMID:21810424 .
  10. Ly, T, Gupta, N, Weinreb, RN, Kaufman, PL, Yücel, YH. Dendrite plasticity in the lateral geniculate nucleus in primate glaucoma. Vision Res. 2011;51 (2):243-50. doi: 10.1016/j.visres.2010.08.003. PubMed PMID:20692280 PubMed Central PMC3125971.
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Affiliations & Other Activities

  • Scientist, Li Ka Shing Knowledge Institute of St. Michael’s Hospital
  • Director, Glaucoma Unit, Dept. of Ophthalmology, St. Michael’s Hospital / University of Toronto
  • Dorothy Pitts Chair, Ophthalmology & Vision Sciences, St. Michael’s Hospital
  • Co-Founder and CEO, Human Eye Biobank for Research, St.Michael’s
  • Professor, Ophthalmology & Vision Sciences, Faculty of Medicine, University of Toronto
  • Professor, Laboratory Medicine & Pathobiology, University of Toronto
  • Member, Institute of Medical Science, University of Toronto
  • Member, Graduate Studies, Dept. of Laboratory Medicine & Pathobiology, University of Toronto
  • Chief of Glaucoma, University of Toronto
  • Immediate Past-President, Canadian Glaucoma Society
  • Chair, Advisory Board to the International Council of Ophthalmology
  • Board of Directors, International Council of Ophthalmology
  • Diabetic Eye Care Task Force, International Council of Ophthalmology
  • Chair, Glaucoma Task Force, International Council of Ophthalmology
  • Scientific Advisory Board, Glaucoma Foundation, New York, USA
  • Editorial Board, Investigative Ophthalmology and Vision Science
  • Editor, Translational Vision Science & Technology, Canadian Journal of Ophthalmology
  • Editorial Board, Asia-Pacific Journal of Ophthalmology
  • Editorial Board, Eye and Brain
  • Editorial Board, International Glaucoma Review