Neeru Gupta



Research Programs


Research Interests

Retinal disease, glaucoma, degeneration of vision pathways, neuroprotection and pharmacological treatment strategies, intraocular pressure regulation, the role of the lymphatic circulation in the eye, neuroimaging and clinical trials

Research Activities

I have a longstanding and broad interest in vision science, covering a variety of topics. These include retinal disease, the neuropharmacology of glaucoma, glaucoma as a neurodegenerative disease, the regulation of intraocular pressure, and the lymphatic circulation. Studies in the laboratory support and complement ongoing clinical studies and trials.

Recent Publications

  1. Cardinell, K, Gupta, N, Koivisto, BD, Kumaradas, JC, Zhou, X, Irving, H et al.. A novel photoacoustic-fluorescent contrast agent for quantitative imaging of lymphatic drainage. Photoacoustics. 2021;21 :100239. doi: 10.1016/j.pacs.2021.100239. PubMed PMID:33520651 PubMed Central PMC7820935.
  2. Sharma, K, Amin Mohammed Amin, M, Gupta, N, Zinman, L, Zhou, X, Irving, H et al.. Retinal Spheroids and Axon Pathology Identified in Amyotrophic Lateral Sclerosis. Invest Ophthalmol Vis Sci. 2020;61 (13):30. doi: 10.1167/iovs.61.13.30. PubMed PMID:33226405 PubMed Central PMC7691787.
  3. Yücel, YH, Cheng, F, Cardinell, K, Zhou, X, Irving, H, Gupta, N et al.. Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study. Exp Eye Res. 2020;194 :108029. doi: 10.1016/j.exer.2020.108029. PubMed PMID:32251650 .
  4. Jin, S, Chan, SWS, Gupta, N. Distribution gaps in cataract surgery care and impact on seniors across Ontario. Can J Ophthalmol. 2019;54 (4):451-457. doi: 10.1016/j.jcjo.2018.10.022. PubMed PMID:31358143 .
  5. Gupta, N. Incision-Free Minimally Invasive Conjunctival Surgery (MICS) for Late-Onset Bleb Leaks After Trabeculectomy (An American Ophthalmological Society Thesis). Am J Ophthalmol. 2019;207 :333-342. doi: 10.1016/j.ajo.2019.04.031. PubMed PMID:31095952 .
  6. Mathieu, E, Gupta, N, Paczka-Giorgi, LA, Zhou, X, Ahari, A, Lani, R et al.. Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma. Invest Ophthalmol Vis Sci. 2018;59 (15):5876-5884. doi: 10.1167/iovs.18-24521. PubMed PMID:30543343 .
  7. Chan, SWS, Yucel, Y, Gupta, N. New trends in corneal transplants at the University of Toronto. Can J Ophthalmol. 2018;53 (6):580-587. doi: 10.1016/j.jcjo.2018.02.023. PubMed PMID:30502981 .
  8. Khattak, S, Gupta, N, Zhou, X, Pires, L, Wilson, BC, Yucel, YH et al.. Non-invasive dynamic assessment of conjunctival melanomas by photoacoustic imaging. Exp Eye Res. 2019;179 :157-167. doi: 10.1016/j.exer.2018.11.014. PubMed PMID:30447197 .
  9. Diamond, MA, Chan, SWS, Zhou, X, Glinka, Y, Girard, E, Yucel, Y et al.. Lymphatic vessels identified in failed corneal transplants with neovascularisation. Br J Ophthalmol. 2019;103 (3):421-427. doi: 10.1136/bjophthalmol-2018-312630. PubMed PMID:30348644 PubMed Central PMC6579550.
  10. Hanna, J, Yücel, YH, Zhou, X, Mathieu, E, Paczka-Giorgi, LA, Gupta, N et al.. Progressive loss of retinal blood vessels in a live model of retinitis pigmentosa. Can J Ophthalmol. 2018;53 (4):391-401. doi: 10.1016/j.jcjo.2017.10.014. PubMed PMID:30119795 .
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Affiliations & Other Activities

  • Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Director, Glaucoma Unit, Department of Ophthalmology, St. Michael’s Hospital / University of Toronto
  • Co-Founder and CEO, Human Eye Biobank for Research, St.Michael’s
  • Professor, Ophthalmology & Vision Sciences, Faculty of Medicine, University of Toronto
  • Professor, Laboratory Medicine & Pathobiology, University of Toronto
  • Member, Institute of Medical Science, University of Toronto
  • Member, Graduate Studies, Department of Laboratory Medicine & Pathobiology, University of Toronto
  • Chief of Glaucoma, University of Toronto
  • Immediate Past-President, Canadian Glaucoma Society
  • Chair, Advisory Board to the International Council of Ophthalmology
  • Board of Directors, International Council of Ophthalmology
  • Diabetic Eye Care Task Force, International Council of Ophthalmology
  • Chair, Glaucoma Task Force, International Council of Ophthalmology
  • Scientific Advisory Board, Glaucoma Foundation, New York, USA
  • Editorial Board, Investigative Ophthalmology and Vision Science
  • Editor, Translational Vision Science & Technology, Canadian Journal of Ophthalmology
  • Editorial Board, Asia-Pacific Journal of Ophthalmology
  • Editorial Board, Eye and Brain
  • Editorial Board, International Glaucoma Review