Neeru Gupta


Scientist, Keenan Research Centre for Biomedical Science

Tel: 416-864-5444
LinkedIn: Neeru Gupta

Research Programs


Research Interests

Retinal disease, glaucoma, degeneration of vision pathways, neuroprotection and pharmacological treatment strategies, intraocular pressure regulation, the role of the lymphatic circulation in the eye, neuroimaging and clinical trials

Research Activities

I have a longstanding and broad interest in vision science, covering a variety of topics. These include retinal disease, the neuropharmacology of glaucoma, glaucoma as a neurodegenerative disease, the regulation of intraocular pressure, and the lymphatic circulation. Studies in the laboratory support and complement ongoing clinical studies and trials.

Recent Publications

  1. Hanna, J, Yücel, YH, Zhou, X, Mathieu, E, Paczka-Giorgi, LA, Gupta, N et al.. Progressive loss of retinal blood vessels in a live model of retinitis pigmentosa. Can. J. Ophthalmol. 2018;53 (4):391-401. doi: 10.1016/j.jcjo.2017.10.014. PubMed PMID:30119795 .
  2. Yücel, YH, Cardinell, K, Khattak, S, Zhou, X, Lapinski, M, Cheng, F et al.. Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles. Invest. Ophthalmol. Vis. Sci. 2018;59 (7):2699-2707. doi: 10.1167/iovs.17-22850. PubMed PMID:29860456 .
  3. Wong, TY, Sun, J, Kawasaki, R, Ruamviboonsuk, P, Gupta, N, Lansingh, VC et al.. Guidelines on Diabetic Eye Care: The International Council of Ophthalmology Recommendations for Screening, Follow-up, Referral, and Treatment Based on Resource Settings. Ophthalmology. 2018;125 (10):1608-1622. doi: 10.1016/j.ophtha.2018.04.007. PubMed PMID:29776671 .
  4. Yucel, Y, Mathieu, E, Gupta, N. Author Response: The "Ocular Glymphatic System": An Important Missing Piece in the Puzzle of Optic Disc Edema in Astronauts?. Invest. Ophthalmol. Vis. Sci. 2018;59 (5):2092-2093. doi: 10.1167/iovs.17-23407. PubMed PMID:29677372 .
  5. Yucel, YH, Mathieu, E, Gupta, N. Author Response: The First Histologic Evidence of a Paravascular Pathway Within the Optic Nerve. Invest. Ophthalmol. Vis. Sci. 2018;59 (5):1718. doi: 10.1167/iovs.18-24164. PubMed PMID:29610855 .
  6. Ozturker, ZK, Munro, K, Gupta, N. Optic disc hemorrhages in glaucoma and common clinical features. Can. J. Ophthalmol. 2017;52 (6):583-591. doi: 10.1016/j.jcjo.2017.04.011. PubMed PMID:29217027 .
  7. Chan, SWS, Khattak, S, Yücel, N, Gupta, N, Yücel, YH. A decade of surgical eye removals in Ontario: a clinical-pathological study. Can. J. Ophthalmol. 2017;52 (5):486-493. doi: 10.1016/j.jcjo.2017.02.025. PubMed PMID:28985809 .
  8. Mathieu, E, Gupta, N, Ahari, A, Zhou, X, Hanna, J, Yücel, YH et al.. Evidence for Cerebrospinal Fluid Entry Into the Optic Nerve via a Glymphatic Pathway. Invest. Ophthalmol. Vis. Sci. 2017;58 (11):4784-4791. doi: 10.1167/iovs.17-22290. PubMed PMID:28973323 .
  9. Le, R, Yucel, N, Khattak, S, Yucel, YH, Prud'homme, GJ, Gupta, N et al.. Current indications and surgical approaches to corneal transplants at the University of Toronto: A clinical-pathological study. Can. J. Ophthalmol. 2017;52 (1):74-79. doi: 10.1016/j.jcjo.2016.07.005. PubMed PMID:28237153 .
  10. Le, R, Berger, AR, Gupta, N. Long-term Follow-up of a Case of Gold Shunt Surgery for Refractory Silicone Oil-induced Glaucoma. J. Glaucoma. 2016;25 (8):e734-7. doi: 10.1097/IJG.0000000000000450. PubMed PMID:27253968 PubMed Central PMC4972476.
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Affiliations & Other Activities

  • Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Director, Glaucoma Unit, Department of Ophthalmology, St. Michael’s Hospital / University of Toronto
  • Co-Founder and CEO, Human Eye Biobank for Research, St.Michael’s
  • Professor, Ophthalmology & Vision Sciences, Faculty of Medicine, University of Toronto
  • Professor, Laboratory Medicine & Pathobiology, University of Toronto
  • Member, Institute of Medical Science, University of Toronto
  • Member, Graduate Studies, Department of Laboratory Medicine & Pathobiology, University of Toronto
  • Chief of Glaucoma, University of Toronto
  • Immediate Past-President, Canadian Glaucoma Society
  • Chair, Advisory Board to the International Council of Ophthalmology
  • Board of Directors, International Council of Ophthalmology
  • Diabetic Eye Care Task Force, International Council of Ophthalmology
  • Chair, Glaucoma Task Force, International Council of Ophthalmology
  • Scientific Advisory Board, Glaucoma Foundation, New York, USA
  • Editorial Board, Investigative Ophthalmology and Vision Science
  • Editor, Translational Vision Science & Technology, Canadian Journal of Ophthalmology
  • Editorial Board, Asia-Pacific Journal of Ophthalmology
  • Editorial Board, Eye and Brain
  • Editorial Board, International Glaucoma Review