Ori Rotstein


Vice-President of Research and Innovation


Dr. Ori Rotstein is the Vice President of Research and Innovation at Unity Health Toronto. He is also a Professor and Associate Chair of the Department of Surgery at the University of Toronto.

In addition to his role as VP, Dr. Rotstein is a practicing General Surgeon, and is an acknowledged expert in the management of intra-abdominal infection and inflammation. He is the former Director of the Institute of Medical Science, University of Toronto, the postgraduate arm of the Faculty of Medicine at the University of Toronto from 2001-2011 that was responsible for graduate training programs for more than 500 MSc/PhD students. In 2012, the Institute of Medical Science honoured him with an annual lecture ‘The Ori D. Rotstein Lectureship in Translational Research’. He is a member of several prestigious medical societies including the Canadian Academy of Health Sciences, the American Surgical Association, and the American Society for Clinical Investigation. He is a Past President of the Surgical Infection Society and has contributed significantly to the activities of the American College of Surgeons through his participation on the Program Committee, Surgical Forum Committee, and the Scholarship Executive Committee.

Research Interests

Dr. Rotstein has a major interest in understanding how traumatic injury leads to alterations in the immune response of patients. He uses his clinical insights into the mechanisms of disease to generate novel therapeutic approaches to preventing poor outcome in these patients. His work spans the “bench to bedside” continuum, wherein he investigates cellular and animal models with a view to translating these to novel therapies in humans. This translational research has led to the investigation of the use of additives in resuscitation fluids in patients sustaining such injuries.

Recent Publications

  1. Hess, DA, Terenzi, DC, Trac, JZ, Quan, A, Mason, T, Al-Omran, M et al.. SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus. Cell Metab. 2019;30 (4):609-613. doi: 10.1016/j.cmet.2019.08.015. PubMed PMID:31477497 .
  2. Bialik, JF, Ding, M, Speight, P, Dan, Q, Miranda, MZ, Di Ciano-Oliveira, C et al.. Profibrotic epithelial phenotype: a central role for MRTF and TAZ. Sci Rep. 2019;9 (1):4323. doi: 10.1038/s41598-019-40764-7. PubMed PMID:30867502 PubMed Central PMC6416270.
  3. Leung, CH, Caldarone, CA, Guan, R, Wen, XY, Ailenberg, M, Kapus, A et al.. Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates the Hepatoprotective Effects of Remote Ischemic Conditioning in Hemorrhagic Shock. Antioxid. Redox Signal. 2019;30 (14):1760-1773. doi: 10.1089/ars.2018.7541. PubMed PMID:30403148 .
  4. Aarts, MA, Rotstein, OD, Pearsall, EA, Victor, JC, Okrainec, A, McKenzie, M et al.. Postoperative ERAS Interventions Have the Greatest Impact on Optimal Recovery: Experience With Implementation of ERAS Across Multiple Hospitals. Ann. Surg. 2018;267 (6):992-997. doi: 10.1097/SLA.0000000000002632. PubMed PMID:29303803 .
  5. Amoozadeh, Y, Anwer, S, Dan, Q, Venugopal, S, Shi, Y, Branchard, E et al.. Cell confluence regulates claudin-2 expression: possible role for ZO-1 and Rac. Am. J. Physiol., Cell Physiol. 2018;314 (3):C366-C378. doi: 10.1152/ajpcell.00234.2017. PubMed PMID:29187366 .
  6. Hassinger, TE, Guidry, CA, Rotstein, OD, Duane, TM, Evans, HL, Cook, CH et al.. Longer-Duration Antimicrobial Therapy Does Not Prevent Treatment Failure in High-Risk Patients with Complicated Intra-Abdominal Infections. Surg Infect (Larchmt). ;18 (6):659-663. doi: 10.1089/sur.2017.084. PubMed PMID:28650745 PubMed Central PMC5576191.
  7. Farmer, D, Tessier, JM, Sanders, JM, Sawyer, RG, Rotstein, OD, Dellinger, EP et al.. Age and Its Impact on Outcomes with Intra-Abdominal Infection. Surg Infect (Larchmt). ;18 (2):77-82. doi: 10.1089/sur.2016.184. PubMed PMID:28005468 .
  8. Rattan, R, Allen, CJ, Sawyer, RG, Mazuski, J, Duane, TM, Askari, R et al.. Patients with Risk Factors for Complications Do Not Require Longer Antimicrobial Therapy for Complicated Intra-Abdominal Infection. Am Surg. 2016;82 (9):860-6. . PubMed PMID:27670577 .
  9. Rattan, R, Allen, CJ, Sawyer, RG, Askari, R, Banton, KL, Coimbra, R et al.. Percutaneously drained intra-abdominal infections do not require longer duration of antimicrobial therapy. J Trauma Acute Care Surg. 2016;81 (1):108-13. doi: 10.1097/TA.0000000000001019. PubMed PMID:26953758 .
  10. Rattan, R, Allen, CJ, Sawyer, RG, Askari, R, Banton, KL, Claridge, JA et al.. Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy. J. Am. Coll. Surg. 2016;222 (4):440-6. doi: 10.1016/j.jamcollsurg.2015.12.050. PubMed PMID:26920994 .
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Affiliations & Other Activities

  • Vice-President of Research and Innovation, Unity Health Toronto
  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Associate Chair, Department of Surgery, University of Toronto
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University