Peter Vadas

MD, FRCPC,PhD

Project Investigator, Li Ka Shing Knowledge Institute

Biography

Additional research specialties

Anaphylaxis, peanut allergy, platelet activating factor, PAF acetylhydrolase, induction of oral tolerance.

Research Activities

Secretion of peanut protein in breast milk of lactating women

Use of activated charcoal in treating peanut-induced allergic reactions

Role of platelet activating factor (PAF) and PAF acetylhydrolase in severe and fatal anaphylaxis

Mechanism of action of epinephrine as a rescue medication in acute anaphylaxis

Risk factors that predispose to severe anaphylaxis

Undeclared peanut protein in prepared foods imported into Canada

Catemenial anaphylaxis: response to treatment

Recent Publications

  1. Wong, BN, Vadas, P. Angioedema suppressed by a combination of anti-histamine and leukotriene modifier. Allergy Asthma Clin Immunol. 2017;13 :28. doi: 10.1186/s13223-017-0201-1. PubMed PMID:28616043 PubMed Central PMC5469062.
  2. Vadas, P. The platelet-activating factor pathway in food allergy and anaphylaxis. Ann. Allergy Asthma Immunol. 2016;117 (5):455-457. doi: 10.1016/j.anai.2016.05.003. PubMed PMID:27788869 .
  3. Vadas, P, Sinilaite, A, Chaim, M. Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity. J Allergy Clin Immunol Pract. ;4 (2):284-91. doi: 10.1016/j.jaip.2015.09.021. PubMed PMID:26619922 .
  4. Gill, P, Jindal, NL, Jagdis, A, Vadas, P. Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis. J. Allergy Clin. Immunol. 2015;135 (6):1424-32. doi: 10.1016/j.jaci.2015.04.019. PubMed PMID:26051949 .
  5. Sussman, G, Hébert, J, Gulliver, W, Lynde, C, Waserman, S, Kanani, A et al.. Insights and advances in chronic urticaria: a Canadian perspective. Allergy Asthma Clin Immunol. 2015;11 (1):7. doi: 10.1186/s13223-015-0072-2. PubMed PMID:25705232 PubMed Central PMC4336710.
  6. Jagdis, A, Vadas, P. Omalizumab effectively prevents recurrent refractory anaphylaxis in a patient with monoclonal mast cell activation syndrome. Ann. Allergy Asthma Immunol. 2014;113 (1):115-6. doi: 10.1016/j.anai.2014.05.001. PubMed PMID:24950847 .
  7. Perelman, B, Adil, A, Vadas, P. Relationship between platelet activating factor acetylhydrolase activity and apolipoprotein B levels in patients with peanut allergy. Allergy Asthma Clin Immunol. 2014;10 (1):20. doi: 10.1186/1710-1492-10-20. PubMed PMID:24808915 PubMed Central PMC4012516.
  8. Vadas, P, Liss, G. Anaphylaxis: Clinical features and mediator release patterns. J. Allergy Clin. Immunol. 2013;132 (6):1456-7. doi: 10.1016/j.jaci.2013.09.012. PubMed PMID:24182683 .
  9. Van Wert, R, McKenna, AM, Smith, CA, Vadas, P, Detsky, AS, Mourad, O et al.. A missed opportunity. J Gen Intern Med. 2013;28 (5):728-32. doi: 10.1007/s11606-012-2248-5. PubMed PMID:23150069 PubMed Central PMC3631074.
  10. Vadas, P, Perelman, B, Liss, G. Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. J. Allergy Clin. Immunol. 2013;131 (1):144-9. doi: 10.1016/j.jaci.2012.08.016. PubMed PMID:23040367 .
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Affiliations & Other Activities

  • Head, Allergy and Clinical Immunology, St. Michael’s Hospital
  • Medical Advisory Board, Anaphylaxis Canada
  • Scientific Advisory Committee, National Peanut Board
  • Past chair, Anaphylaxis Committee, American Academy of Allergy and Clinical Immunology
  • Past chair, Anaphylaxis Committee, Canadian Society of Allergy and Clinical Immunology
  • Executive, Allergy, Asthma and Immunology Society of Ontario