Philip Connelly

PhD, BA

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Phil Connelly is a Staff Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital and has a primary academic appointment in the Department of Medicine, St. Michael’s Hospital and University of Toronto as well as a graduate appointment in the Department of Laboratory Medicine and Pathobiology. Dr. Connelly’s current basic research is focused on the metabolism of hydroxy fatty aldehydes. The chemistry of this system involves glutathione and the products are readily exported from the cells to undergo further metabolism. The products are known to be proinflammatory and, we hypothesize, atherothrombotic.

Collaborative research on patient populations is focused on renal transplant recipients, women with gestational diabetes and subjects with pre-diabetes.

Recent Publications

  1. Retnakaran, R, Ye, C, Connelly, PW, Hanley, AJ, Sermer, M, Zinman, B et al.. Impact of Changes Over Time in Adipokines and Inflammatory Proteins on Changes in Insulin Sensitivity, β-Cell Function, and Glycemia in Women With Previous Gestational Dysglycemia. Diabetes Care. 2017;40 (8):e101-e102. doi: 10.2337/dc17-0781. PubMed PMID:28615242 .
  2. Kramer, CK, Zinman, B, Choi, H, Connelly, PW, Retnakaran, R. Impact of the Glucagon Assay When Assessing the Effect of Chronic Liraglutide Therapy on Glucagon Secretion. J. Clin. Endocrinol. Metab. 2017;102 (8):2729-2733. doi: 10.1210/jc.2017-00928. PubMed PMID:28472325 .
  3. Arya, S, Ye, C, Connelly, PW, Hanley, AJ, Sermer, M, Zinman, B et al.. Asymmetric dimethylarginine and arginine metabolites in women with and without a history of gestational diabetes. J. Diabetes Complicat. 2017;31 (6):964-970. doi: 10.1016/j.jdiacomp.2017.03.009. PubMed PMID:28392044 .
  4. Kramer, CK, Zinman, B, Choi, H, Connelly, PW, Retnakaran, R. Chronic liraglutide therapy induces an enhanced endogenous glucagon-like peptide-1 secretory response in early type 2 diabetes. Diabetes Obes Metab. 2017;19 (5):744-748. doi: 10.1111/dom.12858. PubMed PMID:28181363 .
  5. Mansuri, S, Badawi, A, Kayaniyil, S, Cole, DE, Harris, SB, Mamakeesick, M et al.. Traditional foods and 25(OH)D concentrations in a subarctic First Nations community. Int J Circumpolar Health. 2016;75 (1):31956. doi: 10.3402/ijch.v75.31956. PubMed PMID:28156417 PubMed Central PMC5035507.
  6. Ray, JG, De Souza, LR, Park, AL, Connelly, PW, Bujold, E, Berger, H et al.. Preeclampsia and Preterm Birth Associated With Visceral Adiposity in Early Pregnancy. J Obstet Gynaecol Can. 2017;39 (2):78-81. doi: 10.1016/j.jogc.2016.10.007. PubMed PMID:27998690 .
  7. Bajaj, H, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Prior lactation reduces future diabetic risk through sustained postweaning effects on insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 2017;312 (3):E215-E223. doi: 10.1152/ajpendo.00403.2016. PubMed PMID:27965206 .
  8. Liu, X, Kris-Etherton, PM, West, SG, Lamarche, B, Jenkins, DJ, Fleming, JA et al.. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity (Silver Spring). 2016;24 (11):2261-2268. doi: 10.1002/oby.21584. PubMed PMID:27804268 PubMed Central PMC5119743.
  9. Connelly, PW, Hanley, AJ. Adiponectin, Adipokines, and the Need for Long-Term Human Studies With Comprehensive End Points. Arterioscler. Thromb. Vasc. Biol. 2016;36 (11):2136-2137. doi: 10.1161/ATVBAHA.116.308402. PubMed PMID:27784699 .
  10. Retnakaran, R, Ye, C, Kramer, CK, Connelly, PW, Hanley, AJ, Sermer, M et al.. Maternal Serum Prolactin and Prediction of Postpartum β-Cell Function and Risk of Prediabetes/Diabetes. Diabetes Care. 2016;39 (7):1250-8. doi: 10.2337/dc16-0043. PubMed PMID:27208323 .
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Affiliations & Other Activities

  • Director, J. Alick Little Lipid Research Laboratory, St. Michael’s Hospital
  • Professor, Medicine/Endocrinology, University of Toronto
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto
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