Philip Connelly


Scientist, Keenan Research Centre for Biomedical Science


Dr. Phil Connelly is a Staff Scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He has a primary academic appointment in the Department of Medicine at the University of Toronto, as well as a graduate appointment in the Department of Laboratory Medicine and Pathobiology. Dr. Connelly’s current basic research is focused on the metabolism of hydroxy fatty aldehydes. The chemistry of this system involves glutathione and the products are readily exported from the cells to undergo further metabolism. The products are known to be proinflammatory and, we hypothesize, atherothrombotic.

Collaborative research on patient populations is focused on renal transplant recipients, women with gestational diabetes and subjects with pre-diabetes.

Recent Publications

  1. Hare, GMT, Han, K, Leshchyshyn, Y, Mistry, N, Kei, T, Dai, SY et al.. Potential biomarkers of tissue hypoxia during acute hemodilutional anemia in cardiac surgery: A prospective study to assess tissue hypoxia as a mechanism of organ injury. Can J Anaesth. 2018; :. doi: 10.1007/s12630-018-1140-0. PubMed PMID:29696581 .
  2. De Souza, LR, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Circulating B-type natriuretic peptide in women with and without recent gestational diabetes: The impact of current glucose intolerance. Clin. Endocrinol. (Oxf). 2018;88 (2):227-233. doi: 10.1111/cen.13510. PubMed PMID:29112786 .
  3. Retnakaran, R, Ye, C, Connelly, PW, Hanley, AJ, Sermer, M, Zinman, B et al.. Impact of Changes Over Time in Adipokines and Inflammatory Proteins on Changes in Insulin Sensitivity, β-Cell Function, and Glycemia in Women With Previous Gestational Dysglycemia. Diabetes Care. 2017;40 (8):e101-e102. doi: 10.2337/dc17-0781. PubMed PMID:28615242 .
  4. Kramer, CK, Zinman, B, Choi, H, Connelly, PW, Retnakaran, R. Impact of the Glucagon Assay When Assessing the Effect of Chronic Liraglutide Therapy on Glucagon Secretion. J. Clin. Endocrinol. Metab. 2017;102 (8):2729-2733. doi: 10.1210/jc.2017-00928. PubMed PMID:28472325 .
  5. Arya, S, Ye, C, Connelly, PW, Hanley, AJ, Sermer, M, Zinman, B et al.. Asymmetric dimethylarginine and arginine metabolites in women with and without a history of gestational diabetes. J. Diabetes Complicat. 2017;31 (6):964-970. doi: 10.1016/j.jdiacomp.2017.03.009. PubMed PMID:28392044 .
  6. Kramer, CK, Zinman, B, Choi, H, Connelly, PW, Retnakaran, R. Chronic liraglutide therapy induces an enhanced endogenous glucagon-like peptide-1 secretory response in early type 2 diabetes. Diabetes Obes Metab. 2017;19 (5):744-748. doi: 10.1111/dom.12858. PubMed PMID:28181363 .
  7. Mansuri, S, Badawi, A, Kayaniyil, S, Cole, DE, Harris, SB, Mamakeesick, M et al.. Traditional foods and 25(OH)D concentrations in a subarctic First Nations community. Int J Circumpolar Health. 2016;75 (1):31956. doi: 10.3402/ijch.v75.31956. PubMed PMID:28156417 PubMed Central PMC5035507.
  8. Ray, JG, De Souza, LR, Park, AL, Connelly, PW, Bujold, E, Berger, H et al.. Preeclampsia and Preterm Birth Associated With Visceral Adiposity in Early Pregnancy. J Obstet Gynaecol Can. 2017;39 (2):78-81. doi: 10.1016/j.jogc.2016.10.007. PubMed PMID:27998690 .
  9. Bajaj, H, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Prior lactation reduces future diabetic risk through sustained postweaning effects on insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 2017;312 (3):E215-E223. doi: 10.1152/ajpendo.00403.2016. PubMed PMID:27965206 .
  10. Liu, X, Kris-Etherton, PM, West, SG, Lamarche, B, Jenkins, DJ, Fleming, JA et al.. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity (Silver Spring). 2016;24 (11):2261-2268. doi: 10.1002/oby.21584. PubMed PMID:27804268 PubMed Central PMC5119743.
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Affiliations & Other Activities

  • Director, J. Alick Little Lipid Research Laboratory, St. Michael’s Hospital
  • Professor, Department of Medicine, Division of Endocrinology, University of Toronto
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto