R. Loch Macdonald

MD, FRCSC, FASC, PhD

Associate Scientist, Keenan Research Centre for Biomedical Science

Research Programs

Biography

My major research interests are in the field of aneurismal subarachnoid hemorrhage and cerebral vasospasm. We are investigating causes of delayed neurological deterioration after subarachnoid hemorrhage using animal models and testing hippocampal electrophysiology and function, animal behavior, learning and memory and changes in gene expression and function. We also are studying mechanisms of large artery vasospasm after aneurismal subarachnoid hemorrhage and effects of intracerebral and subdural hemorrhage on the brain. All of this work is laboratory-based as well as clinical with clinical trials and patient-based studies conducted testing similar hypotheses.

Recent Publications

  1. Guha, D, Macdonald, RL. Perioperative Management of Anticoagulation. Neurosurg. Clin. N. Am. 2017;28 (2):287-295. doi: 10.1016/j.nec.2016.11.011. PubMed PMID:28325463 .
  2. Hänggi, D, Macdonald, RL. Response by Hänggi and Macdonald to Letter Regarding Article, "Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])". Stroke. 2017; :. doi: 10.1161/STROKEAHA.117.016603. PubMed PMID:28283608 .
  3. Murphy, A, de Oliveira Manoel, AL, Macdonald, RL, Baker, A, Lee, TY, Marotta, T et al.. Changes in Cerebral Perfusion with Induced Hypertension in Aneurysmal Subarachnoid Hemorrhage: A Pilot and Feasibility Study. Neurocrit Care. 2017; :. doi: 10.1007/s12028-017-0379-6. PubMed PMID:28244000 .
  4. Grasso, G, Alafaci, C, Macdonald, RL. Management of aneurysmal subarachnoid hemorrhage: State of the art and future perspectives. Surg Neurol Int. 2017;8 :11. doi: 10.4103/2152-7806.198738. PubMed PMID:28217390 PubMed Central PMC5288992.
  5. Alotaibi, NM, Guha, D, Ahuja, CS, Spears, J, Muller, PJ, Tucker, WS et al.. History of neurosurgery at University of Toronto: the St. Michael's story. J. Neurosurg. 2017; :1-9. doi: 10.3171/2016.9.JNS161119. PubMed PMID:28128690 .
  6. Rawal, S, Alcaide-Leon, P, Macdonald, RL, Rinkel, GJ, Victor, JC, Krings, T et al.. Meta-analysis of timing of endovascular aneurysm treatment in subarachnoid haemorrhage: inconsistent results of early treatment within 1 day. J. Neurol. Neurosurg. Psychiatr. 2017;88 (3):241-248. doi: 10.1136/jnnp-2016-314596. PubMed PMID:28100721 .
  7. Alotaibi, NM, Elkarim, GA, Samuel, N, Ayling, OG, Guha, D, Fallah, A et al.. Effects of decompressive craniectomy on functional outcomes and death in poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J. Neurosurg. 2017; :1-11. doi: 10.3171/2016.9.JNS161383. PubMed PMID:28059660 .
  8. Bell, JD, Rhind, SG, Di Battista, AP, Macdonald, RL, Baker, AJ. Biomarkers of Glycocalyx Injury are Associated with Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage: A Case Series Supporting a New Hypothesis. Neurocrit Care. 2016; :. doi: 10.1007/s12028-016-0357-4. PubMed PMID:28000132 .
  9. Bosche, B, Molcanyi, M, Rej, S, Doeppner, TR, Obermann, M, Müller, DJ et al.. Low-Dose Lithium Stabilizes Human Endothelial Barrier by Decreasing MLC Phosphorylation and Universally Augments Cholinergic Vasorelaxation Capacity in a Direct Manner. Front Physiol. 2016;7 :593. doi: 10.3389/fphys.2016.00593. PubMed PMID:27999548 PubMed Central PMC5138228.
  10. Hänggi, D, Etminan, N, Aldrich, F, Steiger, HJ, Mayer, SA, Diringer, MN et al.. Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]). Stroke. 2017;48 (1):145-151. doi: 10.1161/STROKEAHA.116.014250. PubMed PMID:27932607 .
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Affiliations & Other Activities

  • Associate Scientist, Li Ka Shing Knowledge Institute
  • Professor, Surgery/Neurosurgery, University of Toronto
  • Keenan Endowed Chair, Surgery, St. Michael’s Hospital