R. Loch Macdonald


Associate Scientist, Keenan Research Centre for Biomedical Science

Research Programs


My major research interests are in the field of aneurismal subarachnoid hemorrhage and cerebral vasospasm. We are investigating causes of delayed neurological deterioration after subarachnoid hemorrhage using animal models and testing hippocampal electrophysiology and function, animal behavior, learning and memory and changes in gene expression and function. We also are studying mechanisms of large artery vasospasm after aneurismal subarachnoid hemorrhage and effects of intracerebral and subdural hemorrhage on the brain. All of this work is laboratory-based as well as clinical with clinical trials and patient-based studies conducted testing similar hypotheses.

Please note: Dr. Macdonald is currently on sabbatical leave, will not take students in summer 2018.

Recent Publications

  1. de Oliveira Manoel, AL, Macdonald, RL. Neuroinflammation as a Target for Intervention in Subarachnoid Hemorrhage. Front Neurol. 2018;9 :292. doi: 10.3389/fneur.2018.00292. PubMed PMID:29770118 PubMed Central PMC5941982.
  2. Hird, MA, Vesely, KA, Tasneem, T, Saposnik, G, Macdonald, RL, Schweizer, TA et al.. A Case-Control Study Investigating Simulated Driving Errors in Ischemic Stroke and Subarachnoid Hemorrhage. Front Neurol. 2018;9 :54. doi: 10.3389/fneur.2018.00054. PubMed PMID:29487561 PubMed Central PMC5816745.
  3. Alotaibi, NM, Samuel, N, Mansouri, A, Nejad, R, Macdonald, RL. Glioblastoma Following Ischemic Stroke. Can J Neurol Sci. 2017;44 (6):732-733. doi: 10.1017/cjn.2017.220. PubMed PMID:29391081 .
  4. Jaja, BNR, Saposnik, G, Lingsma, HF, Macdonald, E, Thorpe, KE, Mamdani, M et al.. Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study. BMJ. 2018;360 :j5745. . PubMed PMID:29348138 .
  5. Ayling, OGS, Alotaibi, NM, Wang, JZ, Fatehi, M, Ibrahim, GM, Benavente, O et al.. Suboccipital Decompressive Craniectomy for Cerebellar Infarction: A Systematic Review and Meta-Analysis. World Neurosurg. 2018;110 :450-459.e5. doi: 10.1016/j.wneu.2017.10.144. PubMed PMID:29104155 .
  6. Alotaibi, NM, Wang, JZ, Pasarikovski, CR, Guha, D, Al-Mufti, F, Mamdani, M et al.. Management of raised intracranial pressure in aneurysmal subarachnoid hemorrhage: time for a consensus?. Neurosurg Focus. 2017;43 (5):E13. doi: 10.3171/2017.7.FOCUS17426. PubMed PMID:29088956 .
  7. Jaja, BNR, Schweizer, TA, Claassen, J, Le Roux, P, Mayer, SA, Macdonald, RL et al.. The SAFARI Score to Assess the Risk of Convulsive Seizure During Admission for Aneurysmal Subarachnoid Hemorrhage. Neurosurgery. 2018;82 (6):887-893. doi: 10.1093/neuros/nyx334. PubMed PMID:28973169 .
  8. Germans, MR, Jaja, BNR, de Oliviera Manoel, AL, Cohen, AH, Macdonald, RL. Sex differences in delayed cerebral ischemia after subarachnoid hemorrhage. J. Neurosurg. 2017; :1-7. doi: 10.3171/2017.3.JNS162808. PubMed PMID:28862545 .
  9. Alotaibi, NM, Ibrahim, GM, Wang, J, Guha, D, Mamdani, M, Schweizer, TA et al.. Neurosurgeon academic impact is associated with clinical outcomes after clipping of ruptured intracranial aneurysms. PLoS ONE. 2017;12 (7):e0181521. doi: 10.1371/journal.pone.0181521. PubMed PMID:28727832 PubMed Central PMC5519166.
  10. Pasarikovski, CR, Alotaibi, NM, Al-Mufti, F, Macdonald, RL. Hypertonic Saline for Increased Intracranial Pressure After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review. World Neurosurg. 2017;105 :1-6. doi: 10.1016/j.wneu.2017.05.085. PubMed PMID:28549643 .
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Affiliations & Other Activities

  • Associate Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Professor, Department of Surgery, Division of Neurosurgery, University of Toronto