R. Loch Macdonald


Associate Scientist, Keenan Research Centre for Biomedical Science

Research Programs


Please note: Dr. Macdonald will not take students in summer 2019.

My major research interests are in the field of aneurismal subarachnoid hemorrhage and cerebral vasospasm. We are investigating causes of delayed neurological deterioration after subarachnoid hemorrhage using animal models and testing hippocampal electrophysiology and function, animal behavior, learning and memory and changes in gene expression and function. We also are studying mechanisms of large artery vasospasm after aneurismal subarachnoid hemorrhage and effects of intracerebral and subdural hemorrhage on the brain. All of this work is laboratory-based as well as clinical with clinical trials and patient-based studies conducted testing similar hypotheses.


Recent Publications

  1. Suarez, JI, Macdonald, RL. The End of the Tower of Babel in Subarachnoid Hemorrhage: Common Data Elements at Last. Neurocrit Care. 2019; :. doi: 10.1007/s12028-019-00751-2. PubMed PMID:31152313 .
  2. Chou, SH, Macdonald, RL, Keller, E, Unruptured Intracranial Aneurysms and SAH CDE Project Investigators. Biospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations. Neurocrit Care. 2019; :. doi: 10.1007/s12028-019-00725-4. PubMed PMID:31144274 .
  3. Stienen, MN, Visser-Meily, JM, Schweizer, TA, Hänggi, D, Macdonald, RL, Vergouwen, MDI et al.. Prioritization and Timing of Outcomes and Endpoints After Aneurysmal Subarachnoid Hemorrhage in Clinical Trials and Observational Studies: Proposal of a Multidisciplinary Research Group. Neurocrit Care. 2019; :. doi: 10.1007/s12028-019-00737-0. PubMed PMID:31123994 .
  4. de Oliveira Manoel, AL, van der Jagt, M, Amin-Hanjani, S, Bambakidis, NC, Brophy, GM, Bulsara, K et al.. Common Data Elements for Unruptured Intracranial Aneurysms and Aneurysmal Subarachnoid Hemorrhage: Recommendations from the Working Group on Hospital Course and Acute Therapies-Proposal of a Multidisciplinary Research Group. Neurocrit Care. 2019; :. doi: 10.1007/s12028-019-00726-3. PubMed PMID:31119687 .
  5. Hackenberg, KAM, Etminan, N, Wintermark, M, Meyers, PM, Lanzino, G, Rüfenacht, D et al.. Common Data Elements for Radiological Imaging of Patients with Subarachnoid Hemorrhage: Proposal of a Multidisciplinary Research Group. Neurocrit Care. 2019; :. doi: 10.1007/s12028-019-00728-1. PubMed PMID:31115823 .
  6. Suarez, JI, Sheikh, MK, Macdonald, RL, Amin-Hanjani, S, Brown, RD Jr, de Oliveira Manoel, AL et al.. Common Data Elements for Unruptured Intracranial Aneurysms and Subarachnoid Hemorrhage Clinical Research: A National Institute for Neurological Disorders and Stroke and National Library of Medicine Project. Neurocrit Care. 2019; :. doi: 10.1007/s12028-019-00723-6. PubMed PMID:31087257 .
  7. Macdonald, RL, Katan, M. Haptoglobin and hemoglobin in subarachnoid hemorrhage: A tale of 2 globins. Neurology. 2019;92 (18):831-832. doi: 10.1212/WNL.0000000000007399. PubMed PMID:30952791 .
  8. Mikhail, M, Ayling, OGS, Eagles, ME, Ibrahim, GM, Macdonald, RL. Association between weekend admissions and mortality after aneurysmal subarachnoid hemorrhage: the "weekend effect" revisited. J. Neurosurg. 2019; :1-7. doi: 10.3171/2019.1.JNS183185. PubMed PMID:30925472 .
  9. Taslimi, S, Ku, JC, Modabbernia, A, Macdonald, RL. Hemorrhage, seizures, and dynamic changes of familial versus non-familial cavernous malformation: systematic review and meta-analysis. World Neurosurg. 2019; :. doi: 10.1016/j.wneu.2019.02.115. PubMed PMID:30851471 .
  10. Eagles, ME, Tso, MK, Macdonald, RL. Cognitive Impairment, Functional Outcome, and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2019; :. doi: 10.1016/j.wneu.2018.12.152. PubMed PMID:30639483 .
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Affiliations & Other Activities

  • Associate Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Professor, Department of Surgery, Division of Neurosurgery, University of Toronto