Richard S. T. Leung

MD, PhD

Associate Scientist, Li Ka Shing Knowledge Institute

Biography

Research Interests

Sleep apnea, Cheyne-Stokes respiration, autonomic nervous system, heart rate variability

Research Activities

My main area of interest is the autonomic and cardiac effects of sleep apnea. In particular I am interested in ways in which sleep apnea can cause arrhythmias and other cardiac diseases. I perform both physiological studies in patients and healthy volunteers, as well as epidemiologic studies.

Recent Publications

  1. Lyons, OD, Floras, JS, Logan, AG, Beanlands, R, Cantolla, JD, Fitzpatrick, M et al.. Design of the effect of adaptive servo-ventilation on survival and cardiovascular hospital admissions in patients with heart failure and sleep apnoea: the ADVENT-HF trial. Eur. J. Heart Fail. 2017;19 (4):579-587. doi: 10.1002/ejhf.790. PubMed PMID:28371141 .
  2. Kendzerska, T, Leung, RS, Gershon, AS, Tomlinson, G, Ayas, N. The Interaction of Obesity and Nocturnal Hypoxemia on Cardiovascular Consequences in Adults with Suspected Obstructive Sleep Apnea. A Historical Observational Study. Ann Am Thorac Soc. 2016;13 (12):2234-2241. doi: 10.1513/AnnalsATS.201604-263OC. PubMed PMID:27690206 .
  3. Kendzerska, T, Leung, RS. Going Beyond the Apnea-Hypopnea Index. Chest. 2016;149 (5):1349-50. doi: 10.1016/j.chest.2016.02.671. PubMed PMID:27157221 .
  4. Kendzerska, T, Gershon, AS, Tomlinson, G, Leung, RS. The Effect of Patient Neighborhood Income Level on the Purchase of Continuous Positive Airway Pressure Treatment among Patients with Sleep Apnea. Ann Am Thorac Soc. 2016;13 (1):93-100. doi: 10.1513/AnnalsATS.201505-294OC. PubMed PMID:26473580 .
  5. Kendzerska, T, Leung, RS, Hawker, G, Tomlinson, G, Gershon, AS. Obstructive sleep apnea and the prevalence and incidence of cancer. CMAJ. 2014;186 (13):985-92. doi: 10.1503/cmaj.140238. PubMed PMID:25096668 PubMed Central PMC4162778.
  6. Kendzerska, T, Gershon, AS, Hawker, G, Tomlinson, G, Leung, RS. Obstructive sleep apnea and incident diabetes. A historical cohort study. Am. J. Respir. Crit. Care Med. 2014;190 (2):218-25. doi: 10.1164/rccm.201312-2209OC. PubMed PMID:24897551 .
  7. Kendzerska, T, Gershon, AS, Hawker, G, Leung, RS, Tomlinson, G. Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study. PLoS Med. 2014;11 (2):e1001599. doi: 10.1371/journal.pmed.1001599. PubMed PMID:24503600 PubMed Central PMC3913558.
  8. Kendzerska, TB, Smith, PM, Brignardello-Petersen, R, Leung, RS, Tomlinson, GA. Evaluation of the measurement properties of the Epworth sleepiness scale: a systematic review. Sleep Med Rev. 2014;18 (4):321-31. doi: 10.1016/j.smrv.2013.08.002. PubMed PMID:24135493 .
  9. Kendzerska, T, Mollayeva, T, Gershon, AS, Leung, RS, Hawker, G, Tomlinson, G et al.. Untreated obstructive sleep apnea and the risk for serious long-term adverse outcomes: a systematic review. Sleep Med Rev. 2014;18 (1):49-59. doi: 10.1016/j.smrv.2013.01.003. PubMed PMID:23642349 .
  10. Leung, RS, Comondore, VR, Ryan, CM, Stevens, D. Mechanisms of sleep-disordered breathing: causes and consequences. Pflugers Arch. 2012;463 (1):213-30. doi: 10.1007/s00424-011-1055-x. PubMed PMID:22083643 .
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Affiliations & Other Activities

  • Director, Sleep Laboratory, St. Michael’s Hospital
  • Staff Physician, Respirology, St. Michael’s Hospital
  • Assistant Professor, Medicine, University of Toronto
  • Program Committee, Sleep and Respiratory Neurobiology Section, American Thoracic Society