Richard S. T. Leung




Research Interests

Sleep apnea, Cheyne-Stokes respiration, autonomic nervous system, heart rate variability

Research Activities

My main area of interest is the autonomic and cardiac effects of sleep apnea. In particular, I am interested in the ways sleep apnea can cause arrhythmias and other cardiac diseases. I perform both physiological studies in patients and healthy volunteers, as well as epidemiologic studies.

Recent Publications

  1. Kendzerska, T, Leung, RS, Boulos, MI, McIsaac, DI, Murray, BJ, Bryson, GL et al.. An Association Between Positive Airway Pressure (PAP) Device Manufacturer and Incident Cancer?: A Secondary Data Analysis. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202107-1734LE. PubMed PMID:34587472 .
  2. Ahmad, A, Ahmad, R, Meteb, M, Ryan, CM, Leung, RS, Montandon, G et al.. The relationship between opioid use and obstructive sleep apnea: A systematic review and meta-analysis. Sleep Med Rev. 2021;58 :101441. doi: 10.1016/j.smrv.2021.101441. PubMed PMID:33567395 .
  3. Kendzerska, T, Povitz, M, Leung, RS, Boulos, MI, McIsaac, DI, Murray, BJ et al.. Obstructive Sleep Apnea and Incident Cancer: A Large Retrospective Multicenter Clinical Cohort Study. Cancer Epidemiol Biomarkers Prev. 2021;30 (2):295-304. doi: 10.1158/1055-9965.EPI-20-0975. PubMed PMID:33268490 PubMed Central PMC7867627.
  4. Kendzerska, T, Leung, RS, Atzema, CL, Chandy, G, Meteb, M, Malhotra, A et al.. Cardiovascular consequences of obstructive sleep apnea in women: a historical cohort study. Sleep Med. 2020;68 :71-79. doi: 10.1016/j.sleep.2019.08.021. PubMed PMID:32028229 PubMed Central PMC7075717.
  5. Perger, E, Lyons, OD, Inami, T, Smith, S, Floras, JS, Logan, AG et al.. Predictors of 1-year compliance with adaptive servoventilation in patients with heart failure and sleep disordered breathing: preliminary data from the ADVENT-HF trial. Eur Respir J. 2019;53 (2):. doi: 10.1183/13993003.01626-2018. PubMed PMID:30409822 .
  6. Kendzerska, T, Leung, RS, Aaron, SD, Ayas, N, Sandoz, JS, Gershon, AS et al.. Cardiovascular Outcomes and All-Cause Mortality in Patients with Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease (Overlap Syndrome). Ann Am Thorac Soc. 2019;16 (1):71-81. doi: 10.1513/AnnalsATS.201802-136OC. PubMed PMID:30372124 .
  7. Leung, RS. Arousability in Obstructive Sleep Apnea: Friend or Foe?. Am J Respir Crit Care Med. 2019;199 (7):821-822. doi: 10.1164/rccm.201810-1935ED. PubMed PMID:30372123 PubMed Central PMC6444655.
  8. Kendzerska, T, Gershon, AS, Atzema, C, Dorian, P, Mangat, I, Hawker, G et al.. Sleep Apnea Increases the Risk of New Hospitalized Atrial Fibrillation: A Historical Cohort Study. Chest. 2018;154 (6):1330-1339. doi: 10.1016/j.chest.2018.08.1075. PubMed PMID:30243978 .
  9. Perger, E, Inami, T, Lyons, OD, Alshaer, H, Smith, S, Floras, JS et al.. Distinct Patterns of Hyperpnea During Cheyne-Stokes Respiration: Implication for Cardiac Function in Patients With Heart Failure. J Clin Sleep Med. 2017;13 (11):1235-1241. doi: 10.5664/jcsm.6788. PubMed PMID:29065956 PubMed Central PMC5656472.
  10. Kendzerska, T, Gershon, AS, Hawker, GA, Tomlinson, GA, Leung, RS. Obstructive sleep apnoea is not a risk factor for incident hospitalised depression: a historical cohort study. Eur Respir J. 2017;49 (6):. doi: 10.1183/13993003.01361-2016. PubMed PMID:28572118 .
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Affiliations & Other Activities

  • Director, Sleep Laboratory, St. Michael’s Hospital
  • Staff Physician, Division of Respirology, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Program Committee, Sleep and Respiratory Neurobiology Section, American Thoracic Society