Richard S. T. Leung


Associate Scientist, Li Ka Shing Knowledge Institute


Research Interests

Sleep apnea, Cheyne-Stokes respiration, autonomic nervous system, heart rate variability

Research Activities

My main area of interest is the autonomic and cardiac effects of sleep apnea. In particular, I am interested in the ways sleep apnea can cause arrhythmias and other cardiac diseases. I perform both physiological studies in patients and healthy volunteers, as well as epidemiologic studies.

Recent Publications

  1. Perger, E, Inami, T, Lyons, OD, Alshaer, H, Smith, S, Floras, JS et al.. Distinct Patterns of Hyperpnea During Cheyne-Stokes Respiration: Implication for Cardiac Function in Patients With Heart Failure. J Clin Sleep Med. 2017;13 (11):1235-1241. doi: 10.5664/jcsm.6788. PubMed PMID:29065956 PubMed Central PMC5656472.
  2. Kendzerska, T, Gershon, AS, Hawker, GA, Tomlinson, GA, Leung, RS. Obstructive sleep apnoea is not a risk factor for incident hospitalised depression: a historical cohort study. Eur. Respir. J. 2017;49 (6):. doi: 10.1183/13993003.01361-2016. PubMed PMID:28572118 .
  3. Lyons, OD, Floras, JS, Logan, AG, Beanlands, R, Cantolla, JD, Fitzpatrick, M et al.. Design of the effect of adaptive servo-ventilation on survival and cardiovascular hospital admissions in patients with heart failure and sleep apnoea: the ADVENT-HF trial. Eur. J. Heart Fail. 2017;19 (4):579-587. doi: 10.1002/ejhf.790. PubMed PMID:28371141 .
  4. Kendzerska, T, Leung, RS, Gershon, AS, Tomlinson, G, Ayas, N. The Interaction of Obesity and Nocturnal Hypoxemia on Cardiovascular Consequences in Adults with Suspected Obstructive Sleep Apnea. A Historical Observational Study. Ann Am Thorac Soc. 2016;13 (12):2234-2241. doi: 10.1513/AnnalsATS.201604-263OC. PubMed PMID:27690206 .
  5. Kendzerska, T, Leung, RS. Going Beyond the Apnea-Hypopnea Index. Chest. 2016;149 (5):1349-50. doi: 10.1016/j.chest.2016.02.671. PubMed PMID:27157221 .
  6. Kendzerska, T, Gershon, AS, Tomlinson, G, Leung, RS. The Effect of Patient Neighborhood Income Level on the Purchase of Continuous Positive Airway Pressure Treatment among Patients with Sleep Apnea. Ann Am Thorac Soc. 2016;13 (1):93-100. doi: 10.1513/AnnalsATS.201505-294OC. PubMed PMID:26473580 .
  7. Kendzerska, T, Leung, RS, Hawker, G, Tomlinson, G, Gershon, AS. Obstructive sleep apnea and the prevalence and incidence of cancer. CMAJ. 2014;186 (13):985-92. doi: 10.1503/cmaj.140238. PubMed PMID:25096668 PubMed Central PMC4162778.
  8. Kendzerska, T, Gershon, AS, Hawker, G, Tomlinson, G, Leung, RS. Obstructive sleep apnea and incident diabetes. A historical cohort study. Am. J. Respir. Crit. Care Med. 2014;190 (2):218-25. doi: 10.1164/rccm.201312-2209OC. PubMed PMID:24897551 .
  9. Kendzerska, T, Gershon, AS, Hawker, G, Leung, RS, Tomlinson, G. Obstructive sleep apnea and risk of cardiovascular events and all-cause mortality: a decade-long historical cohort study. PLoS Med. 2014;11 (2):e1001599. doi: 10.1371/journal.pmed.1001599. PubMed PMID:24503600 PubMed Central PMC3913558.
  10. Kendzerska, TB, Smith, PM, Brignardello-Petersen, R, Leung, RS, Tomlinson, GA. Evaluation of the measurement properties of the Epworth sleepiness scale: a systematic review. Sleep Med Rev. 2014;18 (4):321-31. doi: 10.1016/j.smrv.2013.08.002. PubMed PMID:24135493 .
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Affiliations & Other Activities

  • Director, Sleep Laboratory, St. Michael’s Hospital
  • Staff Physician, Division of Respirology, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Program Committee, Sleep and Respiratory Neurobiology Section, American Thoracic Society