Robert G. Josse

Dr. Josse will no longer be accepting any new summer students

Project Investigator, Li Ka Shing Knowledge Institute


Please note: Dr. Josse is not taking any summer students in 2019.

I have obtained peer reviewed and non-peer reviewed grants (mostly Phase II and III pharmaceutically funded multi-centre national and international studies) as principal, co-principal or co-investigator. These studies have investigated the effects of various new drugs on diabetes control, hyperlipidemia and prevention or treatment of diabetes complications. I have been particularly interested in the nutritional management of diabetes with other colleagues in the division (Jenkins, Vuksan, Wolever): we have promulgated the concept of the glycemic index of foods and the importance of meal frequency as therapeutic principles. Our more recent studies have moved into the area of disease prevention, e.g. diabetes, cardiovascular disease and osteoporosis using different nutraceuticals as well as drugs. We have also been investigating the potential efficacy of herbal and alternative medicine remedies, e.g. ginseng, Konjac-mannan.

Our group has been involved in a number of national and international osteoporosis studies in epidemiology, as well as phase III clinical drug trials. We collaborate widely with the Women’s Health Centre, rheumatology, physiatry, orthopedics and other disciplines within the hospital and city-wide. I am the director of the Toronto Centre of the CIHR-funded Canadian Multicentre Osteoporosis Study (CaMOS). The osteoporosis centre (of which I am the director) is a focus for clinical and epidemiologic research, as well as graduate and postgraduate education and general patient care.

Recent Publications

  1. Adachi, JD, Berger, C, Barron, R, Weycker, D, Anastassiades, TP, Davison, KS et al.. Predictors of imminent non-vertebral fracture in elderly women with osteoporosis, low bone mass, or a history of fracture, based on data from the population-based Canadian Multicentre Osteoporosis Study (CaMos). Arch Osteoporos. 2019;14 (1):53. doi: 10.1007/s11657-019-0598-x. PubMed PMID:31098708 .
  2. Bethel, MA, Engel, SS, Stevens, SR, Lokhnygina, Y, Ding, J, Josse, RG et al.. Progression of glucose-lowering diabetes therapy in TECOS. Endocrinol Diabetes Metab. 2019;2 (1):e00053. doi: 10.1002/edm2.53. PubMed PMID:30815579 PubMed Central PMC6354756.
  3. Li, G, Prior, JC, Leslie, WD, Thabane, L, Papaioannou, A, Josse, RG et al.. Frailty and Risk of Fractures in Patients With Type 2 Diabetes. Diabetes Care. 2019;42 (4):507-513. doi: 10.2337/dc18-1965. PubMed PMID:30692240 .
  4. Jenkins, DJA, Kendall, CWC, Lamarche, B, Banach, MS, Srichaikul, K, Vidgen, E et al.. Correction to: Nuts as a replacement for carbohydrates in the diabetic diet: a reanalysis of a randomised controlled trial. Diabetologia. 2019;62 (3):549-552. doi: 10.1007/s00125-018-4795-8. PubMed PMID:30617725 .
  5. Bliuc, D, Tran, T, van Geel, T, Adachi, JD, Berger, C, van den Bergh, J et al.. Mortality risk reduction differs according to bisphosphonate class: a 15-year observational study. Osteoporos Int. 2019;30 (4):817-828. doi: 10.1007/s00198-018-4806-0. PubMed PMID:30607457 .
  6. Braunstein, CR, Noronha, JC, Glenn, AJ, Viguiliouk, E, Noseworthy, R, Khan, TA et al.. A Double-Blind, Randomized Controlled, Acute Feeding Equivalence Trial of Small, Catalytic Doses of Fructose and Allulose on Postprandial Blood Glucose Metabolism in Healthy Participants: The Fructose and Allulose Catalytic Effects (FACE) Trial. Nutrients. 2018;10 (6):. doi: 10.3390/nu10060750. PubMed PMID:29890724 PubMed Central PMC6024645.
  7. Jenkins, DJA, Kendall, CWC, Lamarche, B, Banach, MS, Srichaikul, K, Vidgen, E et al.. Nuts as a replacement for carbohydrates in the diabetic diet: a reanalysis of a randomised controlled trial. Diabetologia. 2018;61 (8):1734-1747. doi: 10.1007/s00125-018-4628-9. PubMed PMID:29789878 PubMed Central PMC6061153.
  8. Gajic-Veljanoski, O, Papaioannou, A, Kennedy, C, Ioannidis, G, Berger, C, Wong, AKO et al.. Osteoporotic fractures and obesity affect frailty progression: a longitudinal analysis of the Canadian multicentre osteoporosis study. BMC Geriatr. 2018;18 (1):4. doi: 10.1186/s12877-017-0692-0. PubMed PMID:29304836 PubMed Central PMC5756402.
  9. Pagidipati, NJ, Navar, AM, Pieper, KS, Green, JB, Bethel, MA, Armstrong, PW et al.. Secondary Prevention of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus: International Insights From the TECOS Trial (Trial Evaluating Cardiovascular Outcomes With Sitagliptin). Circulation. 2017;136 (13):1193-1203. doi: 10.1161/CIRCULATIONAHA.117.027252. PubMed PMID:28626088 PubMed Central PMC5614823.
  10. Gibbs, JC, Giangregorio, LM, Wong, AKO, Josse, RG, Cheung, AM. Appendicular and whole body lean mass outcomes are associated with finite element analysis-derived bone strength at the distal radius and tibia in adults aged 40years and older. Bone. 2017;103 :47-54. doi: 10.1016/j.bone.2017.06.006. PubMed PMID:28614701 .
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Affiliations & Other Activities

  • Medical Director, Department of Medicine, Osteoporosis Centre, St. Michael’s Hospital
  • Professor, Department of Medicine, University of Toronto
  • Professor, Department of Nutritional Sciences, University of Toronto