Robert G. Josse

MBBS, BSc
Dr. Josse will no longer be accepting any new summer students

Investigator

Biography

Please note: Dr. Josse is not taking any summer students.

I have obtained peer reviewed and non-peer reviewed grants (mostly Phase II and III pharmaceutically funded multi-centre national and international studies) as principal, co-principal or co-investigator. These studies have investigated the effects of various new drugs on diabetes control, hyperlipidemia and prevention or treatment of diabetes complications. I have been particularly interested in the nutritional management of diabetes with other colleagues in the division (Jenkins, Vuksan, Wolever): we have promulgated the concept of the glycemic index of foods and the importance of meal frequency as therapeutic principles. Our more recent studies have moved into the area of disease prevention, e.g. diabetes, cardiovascular disease and osteoporosis using different nutraceuticals as well as drugs. We have also been investigating the potential efficacy of herbal and alternative medicine remedies, e.g. ginseng, Konjac-mannan.

Our group has been involved in a number of national and international osteoporosis studies in epidemiology, as well as phase III clinical drug trials. We collaborate widely with the Women’s Health Centre, rheumatology, physiatry, orthopedics and other disciplines within the hospital and city-wide. I am the director of the Toronto Centre of the CIHR-funded Canadian Multicentre Osteoporosis Study (CaMOS). The osteoporosis centre (of which I am the director) is a focus for clinical and epidemiologic research, as well as graduate and postgraduate education and general patient care.

Recent Publications

  1. Lentle, BC, Berger, C, Brown, JP, Probyn, L, Langsetmo, L, Hammond, I et al.. Vertebral Fractures: Which Radiological Criteria Are Better Associated With the Clinical Course of Osteoporosis?. Can Assoc Radiol J. 2021;72 (1):150-158. doi: 10.1177/0846537120943529. PubMed PMID:32755312 .
  2. Tran, T, Bliuc, D, Pham, HM, van Geel, T, Adachi, JD, Berger, C et al.. A Risk Assessment Tool for Predicting Fragility Fractures and Mortality in the Elderly. J Bone Miner Res. 2020;35 (10):1923-1934. doi: 10.1002/jbmr.4100. PubMed PMID:32460361 .
  3. Dhaliwal, R, Hans, D, Hattersley, G, Mitlak, B, Fitzpatrick, LA, Wang, Y et al.. Abaloparatide in Postmenopausal Women With Osteoporosis and Type 2 Diabetes: A Post Hoc Analysis of the ACTIVE Study. JBMR Plus. 2020;4 (4):e10346. doi: 10.1002/jbm4.10346. PubMed PMID:32258965 PubMed Central PMC7117849.
  4. Braunstein, CR, Noronha, JC, Khan, TA, Mejia, SB, Wolever, TM, Josse, RG et al.. Effect of fructose and its epimers on postprandial carbohydrate metabolism: A systematic review and meta-analysis. Clin Nutr. 2020;39 (11):3308-3318. doi: 10.1016/j.clnu.2020.03.002. PubMed PMID:32220498 .
  5. Li, G, Leslie, WD, Kovacs, CS, Prior, J, Josse, RG, Towheed, T et al.. Combining Frailty and Trabecular Bone Score Did Not Improve Predictive Accuracy in Risk of Major Osteoporotic Fractures. J Bone Miner Res. 2020;35 (6):1058-1064. doi: 10.1002/jbmr.3971. PubMed PMID:31995642 .
  6. Kamalinia, S, Josse, RG, Donio, PJ, Leduc, L, Shah, BR, Tobe, SW et al.. Risk of any hypoglycaemia with newer antihyperglycaemic agents in patients with type 2 diabetes: A systematic review and meta-analysis. Endocrinol Diabetes Metab. 2020;3 (1):e00100. doi: 10.1002/edm2.100. PubMed PMID:31922027 PubMed Central PMC6947712.
  7. Gregoire, P, Srinivasan Sridhar, V, Josse, RG, Reich, HN. The Case | Severe symptomatic hypocalcemia in a patient with sickle cell disease. Kidney Int. 2019;96 (6):1429-1430. doi: 10.1016/j.kint.2019.05.013. PubMed PMID:31759495 .
  8. Adachi, JD, Berger, C, Barron, R, Weycker, D, Anastassiades, TP, Davison, KS et al.. Predictors of imminent non-vertebral fracture in elderly women with osteoporosis, low bone mass, or a history of fracture, based on data from the population-based Canadian Multicentre Osteoporosis Study (CaMos). Arch Osteoporos. 2019;14 (1):53. doi: 10.1007/s11657-019-0598-x. PubMed PMID:31098708 .
  9. Bethel, MA, Engel, SS, Stevens, SR, Lokhnygina, Y, Ding, J, Josse, RG et al.. Progression of glucose-lowering diabetes therapy in TECOS. Endocrinol Diabetes Metab. 2019;2 (1):e00053. doi: 10.1002/edm2.53. PubMed PMID:30815579 PubMed Central PMC6354756.
  10. Li, G, Prior, JC, Leslie, WD, Thabane, L, Papaioannou, A, Josse, RG et al.. Frailty and Risk of Fractures in Patients With Type 2 Diabetes. Diabetes Care. 2019;42 (4):507-513. doi: 10.2337/dc18-1965. PubMed PMID:30692240 .
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Affiliations & Other Activities

  • Medical Director, Department of Medicine, Osteoporosis Centre, St. Michael’s Hospital
  • Professor, Department of Medicine, University of Toronto
  • Professor, Department of Nutritional Sciences, University of Toronto
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