Sandro B. Rizoli

MD, FRCSC, FACS, PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Sandro Rizoli received his Doctor of Medicine and completed a General Surgery residency in Brazil. Following medical school and residency, he moved to Canada in 1992 where he underwent a second residency in General Surgery, fellowships in Trauma and Critical Care and a Doctor of Philosophy under Dr. Ori Rotstein, St. Michael’s Surgeon-in-Chief.

In July 2002, Dr. Rizoli became Assistant Professor of Surgery and Critical Care Medicine at Sunnybrook, and was promoted to Full Professor in 2012. His life-long research focuses fall into two major areas: The immunological and anti-inflammatory effects of hypertonic fluids; and the physiopathology and management of hemorrhagic shock in trauma.

Dr. Rizoli was also appointed as the first St. Michael’s Hospital-University of Toronto Endowed Chair in Trauma Research beginning in July 2013. The five-year chair will support Dr. Rizoli’s research and innovation in trauma care. As a national leader in trauma resuscitation research, he plans to use the chair’s support to continue his work in developing new, more effective approaches to stopping life-threatening bleeding and ensuring that blood products are used appropriately in acute trauma patients.

As the director of trauma at St. Michael’s Hospital, Dr. Rizoli is uniquely positioned to apply his research discoveries to improve outcomes for trauma patients. St. Michael’s is one of 11 Ontario hospitals designated by the Ontario Ministry of Health and Long-Term Care as a Level 1 trauma center, equipped to receive the most severely injured patients.

Dr. Rizoli is also a full professor in the Department of Surgery and Critical Care Medicine at the University of Toronto and a research scientist at the Keenan Research Centre of the Li Ka Shing Knowledge Institute, chief of Region XII (Eastern Canada) of the Committee on Trauma of the American College of Surgeons and president of the Trauma Association of Canada.

Recent Publications

  1. Mahamad, S, Chaudhry, H, Nisenbaum, R, McFarlan, A, Rizoli, S, Ackery, A et al.. Exploring the effect of factor Xa inhibitors on rotational thromboelastometry: a case series of bleeding patients. J. Thromb. Thrombolysis. 2018; :. doi: 10.1007/s11239-018-1785-0. PubMed PMID:30506352 .
  2. Jones, AR, Patel, RP, Marques, MB, Donnelly, JP, Griffin, RL, Pittet, JF et al.. Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial. Ann Emerg Med. 2018; :. doi: 10.1016/j.annemergmed.2018.09.033. PubMed PMID:30447946 .
  3. Lester, ELW, Fox, EE, Holcomb, JB, Brasel, KJ, Bulger, EM, Cohen, MJ et al.. THE IMPACT OF HYPOTHERMIA ON OUTCOMES IN MASSIVELY TRANSFUSED PATIENTS. J Trauma Acute Care Surg. 2018; :. doi: 10.1097/TA.0000000000002144. PubMed PMID:30444856 .
  4. Jones, DG, Nantais, J, Rezende-Neto, JB, Yazdani, S, Vegas, P, Rizoli, S et al.. Crystalloid resuscitation in trauma patients: deleterious effect of 5L or more in the first 24h. BMC Surg. 2018;18 (1):93. doi: 10.1186/s12893-018-0427-y. PubMed PMID:30400852 PubMed Central PMC6219036.
  5. Wei, S, Gonzalez Rodriguez, E, Chang, R, Holcomb, JB, Kao, LS, Wade, CE et al.. Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial. J. Am. Coll. Surg. 2018;227 (6):587-595. doi: 10.1016/j.jamcollsurg.2018.09.003. PubMed PMID:30243993 PubMed Central PMC6252161.
  6. Lipowicz, AA, Cheskes, S, Gray, SH, Jeejeebhoy, F, Lee, J, Scales, DC et al.. Incidence, outcomes and guideline compliance of out-of-hospital maternal cardiac arrest resuscitations: A population-based cohort study. Resuscitation. 2018;132 :127-132. doi: 10.1016/j.resuscitation.2018.09.003. PubMed PMID:30201534 .
  7. Ten Broek, RPG, Krielen, P, Di Saverio, S, Coccolini, F, Biffl, WL, Ansaloni, L et al.. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group. World J Emerg Surg. 2018;13 :24. doi: 10.1186/s13017-018-0185-2. PubMed PMID:29946347 PubMed Central PMC6006983.
  8. Henry, B, Perez, A, Trpcic, S, Rizoli, S, Nascimento, B. Protecting study participants in emergency research: is community consultation before trial commencement enough?. Trauma Surg Acute Care Open. 2017;2 (1):e000084. doi: 10.1136/tsaco-2017-000084. PubMed PMID:29766088 PubMed Central PMC5877900.
  9. Gomez-Builes, JC, Acuna, SA, Nascimento, B, Madotto, F, Rizoli, SB. Harmful or Physiologic: Diagnosing Fibrinolysis Shutdown in a Trauma Cohort With Rotational Thromboelastometry. Anesth. Analg. 2018;127 (4):840-849. doi: 10.1213/ANE.0000000000003341. PubMed PMID:29683829 PubMed Central PMC6135473.
  10. Kelly, JM, Rizoli, S, Veigas, P, Hollands, S, Min, A. Using rotational thromboelastometry clot firmness at 5 minutes (ROTEM® EXTEM A5) to predict massive transfusion and in-hospital mortality in trauma: a retrospective analysis of 1146 patients. Anaesthesia. 2018;73 (9):1103-1109. doi: 10.1111/anae.14297. PubMed PMID:29658985 PubMed Central PMC6120456.
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Affiliations & Other Activities

  • Medical Director, Trauma and Acute Care Surgery, St. Michael’s Hospital
  • Chair in Trauma Research, St. Michael’s Hospital
  • Professor, Surgery and Critical Care Medicine, University of Toronto
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