Sharmistha Mishra

MD, PhD, MSc

Scientist, Li Ka Shing Knowledge Institute


Dr. Sharmistha Mishra is an infectious disease physician and mathematical modeler. After completing medical school and residency training (Internal Medicine, Infectious Diseases) at the University of Toronto, she obtained a Masters of Science degree in epidemiology and a Doctor of Philosophy in mathematical modelling at Imperial College London. She joined St. Michael’s Hospital in September 2014. She was also involved in the 2014-2015 Ebola response in Sierra Leone, as a consultant with the World Health Organization, from December 2014 to July 2015.

Graduate trainee supervisory appointments:

1. Institute of Medical Sciences
2. Dalla Lana School of Public Health Institute of Health Policy, Management, and Evaluation.

Mathematical modeling and epidemiology for HIV/STI Program Science

Our research focuses on answering questions about the biological, behavioural, and environmental (health systems and structural) mechanisms that underpin HIV and other sexually transmitted infection (STI) epidemics in different geo-social contexts. We develop and integrate mathematical models with the best available data to test hypotheses and to better inform clinical, programmatic, and policy decisions under a Program Science framework. We collaborate with the Ontario HIV Applied Epidemiology Unit, Public Health Ontario, and Winnipeg Regional Health Authority. We work closely with the Toronto Clinical HIV Prevention Unit, Centre for Global Public Health (University of Manitoba), HIV Modeling Consortium and the HPTN Modeling Centre (Imperial College), Karnataka Health Promotion Trust, Kenya HIV Technical Support Unit, Ukrainian Institute of Social Research, Johns Hopkins University Center for Public Health and Human Rights Key Population Program, and with program implementers and persons living with – and communities affected by – HIV/STIs in Canada (Ontario, Manitoba), India, Kenya, South Africa, and Ukraine.

Our objectives are to:

1) Appraise HIV/STI Epidemics (“know your epidemic”): to understand why HIV/STI epidemics establish and persist where and when they do, and what leads to differences in their trajectories, size, and characteristics across regions.

2) Maximize HIV/STI Program Impact (“plan the response”): to optimize the design and delivery of HIV/STI programs by health-system and epidemic context.

3) Forecast Data Priorities (“monitor and adapt the response”): to systematically assess the influence of data uncertainty on model projections in order to prioritize future data collection.

We have recently engaged in operational, clinical, and mathematical modeling studies on Ebola transmission and health-systems effects in Sierra Leone, and on tuberculosis transmission in urban India.

Our research is funded by CIHR, OHTN, NIH, and USAID.  Learn more about what we do via the IMS Raw Talk Podcast 


The team is recruiting data scientists (analysts and modelers), post-doctoral fellows, and welcomes graduate students at all levels and from diverse fields (computer science, physics, engineering, mathematics, epidemiology, statistics, geography, ecology, medicine, etc.) for supervision as part of IMS or IHPME. Students with quantitative and computer programming skills (in scripting and/or programming languages) and strong interest in mathematical modeling of HIV/STIs, complex adaptive systems, infectious disease epidemiology, classical epidemiology, statistics, data science, data visualization, or those interested in systematic reviews and meta-analyses to better inform modeling studies, are encouraged to touch base with us anytime.



Recent Publications

  1. Verma, TR, Painuly, NK, Mishra, SP, Singh, N, Bhatt, MLB, Jamal, N et al.. Evaluation of dose calculation accuracy of various algorithms in lung equivalent inhomogeneity: Comparison of calculated data with Gafchromic film measured results. J Cancer Res Ther. ;13 (6):1007-1014. doi: 10.4103/0973-1482.168992. PubMed PMID:29237967 .
  2. Gonzales, M, Qeadan, F, Mishra, SI, Rajput, A, Hoffman, RM. Racial-Ethnic Disparities in Late-Stage Colorectal Cancer Among Hispanics and Non-Hispanic Whites of New Mexico. Hisp Health Care Int. 2017;15 (4):180-188. doi: 10.1177/1540415317746317. PubMed PMID:29237342 .
  3. Houser, J, Kozmon, S, Mishra, D, Mishra, SK, Romano, PR, Wimmerová, M et al.. Influence of Trp flipping on carbohydrate binding in lectins. An example on Aleuria aurantia lectin AAL. PLoS ONE. 2017;12 (12):e0189375. doi: 10.1371/journal.pone.0189375. PubMed PMID:29232414 .
  4. Mishra, SK, Suryaprakash, N. Orchestrated Approaches Using Pure Shift NMR: Extraction of Spectral Parameters, Ultra High Resolution and Sensitivity Enhancement. Magn Reson Chem. 2017; :. doi: 10.1002/mrc.4696. PubMed PMID:29230870 .
  5. Zi Xu, YX, Ande, SR, Mishra, S. Prohibitin: A new player in immunometabolism and in linking obesity and inflammation with cancer. Cancer Lett. 2017; :. doi: 10.1016/j.canlet.2017.12.001. PubMed PMID:29222040 .
  6. Poshetti, D, Mishra, SK, Suryaprakash, N. The Intramolecular HB Interactions Evidenced in Dibenzoyl Oxalamide Derivatives : NMR, QTAIM, NCI Studies. J Phys Chem A. 2017; :. doi: 10.1021/acs.jpca.7b10598. PubMed PMID:29220174 .
  7. Thukral, V, Varshney, B, Ramly, RB, Ponia, SS, Mishra, SK, Olsen, CM et al.. s8ORF2 protein of infectious salmon anaemia virus is a RNA-silencing suppressor and interacts with Salmon salar Mov10 (SsMov10) of the host RNAi machinery. Virus Genes. 2017; :. doi: 10.1007/s11262-017-1526-z. PubMed PMID:29218433 .
  8. Dewangan, J, Srivastava, S, Mishra, S, Pandey, PK, Divakar, A, Rath, SK et al.. Chetomin induces apoptosis in human triple-negative breast cancer cells by promoting calcium overload and mitochondrial dysfunction. Biochem. Biophys. Res. Commun. 2017; :. doi: 10.1016/j.bbrc.2017.11.199. PubMed PMID:29208466 .
  9. Singh, A, Mandal, A, Patel, A, Mishra, S. Autoimmune Haemolytic Anaemia-A Spectrum of Presentation in Children. J Clin Diagn Res. 2017;11 (9):SR01-SR02. doi: 10.7860/JCDR/2017/27895.10646. PubMed PMID:29207801 PubMed Central PMC5713823.
  10. Osman, M, Paleti, R, Mishra, S. Analysis of passenger-car crash injury severity in different work zone configurations. Accid Anal Prev. 2017;111 :161-172. doi: 10.1016/j.aap.2017.11.026. PubMed PMID:29207311 .
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Affiliations & Other Activities

  • Clinician Scientist, Division of Infectious Disease, Department of Medicine, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto