Sheldon Cheskes



Research Programs


Dr. Sheldon Cheskes is an Associate Professor with the Division of Emergency Medicine, Department of Family and Community Medicine at the University of Toronto, and a scientist at the Li Ka Shing Knowledge Institute at St. Michael’s Hospital in Toronto, Ontario, Canada. He is the Medical Director for the Regions of Halton and Peel with the Sunnybrook Centre for Prehospital Medicine. He is one of the principal investigators for the Canadian Resuscitation Outcomes Consortium (CanROC) and is a recognized international authority in the area of CPR quality and out-of-hospital cardiac arrest resuscitation. Dr. Cheskes has published over 100 manuscripts in high impact journals such as the New England Journal of Medicine, Circulation, CMAJ and Resuscitation that have changed resuscitation practice around the world.

He is the principal investigator of the DOuble Sequential External Defibrillation in Refractory Ventricular Fibrillation (DOSE VF) trial. This study will be the first cluster randomized trial to clinically evaluate two novel therapeutic defibrillation strategies (double sequential external defibrillation and vector change defibrillation) against standard practice for patients remaining in refractory ventricular fibrillation during out-of-hospital cardiac arrest. He is also studying methods to improve public access defibrillation in rural and remote areas through the use of community responder programs and drone delivery of automated external defibrillators.

Recent Publications

  1. Cheskes, S, Hunter, M, Drennan, I. Just the facts: double sequential external defibrillation for refractory ventricular fibrillation. CJEM. 2021;23 (2):156-158. doi: 10.1007/s43678-020-00039-x. PubMed PMID:33709364 .
  2. Vaillancourt, C, Charette, M, Naidoo, S, Taljaard, M, Church, M, Hodges, S et al.. Multi-centre implementation of an Educational program to improve the Cardiac Arrest diagnostic accuracy of ambulance Telecommunicators and survival outcomes for sudden cardiac arrest victims: the EduCATe study design and methodology. BMC Emerg Med. 2021;21 (1):26. doi: 10.1186/s12873-021-00416-4. PubMed PMID:33663395 PubMed Central PMC7931555.
  3. Chu, J, Leung, KHB, Snobelen, P, Nevils, G, Drennan, IR, Cheskes, S et al.. Machine learning-based dispatch of drone-delivered defibrillators for out-of-hospital cardiac arrest. Resuscitation. 2021;162 :120-127. doi: 10.1016/j.resuscitation.2021.02.028. PubMed PMID:33631293 .
  4. Mohindra, R, Cheskes, S. Look through and see: Validation of a CPR artifact removal algorithm for AEDs used in OHCA. Resuscitation. 2021; :. doi: 10.1016/j.resuscitation.2021.02.027. PubMed PMID:33631290 .
  5. Leong, YC, Cheskes, S, Drennan, IR, Buick, JE, Latchmansingh, RG, Verbeek, PR et al.. Clinical considerations for out-of-hospital cardiac arrest management during COVID-19. Resusc Plus. 2020;4 :100027. doi: 10.1016/j.resplu.2020.100027. PubMed PMID:33403363 PubMed Central PMC7489886.
  6. Mody, P, Pandey, A, Slutsky, AS, Segar, MW, Kiss, A, Dorian, P et al.. Gender-Based Differences in Outcomes Among Resuscitated Patients With Out-of-Hospital Cardiac Arrest. Circulation. 2021;143 (7):641-649. doi: 10.1161/CIRCULATIONAHA.120.050427. PubMed PMID:33317326 .
  7. Drennan, IR, Dorian, P, McLeod, S, Pinto, R, Scales, DC, Turner, L et al.. DOuble SEquential External Defibrillation for Refractory Ventricular Fibrillation (DOSE VF): study protocol for a randomized controlled trial. Trials. 2020;21 (1):977. doi: 10.1186/s13063-020-04904-z. PubMed PMID:33243277 PubMed Central PMC7689391.
  8. Pepe, PE, Aufderheide, TP, Lamhaut, L, Davis, DP, Lick, CJ, Polderman, KH et al.. Rationale and Strategies for Development of an Optimal Bundle of Management for Cardiac Arrest. Crit Care Explor. 2020;2 (10):e0214. doi: 10.1097/CCE.0000000000000214. PubMed PMID:33134932 PubMed Central PMC7566870.
  9. Cheskes, S, Drennan, IR. Refibrillation after defibrillation: The shocking truth. Resuscitation. 2020;157 :269-271. doi: 10.1016/j.resuscitation.2020.10.010. PubMed PMID:33080367 .
  10. Natarajan, MK, Wijeysundera, HC, Oakes, G, Cantor, WJ, Miner, SES, Welsford, M et al.. Early Observations During the COVID-19 Pandemic in Cardiac Catheterization Procedures for ST-Elevation Myocardial Infarction Across Ontario. CJC Open. 2020;2 (6):678-683. doi: 10.1016/j.cjco.2020.07.015. PubMed PMID:32838257 PubMed Central PMC7376355.
Search PubMed

Affiliations & Other Activities

  • Associate Professor, Department of Family and Community Medicine, Division of Emergency Medicine, University of Toronto
  • Medical Director, Sunnybrook Centre for Prehospital Medicine