Sidney Kennedy


Scientist, Li Ka Shing Knowledge Institute

Research Programs


Dr. Sidney H. Kennedy is Professor of Psychiatry at the University of Toronto, the Arthur Sommer Rotenberg Chair in Suicide and Depression Studies, and a Scientist at Li Ka Shing Knowledge Institute and Toronto Western Research Institute, Toronto, Canada. Dr. Kennedy is the lead investigator for a large depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

He has published more than 350 peer reviewed publications and 11 books on depression and related topics.

Recent Publications

  1. Conde-Agudelo, A, Villar, J, Kennedy, SH, Papageorghiou, AT. Predictive accuracy of cerebroplacental ratio for adverse perinatal and neurodevelopmental outcomes in suspected fetal growth restriction: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018; :. doi: 10.1002/uog.19117. PubMed PMID:29920817 .
  2. Kennedy, SH, Heun, R, Avedisova, A, Ahokas, A, Olivier, V, Picarel-Blanchot, F et al.. Effect of agomelatine 25-50 mg on functional outcomes in patients with major depressive disorder. J Affect Disord. 2018;238 :122-128. doi: 10.1016/j.jad.2018.05.060. PubMed PMID:29879606 .
  3. Blumberger, DM, Vila-Rodriguez, F, Thorpe, KE, Feffer, K, Noda, Y, Giacobbe, P et al.. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial. Lancet. 2018;391 (10131):1683-1692. doi: 10.1016/S0140-6736(18)30295-2. PubMed PMID:29726344 .
  4. Lambert, C, Da Silva, S, Ceniti, AK, Rizvi, SJ, Foussias, G, Kennedy, SH et al.. Anhedonia in depression and schizophrenia: A transdiagnostic challenge. CNS Neurosci Ther. 2018;24 (7):615-623. doi: 10.1111/cns.12854. PubMed PMID:29687627 .
  5. Fettes, PW, Moayedi, M, Dunlop, K, Mansouri, F, Vila-Rodriguez, F, Giacobbe, P et al.. Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3 (4):337-347. doi: 10.1016/j.bpsc.2017.12.003. PubMed PMID:29628066 .
  6. Yatham, LN, Kennedy, SH, Parikh, SV, Schaffer, A, Bond, DJ, Frey, BN et al.. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord. 2018;20 (2):97-170. doi: 10.1111/bdi.12609. PubMed PMID:29536616 PubMed Central PMC5947163.
  7. Murray, E, Fernandes, M, Newton, CRJ, Abubakar, A, Kennedy, SH, Villar, J et al.. Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children. PLoS ONE. 2018;13 (2):e0193406. doi: 10.1371/journal.pone.0193406. PubMed PMID:29489865 PubMed Central PMC5831101.
  8. Parikh, SV, Kennedy, SH. More data, more answers: picking the optimal antidepressant. Lancet. 2018;391 (10128):1333-1334. doi: 10.1016/S0140-6736(18)30421-5. PubMed PMID:29477249 .
  9. Giacobbe, P, Rakita, U, Penner-Goeke, K, Feffer, K, Flint, AJ, Kennedy, SH et al.. Improvements in Health-Related Quality of Life With Electroconvulsive Therapy: A Meta-analysis. J ECT. 2018;34 (2):87-94. doi: 10.1097/YCT.0000000000000486. PubMed PMID:29461332 .
  10. Papageorghiou, AT, Kennedy, SH, Salomon, LJ, Altman, DG, Ohuma, EO, Stones, W et al.. The INTERGROWTH-21 fetal growth standards: toward the global integration of pregnancy and pediatric care. Am. J. Obstet. Gynecol. 2018;218 (2S):S630-S640. doi: 10.1016/j.ajog.2018.01.011. PubMed PMID:29422205 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network