Sidney Kennedy


Scientist, Li Ka Shing Knowledge Institute

Research Programs


Dr. Sidney H. Kennedy is Professor of Psychiatry at the University of Toronto, the Arthur Sommer Rotenberg Chair in Suicide and Depression Studies, and a Scientist at Li Ka Shing Knowledge Institute and Toronto Western Research Institute, Toronto, Canada. Dr. Kennedy is the lead investigator for a large depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

He has published more than 350 peer reviewed publications and 11 books on depression and related topics.

Recent Publications

  1. Daniels, S, Horman, T, Lapointe, T, Melanson, B, Storace, A, Kennedy, SH et al.. Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers. J Affect Disord. 2019;263 :353-366. doi: 10.1016/j.jad.2019.11.108. PubMed PMID:31969265 .
  2. Marshe, VS, Islam, F, Maciukiewicz, M, Fiori, LM, Yerko, V, Yang, J et al.. Validation study of microRNAs previously associated with antidepressant response in older adults treated for late-life depression with venlafaxine. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2020; :109867. doi: 10.1016/j.pnpbp.2020.109867. PubMed PMID:31954757 .
  3. Drukker, L, Staines-Urias, E, Villar, J, Barros, FC, Carvalho, M, Munim, S et al.. International gestational age-specific centiles for umbilical artery Doppler indices: a longitudinal prospective cohort study of the INTERGROWTH-21st Project. Am. J. Obstet. Gynecol. 2020; :. doi: 10.1016/j.ajog.2020.01.012. PubMed PMID:31954701 .
  4. Santesteban-Echarri, O, MacQueen, G, Goldstein, BI, Wang, J, Kennedy, SH, Bray, S et al.. Personality and risk for serious mental illness. Early Interv Psychiatry. 2020; :. doi: 10.1111/eip.12921. PubMed PMID:31910491 .
  5. Zhdanov, A, Atluri, S, Wong, W, Vaghei, Y, Daskalakis, ZJ, Blumberger, DM et al.. Use of Machine Learning for Predicting Escitalopram Treatment Outcome From Electroencephalography Recordings in Adult Patients With Depression. JAMA Netw Open. 2020;3 (1):e1918377. doi: 10.1001/jamanetworkopen.2019.18377. PubMed PMID:31899530 .
  6. Stowkowy, J, Goldstein, BI, MacQueen, G, Wang, J, Kennedy, SH, Bray, S et al.. Trauma in Youth At-Risk for Serious Mental Illness. J. Nerv. Ment. Dis. 2020;208 (1):70-76. doi: 10.1097/NMD.0000000000001069. PubMed PMID:31834192 .
  7. Yrondi, A, Fiori, LM, Frey, BN, Lam, RW, MacQueen, GM, Milev, R et al.. Association between side effects and blood microRNA expression levels and their targeted pathways in patients with major depressive disorder treated by a selective serotonin reuptake inhibitor, escitalopram: a CAN-BIND-1 report. Int. J. Neuropsychopharmacol. 2019; :. doi: 10.1093/ijnp/pyz066. PubMed PMID:31819986 .
  8. Hassel, S, Sharma, GB, Alders, GL, Davis, AD, Arnott, SR, Frey, BN et al.. Reliability of a functional magnetic resonance imaging task of emotional conflict in healthy participants. Hum Brain Mapp. 2019; :. doi: 10.1002/hbm.24883. PubMed PMID:31794150 .
  9. Alders, GL, Davis, AD, MacQueen, G, Strother, SC, Hassel, S, Zamyadi, M et al.. Escitalopram ameliorates differences in neural activity between healthy comparison and major depressive disorder groups on an fMRI Emotional conflict task: A CAN-BIND-1 study. J Affect Disord. 2019; :. doi: 10.1016/j.jad.2019.11.068. PubMed PMID:31757619 .
  10. Fonseka, TM, Pong, JT, Kcomt, A, Kennedy, SH, Parikh, SV. Collaborating with individuals with lived experience to adapt CANMAT clinical depression guidelines into a patient treatment guide: The CHOICE-D co-design process. J Eval Clin Pract. 2019; :. doi: 10.1111/jep.13308. PubMed PMID:31729117 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network