Sidney Kennedy


Scientist, Li Ka Shing Knowledge Institute

Research Programs


Dr. Sidney H. Kennedy is Professor of Psychiatry at the University of Toronto, the Arthur Sommer Rotenberg Chair in Suicide and Depression Studies, and a Scientist at Li Ka Shing Knowledge Institute and Toronto Western Research Institute, Toronto, Canada. Dr. Kennedy is the lead investigator for a large depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

He has published more than 350 peer reviewed publications and 11 books on depression and related topics.

Recent Publications

  1. Kennedy, SH, Lam, RW, Rotzinger, S, Milev, RV, Blier, P, Downar, J et al.. Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report. J Clin Psychiatry. 2019;80 (2):. doi: 10.4088/JCP.18m12202. PubMed PMID:30840787 .
  2. MacQueen, GM, Hassel, S, Arnott, SR, Jean, A, Bowie, CR, Bray, SL et al.. The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols. J Psychiatry Neurosci. 2019;44 (3):1-14. doi: 10.1503/jpn.180036. PubMed PMID:30840428 .
  3. Kaster, TS, Downar, J, Vila-Rodriguez, F, Thorpe, KE, Feffer, K, Noda, Y et al.. Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study. Am J Psychiatry. 2019; :appiajp201818091096. doi: 10.1176/appi.ajp.2018.18091096. PubMed PMID:30764649 .
  4. Slyepchenko, A, Allega, OR, Leng, X, Minuzzi, L, Eltayebani, MM, Skelly, M et al.. Association of functioning and quality of life with objective and subjective measures of sleep and biological rhythms in major depressive and bipolar disorder. Aust N Z J Psychiatry. 2019; :4867419829228. doi: 10.1177/0004867419829228. PubMed PMID:30759998 .
  5. Dhanju, S, Kennedy, SH, Abbey, S, Katz, J, Weinrib, A, Clarke, H et al.. The impact of comorbid pain and depression in the United States: results from a nationally representative survey. Scand J Pain. 2019; :. doi: 10.1515/sjpain-2018-0323. PubMed PMID:30759071 .
  6. Addington, J, Liu, L, Goldstein, BI, Wang, J, Kennedy, SH, Bray, S et al.. Clinical staging for youth at-risk for serious mental illness. Early Interv Psychiatry. 2019; :. doi: 10.1111/eip.12786. PubMed PMID:30672153 .
  7. Hirst, JE, Knight, HE, Ohuma, EO, Dwyer, T, Hennig, BD, Papageorghiou, AT et al.. Social gradient of birthweight in England assessed using the INTERGROWTH-21st gestational age-specific standard. Arch. Dis. Child. Fetal Neonatal Ed. 2018; :. doi: 10.1136/archdischild-2018-315295. PubMed PMID:30464006 .
  8. Arrua-Duarte, E, Migoya-Borja, M, Barrigón, ML, Barahona, I, Delgado-Gomez, D, Courtet, P et al.. Spanish adaptation of the Dimensional Anhedonia Rating Scale (DARS). J Affect Disord. 2019;245 :702-707. doi: 10.1016/j.jad.2018.11.040. PubMed PMID:30447569 .
  9. Romanowska, S, MacQueen, G, Goldstein, BI, Wang, J, Kennedy, SH, Bray, S et al.. Neurocognitive deficits in a transdiagnostic clinical staging model. Psychiatry Res. 2018;270 :1137-1142. doi: 10.1016/j.psychres.2018.10.030. PubMed PMID:30360915 .
  10. Allen, TA, Lam, RW, Milev, R, Rizvi, SJ, Frey, BN, MacQueen, GM et al.. Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: a CAN-BIND-1 report. Psychol Med. 2018; :1-10. doi: 10.1017/S0033291718002441. PubMed PMID:30220263 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network