Sidney Kennedy


Scientist, Li Ka Shing Knowledge Institute

Research Programs


Dr. Sidney H. Kennedy is Professor of Psychiatry at the University of Toronto, the Arthur Sommer Rotenberg Chair in Suicide and Depression Studies, and a Scientist at Li Ka Shing Knowledge Institute and Toronto Western Research Institute, Toronto, Canada. Dr. Kennedy is the lead investigator for a large depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

He has published more than 350 peer reviewed publications and 11 books on depression and related topics.

Recent Publications

  1. Sankar, T, Chakravarty, MM, Jawa, N, Li, SX, Giacobbe, P, Kennedy, SH et al.. Neuroanatomical predictors of response to subcallosal cingulate deep brain stimulation for treatment-resistant depression. J Psychiatry Neurosci. 2019;44 (6):1-10. doi: 10.1503/jpn.180207. PubMed PMID:31525860 .
  2. Romanowska, S, MacQueen, G, Goldstein, BI, Wang, J, Kennedy, SH, Bray, S et al.. Social and role functioning in youth at risk of serious mental illness. Early Interv Psychiatry. 2019; :. doi: 10.1111/eip.12872. PubMed PMID:31502422 .
  3. Davis, AD, Hassel, S, Arnott, SR, Harris, J, Lam, RW, Milev, R et al.. White Matter Indices of Medication Response in Major Depression: A Diffusion Tensor Imaging Study. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019; :. doi: 10.1016/j.bpsc.2019.05.016. PubMed PMID:31471185 .
  4. Alders, GL, Davis, AD, MacQueen, G, Strother, SC, Hassel, S, Zamyadi, M et al.. Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study. J Affect Disord. 2019;257 :765-773. doi: 10.1016/j.jad.2019.07.037. PubMed PMID:31400735 .
  5. Kennedy, SH, Gasonoo, M, Klumpp, DA. Superelectrophilic carbocations: preparation and reactions of a substrate with six ionizable groups. Beilstein J Org Chem. 2019;15 :1515-1520. doi: 10.3762/bjoc.15.153. PubMed PMID:31354869 PubMed Central PMC6633208.
  6. Fonseka, TM, Bhat, V, Kennedy, SH. The utility of artificial intelligence in suicide risk prediction and the management of suicidal behaviors. Aust N Z J Psychiatry. 2019; :4867419864428. doi: 10.1177/0004867419864428. PubMed PMID:31347389 .
  7. Brietzke, E, Hawken, ER, Idzikowski, M, Pong, J, Kennedy, SH, Soares, CN et al.. Integrating digital phenotyping in clinical characterization of individuals with mood disorders. Neurosci Biobehav Rev. 2019;104 :223-230. doi: 10.1016/j.neubiorev.2019.07.009. PubMed PMID:31330197 .
  8. Murphy, JK, Michalak, EE, Colquhoun, H, Woo, C, Ng, CH, Parikh, SV et al.. Methodological approaches to situational analysis in global mental health: a scoping review. Glob Ment Health (Camb). 2019;6 :e11. doi: 10.1017/gmh.2019.9. PubMed PMID:31258925 PubMed Central PMC6582459.
  9. Kennedy, SH, Victora, CG, Craik, R, Ash, S, Barros, FC, Barsosio, HC et al.. Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21 st Newborn Case-Control Study protocol. Gates Open Res. 2018;2 :49. doi: 10.12688/gatesopenres.12869.2. PubMed PMID:31172050 PubMed Central PMC6545521.
  10. Braun Janzen, T, Al Shirawi, MI, Rotzinger, S, Kennedy, SH, Bartel, L. A Pilot Study Investigating the Effect of Music-Based Intervention on Depression and Anhedonia. Front Psychol. 2019;10 :1038. doi: 10.3389/fpsyg.2019.01038. PubMed PMID:31133945 PubMed Central PMC6517496.
Search PubMed

Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network