Sidney Kennedy


Scientist, Li Ka Shing Knowledge Institute

Research Programs


Dr. Sidney H. Kennedy is Professor of Psychiatry at the University of Toronto, the Arthur Sommer Rotenberg Chair in Suicide and Depression Studies, and a Scientist at Li Ka Shing Knowledge Institute and Toronto Western Research Institute, Toronto, Canada. Dr. Kennedy is the lead investigator for a large depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

He has published more than 350 peer reviewed publications and 11 books on depression and related topics.

Recent Publications

  1. McInerney, SJ, Fallahi, A, Edgar, NE, Ceniti, AK, Rizvi, SJ, Beder, M et al.. Suicide-related presentations of homeless individuals to an inner-city emergency department. Gen Hosp Psychiatry. 2019; :. doi: 10.1016/j.genhosppsych.2019.05.001. PubMed PMID:31104829 .
  2. Belzeaux, R, Fiori, LM, Lopez, JP, Boucekine, M, Boyer, L, Blier, P et al.. Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment. J Clin Psychiatry. 2019;80 (3):. doi: 10.4088/JCP.18m12556. PubMed PMID:31087825 .
  3. Nogovitsyn, N, Souza, R, Muller, M, Srajer, A, Hassel, S, Arnott, SR et al.. Testing a deep convolutional neural network for automated hippocampus segmentation in a longitudinal sample of healthy participants. Neuroimage. 2019;197 :589-597. doi: 10.1016/j.neuroimage.2019.05.017. PubMed PMID:31075395 .
  4. Boschloo, L, Bekhuis, E, Weitz, ES, Reijnders, M, DeRubeis, RJ, Dimidjian, S et al.. The symptom-specific efficacy of antidepressant medication vs. cognitive behavioral therapy in the treatment of depression: results from an individual patient data meta-analysis. World Psychiatry. 2019;18 (2):183-191. doi: 10.1002/wps.20630. PubMed PMID:31059603 PubMed Central PMC6502416.
  5. Andreazza, AC, Laksono, I, Fernandes, BS, Toben, C, Lewczuk, P, Riederer, P et al.. Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity - a consensus of the Biomarkers Task Force from the WFSBP. World J. Biol. Psychiatry. 2019; :1-12. doi: 10.1080/15622975.2019.1574024. PubMed PMID:30907211 .
  6. Kennedy, SH, Lam, RW, Rotzinger, S, Milev, RV, Blier, P, Downar, J et al.. Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report. J Clin Psychiatry. 2019;80 (2):. doi: 10.4088/JCP.18m12202. PubMed PMID:30840787 .
  7. MacQueen, GM, Hassel, S, Arnott, SR, Jean, A, Bowie, CR, Bray, SL et al.. The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols. J Psychiatry Neurosci. 2019;44 (3):1-14. doi: 10.1503/jpn.180036. PubMed PMID:30840428 .
  8. Kaster, TS, Downar, J, Vila-Rodriguez, F, Thorpe, KE, Feffer, K, Noda, Y et al.. Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study. Am J Psychiatry. 2019;176 (5):367-375. doi: 10.1176/appi.ajp.2018.18091096. PubMed PMID:30764649 .
  9. Slyepchenko, A, Allega, OR, Leng, X, Minuzzi, L, Eltayebani, MM, Skelly, M et al.. Association of functioning and quality of life with objective and subjective measures of sleep and biological rhythms in major depressive and bipolar disorder. Aust N Z J Psychiatry. 2019; :4867419829228. doi: 10.1177/0004867419829228. PubMed PMID:30759998 .
  10. Dhanju, S, Kennedy, SH, Abbey, S, Katz, J, Weinrib, A, Clarke, H et al.. The impact of comorbid pain and depression in the United States: results from a nationally representative survey. Scand J Pain. 2019;19 (2):319-325. doi: 10.1515/sjpain-2018-0323. PubMed PMID:30759071 .
Search PubMed

Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network