Subodh Verma

MD, FRCSC, FAHA, PhD

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Subodh Verma is a cardiac surgeon-scientist at St. Michael’s Hospital, Professor at the University of Toronto and the Canada Research Chair in Atherosclerosis. He has been on the India Abroad Power List, recognized as one of Canada’s Top 40 under 40, and honoured with the Howard Morgan Award from the International Academy of Cardiovascular Sciences and the Royal College of Physicians and Surgeons of Canada Gold Medal in Surgery. He is a member of the Royal Society of Canada College of New Scholars, Artists and Scientists, and an inductee of the American Association of Thoracic Surgeons. Dr.Verma runs a practice that encompasses the entire spectrum of adult cardiac surgery (with a special interest in mitral valve repair and bicuspid aortopathy).

He is involved in several clinical trials and oversees a dynamic pre-clinical research laboratory that focuses on the roles of risk factors, inflammation and autophagy in cardiovascular health. His innovative research has culminated in nearly 300 peer-reviewed papers and two United States patents. Dr.Verma’s meta-analysis revealing that bypass surgery is superior to angioplasty in patients with diabetes has been used by the American College of Cardiology and the Canadian Cardiovascular Society (CCS) to shape the recommendations around the best clinical choice for revascularization procedures involving individuals with diabetes. He has contributed to the CCS guidelines for antiplatelet therapy, atrial fibrillation, dyslipidemia, peripheral arterial disease, and stable coronary artery disease; Canadian Cardiovascular Surgery Position Statement and Canadian Cardiometabolic Risk Position Paper. Dr.Verma spearheads the CARDIOLINK platform that will conduct clinical trials in atrial fibrillation, aneurysm and cerebral protection, diabetes and secondary prevention, valvular heart disease, and critical limb ischemia. He (co-)founded and (co-)chairs many regional and national educational initiatives that include the Landmark Lecture, State of the Heart Symposium, Toronto Acute Coronary Syndrome Summit, St. Michael’s Heart Valve Summit, Advances in Cardiology, Current Issues in Cardiology, and At the Heart of Diabetes programs.

 

Recent Publications

  1. Mancini, GBJ, Farkouh, M, Verma, S. Revascularization for patients with diabetes mellitus and stable ischemic heart disease: an update. Curr. Opin. Cardiol. 2017; :. doi: 10.1097/HCO.0000000000000421. PubMed PMID:28538000 .
  2. Mantella, LE, Singh, KK, Sandhu, P, Kantores, C, Ramadan, A, Khyzha, N et al.. Fingerprint of long non-coding RNA regulated by cyclic mechanical stretch in human aortic smooth muscle cells: implications for hypertension. Mol. Cell. Biochem. 2017; :. doi: 10.1007/s11010-017-3065-2. PubMed PMID:28526936 .
  3. Hussain, MA, Mamdani, M, Tu, JV, Saposnik, G, Aljabri, B, Bhatt, DL et al.. Long-term Outcomes of Carotid Endarterectomy Versus Stenting in a Multicenter Population-based Canadian Study. Ann. Surg. 2017; :. doi: 10.1097/SLA.0000000000002301. PubMed PMID:28498234 .
  4. Verma, S, Goldenberg, RM, Bhatt, DL, Farkouh, ME, Quan, A, Teoh, H et al.. Dipeptidyl peptidase-4 inhibitors and the risk of heart failure: a systematic review and meta-analysis. CMAJ Open. ;5 (1):E152-E177. doi: 10.9778/cmajo.20160058. PubMed PMID:28459046 PubMed Central PMC5403656.
  5. McCarthy, CP, Verma, S, Bhatt, DL. The Management of Antiplatelet and Antithrombotic Regimens in Patients With Mechanical Valves Undergoing Percutaneous Coronary Intervention: A Forgotten Cohort?. JAMA Cardiol. 2017; :. doi: 10.1001/jamacardio.2017.0930. PubMed PMID:28445573 .
  6. Yau, JW, Singh, KK, Hou, Y, Lei, X, Ramadan, A, Quan, A et al.. Endothelial-specific deletion of autophagy-related 7 (ATG7) attenuates arterial thrombosis in mice. J. Thorac. Cardiovasc. Surg. 2017; :. doi: 10.1016/j.jtcvs.2017.02.058. PubMed PMID:28400112 .
  7. Shi, X, Verma, S, Yun, J, Brand-Arzamendi, K, Singh, KK, Liu, X et al.. Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?. Mol. Cell. Biochem. 2017; :. doi: 10.1007/s11010-017-3018-9. PubMed PMID:28391552 .
  8. Singh, KK, Matkar, PN, Pan, Y, Quan, A, Gupta, V, Teoh, H et al.. Endothelial long non-coding RNAs regulated by oxidized LDL. Mol. Cell. Biochem. 2017; :. doi: 10.1007/s11010-017-2984-2. PubMed PMID:28316063 .
  9. Quan, A, Pan, Y, Singh, KK, Polemidiotis, J, Teoh, H, Leong-Poi, H et al.. Cardiovascular inflammation is reduced with methotrexate in diabetes. Mol. Cell. Biochem. 2017; :. doi: 10.1007/s11010-017-3006-0. PubMed PMID:28303409 .
  10. Yanagawa, B, Verma, S, Mazine, A, Tam, DY, Jüni, P, Puskas, JD et al.. Impact of total arterial revascularization on long term survival: A systematic review and meta-analysis of 130,305 patients. Int. J. Cardiol. 2017;233 :29-36. doi: 10.1016/j.ijcard.2017.02.010. PubMed PMID:28185702 .
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Affiliations & Other Activities

  • Staff Surgeon, Division of Cardiology , St. Michael’s Hospital
  • Professor, Department of Surgery and Pharmacology & Toxicology, University of Toronto